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Seth E. Karol
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Journal Articles

Outcomes in patients with ETV6 :: RUNX1 or high-hyperdiploid B-ALL treated in the St. Jude Total Therapy XV/XVI studies

Clinical Trials & Observations
Katelyn Purvis, Yinmei Zhou, Seth E. Karol, Jeffrey E. Rubnitz, Raul C. Ribeiro, Shawn Lee, Jun J. Yang, W. Paul Bowman, Lu Wang, Stephanie B. Dixon, Kathryn G. Roberts, Qingsong Gao, Cheng Cheng, Charles G. Mullighan, Sima Jeha, Ching-Hon Pui, Hiroto Inaba
Journal: Blood
Blood (2025) 145 (2): 190–201.
https://doi.org/10.1182/blood.2024024936
Published: 2025
Includes: Supplemental data
Journal Articles

A Retrospective Study of First and Recurrent Venous Thromboembolism in Patients with Acute Lymphoblastic Leukemia Treated on Total XV and Total Xvi Protocols

Rohith Jesudas, Justin Kirkham, Tomas Bryndziar, Hiroto Inaba, Timothy Jacobs, Sima Jeha, Victoria Okhomina, Guolian Kang, Cheng Cheng, Clifford M. Takemoto, Ching-Hon Pui, Seth E. Karol
Journal: Blood
Blood (2024) 144 (Supplement 1): 7707.
https://doi.org/10.1182/blood-2024-210355
Published: 2024
Journal Articles

Retrospective Cohort Analysis of Response and Survival of Children, Adolescents, and Young Adults (CAYA) with Relapsed and/or Refractory (R/R) T-Cell Acute Lymphoblastic Leukemia (T-ALL) and Lymphoma (T-LL) Treated with Curative Intent: A TACL Consortium Study

Melinda G Pauly, Yueh-Yun Chi, Jemily Malvar, Roy Leong, Susan Colace, Nathan Gossai, Nobuko Hijiya, Chintan Parekh, Susan R Rheingold, Anupam Verma, Bill H Chang, Todd M Cooper, Andrew Doan, Yamilet Huerta, Kelly Elizabeth Faulk, Diane Hanna, Kenneth Matthew Heym, Mallorie M. Heneghan, Joel Kaplan, Luciano Dalla-Pozza, Seth E. Karol, Andrew E. Place, Jenna Rossoff, Eric S. Schafer, Tamra Slone, Michelle L. Hermiston, Maria Luisa Sulis
Journal: Blood
Blood (2024) 144 (Supplement 1): 4187.
https://doi.org/10.1182/blood-2024-209138
Published: 2024
Journal Articles

Safety and Feasibility of Blinatumomab As Frontline Therapy for Pediatric Patients with B-Acute Lymphoblastic Leukemia and Lymphoma: St. Jude Total Therapy Study XVII

Caitlyn Duffy, Elizabeth Dang, Zhou Yinmei, Jessica Bell, Nickhill Bhakta, Meret Henry, Kenneth Matthew Heym, Sima Jeha, Norman J. Lacayo, Seth E. Karol, Seong Lin Khaw, Raul C. Ribeiro, Deborah E. Schiff, Charles G. Mullighan, Jun J. Yang, Cheng Cheng, Ching-Hon Pui, Hiroto Inaba
Journal: Blood
Blood (2024) 144 (Supplement 1): 4208.
https://doi.org/10.1182/blood-2024-209284
Published: 2024
Journal Articles

Oncogenic Potential and Sensitivity to Menin Inhibitors of a Novel Fusion KAT6B::NUTM2B in Congenital Myeloid Sarcoma with Bone Marrow Involvement

Rebecca Voss, Wenqing Qi, Yen-Chun Liu, Jing Ma, La'Ron Browne, Mahsa Khanlari, Juan M Barajas, Melvin Thomas, III, Victor B Pastor Loyola, Hui Cao, Seth E. Karol, Jeffrey E. Rubnitz, Jeffery M Klco, Lu Wang
Journal: Blood
Blood (2024) 144 (Supplement 1): 1352.
https://doi.org/10.1182/blood-2024-208358
Published: 2024
Journal Articles

