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Laura B. Ramsey
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Journal Articles

Understanding the Associations between High-Dose Methotrexate Pharmacokinetics and the Risk of Adverse Events in Children and Adolescents with Down Syndrome Associated High-Risk Acute Lymphoblastic Leukemia

Kate D. Westmoreland, Zachary L Taylor, Tamara P. Miller, Ashley Chavana, Karen R Rabin, Austin L Brown, Melanie Brooke Bernhardt, Eric S. Schafer, Maureen M. O'Brien, Sharon M. Castellino, Laura B. Ramsey
Journal: Blood
Blood (2024) 144 (Supplement 1): 1438.
https://doi.org/10.1182/blood-2024-211870
Published: 2024
Journal Articles

Severe Adverse Events Associated with Concentrations of High Dose Methotrexate in Pediatric Acute Lymphoblastic Leukemia Patients

Tamara P. Miller, Nicholas P. DeGroote, Zachary Taylor, Lauren Pommert, Oluwafunbi Awoniyi, Sarah Board, Ngozi Ugboh, Vivek Joshi, Allison Weisnicht, Nicholas Ambrosino, Melanie Brooke Bernhardt, Eric S Schafer, Maureen M. O'Brien, Sharon M. Castellino, Laura B. Ramsey
Journal: Blood
Blood (2022) 140 (Supplement 1): 2185–2186.
https://doi.org/10.1182/blood-2022-169741
Published: 2022
Journal Articles

Comparison of Severe Toxicities Following High Dose Methotrexate Administration By Demographics and over Time in Pediatric Patients with Acute Lymphoblastic Leukemia

Tamara P. Miller, Nicholas P. DeGroote, Lauren Pommert, Oluwafunbi Awoniyi, Sarah Board, Ngozi Ugboh, Vivek Joshi, Nicholas Ambrosino, Allison Weisnicht, Heidi Hsiao, Melanie Brooke Bernhardt, Eric S Schafer, Maureen M. O'Brien, Sharon M. Castellino, Laura B. Ramsey
Journal: Blood
Blood (2021) 138 (Supplement 1): 1970.
https://doi.org/10.1182/blood-2021-151081
Published: 2021
Journal Articles

The Effect of Asparaginase on Serum Triglycerides during Therapy for Acute Lymphoblastic Leukemia

Emily R Finch, PhD, Colton A Smith, PhD, Wenjian Yang, PhD, Nancy M Kornegay, John C Panetta, PhD, Kristine R Crews, PharmD, Alejandro R Molinelli, PhD, Cheng Cheng, PhD, Deqing Pei, MS, Laura B. Ramsey, PhD, Seth E Karol, MD, Hiroto Inaba, MD, John T. Sandlund, MD, Monika Metzger, MD, William E. Evans, PharmD, Sima Jeha, MD, Ching-Hon Pui, MD, Mary V Relling, PharmD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2665.
https://doi.org/10.1182/blood-2018-99-117093
Published: 2018
Journal Articles

Genetic risk factors for the development of osteonecrosis in children under age 10 treated for acute lymphoblastic leukemia

Clinical Trials & Observations
Seth E. Karol, Leonard A. Mattano, Jr, Wenjian Yang, Kelly W. Maloney, Colton Smith, ChengCheng Liu, Laura B. Ramsey, Christian A. Fernandez, Tamara Y. Chang, Geoffrey Neale, Cheng Cheng, Elaine Mardis, Robert Fulton, Paul Scheet, F. Anthony San Lucas, Eric C. Larsen, Mignon L. Loh, Elizabeth A. Raetz, Stephen P. Hunger, Meenakshi Devidas, Mary V. Relling
Journal: Blood
Blood (2016) 127 (5): 558–564.
https://doi.org/10.1182/blood-2015-10-673848
Published: 2016
Includes: Supplemental data
Journal Articles

Genome-Wide Association Study Identifies PNPLA3 I148M Variant Associated with Elevated Transaminase Levels after Induction Therapy in Pediatric ALL Patients

Christian A. Fernandez, PhD, Colton Smith, PhD, Wenjian Yang, PhD, Chengcheng Liu, B.S, Laura B. Ramsey, PhD, Seth E. Karol, MD, Ching-Hon Pui, MD, William E. Evans, PharmD, Sima Jeha, MD, Mary V. Relling, PharmD
Journal: Blood
Blood (2015) 126 (23): 3714.
https://doi.org/10.1182/blood.V126.23.3714.3714
Published: 2015
Journal Articles

Genetic Risk Factors for the Development of Osteonecrosis in Children Under Age 10 Treated for Acute Lymphoblastic Leukemia

