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Journal Articles

Novel Method to Evaluate the Quantitative Immune Functionality of CAR T-Cells to Analyze the Localization Change of CAR Molecules

Hiroshi Yasui, Keiji Hirano, Asako Kobayashi, Lihua Li, Takuya Takahashi, Margarita Artemenko, Naotaka Noda, Daichi Sadato, Kyoko Haraguchi, Ayako Arai, Kohzoh Imai, Noriko Doki, Masatoshi Yanagida, Tomohiro Ishigaki

Blood (2024) 144 (Supplement 1): 4851.

https://doi.org/10.1182/blood-2024-198277

Published: 2024

Journal Articles

Immune Function of Chimeric Antigen Receptor T Cells Quantitatively Assessed Via Molecular Imaging Flow Cytometry

Hiroshi Yasui, Kenji Hirano, Kiyosumi Ochi, Asako Kobayashi, Lihua Li, Daichi Sadato, Noriko Doki, Masatoshi Yanagida, Tomohiro Ishigaki

Blood (2023) 142 (Supplement 1): 6821.

https://doi.org/10.1182/blood-2023-173065

Published: 2023

Journal Articles

Combined Inhibition of HDAC and AKT As a Strategy to Overcome Multi-Drug Resistance in Patients with Multiple Myeloma

Mitsuhito Hirano, MD, Yoichi Imai, MD PhD, Takahiko Murayama, PhD, Kota Sato, MD PhD, Junichi Yamamoto, PhD, Takumi Ito, PhD, Muneyoshi Futami, MD PhD, Masaki Ri, Hiroshi Yasui, MD PhD, Noriko Gotoh, MD, Shinsuke Iida, MD PhD, Tadao Ishida, MD PhD, Hiroshi Handa, MD PhD, Arinobu Tojo, MD PhD

Blood (2019) 134 (Supplement_1): 4325.

https://doi.org/10.1182/blood-2019-122662

Published: 2019

Journal Articles

The Trifunctional Antibody (tri-31C2) Targeting CD38 and CD3 Has a Stronger Anti-Myeloma Effect Than the Chimeric Anti-CD38 Monoclonal Antibody (ch-31C2)

Tadao Ishida, MD PhD, Hiroshi Yasui, MD PhD, Kazuya Ishiguro, MD, Yuka Aoki, MD PhD, Hiroshi Ikeda, MD PhD

Blood (2016) 128 (22): 2097.

https://doi.org/10.1182/blood.V128.22.2097.2097

Published: 2016

Journal Articles

The Relationship of Myeloma Cells, Stromal Cells and Monocytes Under Bone Marrow Microenvironment

Hiroshi Ikeda, MD, PhD, Yuka Aoki, MD, Nasanori Nojima, MD, PhD, Hiroshi Yasui, MD, PhD, Toshiaki Hayashi, MD, PhD, Tadao Ishida, MD, PhD

Blood (2012) 120 (21): 4987.

https://doi.org/10.1182/blood.V120.21.4987.4987

Published: 2012

Journal Articles

Role of Allogeneic Stem Cell Transplantation for Adult T-Cell Leukemia in an HTLV-1 Non-Endemic Area of Japan.

Akio Shigematsu, MD, PhD, Junji Tanaka, MD, PhD, Naoki Kobayashi, MD, PhD, Hiroshi Yasui, MD, PhD, Motohiro Shindo, MD, PhD, Yasutaka Kakinoki, MD, PhD, Kakinoki Yasutaka, MD, PhD, Satoshi Iyama, MD, PhD, Kuroda HIroyuki, MD, PhD, Tsutsumi Yutaka, MD.PhD, Satoshi Hashino, MD, PhD, Masahiro Imamura, MD, PhD, Takanori Teshima, MD, PhD

Blood (2012) 120 (21): 3089.

https://doi.org/10.1182/blood.V120.21.3089.3089

Published: 2012

Journal Articles

PI3K/p110δ is a novel therapeutic target in multiple myeloma

Blood (2010) 116 (9): 1460–1468.

https://doi.org/10.1182/blood-2009-06-222943

Published: 2010

Includes: Supplemental data

Journal Articles

SNX-2112, a selective Hsp90 inhibitor, potently inhibits tumor cell growth, angiogenesis, and osteoclastogenesis in multiple myeloma and other hematologic tumors by abrogating signaling via Akt and ERK

