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Journal Articles

Luspatercept Promotes Heme Biosynthesis and Erythroblast Island Formation in a Novel Low-Risk MDS Mouse Model

Maiko Sezaki, Asumi Yokota, Xuan Zhang, Mingzhe Pan, Zhihong Wang, Michihiro Hashimoto, Zohra Nooruddin, Eric M. Pietras, Nathan Salomonis, H. Leighton Grimes, Gang Huang

Blood (2024) 144 (Supplement 1): 877.

https://doi.org/10.1182/blood-2024-203695

Published: 2024

Journal Articles

MISTRG6kit W41 : Enhanced Engraftment in a Cytokine Humanized Patient-Derived Xenotransplantation Mouse Model

Amro Baassiri, Jamie Maziarz, Holly Nicole Blackburn, Hannah Maul-Newby, Jennifer VanOudenhove, Xuan Zhang, Martin Matthews, Sambuddha Paul, Wei Liu, Esen Sefik, Nathan Salomonis, H. Leighton Grimes, Richard Flavell, Stephanie Halene

Blood (2024) 144 (Supplement 1): 1815.

https://doi.org/10.1182/blood-2024-211908

Published: 2024

Journal Articles

Clonal Dissection of MDS and Secondary AML Resolves Shared Splicing Neoantigens and Mechanistic Underpinnings of Hypomethylating Agent Therapeutic Response

Xuan Zhang, Guangyuan Li, Anna Oliverio, Jennifer VanOudenhove, Amy E. DeZern, Gabriel Ghiaur, Stephanie Halene, H. Leighton Grimes, Nathan Salomonis

Blood (2024) 144 (Supplement 1): 1810.

https://doi.org/10.1182/blood-2024-211099

Published: 2024

Journal Articles

Real-World Clinical Outcomes in Patients Initiating Covalent Btki (cBTKi) with and without Incident Cardiovascular Adverse Events By Line of Therapy for Chronic Lymphocytic Leukemia (CLL) and Small Lymphocytic Lymphoma (SLL)

David Dingli, Enrico De Nigris, Siyang Leng, Mohammed Z. H. Farooqui, Halit O. Yapici, Ian Weimer, Weiqi Jiao, Hayden W. Hyatt, Xuan Zhang, Kunal Lodaya, Mavis Obeng-Kusi

Blood (2024) 144 (Supplement 1): 3722.

https://doi.org/10.1182/blood-2024-198469

Published: 2024

Journal Articles

Healthcare Resource Utilization and Costs in Patients with Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Lymphoma (SLL) Treated with Covalent Btki (cBTKi): Real-World Impact of Cardiovascular Adverse Events

Mavis Obeng-Kusi, Enrico De Nigris, Siyang Leng, Mohammed Z. H. Farooqui, Halit O. Yapici, Ian Weimer, Weiqi Jiao, Hayden W. Hyatt, Xuan Zhang, Kunal Lodaya, David Dingli

Blood (2024) 144 (Supplement 1): 3738.

https://doi.org/10.1182/blood-2024-200345

Published: 2024

Journal Articles

Single-Cell Multiomics Reveal Hypomethylating Agent Partially Restores Hematopoiesis in a LR-MDS Patient at the Cost of Leukemic Transformation

Xuan Zhang, Baobao (Annie) Song, Mohammad Daud Khan, Kyle Ferchen, Chih-Hsing Chou, Guangyuan Li, Amy E. DeZern, Gabriel Ghiaur, Stephanie Halene, Nathan Salomonis, H. Leighton Grimes

Blood (2022) 140 (Supplement 1): 9759–9760.

https://doi.org/10.1182/blood-2022-169300

Published: 2022

Journal Articles

Identification and Isolation of Hematopoietic Stem Cells and Progenitors with Discrete Developmental Gene Expression Programs

Kyle Ferchen, Baobao (Annie) Song, Chih-Hsing Chou, Xuan Zhang, Nathan Salomonis, H. Leighton Grimes

Blood (2022) 140 (Supplement 1): 2856.

https://doi.org/10.1182/blood-2022-169525

Published: 2022

Journal Articles

NOX2: is the best defense a good offense?

