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Journal Articles

Atg7 suppression enhances chemotherapeutic agent sensitivity and overcomes stroma-mediated chemoresistance in acute myeloid leukemia

Sujan Piya, Steven M. Kornblau, Vivian R. Ruvolo, Hong Mu, Peter P. Ruvolo, Teresa McQueen, R. Eric Davis, Numsen Hail, Jr, Hagop Kantarjian, Michael Andreeff, Gautam Borthakur

Blood (2016) 128 (9): 1260–1269.

https://doi.org/10.1182/blood-2016-01-692244

Published: 2016

Includes: Supplemental data

Journal Articles

Inhibition of Mcl-1 with the pan–Bcl-2 family inhibitor (–)BI97D6 overcomes ABT-737 resistance in acute myeloid leukemia

Rongqing Pan, Vivian R. Ruvolo, Jun Wei, Marina Konopleva, John C. Reed, Maurizio Pellecchia, Michael Andreeff, Peter P. Ruvolo

Blood (2015) 126 (3): 363–372.

https://doi.org/10.1182/blood-2014-10-604975

Published: 2015

Includes: Supplemental data

Journal Articles

ONC201 Induces p53-Independent Apoptosis and Cell Cycle Arrest in Hematological Malignancies and Leukemic Stem/Progenitor Cells By Inducing ER Stress and mTOR Inhibition

Jo Ishizawa, MD PhD, Kensuke Kojima, MD PhD, Dhruv Chachad, MS, Peter P. Ruvolo, PhD, Vivian R Ruvolo, MA, Rodrigo Jacamo, PhD, Archana Dilip, MS, Hong Mu, MD PhD, Zhihong Zeng, MD, Polina Matre, PhD, Joshua E. Allen, PhD, Sattva S Neelapu, MD, Timothy J. McDonnell, MD PhD, Roberto N. Miranda, MD, Larry W. Kwak, MD PhD, Hagop M. Kantarjian, MD, Marina Konopleva, MD PhD, R Eric Davis, MD, Michael Andreeff, MD PhD

Blood (2014) 124 (21): 3122.

https://doi.org/10.1182/blood.V124.21.3122.3122

Published: 2014

Journal Articles

Reverse Phase Protein Analysis of Mesenchymal Stem Cells from AML Patients and Healthy Donors Reveals Distinct Patterns of Protein Expression Reflecting Differences in Senescence, Differentiation and Survival Signaling

Peter P. Ruvolo, PhD, Venkata Lokesh Battula, PhD, YiHua Qui, MD, Vivian R Ruvolo, MA, Rodrigo Jacamo, PhD, Zhihong Zeng, MD, Rui-Yu Wang, MD PhD, Teresa McQueen, BS, Arvind Rao, SukYoung Yoo, Phuong M Le, Numsen Hail, PhD, Bing Z Carter, PhD, Steven M. Kornblau, MD, Michael Andreeff, MD PhD

Blood (2014) 124 (21): 4376.

https://doi.org/10.1182/blood.V124.21.4376.4376

Published: 2014

Journal Articles

Ablation of Autophagy-Related E1 Ligase Atg7 Primes Acute Myelogenous Leukemia Cells to Apoptosis, Sensitizes to Chemotherapy and Overcomes Stroma Mediated Protection

Sujan Piya, PhD, Vivian R Ruvolo, MA, Peter P. Ruvolo, PhD, Richard E. Davis, MD, Zhiqiang Wang, Teresa McQueen, BS, Wendy D Schober, PhD, Michael Andreeff, MD PhD, Gautam Borthakur, MD

Blood (2014) 124 (21): 901.

https://doi.org/10.1182/blood.V124.21.901.901

Published: 2014

Journal Articles

AML Genotype-Specific and Non-Specific Regulation of Mesenchymal Stromal Cell Transcriptome in the Bone Marrow Microenvironment