Zegocractin to Reduce the Severity of Asparaginase Associated Pancreatitis in Children with Acute Lymphoblastic Leukemia: Results of the Phase 1 Portion of the Crspa Study

Seth E. Karol, Haitao Pan, Zhou Yinmei, Jeffrey E. Rubnitz, Nickhill Bhakta, Sima Jeha, Mary V. Relling, Kristine R Crews, John C Panetta, Cara Morin, Cheng Cheng, Ching-Hon Pui, Hiroto Inaba, M Beth McCarville
Journal: Blood
Blood (2023) 142 (Supplement 1): 2837.
https://doi.org/10.1182/blood-2023-188357
Published: 2023
Journal Articles

Preliminary Safety and Efficacy of Venetoclax and Selinexor in Combination with Chemotherapy in Pediatric and Young Adult Patients with Relapsed or Refractory Acute Myeloid Leukemia: Selclax

Sara Zarnegar-Lumley, Seth E. Karol, Stanley Pounds, Jeffery M. Klco, Maria Luisa Sulis, Dennis John Kuo, Kenneth Matthew Heym, Kathleen Ludwig, Alexandra McLean Stevens, Thomas B. Alexander, Kelly Elizabeth Faulk, Himalee S. Sabnis, Sarah K. Tasian, Jeffrey Taub, Andrew E. Place, Jeffrey E. Rubnitz
Journal: Blood
Blood (2023) 142 (Supplement 1): 56.
https://doi.org/10.1182/blood-2023-174342
Published: 2023
Journal Articles

The Impact of Age and Genomics on Drug Sensitivity in 1,076 Children and Adults with B-Cell Acute Lymphoblastic Leukemia

Satoshi Yoshimura, Zhenhua Li, Yoshihiro Gocho, Wenjian Yang, Kristine R Crews, Shawn H.R. Lee, Kathryn G. Roberts, Charles G. Mullighan, Mary V. Relling, Federico Antillon-Klussmann, Allen Eng Juh Yeoh, Mignon L. Loh, Mark R. Litzow, Sima Jeha, Seth E. Karol, Hiroto Inaba, Ching-Hon Pui, Marina Y. Konopleva, Nitin Jain, Wendy Stock, Elisabeth Paietta, Elias Jabbour, Steven M. Kornblau, William E. Evans, Jun J. Yang
Journal: Blood
Blood (2023) 142 (Supplement 1): 596.
https://doi.org/10.1182/blood-2023-181788
Published: 2023
Journal Articles

Intensification of Therapy and Pharmacogenetic Personalization Mitigate Racial Disparities in Pediatric Acute Myeloid Leukemia Outcomes

Jatinder K. Lamba, Richard J Marrero, Huiyun Wu, Xueyuan Cao, Phani Krishna Parcha, Seth E. Karol, Hiroto Inaba, Dennis John Kuo, Barbara Degar, Kenneth Matthew Heym, Jeffrey Taub, Norman J. Lacayo, Ching-Hon Pui, Raul C. Ribeiro, Stanley Pounds, Jeffrey E. Rubnitz
Journal: Blood
Blood (2023) 142 (Supplement 1): 386.
https://doi.org/10.1182/blood-2023-173617
Published: 2023
Journal Articles

ITCC-101/APAL2020D: A Randomized Phase 3 Trial of Fludarabine/Cytarabine/Gemtuzumab Ozogamycin with or without Venetoclax in Children with Relapsed Acute Myeloid Leukemia

