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Tomoko Yasuhiro
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Journal Articles

ONO-7018, a First-in-Class MALT1 Inhibitor, Provides Novel Therapeutic Strategies for B Cell Malignancies: Overcoming BTK Inhibitor Acquired Resistance and Enhancing the Antitumor Effect of BTK Inhibitors

Ryu Fujikawa, Yuka Komichi, Kazuya Ono, Tomoko Yasuhiro, Sergio Prados, Takao Yoshida, Ryohei Kozaki
Journal: Blood
Blood (2023) 142 (Supplement 1): 5779.
https://doi.org/10.1182/blood-2023-185997
Published: 2023
Journal Articles

AXL/Mertk Inhibitor ONO-7475 Potently Synergizes with BCL2 Inhibitor ABT-199, Overcomes ABT-199 Resistance Mechanisms, and Kills FLT3 ITD AML Cells

Sean M Post, PhD, Huaxian Ma, MS, Vivian Ruvolo, Xiaorui Zhang, BS, Tomoko Yasuhiro, Kohei Tanaka, Ryohei Kozaki, Toshio Yoshizawa, PhD, Jorge E. Cortes, MD, Courtney D. DiNardo, MDMSc, Marina Y Konopleva, MD PhD, Steven M. Kornblau, MD, Joseph D. Khoury, MD, Michael Andreeff, MD PhD, Peter P. Ruvolo, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2550.
https://doi.org/10.1182/blood-2019-128626
Published: 2019
Journal Articles

TAM Inhibitor ONO-7475 Combination with Sorafenib Is Effective Using in Vitro and In Vivo Models of FLT3 ITD Acute Myeloid Leukemia

Peter P. Ruvolo, PhD, Huaxian Ma, MS, Vivian Ruvolo, MS, Xiaorui Zhang, BS, Hong Mu, MD PhD, Tomoko Yasuhiro, Kohei Tanaka, Toshio Yoshizawa, PhD, Weiguo Zhang, MD PhD, Jorge E. Cortes, MD, Michael Andreeff, MD PhD, Sean M Post, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2642.
https://doi.org/10.1182/blood-2018-99-112211
Published: 2018
Journal Articles

AXL Inhibitor ONO-9330547 Suppresses PLK1 Gene and Protein Expression and Effectively Induces Growth Arrest and Apoptosis in FLT3 ITD Acute Myeloid Leukemia Cells

Peter Ruvolo, PhD, Huaxian Ma, BS, Vivian Ruvolo, MS, Hong Mu, MD PhD, Wendy Schober, Tomoko Yasuhiro, Toshio Yoshizawa, PhD, Miguel Gallardo, PhD, Xiaorui Zhang, BS, Joseph D Khoury, MD, Jorge Cortes, MD, Michael Andreeff, MD PhD, Sean M. Post, PhD
Journal: Blood
Blood (2016) 128 (22): 3939.
https://doi.org/10.1182/blood.V128.22.3939.3939
Published: 2016
Journal Articles

ONO-4059—a Potent and Selective Reversible Bruton’s Tyrosine Kinase (Btk) Inhibitor: Single Agent, Twice Daily (BD) Dosing and Dosing with Food Results in Sustained, High Trough Levels of ONO-4059, Translating into 100% Tumour Remission in a TMD-8 Xenograft Model

Toshio Yoshizawa, Tomoko Yasuhiro, Hideyuki Honda, Kazuhito Kawabata, PhD
Journal: Blood
Blood (2014) 124 (21): 4502.
https://doi.org/10.1182/blood.V124.21.4502.4502
Published: 2014
Journal Articles

The Bruton’s Tyrosine Kinase (BTK) Inhibitor ONO-4059: Promising Single Agent Activity and Well Tolerated in Patients with High Risk Chronic Lymphocytic Leukaemia (CLL)

Christopher Fegan, Joanne Bagshawe, Gilles Salles, MDPhD, Lionel Karlin, Simon Rule, Nimish Shah, Franck Morschhauser, Louis Terriou, Martin JS Dyer, Harriet Walter, Claire Hutchinson, Guillaume Cartron, MD, John Sharpe, Kevin Duffy, Akhisa Nishimura, Shin-ichiro Abe, Hideyuki Honda, Tomoko Yasuhiro, Toshio Yoshizawa, Joseph Birkett, Nigel Courtenay-Luck
Journal: Blood
Blood (2014) 124 (21): 3328.
https://doi.org/10.1182/blood.V124.21.3328.3328
Published: 2014
Journal Articles

Development of an Axl/Mer Dual Inhibitor, ONO-9330547: Promising Single Agent Activity in an Acute Myeloid Leukemia (AML) Model

Tomoko Yasuhiro, Toshio Yoshizawa, Ryu Fujikawa, PhD, Kohei Tanaka, PhD, Tomoya Koike, Kazuhito Kawabata, PhD
Journal: Blood
Blood (2014) 124 (21): 999.
https://doi.org/10.1182/blood.V124.21.999.999
Published: 2014
Journal Articles

Anti-Tumour Efficacy Study Of The Bruton’s Tyrosine Kinase (Btk) Inhibitor, ONO-4059, In Combination With The Glycoengineered Type II Anti-CD20 Monoclonal Antibody, Obinutuzumab (GA101) Demonstrates Superior In Vivo Efficacy Compared To ONO-4059 In Combination With Rituximab

Toshio Yoshizawa, PhD, Tomoko Yasuhiro, Joseph TP Birkett, PhD, Christian Klein, PhD, Kazuhito Kawabata, PhD
Journal: Blood
Blood (2013) 122 (21): 3069.
https://doi.org/10.1182/blood.V122.21.3069.3069
Published: 2013
Journal Articles

ONO-4059, A Novel Bruton’s Tyrosine Kinase (Btk) Inhibitor: Synergistic Activity In Combination With Chemotherapy In a ABC-DLBCL Cell Line

Tomoko Yasuhiro, Toshio Yoshizawa, PhD, Joseph TP Birkett, PhD, Kazuhito Kawabata, PhD
Journal: Blood
Blood (2013) 122 (21): 5151.
https://doi.org/10.1182/blood.V122.21.5151.5151
Published: 2013
Journal Articles

Development of a Bruton's Tyrosine Kinase (Btk) Inhibitor, ONO-WG-307: Efficacy in ABC-DLBCL Xenograft Model – Potential Treatment for B-Cell Malignancies,

Ryohei Kozaki, Toshio Yoshizawa, Shuji Tohda, MD, PhD, Tomoko Yasuhiro, Shingo Hotta, Yuko Ariza, Yoshiko Ueda, Masami Narita, Kazuhito Kawabata
Journal: Blood
Blood (2011) 118 (21): 3731.
https://doi.org/10.1182/blood.V118.21.3731.3731
Published: 2011