Rodrigo Jacamo, PhD, Xiaoyang Ling, PhD, Zhiqiang Wang, Wencai Ma, PhD, Min Zhang, PhD, Peter P. Ruvolo, PhD, Vivian R Ruvolo, MA, Scott W. Lowe, PhD, Johannes Zuber, MD, Marina Konopleva, MD PhD, R Eric Davis, MD, Michael Andreeff, MD PhD

Blood (2014) 124 (21): 1586.

https://doi.org/10.1182/blood.V124.21.1586.1586

Published: 2014

Journal Articles

GCS-100 Induces Apoptosis of Acute Myeloid Leukemia Cells By Disrupting Galectin-Mediated Survival Signaling

Richard E. Davis, MD, Vivian R Ruvolo, MA, Zhiqiang Wang, Wencai Ma, PhD, Wendy D. Schober, MLT (ASCP), James Rolke, George Tidmarsh, MD PhD, Michael Andreeff, MD PhD, Peter P. Ruvolo, PhD

Blood (2014) 124 (21): 904.

https://doi.org/10.1182/blood.V124.21.904.904

Published: 2014

Journal Articles

Activation of p53 By Novel MDM2 Antagonist RG7388 Overcomes AML Inherent and Acquired Resistance to Bcl-2 Inhibitor ABT-199 (GDC-0199)

Rongqing Pan, MS, Kensuke Kojima, MD PhD, Zhuanzhen Zheng, MD PhD, Vivian R Ruvolo, MA, Gwen Nichols, MD, Joel D. Leverson, PhD, Markus Dangl, PhD, Marina Konopleva, MD PhD, Michael Andreeff, MD PhD

Blood (2014) 124 (21): 2162.

https://doi.org/10.1182/blood.V124.21.2162.2162

Published: 2014

Journal Articles

Proteomic, Gene Expression, and Micro-RNA Analysis Of Bone Marrow Mesenchymal Stromal Cells In Acute Myeloid Leukemia Identifies Pro-Inflammatory, Pro-Survival Signatures In Vitro and In Vivo

Blood (2013) 122 (21): 3685.

https://doi.org/10.1182/blood.V122.21.3685.3685

Published: 2013

Journal Articles

Phosphorylation Of GSK3β Is Associated With Inferior Survival In Acute Myeloid Leukemia and Is An Indicator Of AKT Activation In AML Blasts and Bone Marrow Mesenchymal Stem Cells

Peter P. Ruvolo, PhD, Rui-yu Wang, MD, PhD, Vivian R Ruvolo, MA, Rodrigo Jacamo, PhD, Teresa McQueen, BS, Gautam Borthakur, MD, Yihua Qiu, MD, Kevin R. Coombes, PhD, Nianxiang Zhang, Elizabeth J Shpall, MD, Richard E Champlin, MD, Ramiro Garzon, MD, Guido Marcucci, MD, Carlo M. Croce, MD, Marina Konopleva, MD, PhD, Michael Andreeff, MD, PhD, Steven M. Kornblau, MD

Blood (2013) 122 (21): 2551.

https://doi.org/10.1182/blood.V122.21.2551.2551

Published: 2013

Journal Articles

Study Of Activity Of E6201, a Dual FLT3 and MEK Inhibitor, In Acute Myelogenous Leukemia With FLT3 Or RAS Mutation

Weiguo Zhang, M.D., Ph.D., Gautam Borthakur, MD, Chen Gao, Ye Chen, Yong S. Lan, PhD, Vivian R Ruvolo, MA, Kenichi Nomoto, PhD, Nanding Zhao, PhD, Marina Konopleva, MD, PhD, Michael Andreeff, MD, PhD

Blood (2013) 122 (21): 2683.

https://doi.org/10.1182/blood.V122.21.2683.2683

Published: 2013

Journal Articles

ONC201 Exerts p53-Independent Cytotoxicity Through TRAIL and DR5 Induction In Mantle Cell Lymphomas

Jo Ishizawa, MD, PhD, Kensuke Kojima, MD, PhD, Archana Dilip, MS, Vivian R Ruvolo, MA, Bing Z Carter, PhD, Joshua E Allen, PhD, Sattva S. Neelapu, MD, Timothy J. McDonnell, MD, PhD, Mala Kiran Talekar, MD, Wafik S. El-Deiry, MD, Larry W. Kwak, MD, PhD, Michael Andreeff, MD, PhD