Sae Ishimaru, Gwenaëlle Gueguen, Seth E. Karol, Francisco J. Bautista Sirvent, Valeria Ceolin, Bianca F. Goemans, Marlous Bakker, Laura Di Laurenzio, Jennifer Lukin, Harm Van Tinteren, Gauri B. Sunkersett, Maika Onishi, Kristina Unnebrink, Dirk Reinhardt, Gwen L Nichols, E. Anders Kolb, C. Michel Zwaan
Journal: Blood
Blood (2022) 140 (Supplement 1): 3369–3370.
https://doi.org/10.1182/blood-2022-168818
Published: 2022
Journal Articles

Pharmacotypes across the Genomic Landscape of Pediatric Acute Lymphoblastic Leukemia and Impact on Treatment Response

Shawn Lee, Wenjian Yang, Yoshihiro Gocho, August John, Lauren Rowland, Brandon Smart, Hannah Williams, Dylan Maxwell, Jeremy Hunt, Wentao Yang, Kristine R. Crews, Kathryn G Roberts, Sima Jeha, Cheng Cheng, Seth E. Karol, Mary V. Relling, Gary Rosner, Hiroto Inaba, Charles G. Mullighan, Ching-Hon Pui, William E. Evans, Jun J. Yang
Journal: Blood
Blood (2022) 140 (Supplement 1): 1730–1731.
https://doi.org/10.1182/blood-2022-156699
Published: 2022
Journal Articles

Genetics of osteonecrosis in pediatric acute lymphoblastic leukemia and general populations

Wenjian Yang, Meenakshi Devidas, Yiwei Liu, Colton Smith, Yunfeng Dai, Naomi Winick, Stephen P. Hunger, Mignon L. Loh, Elizabeth A. Raetz, Eric C. Larsen, William L. Carroll, Stuart S. Winter, Kimberly P. Dunsmore, Leonard A. Mattano, Jr, Mary V. Relling, Seth E. Karol
Journal: Blood
Blood (2021) 137 (11): 1550–1552.
https://doi.org/10.1182/blood.2020008471
Published: 2021
Includes: Supplemental data
Journal Articles

Dosing-related saturation of toxicity and accelerated drug clearance with pegaspargase treatment

Clinical Trials & Observations
Yiwei Liu, John C. Panetta, Wenjian Yang, Seth E. Karol, Cheng Cheng, Jun J. Yang, William E. Evans, Hiroto Inaba, Ching-Hon Pui, Sima Jeha, Mary V. Relling
Journal: Blood
Blood (2020) 136 (25): 2955–2958.
https://doi.org/10.1182/blood.2020006214
Published: 2020
Includes: Supplemental data
Journal Articles

Pediatric Patients with Relapsed/Refractory Acute Lymphoblastic Leukemia Harboring Heterogeneous Genomic Profiles Respond to Venetoclax in Combination with Chemotherapy

Andrew E. Place, MDPhD, Seth E. Karol, MD, Christopher J. Forlenza, MD, Marion Gambart, MD, Todd M. Cooper, DO, Christopher Fraser, MBBS, Gunnar Cario, MD PhD, Maureen M O'Brien, MD, Nicolas U. Gerber, MD, Phillip Barnette, MD, Dirk Reinhardt, MDPhD, Giridharan Ramsingh, MD, Bo Tong, PhD, Kristina Unnebrink, PhD, Deeksha Vishwamitra, PhD, Fengjiao Dunbar, PhD, Betty A. Prine, BS, Tammy L. Palenski, PhD, Mignon L. Loh, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 37–38.
https://doi.org/10.1182/blood-2020-137376
Published: 2020
Journal Articles

Clinical Benefit and Tolerability of Crenolanib in Children with Relapsed Acute Myeloid Leukemia Harboring Treatment Resistant FLT3 ITD and Variant FLT3 TKD Mutations Treated on Compassionate Access

Katherine Tarlock, MD, Soheil Meshinchi, MDPhD, Jeffrey E. Rubnitz, MD, Seth E. Karol, MD, Barbara Spitzer, MD, Amit J. Sabnis, MD, Asif Pathan, PhD RPh, Boo Messahel, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 23–24.
https://doi.org/10.1182/blood-2020-140399
Published: 2020
Journal Articles

