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Journal Articles

Small-molecule XIAP antagonist restores caspase-9–mediated apoptosis in XIAP-positive diffuse large B-cell lymphoma cells

Saskia A. G. M. Cillessen, John C. Reed, Kate Welsh, Clemencia Pinilla, Richard Houghten, Erik Hooijberg, José Deurhof, Kitty C. M. Castricum, Pim Kortman, Corine J. Hess, Gert J. Ossenkoppele, Chris J. L. M. Meijer, Joost J. Oudejans
Journal: Blood
Blood (2008) 111 (1): 369–375.
https://doi.org/10.1182/blood-2007-04-085480
Published: 2008
Journal Articles

Inhibitors of XIAP sensitize CD40-activated chronic lymphocytic leukemia cells to CD95-mediated apoptosis

Arnon P. Kater, Frank Dicker, Massimo Mangiola, Kate Welsh, Richard Houghten, John Ostresh, Adel Nefzi, John C. Reed, Clemencia Pinilla, Thomas J. Kipps
Journal: Blood
Blood (2005) 106 (5): 1742–1748.
https://doi.org/10.1182/blood-2005-02-0695
Published: 2005
Journal Articles

Small-molecule XIAP inhibitors derepress downstream effector caspases and induce apoptosis of acute myeloid leukemia cells

Bing Z. Carter, Marcela Gronda, Zhiliang Wang, Kate Welsh, Clemencia Pinilla, Michael Andreeff, Wendy D. Schober, Adel Nefzi, Gregory R. Pond, Imtiaz A. Mawji, Richard A. Houghten, John Ostresh, Joseph Brandwein, Mark D. Minden, Andre C. Schuh, Richard A. Wells, Hans Messner, Kathy Chun, John C. Reed, Aaron D. Schimmer
Journal: Blood
Blood (2005) 105 (10): 4043–4050.
https://doi.org/10.1182/blood-2004-08-3168
Published: 2005
Journal Articles

Anti-CD20 Antibody Rituximab and Anti-CD23 Antibody IDEC-152 Induce Apoptosis of Malignant B-Cells in Combination with Chemical Antagonists of XIAP.

Massimo Mangiola, Ph.D, Kate Welsh, Ph.D, Shinichi Kitada, MD, Ph.D., Irene M. Pedersen, Ph.D., Nuzhat Pathan, Ph.D., Clementia Pinilla, Ph.D., Thomas J. Kipps, MD, Ph. D, John C. Reed, MD, Ph.D
Journal: Blood
Blood (2004) 104 (11): 1401.
https://doi.org/10.1182/blood.V104.11.1401.1401
Published: 2004
Journal Articles

Inhibition of XIAP Renders Newly CD40-Activated Chronic Lymphocytic Leukemia Cells Sensitive to Fas (CD95) Mediated Apoptosis.

Arnon P. Kater, MD, Frank Dicker, PhD, Massimo Mangiola, PhD, Kate Welsh, John Ostresh, PhD, Richard Houghten, PhD, John C. Reed, MD, PhD, Thomas J. Kipps, MD, PhD, Clemencia Pinilla, PhD
Journal: Blood
Blood (2004) 104 (11): 3474.
https://doi.org/10.1182/blood.V104.11.3474.3474
Published: 2004
Journal Articles

Inhibition of XIAP Enhances Specific Cytotoxic T Lymphocyte (CTL) Killing and CD20-Directed Antibody-Dependent Cellular Cytotoxicity of Chronic Lymphocytic Leukemia B Cells.

Arnon P. Kater, MD, Roman Rieger, PhD, Kate Welsh, PhD, Adel Nefzi, PhD, Richard Houghten, PhD, John C. Reed, MD. PhD, Clemencia Pinilla, PhD, Thomas J. Kipps, MD, PhD
Journal: Blood
Blood (2004) 104 (11): 3475.
https://doi.org/10.1182/blood.V104.11.3475.3475
Published: 2004
Journal Articles

Small-Molecule XIAP Inhibitors Derepress Downstream Effector Caspases and Induce Apoptosis of Leukemia Cell Lines and Patient Samples.

Aaron D. Schimmer, MD, PhD, Marcela Gronda, MSc, Zhiliang Wang, PhD, Kate Welsh, PhD, Clemencia Pinilla, PhD, Michael Andreeff, MD, PhD, Wendy D. Schober, Adel Nefzi, PhD, Richard Houghten, PhD, Joseph Brandwein, MD, Mark D. Minden, MD, PhD, Andre Schuh, MD, PhD, Richard A. Wells, MD, PhD, Hans Messner, MD, PhD, John C. Reed, MD, PhD, Bing Z. Carter, PhD
Journal: Blood
Blood (2004) 104 (11): 759.
https://doi.org/10.1182/blood.V104.11.759.759
Published: 2004