Yutaka Okawa, Teru Hideshima, Paul Steed, Sonia Vallet, Steven Hall, Ken Huang, John Rice, Amy Barabasz, Brianna Foley, Hiroshi Ikeda, Noopur Raje, Tanyel Kiziltepe, Hiroshi Yasui, Sotaro Enatsu, Kenneth C. Anderson

Blood (2009) 113 (4): 846–855.

https://doi.org/10.1182/blood-2008-04-151928

Published: 2009

Includes: Supplemental data

Journal Articles

The Monoclonal Antibody nBT062 Conjugated to Cytotoxic Maytansinoids Has Potent and Selective Cytotoxicity against CD138 Positive Multiple Myeloma Cells in Vitro and in Vivo.

Blood (2008) 112 (11): 1716.

https://doi.org/10.1182/blood.V112.11.1716.1716

Published: 2008

Journal Articles

Inhibition of Hsp90 Targets Multiple Myeloma Cell Growth, Angiogenesis, and Osteoclastogenesis in the BM Microenvironment.

Yutaka Okawa, Teru Hideshima, Hiroshi Ikeda, Sonia Vallet, Tanyel Kiziltepe, Noopur Raje, Hiroshi Yasui, Sotaro Enatsu, Samantha Pozzi, Iris Breitkreutz, Klaus Podar, Paul G. Richardson, Kenneth C. Anderson

Blood (2007) 110 (11): 2522.

https://doi.org/10.1182/blood.V110.11.2522.2522

Published: 2007

Journal Articles

MLN3897, a novel CCR1 inhibitor, impairs osteoclastogenesis and inhibits the interaction of multiple myeloma cells and osteoclasts

Blood (2007) 110 (10): 3744–3752.

https://doi.org/10.1182/blood-2007-05-093294

Published: 2007

Includes: Supplemental data

Journal Articles

JS-K, a GST-activated nitric oxide generator, induces DNA double-strand breaks, activates DNA damage response pathways, and induces apoptosis in vitro and in vivo in human multiple myeloma cells

Tanyel Kiziltepe, Teru Hideshima, Kenji Ishitsuka, Enrique M. Ocio, Noopur Raje, Laurence Catley, Chun-Qi Li, Laura J. Trudel, Hiroshi Yasui, Sonia Vallet, Jeffery L. Kutok, Dharminder Chauhan, Constantine S. Mitsiades, Joseph E. Saavedra, Gerald N. Wogan, Larry K. Keefer, Paul J. Shami, Kenneth C. Anderson

Blood (2007) 110 (2): 709–718.

https://doi.org/10.1182/blood-2006-10-052845

Published: 2007

Includes: Supplemental data

Journal Articles

MLN3897, a Novel CCR1 Antagonist, Inhibits Osteoclastogenesis by Blocking Early ERK Activation.

Sonia Vallet, MD, Noopur Raje, MD, Kenji Ishitsuka, MD, Teru Hideshima, MD, Klaus Podar, MD, Petter Veiby, Iris Breitkreutz, MD, Tanyel Kizeltepe, PHD, Hiroshi Yasui, MD, Enrique M. Ocio, MD, Norihiko Shiraishi, Marco Ladetto, MD, Mario Boccadoro, MD, Kenneth C. Anderson, MD

Blood (2006) 108 (11): 1636.

https://doi.org/10.1182/blood.V108.11.1636.1636

Published: 2006

Journal Articles

Serotonin Receptor Antagonists Have an In Vitro and In Vivo Anti-Myeloma Effect That Is Mainly Mediated by Caspase Dependent Apoptosis.

Enrique M. Ocio, MD, PhD, Teru Hideshima, MD, PhD, Hiroshi Yasui, MD, PhD, Kiziltepe Tanyel, PhD, Hirosi Ikeda, MD, PhD, Yutaka Okawa, MD, PhD, Sonia Vallet, MD, Janice Jin, MD, Kenji Ishitsuka, MD, PhD, Noopur Raje, MD, Laurence Catley, MD, MBBS, FRACP, Kenneth C. Anderson, MD

Blood (2006) 108 (11): 2597.

https://doi.org/10.1182/blood.V108.11.2597.2597

Published: 2006

Journal Articles

Novel Agent Perifosine Enhances Antitumor Activity of Bortezomib, Rituximab and Other Conventional Therapies in Waldenstrom’s Macroglobulinemia.

