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Sudeep Prajapati
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Journal Articles

REM-422, a Small Molecule MYB mRNA Degrader, Demonstrates Anti-Leukemic Activity As Monotherapy and in Combination with Standards of Care in Preclinical Models of AML

Samantha Levin-Furtney, Michael Thomas, Alycen M. Harney, Mengge Shan, Alexander Ivliev, Adam Stefek, Michael Cameron, Sudeep Prajapati, Michael Seiler, Dominic Reynolds, Silvia Buonamici, Charles Kung
Journal: Blood
Blood (2024) 144 (Supplement 1): 826.
https://doi.org/10.1182/blood-2024-208725
Published: 2024
Journal Articles

REM-422, a Potent, Selective, Oral Small Molecule mRNA Degrader of the MYB Oncogene, Demonstrates Anti-Tumor Activity in Mouse Xenograft Models of AML

Sudeep Prajapati, Michael Cameron, Bryan M. Dunyak, Mengge Shan, Y. Amy Siu, Samantha Levin-Furtney, Joshua Powe, Eileen T.M. Burchfiel, Sarah E. Cabral, Alycen M. Harney, Regina K. Keenan, Kevin M. Larpenteur, Jesper L.V. Maag, Andrew R. Snyder, Dan T. Nguyen, Cecile Blaustein, Silvia Buonamici, Dominic Reynolds, Matthew J. Schnaderbeck, Michael Seiler, Frédéric H. Vaillancourt, Peter Smith, Zaven Kaprielian, Charles Kung
Journal: Blood
Blood (2023) 142 (Supplement 1): 1425.
https://doi.org/10.1182/blood-2023-182676
Published: 2023
Journal Articles

H3B-8800, an Orally Bioavailable Modulator of the SF3b Complex, Shows Efficacy in Spliceosome-Mutant Myeloid Malignancies

Silvia Buonamici, PhD, Akihide Yoshimi, MD PhD, Michael Thomas, Michael Seiler, PhD, Betty Chan, PhD, Benjamin Caleb, Rachel Darman, PhD, Peter Fekkes, PhD, Craig Karr, PhD, Gregg F. Keaney, PhD, Virginia M. Klimek, MD, Kaiko Kunii, Linda Lee, Stanley Chun-Wei Lee, PhD, Xiang Liu, PhD, Carol Meeske, Yoshiharu Mizui, PhD, Eric Padron, MD, Eunice Park, PhD, Ermira Pazolli, PhD, Sudeep Prajapati, PhD, Justin Taylor, MD, John Wang, PhD, Markus Warmuth, MD, Lihua Yu, PhD, Ping Zhu, MD, Omar Abdel-Wahab, MD, Peter G Smith, PhD
Journal: Blood
Blood (2016) 128 (22): 966.
https://doi.org/10.1182/blood.V128.22.966.966
Published: 2016