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Baozhen Ke
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Journal Articles

Targeting Co-Regulatory Feedback Loop of MYC and GSPT1 By MYC/GSPT1 Dual Degradation Is Synthetic Lethal in Combination with Ven/Aza in TP53 Mutant Acute Myeloid Leukemia Stem and Progenitor Cells

Yuki Nishida, Hideaki Mizuno, Edward Ayoub, Eiji Sugihara, Lauren B. Ostermann, Shayaun Khazaei, Darah Scruggs, Po Yee Mak, Baozhen Ke, Bing Z. Carter, Abhishek Maiti, Liandong Ma, Michael Andreeff
Journal: Blood
Blood (2024) 144 (Supplement 1): 2755.
https://doi.org/10.1182/blood-2024-207812
Published: 2024
Journal Articles

Reactivation of p53 in TP53 -Y220C Mutant AML: Mechanism of Action and Mechanism-Based Drug Combinations

Bing Z. Carter, Po Yee Mak, Baozhen Ke, Xiaogang Wu, Steffen Boettcher, Lauren B. Ostermann, Andrea Bedoy, Georgina Gener-Ricos, Jayastu Senapati, Courtney D. DiNardo, Anna Puzio-Kuter, Arnold Levine, Michael Andreeff
Journal: Blood
Blood (2024) 144 (Supplement 1): 4155.
https://doi.org/10.1182/blood-2024-208403
Published: 2024
Journal Articles

Novel Hypomethylating Agent Ntx-301 Exhibits Anti-Leukemia Activity in Venetoclax-Resistant and TP53-Mutant AML

Bing Z. Carter, Po Yee Mak, Baozhen Ke, Andrea Bedoy, Steffen Boettcher, Lauren B. Ostermann, Elizabeth J. Shpall, Michael Andreeff
Journal: Blood
Blood (2023) 142 (Supplement 1): 4158.
https://doi.org/10.1182/blood-2023-180051
Published: 2023
Journal Articles

Calibrated Release IL15 Bivalent CD33 and/or FLT3 and NOT Emcn Logic Gated Gene Circuit CAR-NK Cell Therapy (SENTI-202) in Venetoclax Resistant Patient Derived Xenograft Acute Myeloid Leukemia Models

Muharrem Muftuoglu, Mahesh Basyal, Li Li, Jiangxing Lv, Lauren B. Ostermann, Ran Zhao, Baozhen Ke, Hiroki Akiyama, Po Yee Mak, Bing Z. Carter, Han Deng, Yongshuai Li, Brian S. Garrison, Kanya L. Rajangam, Michael Andreeff
Journal: Blood
Blood (2023) 142 (Supplement 1): 4831.
https://doi.org/10.1182/blood-2023-191127
Published: 2023
Journal Articles

Selective Targeting of TP53-Y220C Mutant AML By PC14586 Results in TP53 Wild-Type Conformation and Synergistical Apoptosis Induction By Concomitant Inhibition of Xpo-1, MDM2, or Bcl-2

Bing Z. Carter, Po Yee Mak, Baozhen Ke, Yuki Nishida, Steffen Boettcher, Andrea Bedoy, Lauren B. Ostermann, Courtney D. DiNardo, Anna Puzio-Kuter, Arnold Levine, Michael Andreeff
Journal: Blood
Blood (2023) 142 (Supplement 1): 2261.
https://doi.org/10.1182/blood-2023-181186
Published: 2023
Journal Articles

ERK1/2 Inhibition Overcomes Resistance to Venetoclax in AML By Inhibiting Drp1 Dependent Mitochondrial Fission

Priyanka Sharma, Lauren B. Ostermann, Sujan Piya, Baozhen Ke, Natalia Baran, Anudishi Tyagi, Muharrem Muftuoglu, Mahesh Basyal, Qi Zhang, Joanne Munck, Kim-Hien Dao, Martin Sims, Bing Z. Carter, Venkata Lokesh Battula, Michael Andreeff, Gautam Borthakur
Journal: Blood
Blood (2023) 142 (Supplement 1): 412.
https://doi.org/10.1182/blood-2023-185700
Published: 2023
Journal Articles

Epichaperome inhibition targets TP53- mutant AML and AML stem/progenitor cells

Bing Z. Carter, Po Yee Mak, Muharrem Muftuoglu, Wenjing Tao, Baozhen Ke, Jingqi Pei, Andrea D. Bedoy, Lauren B. Ostermann, Yuki Nishida, Sevinj Isgandarova, Mary Sobieski, Nghi Nguyen, Reid T. Powell, Margarita Martinez-Moczygemba, Clifford Stephan, Mahesh Basyal, Naveen Pemmaraju, Steffen Boettcher, Benjamin L. Ebert, Elizabeth J. Shpall, Barbara Wallner, Robert A. Morgan, Georgios I. Karras, Ute M. Moll, Michael Andreeff
Journal: Blood
Blood (2023) 142 (12): 1056–1070.
https://doi.org/10.1182/blood.2022019047
Published: 2023
Includes: Supplemental data