Seth E. Karol, MD, Wenjian Yang, PhD, Leonard A. Mattano, Jr., MD, Kelly W. Maloney, MD, Colton Smith, PhD, Chengcheng Liu, B.S, Laura B. Ramsey, PhD, Christian A. Fernandez, PhD, Tamara Y. Chang, MD, Geoffrey A. Neale, PhD, Cheng Cheng, PhD, Elaine R Mardis, PhD, Robert S. Fulton, PhD, Paul Scheet, PhD, Eric C. Larsen, MD, Mignon L. Loh, MD, Elizabeth Raetz, MD, Stephen P Hunger, MD, Meenakshi Devidas, PhD, Mary V. Relling, PharmD
Journal: Blood
Blood (2015) 126 (23): 250.
https://doi.org/10.1182/blood.V126.23.250.250
Published: 2015
Journal Articles

Genome-wide analysis links NFATC2 with asparaginase hypersensitivity

Clinical Trials & Observations
Christian A. Fernandez, Colton Smith, Wenjian Yang, Charles G. Mullighan, Chunxu Qu, Eric Larsen, W. Paul Bowman, Chengcheng Liu, Laura B. Ramsey, Tamara Chang, Seth E. Karol, Mignon L. Loh, Elizabeth A. Raetz, Naomi J. Winick, Stephen P. Hunger, William L. Carroll, Sima Jeha, Ching-Hon Pui, William E. Evans, Meenakshi Devidas, Mary V. Relling
Journal: Blood
Blood (2015) 126 (1): 69–75.
https://doi.org/10.1182/blood-2015-02-628800
Published: 2015
Includes: Supplemental data
Journal Articles

Genetic Variation in NFATC2 Is Associated with a Higher Risk of Asparaginase Allergy

Christian A. Fernandez, PhD, Colton Smith, PhD, Wenjian Yang, PhD, Charles G. Mullighan, MBBS, MSc, MD, Chunxu Qu, PhD, Eric C. Larsen, MD, William Paul Bowman, MD, Chengcheng Liu, Laura B. Ramsey, PhD, Tamara Chang, MD, Seth E. Karol, MD, Mignon L. Loh, MD, Elizabeth A. Raetz, MD, Naomi J. Winick, MD, Stephen Hunger, MD, William L. Carroll, MD, Sima Jeha, MD, Ching-Hon Pui, MD, William E. Evans, PharmD, Meenakshi Devidas, PhD, Mary V. Relling, PharmD
Journal: Blood
Blood (2014) 124 (21): 63.
https://doi.org/10.1182/blood.V124.21.63.63
Published: 2014
Journal Articles

Antileukemic Efficacy of Continuous Vs Discontinuous Dexamethasone in Murine Xenografts of Acute Lymphoblastic Leukemia

Laura B. Ramsey, PhD, Laura Janke, DVM, PhD, Monique A. Payton, B.S., Xiangjun Cai, PhD, Sima Jeha, MD, Ching-Hon Pui, MD, William E. Evans, PharmD, Mary V. Relling, PharmD
Journal: Blood
Blood (2014) 124 (21): 3701.
https://doi.org/10.1182/blood.V124.21.3701.3701
Published: 2014
Journal Articles

A Murine Model of Asparaginase Allergy

Christian A. Fernandez, PhD, Colton Smith, PhD, Seth E. Karol, MD, Laura B. Ramsey, PhD, Chengcheng Liu, Ching-Hon Pui, MD, Sima Jeha, MD, William E. Evans, PharmD, Fred D. Finkelman, PhD, Mary V. Relling, PharmD
Journal: Blood
Blood (2014) 124 (21): 2295.
https://doi.org/10.1182/blood.V124.21.2295.2295
Published: 2014
Journal Articles

HLA-DRB1 *07:01 is associated with a higher risk of asparaginase allergies

Clinical Trials & Observations
Christian A. Fernandez, Colton Smith, Wenjian Yang, Mihir Daté, Donald Bashford, Eric Larsen, W. Paul Bowman, Chengcheng Liu, Laura B. Ramsey, Tamara Chang, Victoria Turner, Mignon L. Loh, Elizabeth A. Raetz, Naomi J. Winick, Stephen P. Hunger, William L. Carroll, Suna Onengut-Gumuscu, Wei-Min Chen, Patrick Concannon, Stephen S. Rich, Paul Scheet, Sima Jeha, Ching-Hon Pui, William E. Evans, Meenakshi Devidas, Mary V. Relling
Journal: Blood
Blood (2014) 124 (8): 1266–1276.
https://doi.org/10.1182/blood-2014-03-563742
Published: 2014
Includes: Supplemental data
Journal Articles

HLA-DRB1*07:01 Is Associated With Asparaginase Allergies In Children With Acute Lymphoblastic Leukemia

