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Journal Articles

Efficacy and Toxicity of Fixed Dose Versus Reduced/PK-Adjusted Dose Pegaspargase in Pediatric Patients with Newly Diagnosed Acute Lymphoblastic Leukemia: Results of DFCI ALL Consortium Protocol 16-001

Melissa A. Burns, Yael Flamand, Lynda M. Vrooman, Victoria B. Koch, Yves Theoret, Sarah M. Cronholm, Sarah K. Hunt, Peter D. Cole, Lisa M. Gennarini, Nobuko Hijiya, Justine M. Kahn, Kara M. Kelly, Bruno Michon, Donna S. Neuberg, Andrew E. Place, Thai Hoa Tran, Jennifer J.G. Welch, Stephen E. Sallan, Lewis B. Silverman
Journal: Blood
Blood (2024) 144 (Supplement 1): 307.
https://doi.org/10.1182/blood-2024-207273
Published: 2024
Journal Articles

Retrospective Cohort Analysis of Response and Survival of Children, Adolescents, and Young Adults (CAYA) with Relapsed and/or Refractory (R/R) T-Cell Acute Lymphoblastic Leukemia (T-ALL) and Lymphoma (T-LL) Treated with Curative Intent: A TACL Consortium Study

Melinda G Pauly, Yueh-Yun Chi, Jemily Malvar, Roy Leong, Susan Colace, Nathan Gossai, Nobuko Hijiya, Chintan Parekh, Susan R Rheingold, Anupam Verma, Bill H Chang, Todd M Cooper, Andrew Doan, Yamilet Huerta, Kelly Elizabeth Faulk, Diane Hanna, Kenneth Matthew Heym, Mallorie M. Heneghan, Joel Kaplan, Luciano Dalla-Pozza, Seth E. Karol, Andrew E. Place, Jenna Rossoff, Eric S. Schafer, Tamra Slone, Michelle L. Hermiston, Maria Luisa Sulis
Journal: Blood
Blood (2024) 144 (Supplement 1): 4187.
https://doi.org/10.1182/blood-2024-209138
Published: 2024
Journal Articles

Feasibility of Adjusting Risk Group and Risk Group-Based Therapy during Induction in the Treatment of B-Cell Acute Lymphoblastic Leukemia: Results from DFCI ALL Consortium Protocol 16-001

Lynda M. Vrooman, Yael Flamand, Melissa A. Burns, Victoria B. Koch, Sarah M. Cronholm, Sarah K. Hunt, Peter D. Cole, Lisa M. Gennarini, Marian H. Harris, Nobuko Hijiya, Justine M. Kahn, Kara M. Kelly, Bruno Michon, Andrew E. Place, Thai Hoa Tran, Jennifer J.G. Welch, Stephen E. Sallan, Lewis B. Silverman
Journal: Blood
Blood (2024) 144 (Supplement 1): 311.
https://doi.org/10.1182/blood-2024-208605
Published: 2024
Journal Articles

Establishing a Sociodemographic Data Banking Study in Patients with Hematologic Disorders - a Feasibility Assessment

Morohuntodun O. Oni, Alexandria Hawkins, Emily Stein, Steven G. Dubois, Katie A. Greenzang, Rahela Aziz-Bose, Christine Duncan, Allison F. O'Neill, Andrew E. Place, Puja J. Umaretiya, Natasha Archer, Kira Bona
Journal: Blood
Blood (2023) 142 (Supplement 1): 2384.
https://doi.org/10.1182/blood-2023-187703
Published: 2023
Journal Articles

Updated Results on a Multicenter Phase II Study of a Dose Intensified Pediatric Regimen in Adults with Acute Lymphoblastic Leukemia: The 06-254 DFCI ALL Consortium Trial

Yannis K. Valtis, Yael Flamand, Shai Shimony, Andrew E. Place, Lewis B. Silverman, Lynda M. Vrooman, Andrew M. Brunner, Stephen E. Sallan, Martha Wadleigh, Jacqueline S. Garcia, Eric S. Winer, Ilene Galinsky, Julie Bergeron, Julie Asch, Matthew D. Seftel, Richard M Stone, Marlise R. Luskin, Daniel J. DeAngelo
Journal: Blood
Blood (2023) 142 (Supplement 1): 4238.
https://doi.org/10.1182/blood-2023-181014
Published: 2023
Journal Articles