Xavier Leleu, MD, Garrett O’Sullivan, Xiaoying Jia, Anne-Sophie Moreau, MD, Hai Ngo, Evdoxia Hatjiharisi, MD, Hiroshi Yasui, Zachary Hunter, Yu-Tsu Tai, PhD, Judith Runnels, PhD, Steven Treon, MD, Teru Hideshima, MD, Kenneth Anderson, MD, Irene Ghobrial, MD

Blood (2006) 108 (11): 2517.

https://doi.org/10.1182/blood.V108.11.2517.2517

Published: 2006

Journal Articles

Epigenetic Modulation by Vidaza™ induces Apoptosis and Overcomes In Vitro Drug Resistance in Human Multiple Myeloma Cells.

Tanyel Kiziltepe, PhD, Laurence Catley, MD, Teru Hideshima, MD,PhD, Noopur Raje, MD, Hiroshi Yasui, MD,PhD, Sonia Vallet, MD, Hiroshi Ikeda, MD,PhD, Yutaka Okawa, MD,PhD, Kenneth C. Anderson, MD

Blood (2006) 108 (11): 5001.

https://doi.org/10.1182/blood.V108.11.5001.5001

Published: 2006

Journal Articles

The Small-Molecule VEGF-Receptor Inhibitor Pazopanib (GW786034B) Targets Both Tumor and Endothelial Cells in Multiple Myeloma.

Klaus Podar, MD, MSc, PhD, Giovanni Tonon, MD, PhD, Martin Sattler, PhD, Yu-Tzu Tai, PhD, Steven LeGouill, MD, Hiroshi Yasui, MD, PhD, Kenji Ishitsuka, MD, PhD, Rakesh Kumar, PhD, Lini N. Pandite, MD, Teru Hideshima, MD, PhD, Dharminder Chauhan, PhD, Kenneth C. Anderson, MD

Blood (2006) 108 (11): 5003.

https://doi.org/10.1182/blood.V108.11.5003.5003

Published: 2006

Journal Articles

Novel Etodolac Analog SDX-308 (CEP-18082) Induces Cytotoxicity in Multiple Myeloma Cells Associated with Inhibition of Wnt/β-Catenin Pathway.

Hiroshi Yasui, MD, PhD, Teru Hideshima, M.D., Ph.D., Hiroshi Ikeda, M.D., Ph.D., Enrique M. Ocio, M.D., Ph.D., Tanyel Kiziltepe, Ph.D., Sonia Vallet, M.D., Ph.D., Yutaka Okawa, M.D., Ph.D., Shweta Chhetri, Kumar Sukhdeo, Kenji Ishitsuka, M.D., Ph.D., Klaus Podar, M.D., Ph.D., Noopur Raje, M.D., Ph.D., Dharminder Chauhan, Ph.D., Daniel R. Cattasco, M.D., Ph.D., Kenneth C. Anderson, M.D.

Blood (2006) 108 (11): 5005.

https://doi.org/10.1182/blood.V108.11.5005.5005

Published: 2006

Journal Articles

Akt Inhibitor Perifosine-Induced Cytotoxicity Is Associated with Significant Downregulation of Survivin in Human Multiple Myeloma (MM) Cells.

Teru Hideshima, MD, PhD, Hiroshi Yasui, MD, PhD, Laurence Catley, MD, Noopur Raje, MD, Dharminder Chauhan, PhD, Kenji Ishitsuka, MD, PhD, Klaus Podar, MD, PhD, Constantine Mitsiades, MD, PhD, Yu-Tzu Tai, PhD, Sonia Vallet, MD, Tanyel Kizitepe, PhD, Enrique Ocio, MD, PhD, Hiroshi Ikeda, MD, PhD, Yutaka Okawa, MD, PhD, Hiromasa Hideshima, Nikhil C. Munshi, MD, Paul G. Richardson, MD, Kenneth C. Anderson, MD

Blood (2006) 108 (11): 3410.

https://doi.org/10.1182/blood.V108.11.3410.3410

Published: 2006

Journal Articles

JS-K, a GST-Activated Nitric Oxide Generator, Induces DNA-Double Strand Breaks and Inhibits Growth and Survival of Multiple Myeloma Cells In Vitro and In Vivo .

