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Liandong Ma
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Journal Articles

Protein degradation of MYC/GSPT1 combined with menin inhibition overcomes resistance to menin inhibition in KMT2A-rearranged Acute Myeloid Leukemia

Free
Shayaun Khazaei, Shreya Nair, Lauren Ostermann, Hideaki Mizuno, Po Yee Mak, Bing Carter, Steffen Boettcher, Liandong Ma, Miriam Garcia, Branko Cuglievan, Alexandra McLean Stevens, Michael Andreeff, Yuki Nishida
Journal: Blood
Blood (2025) 146 (Supplement 1): 1510.
https://doi.org/10.1182/blood-2025-1510
Published: 2025
Journal Articles

Protein degradation of MYC/GSPT1 is a novel treatment modality for aggressive T-cell acute lymphoblastic leukemias

Free
Mikaela Garza, Shayaun Khazaei, Faryal Munir, Phoebe Calkins, Darah Threat, Hideaki Mizuno, Lauren Ostermann, Branko Cuglievan, Miriam Garcia, Liandong Ma, Michael Andreeff, Yuki Nishida
Journal: Blood
Blood (2025) 146 (Supplement 1): 1539.
https://doi.org/10.1182/blood-2025-1539
Published: 2025
Journal Articles

Overcoming midostaurin resistance via dual MYC and GSPT1 degradation by the protac GT19715 in FLT3-amplified AML cells

Free
Xuan Zhang, Kazuhiro Katayama, Namiko Nomura, Eiji Sugihara, Kaori Saito, Fumiaki Sato, Hideaki Mizuno, Mizuki Fuakase, Pei Gao, Jing Bai, Kotoko Yamatani, Liandong Ma, Michael Andreeff, Yuki Nishida, Yoko Tabe
Journal: Blood
Blood (2025) 146 (Supplement 1): 3271.
https://doi.org/10.1182/blood-2025-3271
Published: 2025
Journal Articles

Targeting Co-Regulatory Feedback Loop of MYC and GSPT1 By MYC/GSPT1 Dual Degradation Is Synthetic Lethal in Combination with Ven/Aza in TP53 Mutant Acute Myeloid Leukemia Stem and Progenitor Cells

Free
Yuki Nishida, Hideaki Mizuno, Edward Ayoub, Eiji Sugihara, Lauren B. Ostermann, Shayaun Khazaei, Darah Scruggs, Po Yee Mak, Baozhen Ke, Bing Z. Carter, Abhishek Maiti, Liandong Ma, Michael Andreeff
Journal: Blood
Blood (2024) 144 (Supplement 1): 2755.
https://doi.org/10.1182/blood-2024-207812
Published: 2024
Journal Articles

C-MYC Targeting By Degradation: Novel Dual c-Myc/GSPT1 Degrader GT19715 Induces TP53 -Independent Cell Death in Acute Myeloid Leukemia and Lymphomas

Free
Yuki Nishida, Darah A Scruggs, Edward Ayoub, Tallie Patsilevas, Vivian Ruvolo, Po Yee Mak, Bing Z Carter, Steffen Boettcher, Abhishek Maiti, Qianxiang Zhou, Zhaohui Yang, Honghua Yan, Liandong Ma, Michael Andreeff
Journal: Blood
Blood (2022) 140 (Supplement 1): 483–484.
https://doi.org/10.1182/blood-2022-164968
Published: 2022
Journal Articles

Efficacy of LY2784544, a Small Molecule Inhibitor Selective for Mutant JAK2 Kinase, In JAK2 V617F -Induced Hematologic Malignancy Models

Free
Liandong Ma, Ph., D, Baohui Zhao, Ms, Richard Walgren, MD, PhD, Joshua A Clayton, MS, Wayne D Blosser, Timothy P Burkholder, Ph.D, Michele C Smith, PhD
Journal: Blood
Blood (2010) 116 (21): 4087.
https://doi.org/10.1182/blood.V116.21.4087.4087
Published: 2010
Journal Articles

LY2784544, a Novel JAK2 Inhibitor, Decreases In Vitro Growth of Hematopoietic Human Progenitors From JAK2 V617F Positive Polycythemia Vera Patients

Free
Lourdes Florensa, Beatriz Bellosillo, Leonor Arenillas, Liandong Ma, Ph., D, Richard Walgren, MD, PhD, Alberto Alvarez, Judit Gonzalez, Rosa M Vila, Raquel Longarón, Carles Besses
Journal: Blood
Blood (2010) 116 (21): 5054.
https://doi.org/10.1182/blood.V116.21.5054.5054
Published: 2010