Wen Xuan Zhang, Paul Kubes

Blood (2022) 139 (19): 2851–2853.

https://doi.org/10.1182/blood.2022016192

Published: 2022

Journal Articles

Co-Targeting MCL-1 and BCL-2 Is Highly Synergistic in BH3 Mimetic- and Venetoclax/Hypomethylating Agent-Resistant and TP53 Mutated AML

Bing Z Carter, PhD, Po Yee Mak, Wenjing Tao, Vivian Ruvolo, MS, Xuan Zhang, PhD, Yuki Nishida, MD PhD, Steven M. Kornblau, MD, Paul Hughes, Xiaoyue Chen, PK Morrow, Michael Andreeff, MD PhD

Blood (2020) 136 (Supplement 1): 7.

https://doi.org/10.1182/blood-2020-141417

Published: 2020

Journal Articles

DT2216, a BCL-XL Proteolysis Targeting Chimera (PROTAC), Is a Potent Anti T-Cell Lymphoma Agent That Does Not Induce Significant Thrombocytopenia

Yonghan He, MD, Raphael Koch, Vivekananda Budamagunta, Dongwen Lv, Sajid Khan, Xuan Zhang, Janet S Wiegand, Guangrong Zheng, David M. Weinstock, MD, Daohong Zhou

Blood (2019) 134 (Supplement_1): 303.

https://doi.org/10.1182/blood-2019-125820

Published: 2019

Journal Articles

Targeting BCL-XL By Protac DT2216 Effectively Eliminates Leukemia Cells in T-ALL Pre-Clinical Models

Qi Zhang, PhD, Sajid Khan, PhD, Xuan Zhang, Vinitha Mary Kuruvilla, MSc, Sanaz Ghotbaldini, Julia Wells, PhD, Natalia Baran, PhDMD, Tianyu Cai, PhD, Lina Han, PhD, Adolfo Ferrando, MD, PhD, Yong-Mi Kim, MD MPH, PhD, Guangrong Zheng, Daohong Zhou, Marina Y Konopleva, MD PhD

Blood (2019) 134 (Supplement_1): 3870.

https://doi.org/10.1182/blood-2019-124744

Published: 2019

Journal Articles

Targeting Oncoprotein Translation with Rocaglates in MYC-Driven Lymphoma

Xuan Zhang, BMBS, Chengfeng Bi, MD PhD, Ting Lu, MD PhD, Ting Yue, Weiwei Zhang, PhD, Xiaoyan Zhang, MD, Wang Cheng, MD, Tian Tian, MD, Matthew A. Lunning, DO, Julie M. Vose, MDMBA, Jerry Pelletier, PhD, John A Porco, Jr., PhD, Jianguo Tao, MD PhD, Kai Fu, MD PhD

Blood (2018) 132 (Supplement 1): 38.

https://doi.org/10.1182/blood-2018-99-117659

Published: 2018

Journal Articles

DT2216, a Synthetic Proteolytic Selectively Targeting Bcl-X L for Ubiquitination and Degradation in Tumor Cells but Not in Platelets, Is a Safer and More Potent Antitumor Agent Than Navitoclax

Sajid Khan, PhD, Xuan Zhang, BMBS, Dongwen Lv, PhD, Yonghan He, MD, Peiyi Zhang, MS, Xingui Liu, PhD, Dinesh Thummuri, PhD, Qi Zhang, PhD, Marina Y. Konopleva, MD PhD, Robert A. Hromas, MD, Guangrong Zheng, Daohong Zhou, MD

Blood (2018) 132 (Supplement 1): 2698.

https://doi.org/10.1182/blood-2018-99-114762

Published: 2018

Journal Articles

Wiskott-Aldrich Syndrome: A Retrospective Study on 575 Patients Analyzing the Impact of Splenectomy, Stem Cell Transplantation, or No Definitive Treatment on Frequency of Disease-Related Complications and Physician-Perceived Quality of Life

Jannik S Glasmacher, Tanja C Bittner, MD, Hans D Ochs, MD, Alessandro Aiuti, MD PhD, Peter D Arkwright, MD, Dmitry Balashov, Uta Behrends, Bernd H. Belohradsky, MD, Elisa Bertoni, David K. Buchbinder, MD MSHS, Michael Browning, Anastasiia Bondarenko, Fabio Candotti, MD, Alessandro Cattoni, Liudmyla Chernyshova, Joseph H. Chewning, MD, Peter Ciznar, Theresa Cole, Beatriz T Costa-Carvalho, Wojciech Czogala, Gregor Dueckers, David M Edgar, Fatih Erbey, Anders Fasth, MD PhD, Renata Formankova, MD PhD, Tomas Freiberger, Eleonora Gambineri, Andrew Gennery, MD, Frederick D Goldman, MD, Luis I Gonzalez-Granado, Tiago N Gulmaraes, David Hagin, MD PhD, Fabian Hauck, MD PhD, Tarja Heiskanen-Kosma, Manfred Hoenig, MD, Hanna Juntti, Hirokazu Kanegane, Leena Kainulainen, Neslihan E Karaca, Sara S Kilic, Christoph Klein, MD PhD, Sylwia Koltan, Irina Kondratenko, Dawei Liu, MD, Susanne Matthes, MD, Juliana T L Mazzucchelli, Isabelle Meyts, Siraj Misbah, Zohreh Nademi, Gulnara Nasrullayeva, Lucia D Notarangelo, Pere Soler-Palacin, Olga Pashchenko, Srdjan Pasic, Isabelle Pellier, MD, Claudio Pignata, Camilla Roepstorff, Catharina Schuetz, Ansgar S Schulz, MD PhD Prof., Gesmar R S Segundo, Anna Shcherbina, Joanne Smart, Robert A. Sokolic, MD, Polina Stepensky, MD, Troy Torgerson, MD PhD, Svetlana Vakhlyarskaya, Joris van Montfrans, MD PhD, Kim Vettenranta, MD PD, Beata Wolska-Kusnierz, Xiaodong Zhao, John B Ziegler, Xuan Zhang, Michael H. Albert, MD