Tanyel Kiziltepe, PhD, Teru Hideshima, Noopur Raje, Kenji Ishitsuka, Enrique M. Ocio, Laurence Catley, Chun-Qi Li, Laura Trudel, Hiroshi Yasui, Norihiko Shirashi, Yu-Tzu Tai, Dharminder Chauhan, Constantine Mitsiades, Joseph E. Saavedra, Gerald N. Wogan, Larry K. Keefer, Paul J. Shami, Kenneth C. Anderson

Blood (2006) 108 (11): 3453.

https://doi.org/10.1182/blood.V108.11.3453.3453

Published: 2006

NARROW

Novel Method to Evaluate the Quantitative Immune Functionality of CAR T-Cells to Analyze the Localization Change of CAR Molecules

Immune Function of Chimeric Antigen Receptor T Cells Quantitatively Assessed Via Molecular Imaging Flow Cytometry

Combined Inhibition of HDAC and AKT As a Strategy to Overcome Multi-Drug Resistance in Patients with Multiple Myeloma

The Trifunctional Antibody (tri-31C2) Targeting CD38 and CD3 Has a Stronger Anti-Myeloma Effect Than the Chimeric Anti-CD38 Monoclonal Antibody (ch-31C2)

The Relationship of Myeloma Cells, Stromal Cells and Monocytes Under Bone Marrow Microenvironment

Role of Allogeneic Stem Cell Transplantation for Adult T-Cell Leukemia in an HTLV-1 Non-Endemic Area of Japan.

PI3K/p110δ is a novel therapeutic target in multiple myeloma

SNX-2112, a selective Hsp90 inhibitor, potently inhibits tumor cell growth, angiogenesis, and osteoclastogenesis in multiple myeloma and other hematologic tumors by abrogating signaling via Akt and ERK

The Monoclonal Antibody nBT062 Conjugated to Cytotoxic Maytansinoids Has Potent and Selective Cytotoxicity against CD138 Positive Multiple Myeloma Cells in Vitro and in Vivo.

Inhibition of Hsp90 Targets Multiple Myeloma Cell Growth, Angiogenesis, and Osteoclastogenesis in the BM Microenvironment.

MLN3897, a novel CCR1 inhibitor, impairs osteoclastogenesis and inhibits the interaction of multiple myeloma cells and osteoclasts

JS-K, a GST-activated nitric oxide generator, induces DNA double-strand breaks, activates DNA damage response pathways, and induces apoptosis in vitro and in vivo in human multiple myeloma cells

MLN3897, a Novel CCR1 Antagonist, Inhibits Osteoclastogenesis by Blocking Early ERK Activation.

Serotonin Receptor Antagonists Have an In Vitro and In Vivo Anti-Myeloma Effect That Is Mainly Mediated by Caspase Dependent Apoptosis.

Novel Agent Perifosine Enhances Antitumor Activity of Bortezomib, Rituximab and Other Conventional Therapies in Waldenstrom’s Macroglobulinemia.

Epigenetic Modulation by Vidaza™ induces Apoptosis and Overcomes In Vitro Drug Resistance in Human Multiple Myeloma Cells.

The Small-Molecule VEGF-Receptor Inhibitor Pazopanib (GW786034B) Targets Both Tumor and Endothelial Cells in Multiple Myeloma.

Novel Etodolac Analog SDX-308 (CEP-18082) Induces Cytotoxicity in Multiple Myeloma Cells Associated with Inhibition of Wnt/β-Catenin Pathway.

Akt Inhibitor Perifosine-Induced Cytotoxicity Is Associated with Significant Downregulation of Survivin in Human Multiple Myeloma (MM) Cells.

JS-K, a GST-Activated Nitric Oxide Generator, Induces DNA-Double Strand Breaks and Inhibits Growth and Survival of Multiple Myeloma Cells In Vitro and In Vivo .

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American Society of Hematology

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ASH Publications

American Society of Hematology

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