Christian A Fernandez, PhD, Mary V. Relling, PharmD, Colton Smith, PhD, Wenjian Yang, PhD, Eric C. Larsen, MD, W. Paul Bowman, MD, Chengcheng Liu, Laura B. Ramsey, PhD, Tamara Chang, MD, Victoria Turner, PhD, Mignon L. Loh, MD, Elizabeth A. Raetz, MD, Naomi J. Winick, MD, Stephen P. Hunger, MD, William L. Carroll, MD, Suna Onengut-Gumuscu, PhD, Wei-Min Chen, PhD, Patrick Concannon, PhD, Stephen S Rich, PhD, Paul Scheet, PhD, Sima Jeha, MD, Ching-Hon Pui, MD, William E. Evans, PharmD, Meenakshi Devidas, PhD
Journal: Blood
Blood (2013) 122 (21): 60.
https://doi.org/10.1182/blood.V122.21.60.60
Published: 2013
Journal Articles

Genome-wide study of methotrexate clearance replicates SLCO1B1

Clinical Trials & Observations
Laura B. Ramsey, John C. Panetta, Colton Smith, Wenjian Yang, Yiping Fan, Naomi J. Winick, Paul L. Martin, Cheng Cheng, Meenakshi Devidas, Ching-Hon Pui, William E. Evans, Stephen P. Hunger, Mignon Loh, Mary V. Relling
Journal: Blood
Blood (2013) 121 (6): 898–904.
https://doi.org/10.1182/blood-2012-08-452839
Published: 2013
Includes: Supplemental data
Journal Articles

A Genome-Wide Analysis of Variants Influencing Methotrexate Clearance Replicates SLCO1B1 .

Laura B. Ramsey, PhD, John C Panetta, PhD, Colton Smith, PhD, Wenjian Yang, PhD, Yiping Fan, PhD, Naomi Winick, MD, Paul L. Martin, MD, PhD, Cheng Cheng, PhD, Meenakshi Devidas, PhD, Ching-Hon Pui, MD, William E. Evans, PharmD, Stephen P. Hunger, MD, Mignon L. Loh, MD, Mary V. Relling, PharmD
Journal: Blood
Blood (2012) 120 (21): 2466.
https://doi.org/10.1182/blood.V120.21.2466.2466
Published: 2012
Journal Articles

Host Thiopurine Methyltransferase Status Affects Mercaptopurine Antileukemic Effectiveness

Laura B. Ramsey, PhD, Laura Janke, DVM, PhD, Mathew Edick, PhD, Cheng Cheng, PhD, Richard T Williams, MBBS, PhD, Charles J. Sherr, MD, PhD, William E. Evans, PharmD, Mary V. Relling, PharmD
Journal: Blood
Blood (2012) 120 (21): 3560.
https://doi.org/10.1182/blood.V120.21.3560.3560
Published: 2012
Journal Articles

PDE4B Modulates Glucocorticoid Sensitivity in Childhood Acute Lymphoblastic Leukemia

Jun J. Yang, PhD, Shuyu E, PhD, Shuhong Shen, MD, PhD, Deepa Bhojwani, MD, Huining Kang, PhD, Yani Ma, PhD, Jing Chen, MD, PhD, JingYan Tang, MD, Nita L. Seibel, MD, Heng Xu, PhD, Jin Cheng, Laura B. Ramsey, PhD, Kristine Crews, PharmD, W. Paul Bowman, MD, Michael J. Borowitz, MD, PhD, William L. Carroll, MD, Cheryl L. Willman, MD, Sima Jeha, MD, Ching-Hon Pui, MD, Stephen P. Hunger, MD, Mary V. Relling, PharmD, William E. Evans, PharmD
Journal: Blood
Blood (2012) 120 (21): 530.
https://doi.org/10.1182/blood.V120.21.530.530
Published: 2012
Journal Articles

SLCO1B1 Variation and Methotrexate Disposition in Children with Acute Lymphoblastic Leukemia: The Importance of Rare Variants in Pharmacogenetics

Laura B. Ramsey, PhD, Gitte H Bruun, Wenjian Yang, PhD, Lisa R Trevino, PhD, Selina Vattathil, Paul Scheet, PhD, Cheng Cheng, PhD, Gary Rosner, Kathleen Giacomini, PhD, Yiping Fan, PhD, Alex Sparreboom, PhD, Torben Mikkelsen, MD PhD, Thomas J Corydon, PhD, Ching-Hon Pui, MD, William E. Evans, PharmD, Mary V. Relling, PharmD
Journal: Blood
Blood (2011) 118 (21): 571.
https://doi.org/10.1182/blood.V118.21.571.571
Published: 2011