Blood (2013) 122 (21): 3822.

https://doi.org/10.1182/blood.V122.21.3822.3822

Published: 2013

Journal Articles

ARC Supports Leukemia-Stromal Interactions By Regulating Multiple Receptor-Chemokine Axes In AML

Bing Z Carter, PhD, Po Yee Mak, M.S., Ye Chen, Rodrigo Jacamo, PhD, Vivian R Ruvolo, MA, Michael Andreeff, MD, PhD

Blood (2013) 122 (21): 3947.

https://doi.org/10.1182/blood.V122.21.3947.3947

Published: 2013

Journal Articles

ARC Suppresses Cell Death By Antagonizing p53 Function and Suppressing TRAIL In AML Cells

Po Yee Mak, M.S., Duncan H Mak, M.S., Kensuke Kojima, MD, PhD, Archana Dilip, MS, Vivian R Ruvolo, MA, Rodrigo Jacamo, PhD, Michael Andreeff, MD, PhD, Bing Z Carter, PhD

Blood (2013) 122 (21): 2688.

https://doi.org/10.1182/blood.V122.21.2688.2688

Published: 2013

Journal Articles

BCL-2-Selective BH3 Mimetic ABT-199 Is a Potent Agent For Acute Myeloid Leukemia

Rongqing Pan, MS, LaKeisha Debose, MS, Juliana M Benito, PhD, Leonard S Golfman, PhD, Patrick A Zweidler-McKay, MD, PhD, Lina Han, PhD, Karine G. Harutyunyan, PhD, Hong Mu, MD, PhD, Vivian R Ruvolo, MA, Eugene Park, Markus Muschen, MD, PhD, Joel Leverson, PhD, Gautam Borthakur, MD, Hagop M Kantarjian, MD, Peter P. Ruvolo, PhD, Michael Andreeff, MD, PhD, Marina Konopleva, MD, PhD

Blood (2013) 122 (21): 1456.

https://doi.org/10.1182/blood.V122.21.1456.1456

Published: 2013

Journal Articles

Exosomes Mediate Communication Between the Microenvironment and Leukemic Cells in Acute Myeloid Leukemia

Peter P. Ruvolo, PhD, Rodrigo Jacamo, PhD, Vivian R Ruvolo, MA, Jared K Burks, PhD, V Lokesh Battula, PhD, Teresa McQueen, BS, Marina Konopleva, MD, PhD, Steven M. Kornblau, MD, Ramiro Garzon, MD, Carlo M. Croce, MD, Michael Andreeff, MD, PhD

Blood (2012) 120 (21): 3469.

https://doi.org/10.1182/blood.V120.21.3469.3469

Published: 2012

Journal Articles

PKR Promotes BCL2 Phosphatase Function in ALL Cells by Dual Mechanisms: As a B56α Kinase and by Supporting B56α Expression Via eIF2α And the PI3K/AKT Cascade.

Peter P. Ruvolo, PhD, Vivian R Ruvolo

Blood (2008) 112 (11): 1333.

https://doi.org/10.1182/blood.V112.11.1333.1333

Published: 2008

Journal Articles

Apoptosis Inducing Factor Acts as a Survival Factor in Acute Myelogenous Leukemia through Mitochondrial Complex 1.

Rui-yu Wang, MD, PhD, Ismael J. Samudio, PhD, Teresa McQueen, BS, Wendy D. Schober, MLT, Vivian R. Ruvolo, Steven Kornblau, MD, Marina Konopleva, MD, PhD, Michael Andreeff, MD, PhD

Blood (2007) 110 (11): 1812.

https://doi.org/10.1182/blood.V110.11.1812.1812

Published: 2007

Journal Articles

The B56α PP2A B Regulatory Subunit Promotes Mitochondrial PP2A Activity and Supports Etoposide-Induced Cell Death in Human ALL Derived REH Cells.