Blood (2016) 128 (22): 366.

https://doi.org/10.1182/blood.V128.22.366.366

Published: 2016

Journal Articles

Abnormalities of follicular helper T-cell number and function in Wiskott-Aldrich syndrome

Xuan Zhang, Rongxin Dai, Wenyan Li, Hongyi Zhao, Yongjie Zhang, Lina Zhou, Hongqiang Du, Guangjin Luo, Junfeng Wu, Linlin Niu, Yunfei An, Zhiyong Zhang, Yuan Ding, Wenxia Song, Chaohong Liu, Xiaodong Zhao

Blood (2016) 127 (25): 3180–3191.

https://doi.org/10.1182/blood-2015-06-652636

Published: 2016

Includes: Supplemental data

Journal Articles

Microrna-17~92 Cluster Upregulates NF-KB Activity Via Suppressing Multiple NF-KB Negative Regulators Mediating Ubiquitination

Xianhuo Wang, MD, Huaqing Wang, Chengfeng Bi, Xiaoyan Zhang, Xin Huang, Xuan Zhang, Javeed Iqbal, George W Wright, Louis M Staudt, Wing C Chan, Timothy W McKeithan, Ping Wang, Huilai Zhang, Kai Fu, MD PhD

Blood (2015) 126 (23): 3638.

https://doi.org/10.1182/blood.V126.23.3638.3638

Published: 2015

NARROW

Luspatercept Promotes Heme Biosynthesis and Erythroblast Island Formation in a Novel Low-Risk MDS Mouse Model

MISTRG6kit W41 : Enhanced Engraftment in a Cytokine Humanized Patient-Derived Xenotransplantation Mouse Model

Clonal Dissection of MDS and Secondary AML Resolves Shared Splicing Neoantigens and Mechanistic Underpinnings of Hypomethylating Agent Therapeutic Response

Real-World Clinical Outcomes in Patients Initiating Covalent Btki (cBTKi) with and without Incident Cardiovascular Adverse Events By Line of Therapy for Chronic Lymphocytic Leukemia (CLL) and Small Lymphocytic Lymphoma (SLL)

Healthcare Resource Utilization and Costs in Patients with Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Lymphoma (SLL) Treated with Covalent Btki (cBTKi): Real-World Impact of Cardiovascular Adverse Events

Single-Cell Multiomics Reveal Hypomethylating Agent Partially Restores Hematopoiesis in a LR-MDS Patient at the Cost of Leukemic Transformation

Identification and Isolation of Hematopoietic Stem Cells and Progenitors with Discrete Developmental Gene Expression Programs

NOX2: is the best defense a good offense?

Co-Targeting MCL-1 and BCL-2 Is Highly Synergistic in BH3 Mimetic- and Venetoclax/Hypomethylating Agent-Resistant and TP53 Mutated AML

DT2216, a BCL-XL Proteolysis Targeting Chimera (PROTAC), Is a Potent Anti T-Cell Lymphoma Agent That Does Not Induce Significant Thrombocytopenia

Targeting BCL-XL By Protac DT2216 Effectively Eliminates Leukemia Cells in T-ALL Pre-Clinical Models

Targeting Oncoprotein Translation with Rocaglates in MYC-Driven Lymphoma

DT2216, a Synthetic Proteolytic Selectively Targeting Bcl-X L for Ubiquitination and Degradation in Tumor Cells but Not in Platelets, Is a Safer and More Potent Antitumor Agent Than Navitoclax

Wiskott-Aldrich Syndrome: A Retrospective Study on 575 Patients Analyzing the Impact of Splenectomy, Stem Cell Transplantation, or No Definitive Treatment on Frequency of Disease-Related Complications and Physician-Perceived Quality of Life

Abnormalities of follicular helper T-cell number and function in Wiskott-Aldrich syndrome

Microrna-17~92 Cluster Upregulates NF-KB Activity Via Suppressing Multiple NF-KB Negative Regulators Mediating Ubiquitination

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American Society of Hematology

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ASH Publications

American Society of Hematology

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