Preliminary Safety and Efficacy of Venetoclax and Selinexor in Combination with Chemotherapy in Pediatric and Young Adult Patients with Relapsed or Refractory Acute Myeloid Leukemia: Selclax

Sara Zarnegar-Lumley, Seth E. Karol, Stanley Pounds, Jeffery M. Klco, Maria Luisa Sulis, Dennis John Kuo, Kenneth Matthew Heym, Kathleen Ludwig, Alexandra McLean Stevens, Thomas B. Alexander, Kelly Elizabeth Faulk, Himalee S. Sabnis, Sarah K. Tasian, Jeffrey Taub, Andrew E. Place, Jeffrey E. Rubnitz
Journal: Blood
Blood (2023) 142 (Supplement 1): 56.
https://doi.org/10.1182/blood-2023-174342
Published: 2023
Journal Articles

Venous Thromboembolism in Adolescents and Young Adults with Acute Lymphoblastic Leukemia Treated on a Pediatric-Inspired Regimen

Hari S. Raman, Shai Shimony, Yannis K. Valtis, Yael Flamand, Andrew E. Place, Lewis B. Silverman, Stephen E. Sallan, Lynda M. Vrooman, Andrew M. Brunner, Donna S. Neuberg, Ilene Galinsky, Jacqueline S. Garcia, Eric S. Winer, Martha Wadleigh, Richard M Stone, Jean M. Connors, Daniel J. DeAngelo, Marlise R. Luskin
Journal: Blood
Blood (2023) 142 (Supplement 1): 1456.
https://doi.org/10.1182/blood-2023-178353
Published: 2023
Journal Articles

Body Mass Index Effect on Survival and Toxicities Differs between Age Groups Among Adolescents and Young Adults Treated on DFCI Consortium ALL Trials

Shai Shimony, Yael Flamand, Yannis K. Valtis, Andrew E. Place, Lewis B. Silverman, Lynda M. Vrooman, Andrew M. Brunner, Stephen E. Sallan, Richard M. Stone, Martha Wadleigh, Donna S. Neuberg, Daniel J DeAngelo, Marlise R. Luskin
Journal: Blood
Blood (2022) 140 (Supplement 1): 3164–3165.
https://doi.org/10.1182/blood-2022-158348
Published: 2022
Journal Articles

Adolescent and Young Adults with ALL Who Complete Therapy on DFCI Consortium ALL Trials Have Excellent Long-Term Overall Survival

Yannis K. Valtis, Yael Flamand, Shai Shimony, Andrew E. Place, Lewis B. Silverman, Lynda M. Vrooman, Andrew M. Brunner, Stephen E. Sallan, Martha Wadleigh, Richard M. Stone, Daniel J DeAngelo, Marlise R. Luskin
Journal: Blood
Blood (2022) 140 (Supplement 1): 8901–8903.
https://doi.org/10.1182/blood-2022-159286
Published: 2022
Journal Articles

Nelarabine Combination Therapy for Relapsed or Refractory T-Cell Acute Lymphoblastic Lymphoma/Leukemia

Shai Shimony, Yiwen Liu, Yannis K. Valtis, Jonathan D. Paolino, Andrew E. Place, Andrew M. Brunner, Lachelle D. Weeks, Lewis B. Silverman, Lynda M. Vrooman, Donna S. Neuberg, Richard M. Stone, Daniel J. DeAngelo, Marlise R. Luskin
Journal: Blood
Blood (2022) 140 (Supplement 1): 8989–8990.
https://doi.org/10.1182/blood-2022-157545
Published: 2022
Journal Articles

Single-Cell Multi-Omics Reveals Immune Microenvironment Alterations in T-Cell Acute Lymphoblastic Leukemia

