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Helen J Blair
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Journal Articles

Dual Targeting of MDM2 and BCL2/Bclxl Demonstrates Potent Synergistic Activity in High-Risk Adult Acute Lymphoblastic Leukemia

Hayden L Bell, Mankaran Singh, Helen J Blair, Olaf Heidenreich, Frederik W. van Delft, Anthony V. Moorman, John Lunec, Julie Irving
Journal: Blood
Blood (2022) 140 (Supplement 1): 9181–9182.
https://doi.org/10.1182/blood-2022-159573
Published: 2022
Journal Articles

Epigenetic regulator genes direct lineage switching in  MLL/AF4 leukemia

Ricky Tirtakusuma, Katarzyna Szoltysek, Paul Milne, Vasily V. Grinev, Anetta Ptasinska, Paulynn S. Chin, Claus Meyer, Sirintra Nakjang, Jayne Y. Hehir-Kwa, Daniel Williamson, Pierre Cauchy, Peter Keane, Salam A. Assi, Minoo Ashtiani, Sophie G. Kellaway, Maria R. Imperato, Fotini Vogiatzi, Elizabeth K. Schweighart, Shan Lin, Mark Wunderlich, Janine Stutterheim, Alexander Komkov, Elena Zerkalenkova, Paul Evans, Hesta McNeill, Alex Elder, Natalia Martinez-Soria, Sarah E. Fordham, Yuzhe Shi, Lisa J. Russell, Deepali Pal, Alex Smith, Zoya Kingsbury, Jennifer Becq, Cornelia Eckert, Oskar A. Haas, Peter Carey, Simon Bailey, Roderick Skinner, Natalia Miakova, Matthew Collin, Venetia Bigley, Muzlifah Haniffa, Rolf Marschalek, Christine J. Harrison, Catherine A. Cargo, Denis Schewe, Yulia Olshanskaya, Michael J. Thirman, Peter N. Cockerill, James C. Mulloy, Helen J. Blair, Josef Vormoor, James M. Allan, Constanze Bonifer, Olaf Heidenreich, Simon Bomken
Journal: Blood
Blood (2022) 140 (17): 1875–1890.
https://doi.org/10.1182/blood.2021015036
Published: 2022
Includes: Supplemental data
Journal Articles

Preclinical Investigation of the p53-MDM2 Antagonist Idasanutlin (RG7388) Demonstrates Significant Activity in High Risk Adult Acute Lymphoblastic Leukemia

Hayden L Bell, Mankaran Singh, MSc, Helen J Blair, PhD, Frederik W. van Delft, MD PhD, Anthony V. Moorman, PhD, John Lunec, PhDMRCR(Hon) FRCPath, Julie Irving, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 38.
https://doi.org/10.1182/blood-2020-139536
Published: 2020
Journal Articles

Exploring Pre-B Cell Receptor Signalling As a Therapeutic Target in Acute Lymphoblastic Leukaemia

Ali Alhammer, M.Sc, Marian Case, MSc, Helen J Blair, PhD, Josef Vormoor, MD FRCPCH, Julie Irving, PhD
Journal: Blood
Blood (2016) 128 (22): 4066.
https://doi.org/10.1182/blood.V128.22.4066.4066
Published: 2016
Journal Articles

Inhibition of ATR in Combination with Nucleoside Analogues Eradicates Acute Myeloid Leukaemia in an Orthotopic Murine Xenograft Model

Sarah E Fordham, PhD, Helen J Blair, PhD, Claire J Elstob, PhD, Deepali Pal, PhD, Nicola Curtin, PhD, Paul Milne, PhD, Matthew Collin, MD PhD, Graham H Jackson, MD MBBS, Helen J Marr, MD PhD, Olaf Heidenreich, PhD, Ruth Plummer, John Pollard, PhD, Tobias F. Menne, MD PhD FRCPath, Gail L Jones, MD BMBS, James M Allan, DPhil
Journal: Blood
Blood (2016) 128 (22): 4031.
https://doi.org/10.1182/blood.V128.22.4031.4031
Published: 2016
Journal Articles

Identification of CCND2 As a RUNX1/ETO Target Required for Leukaemic Propagation

Lynsey McKenzie, PhD, Natalia Martinez-Soria, PhD, Julia Draper, DPhil, Sirintra Nakjang, PhD, Helen J Blair, PhD, Christian Wichmann, MD, Josef Vormoor, MD FRCPCH, Constanze Bonifer, PhD, Georges Lacaud, PhD, Olaf Heidenreich, PhD
Journal: Blood
Blood (2016) 128 (22): 835.
https://doi.org/10.1182/blood.V128.22.835.835
Published: 2016
Journal Articles

Development of in Vivo Models of Paediatric Burkitt Lymphoma Allowing Therapeutic Target Analysis and Drug Testing

Natalie Bell, PhD, Helen J Blair, PhD, Josef Vormoor, MD FRCPCH, Chris Bacon, MBChB, PhD, Vikki Rand, PhD, Olaf Heidenreich, PhD, Simon Bomken, PhD MBBS
Journal: Blood
Blood (2014) 124 (21): 5501.
https://doi.org/10.1182/blood.V124.21.5501.5501
Published: 2014
Journal Articles

The Genomic Landscape Of Lineage Switch Acute Leukemia

Olaf Heidenreich, PhD, Ricky Tirtakusuma, MRes, Simon Bomken, PhD, MBBS, Dan Williamson, Sarah E Fordham, PhD, Hesta McNeill, Claus Meyer, PhD, Rolf Marschalek, PhD, Josef Vormoor, MD, Andrew Hall, Julie Irving, PhD, Helen J Blair, PhD, Dan Swan, Bronia Baker, Peter Carey, Nick Bown, David Bourn, Paul Evans, Roderick Skinner, PhD, MBChB, FRCPCH, Simon Bailey, Vikki Rand, PhD, James Allan, PhD
Journal: Blood
Blood (2013) 122 (21): 2552.
https://doi.org/10.1182/blood.V122.21.2552.2552
Published: 2013
Journal Articles

Mir∼17-92 Identifies BCL2 As a Therapeutic Target In BCR-ABL Positive B-Lineage Acute Lymphoblastic Leukemia

Matthias Eder, MD, Alex Elder, David Barzan, Karin Battmer, Simon Bomken, Melanie Ricke-Hoch, Anke Schröder, Letizia Venturini, Heike Pfeiffer, Helen J Blair, PhD, Josef Vormoor, MD, Oliver G. Ottmann, MD, Arnold Ganser, Andreas Pich, Denise Hilfiker-Kleiner, Olaf Heidenreich, PhD, Michaela Scherr
Journal: Blood
Blood (2013) 122 (21): 835.
https://doi.org/10.1182/blood.V122.21.835.835
Published: 2013