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Shrivani Sriskanthadevan
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Journal Articles

Leveraging increased cytoplasmic nucleoside kinase activity to target mtDNA and oxidative phosphorylation in AML

Sanduni U. Liyanage, Rose Hurren, Veronique Voisin, Gaëlle Bridon, Xiaoming Wang, ChangJiang Xu, Neil MacLean, Thirushi P. Siriwardena, Marcela Gronda, Dana Yehudai, Shrivani Sriskanthadevan, Daina Avizonis, Aisha Shamas-Din, Mark D. Minden, Gary D. Bader, Rebecca Laposa, Aaron D. Schimmer
Journal: Blood
Blood (2017) 129 (19): 2657–2666.
https://doi.org/10.1182/blood-2016-10-741207
Published: 2017
Includes: Supplemental data
Journal Articles

Leveraging Increased Nucleoside Kinase Activity to Selectively Deplete Mitochondrial DNA (mtDNA), Impair Oxidative Phosphorylation, and Target AML Cells

Sanduni U. Liyanage, Hon. B. Sc., Rose Hurren, Veronique Voisin, Wang Xiaoming, Gaëlle Bridon, Changjiang Xu, Neil MacLean, Thirushi Siriwardena, Aisha Shamas-Din, PhD, Shrivani Sriskanthadevan, Mark D. Minden, MD PhD, Gary D Bader, Rebecca Laposa, Aaron D. Schimmer, MD PhD
Journal: Blood
Blood (2016) 128 (22): 1573.
https://doi.org/10.1182/blood.V128.22.1573.1573
Published: 2016
Journal Articles

AML cells have low spare reserve capacity in their respiratory chain that renders them susceptible to oxidative metabolic stress

Shrivani Sriskanthadevan, Danny V. Jeyaraju, Timothy E. Chung, Swayam Prabha, Wei Xu, Marko Skrtic, Bozhena Jhas, Rose Hurren, Marcela Gronda, Xiaoming Wang, Yulia Jitkova, Mahadeo A. Sukhai, Feng-Hsu Lin, Neil Maclean, Rob Laister, Carolyn A. Goard, Peter J. Mullen, Stephanie Xie, Linda Z. Penn, Ian M. Rogers, John E. Dick, Mark D. Minden, Aaron D. Schimmer
Journal: Blood
Blood (2015) 125 (13): 2120–2130.
https://doi.org/10.1182/blood-2014-08-594408
Published: 2015
Includes: Supplemental data
Journal Articles

Inhibition of Fatty Acid Oxidation with Avocatin B Selectively Targets AML Cells and Leukemia Stem Cells

Eric A Lee, Leonard Angka, Sarah-Grace Rota, Thomas Hanlon, Rose Hurren, Xiao Ming Wang, Marcela Gronda, MSc, Dannie Bernard, Mark D. Minden, MD PhD, Andrew Mitchell, Andrea Edginton, PhD, Shrivani Sriskanthadevan, PhD, Alessandro Datti, PhD, Jeff Wrana, PhD, Jamie W Joseph, PhD, Joe Quadrilatero, PhD, Aaron D. Schimmer, MD PhD, Paul A Spagnuolo, PhD
Journal: Blood
Blood (2014) 124 (21): 268.
https://doi.org/10.1182/blood.V124.21.268.268
Published: 2014
Journal Articles

AML Cells Have Altered Mitochondrial Biogenesis and Low Spare Reserve Capacity in Their Respiratory Chain That Renders Them Susceptible to Oxidative Metabolic Stress.

Shrivani Sriskanthadevan, PhD, Timothy E Chung, Marko Skrtic, PhD, Bozhena Jhas, BSc, Rose Hurren, BSc, Marcela Gronda, MSc, Xiao Ming Wang, Yulia Jitkova, PhD, Mahadeo A. Sukhai, PhD, Feng-Hsu Lin, PhD, Neil Maclean, BSc, Rob C. Laister, PhD, Peter Mullen, PhD, Stephanie Xie, Linda Penn, PhD, Ian M. Rogers, PhD, John E. Dick, PhD $, Mark D. Minden, MD, PhD, Aaron D Schimmer, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 2581.
https://doi.org/10.1182/blood.V120.21.2581.2581
Published: 2012
Journal Articles

Chronic Inhibition of Mitochondrial Translation Alters Metabolism and Stemness in AML

Jhas Bozhena, BSc, Shrivani Sriskanthadevan, PhD, Marko Skrtic, PhD, Mahadeo A. Sukhai, PhD, Veronique Voisin, PhD, Yulia Jitkova, PhD, Marcela Gronda, MSc, Rose Hurren, BSc, Xiaoming Wang, Rob C. Laister, PhD, Gary D. Bader, Ph.D., Mark D. Minden, MD, PhD, Aaron D. Schimmer, MD
Journal: Blood
Blood (2012) 120 (21): 1364.
https://doi.org/10.1182/blood.V120.21.1364.1364
Published: 2012
Journal Articles

Inhibition of Mitochondrial Translation As a Therapeutic Strategy for Acute Myeloid Leukemia (AML)

Marko Skrtic, BSc, Shrivani Sriskanthadevan, PhD, Bozhena Livak, BSc, Marinella Gebbia, PhD, Xiaoming Wang, Zezhou Wang, PhD, Rose Hurren, BSc, Yulia Jitkova, PhD, Marcela Gronda, MSc, Neil Maclean, BSc, Courteney Lai, BSc, Yanina Eberhard, BSc, PhD, Justyna Bartoszko, BSc, Paul A. Spagnuolo, PhD, Angela Rutledge, PhD, Alessandro Datti, PhD, Troy Ketela, Jason Moffat, Brian H Robinson, PhD, Jessie M Cameron, PhD, Jeff L. Wrana, PhD, Connie J. Eaves, PhD, Mark D. Minden, MD, PhD, Jean C.Y. Wang, MD, PhD, John E. Dick, PhD, R. Keith Humphries, MD, PhD, Corey Nislow, PhD, Guri Giaever, PhD, Aaron D Schimmer, MD, PhD
Journal: Blood
Blood (2011) 118 (21): 233.
https://doi.org/10.1182/blood.V118.21.233.233
Published: 2011
Journal Articles

AML Cells Have Increased Mitochondrial Mass but Less Reserve in Their Respiratory Chain Complexes Leading to Heightened Sensitivity to Inhibition of Mitochondrial Protein Translation,

Shrivani Sriskanthadevan, PhD, Skrtic Marko, BSc, Bozhena Livak, BSc, Yulia Jitkova, PhD, Rose Hurren, BSc, Marcela Gronda, MSc, Rob Laister, PhD, Peter Mullen, PhD, Linda Penn, PhD, Mark D. Minden, MD, PhD, Aaron D Schimmer, MD, PhD
Journal: Blood
Blood (2011) 118 (21): 3585.
https://doi.org/10.1182/blood.V118.21.3585.3585
Published: 2011