Peter P. Ruvolo, PhD, Vivian R. Ruvolo, MA, Svitlana M. Kurinna, MS

Blood (2007) 110 (11): 3358.

https://doi.org/10.1182/blood.V110.11.3358.3358

Published: 2007

Journal Articles

Overexpression of Apoptosis-Inducing Factor (AIF) and Pro-Survival Function in AML.

Rui-Yu Wang, MD, PhD, Vivian R. Ruvolo, Teresa McQueen, Wendy D. Schober, Steven Kornblau, MD, Marina Konopleva, M.D., Ph.D., Michael Andreeff, M.D., PhD.

Blood (2006) 108 (11): 4395.

https://doi.org/10.1182/blood.V108.11.4395.4395

Published: 2006

NARROW

Atg7 suppression enhances chemotherapeutic agent sensitivity and overcomes stroma-mediated chemoresistance in acute myeloid leukemia

Inhibition of Mcl-1 with the pan–Bcl-2 family inhibitor (–)BI97D6 overcomes ABT-737 resistance in acute myeloid leukemia

ONC201 Induces p53-Independent Apoptosis and Cell Cycle Arrest in Hematological Malignancies and Leukemic Stem/Progenitor Cells By Inducing ER Stress and mTOR Inhibition

Reverse Phase Protein Analysis of Mesenchymal Stem Cells from AML Patients and Healthy Donors Reveals Distinct Patterns of Protein Expression Reflecting Differences in Senescence, Differentiation and Survival Signaling

Ablation of Autophagy-Related E1 Ligase Atg7 Primes Acute Myelogenous Leukemia Cells to Apoptosis, Sensitizes to Chemotherapy and Overcomes Stroma Mediated Protection

AML Genotype-Specific and Non-Specific Regulation of Mesenchymal Stromal Cell Transcriptome in the Bone Marrow Microenvironment

GCS-100 Induces Apoptosis of Acute Myeloid Leukemia Cells By Disrupting Galectin-Mediated Survival Signaling

Activation of p53 By Novel MDM2 Antagonist RG7388 Overcomes AML Inherent and Acquired Resistance to Bcl-2 Inhibitor ABT-199 (GDC-0199)

Proteomic, Gene Expression, and Micro-RNA Analysis Of Bone Marrow Mesenchymal Stromal Cells In Acute Myeloid Leukemia Identifies Pro-Inflammatory, Pro-Survival Signatures In Vitro and In Vivo

Phosphorylation Of GSK3β Is Associated With Inferior Survival In Acute Myeloid Leukemia and Is An Indicator Of AKT Activation In AML Blasts and Bone Marrow Mesenchymal Stem Cells

Study Of Activity Of E6201, a Dual FLT3 and MEK Inhibitor, In Acute Myelogenous Leukemia With FLT3 Or RAS Mutation

ONC201 Exerts p53-Independent Cytotoxicity Through TRAIL and DR5 Induction In Mantle Cell Lymphomas

ARC Supports Leukemia-Stromal Interactions By Regulating Multiple Receptor-Chemokine Axes In AML

ARC Suppresses Cell Death By Antagonizing p53 Function and Suppressing TRAIL In AML Cells

BCL-2-Selective BH3 Mimetic ABT-199 Is a Potent Agent For Acute Myeloid Leukemia

Exosomes Mediate Communication Between the Microenvironment and Leukemic Cells in Acute Myeloid Leukemia

PKR Promotes BCL2 Phosphatase Function in ALL Cells by Dual Mechanisms: As a B56α Kinase and by Supporting B56α Expression Via eIF2α And the PI3K/AKT Cascade.

Apoptosis Inducing Factor Acts as a Survival Factor in Acute Myelogenous Leukemia through Mitochondrial Complex 1.

The B56α PP2A B Regulatory Subunit Promotes Mitochondrial PP2A Activity and Supports Etoposide-Induced Cell Death in Human ALL Derived REH Cells.

Overexpression of Apoptosis-Inducing Factor (AIF) and Pro-Survival Function in AML.

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American Society of Hematology

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American Society of Hematology

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