Caroline R.M. Wiggers, Eugene Y. Cho, Justin Hegel, Julia Frede, Hannah Stuart, Klothilda K. Lim, Yana Pikman, Marian H. Harris, Andrew E. Place, Lewis B. Silverman, Jens G. Lohr, Birgit Knoechel
Journal: Blood
Blood (2022) 140 (Supplement 1): 9192–9193.
https://doi.org/10.1182/blood-2022-166511
Published: 2022
Journal Articles

Low Rates of Venoocclusive Disease and Non-Relapse Mortality in Pediatric Patients Undergoing Allogeneic Hematopoietic Cell Transplantation Following Inotuzumab Ozogamicin Reinduction for Relapsed or Refractory B Cell Acute Lymphoblastic Leukemia

Jonathan D. Paolino, Jiemin Yang, Andrew E. Place, Christine N. Duncan, Steven P. Margossian, Leslie E. Lehmann, John T. Horan, Malika Kapadia, Jennifer S. Whangbo, Francesca Alvarez Calderon, Melissa A. Burns, Leslie S. Kean, Lewis B. Silverman, Donna S. Neuberg, Susanne H.C. Baumeister
Journal: Blood
Blood (2021) 138 (Supplement 1): 2853.
https://doi.org/10.1182/blood-2021-152857
Published: 2021
Journal Articles

Vincristine Sulfate Liposome Injection (VSLI, Marqibo®) in Combination with UK ALL-R3 Induction Chemotherapy for Children, Adolescents and Young Adults with Relapsed Acute Lymphoblastic Leukemia (ALL): A Therapeutic Advances in Childhood Leukemia and Lymphoma (TACL) Consortium Trial

Nirali N. Shah, Eric S Schafer, Kenneth Matthew Heym, Andrew E. Place, Melissa A. Burns, Nathan Gossai, Peter Shaw, Michael J. Burke, Bill H. Chang, Michelle L. Hermiston, Reuven J Schore, Teresa Rushing, Paul F Jarosinski, Richard Sposto, Ellynore Florendo, Jemily Malvar, Yueh-Yun Chi, James A. Whitlock, Lewis B. Silverman, Deepa Bhojwani, Alan S. Wayne
Journal: Blood
Blood (2021) 138 (Supplement 1): 3402.
https://doi.org/10.1182/blood-2021-149365
Published: 2021
Journal Articles

Performance of Next Generation Sequencing for Minimal Residual Disease Detection for Pediatric Patients with Acute Lymphoblastic Leukemia: Results from the Prospective Clinical Trial DFCI 16-001

Jonathan D. Paolino, Marian H. Harris, Kristen E. Stevenson, Victoria Koch, Peter D. Cole, Lisa M. Gennarini, Justine M. Kahn, Kara M. Kelly, IIan Kirsch, Bruno Michon, Andrew E. Place, Thai Hoa Tran, Jennifer J.G. Welch, Lewis B. Silverman
Journal: Blood
Blood (2021) 138 (Supplement 1): 3485.
https://doi.org/10.1182/blood-2021-152369
Published: 2021
Journal Articles

Impact of Age, Body Surface Area, and Body Mass Index on Pegaspargase Toxicity and Pharmacokinetics: A Report from the DFCI ALL Consortium

Jonathan D. Paolino, Yael Flamand, Kristen E. Stevenson, Victoria Koch, Uma H. Athale, Peter D. Cole, Lisa M. Gennarini, Justine M. Kahn, Kara M. Kelly, Caroline Laverdiere, Jean-Marie Leclerc, Bruno Michon, Andrew E. Place, Jeffrey G. Supko, Thai Hoa Tran, Jennifer J.G. Welch, Donna S. Neuberg, Stephen E. Sallan, Lewis B. Silverman, Lynda M. Vrooman
Journal: Blood
Blood (2021) 138 (Supplement 1): 3396.
https://doi.org/10.1182/blood-2021-151313
Published: 2021
Journal Articles

Single-cell RNA-seq reveals developmental plasticity with coexisting oncogenic states and immune evasion programs in ETP-ALL