Venetoclax Alone or in Combination with Chemotherapy: Responses in Pediatric Patients with Relapsed/Refractory Acute Myeloid Leukemia with Heterogeneous Genomic Profiles

Seth E. Karol, MD, Henrique Bittencourt, MD PhD, Daniel A. Morgenstern, MD, Margaret E. Macy, MD, Seong Lin Khaw, MD, Todd M. Cooper, DO, Arnaud Petit, MD PhD, Giridharan Ramsingh, MD, Bo Tong, PhD, Kristina Unnebrink, PhD, Deeksha Vishwamitra, PhD, Fengjiao Dunbar, PhD, Betty A. Prine, BS, Tammy L. Palenski, PhD, Andrew E. Place, MDPhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 30–31.
https://doi.org/10.1182/blood-2020-136999
Published: 2020
Journal Articles

Proposed Scheme for Dosing Venetoclax in Pediatric Patients with Relapsed/Refractory Acute Myeloid Leukemia: Analysis of Developmental Pharmacokinetics and Exposure-Response Relationships

Mohamed A Badawi, PhD, Sathej Gopalakrishnan, PhD, Benjamin Engelhardt, PhD, Tammy L. Palenski, PhD, Su Young Kim, Seth E. Karol, MD, Jeffrey E. Rubnitz, MD, Rajeev Menon, PhD, Ahmed Hamed Salem, PhD FCP
Journal: Blood
Blood (2020) 136 (Supplement 1): 11–12.
https://doi.org/10.1182/blood-2020-139593
Published: 2020
Journal Articles

Allogeneic Hematopoietic Cell Transplantation Is Critical to Maintain Remissions after CD19-CAR T-Cell Therapy for Pediatric ALL: A Single Center Experience

Aimee C Talleur, MD, Renee M. Madden, MS, MD, Amr Qudeimat, MD, Ewelina Mamcarz, MD, Akshay Sharma, MBBS, Ashok Srinivasan, MD, Ali Y Suliman, MD, Mireya Paulina Velasquez, MD, Timothy Lockey, PhD, Alisha Gaboriault, Seth E. Karol, MD, Hiroto Inaba, MD PhD, Ying Li, MD PhD, Pam Young, Guolian Kang, PhD, Cheng Cheng, PhD, Wenting Zheng, PhD, Sheng Zhou, PhD, Salem M. Akel, PhD, Terrence L Geiger, MD PhD, Michael M Meagher, PhD, Ching-Hon Pui, MD, Brandon M Triplett, MD, Stephen Gottschalk, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 39–40.
https://doi.org/10.1182/blood-2020-138528
Published: 2020
Journal Articles

Predicting success of desensitization after pegaspargase allergy

Clinical Trials & Observations
Hope D. Swanson, John C. Panetta, Patricia J. Barker, Yiwei Liu, Hiroto Inaba, Mary V. Relling, Ching-Hon Pui, Seth E. Karol
Journal: Blood
Blood (2020) 135 (1): 71–75.
https://doi.org/10.1182/blood.2019003407
Published: 2020
Includes: Supplemental data
Journal Articles

Venetoclax in Combination with High-Dose Chemotherapy Is Active and Well-Tolerated in Children with Relapsed or Refractory Acute Myeloid Leukemia

Seth E Karol, MD, Thomas Alexander, MDMPH, Amit Budraja, PhD, Stanley Pounds, PhD, Kristin E Canavera, PhD, Lei Wang, MS, Joshua Wolf, MBBS, PhD, Jeffery M. Klco, MD PhD, Ahmed Hamed Salem, PhD FCP, Tammy Palenski, PhD, Norman J. Lacayo, MD, Ching-Hon Pui, MD, Joseph T. Opferman, PhD, Jeffrey Rubnitz, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 178.
https://doi.org/10.1182/blood-2019-127716
Published: 2019