Praveen Anand, Amy Guillaumet-Adkins, Valeriya Dimitrova, Huiyoung Yun, Yotam Drier, Noori Sotudeh, Anna Rogers, Madhu M. Ouseph, Monica Nair, Sayalee Potdar, Randi Isenhart, Jake A. Kloeber, Tushara Vijaykumar, Leili Niu, Tiffaney Vincent, Guangwu Guo, Julia Frede, Marian H. Harris, Andrew E. Place, Lewis B. Silverman, David T. Teachey, Andrew A. Lane, Daniel J. DeAngelo, Jon C. Aster, Bradley E. Bernstein, Jens G. Lohr, Birgit Knoechel
Journal: Blood
Blood (2021) 137 (18): 2463–2480.
https://doi.org/10.1182/blood.2019004547
Published: 2021
Includes: Supplemental data
Journal Articles

Pediatric Patients with Relapsed/Refractory Acute Lymphoblastic Leukemia Harboring Heterogeneous Genomic Profiles Respond to Venetoclax in Combination with Chemotherapy

Andrew E. Place, MDPhD, Seth E. Karol, MD, Christopher J. Forlenza, MD, Marion Gambart, MD, Todd M. Cooper, DO, Christopher Fraser, MBBS, Gunnar Cario, MD PhD, Maureen M O'Brien, MD, Nicolas U. Gerber, MD, Phillip Barnette, MD, Dirk Reinhardt, MDPhD, Giridharan Ramsingh, MD, Bo Tong, PhD, Kristina Unnebrink, PhD, Deeksha Vishwamitra, PhD, Fengjiao Dunbar, PhD, Betty A. Prine, BS, Tammy L. Palenski, PhD, Mignon L. Loh, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 37–38.
https://doi.org/10.1182/blood-2020-137376
Published: 2020
Journal Articles

Venetoclax Crosses the Blood Brain Barrier: A Pharmacokinetic Analysis of the Cerebrospinal Fluid in Pediatric Leukemia Patients

Ahmed Hamed Salem, PhD FCP, Mohamed A Badawi, PhD, Andrew E. Place, MDPhD, Tammy L. Palenski, PhD, Richard Arrendale, PhD, Su Young Kim, Sara Federico, MD, Todd M. Cooper, DO, Rajeev Menon, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 30–31.
https://doi.org/10.1182/blood-2020-137197
Published: 2020
Journal Articles

Venetoclax Alone or in Combination with Chemotherapy: Responses in Pediatric Patients with Relapsed/Refractory Acute Myeloid Leukemia with Heterogeneous Genomic Profiles

Seth E. Karol, MD, Henrique Bittencourt, MD PhD, Daniel A. Morgenstern, MD, Margaret E. Macy, MD, Seong Lin Khaw, MD, Todd M. Cooper, DO, Arnaud Petit, MD PhD, Giridharan Ramsingh, MD, Bo Tong, PhD, Kristina Unnebrink, PhD, Deeksha Vishwamitra, PhD, Fengjiao Dunbar, PhD, Betty A. Prine, BS, Tammy L. Palenski, PhD, Andrew E. Place, MDPhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 30–31.
https://doi.org/10.1182/blood-2020-136999
Published: 2020
Journal Articles

Pegaspargase Re-Challenge after Grade 2 Hypersensitivity Reaction in Childhood Acute Lymphoblastic Leukemia: Results from DFCI 16-001

Lynda M. Vrooman, MD, Yael Flamand, MS, Victoria Koch, BS, Melissa A. Burns, MD, Sarah M. Cronholm, BA, Sarah K. Hunt, BS, MPH, Peter D. Cole, MD, Lisa M. Gennarini, MD, Justine M. Kahn, MDMSc, Kara M. Kelly, MD, Bruno Michon, MD FRCPC, Donna S. Neuberg, ScD, Andrew E. Place, MDPhD, Thai Hoa Tran, MD, Jennifer J.G. Welch, MD, Kristen E. Stevenson, MS, Stephen E. Sallan, MD, Lewis B. Silverman, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 30–31.
https://doi.org/10.1182/blood-2020-138840
Published: 2020