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Journal Articles

LNA-mediated anti–miR-155 silencing in low-grade B-cell lymphomas

Yong Zhang, Aldo M. Roccaro, Christopher Rombaoa, Ludmilla Flores, Susanna Obad, Stacey M. Fernandes, Antonio Sacco, Yang Liu, Hai Ngo, Phong Quang, Abdel Kareem Azab, Feda Azab, Patricia Maiso, Michaela Reagan, Jennifer R. Brown, To-Ha Thai, Sakari Kauppinen, Irene M. Ghobrial

Blood (2012) 120 (8): 1678–1686.

https://doi.org/10.1182/blood-2012-02-410647

Published: 2012

Includes: Supplemental data

Journal Articles

Defining the role of TORC1/2 in multiple myeloma

Patricia Maiso, Yi Liu, Brittany Morgan, Abdel Kareem Azab, Pingda Ren, Michel B. Martin, Yong Zhang, Yang Liu, Antonio Sacco, Hai Ngo, Feda Azab, Phong Quang, Scott J. Rodig, Charles P. Lin, Aldo M. Roccaro, Christian Rommel, Irene M. Ghobrial

Blood (2011) 118 (26): 6860–6870.

https://doi.org/10.1182/blood-2011-03-342394

Published: 2011

Includes: Supplemental data

Journal Articles

MicroRNA Changes Occur in Multiple Myeloma Cells in the Context of Bone Marrow Milieu.

Roccaro M. Roccaro, MD, PhD, Antonio Sacco, Abdel Kareem Azab, BPharm, PhD, Feda Azab, BPharm, Hai Ngo, Molly R Melhem, Phong Quong, Judith M. Runnels, PhD, Kenneth C. Anderson, MD, Irene Ghobrial, M.D.

Blood (2009) 114 (22): 1785.

https://doi.org/10.1182/blood.V114.22.1785.1785

Published: 2009

Journal Articles

Selective Inhibition of the Chymotrypsin-Like Activity of the Immunoproteasome and Constitutive Proteasome Represents a Valid Anti-Tumor Strategy in Waldenstrom Macroglobulinemia.

Aldo M. Roccaro, MD, PhD, Antonio Sacco, Monette Aujay, Hai Ngo, Feda Azab, BPharm, Abdel Kareem Azab, PhD, BPharm, Molly Melhem, Judith M. Runnels, PhD, Phong Quang, Susan Demo, PhD, Irene Ghobrial, M.D.

Blood (2009) 114 (22): 4911.

https://doi.org/10.1182/blood.V114.22.4911.4911

Published: 2009

Journal Articles

Carfilzomib Exerts Anti-Neoplastic Activity in Waldenstrom Macroglobulinemia.

Antonio Sacco, Aldo M. Roccaro, MD, PhD, Monette Aujay, PhD, Hai Ngo, Feda Azab, BPharm, Abdel Kareem Azab, Bpharm, PhD, Molly R Melhem, Judith M. Runnels, PhD, Phong Quang, Susan Demo, PhD, Irene Ghobrial, M.D.

Blood (2009) 114 (22): 4916.

https://doi.org/10.1182/blood.V114.22.4916.4916

Published: 2009

Journal Articles

Primary Waldesntrom Macroglobulinemia Cells Harbor Constitutive Activation of Akt, mTOR, Rictor and Raptor: Rational for Testing a Dual Inhibitor of the PI3K/Akt and mTOR Pathways in This Disease.

Aldo M. Roccaro, MD, PhD, Antonio Sacco, Emanuel N. Husu, Costas M Pitsillides, PhD, Steven Vesole, Abdel Kareem Azab, BPharm, PhD, Feda Azab, BPharm, Molly Melhem, Hai Ngo, Phong Quang, Patricia Maiso, PhD, Judith M. Runnels, PhD, Charles P. Lin, PhD, Kenneth C. Anderson, MD, Irene Ghobrial, M.D.

Blood (2009) 114 (22): 3843.

https://doi.org/10.1182/blood.V114.22.3843.3843

Published: 2009

Journal Articles

Gene Transcriptional Activity Analysis in the 6q Region in Waldenstrom Macroglobulinemia (WM) Using ChIP-on-Chip Technology

Xavier Leleu, MD, PhD, Fangxin Hong, PhD, Aldo M. Roccaro, MD, PhD, Xiaoying Jia, Antonio Sacco, Anne-Sophie Moreau, MD, Hai Ngo, Abdel kareem Azab, PhD, Feda Azab, Molly Melhem, Kenneth C. Anderson, MD, Irene M. Ghobrial, MD

Blood (2008) 112 (11): 628.

https://doi.org/10.1182/blood.V112.11.628.628

Published: 2008

Journal Articles

In Vivo Mobilization of Multiple Myeloma Cells Out of the Bone Marrow Using the CXCR4 Inhibitor AMD3100 and Bortezomib: Implications for Sensitization of Myeloma Cells to Apoptosis.

Judith M. Runnels, Abdelkareem Azab, Costas Pitsillides, Anne-Sophie Moreau, Feda Azab, Joel A. Spencer, Xavier Leleu, Alicia L. Carlson, Beatriz E. Ospina, Renee Wright, Xiaoying Jia, Hai Ngo, Andrew L. Kung, Charles P. Lin, Irene M. Ghobrial

Blood (2007) 110 (11): 2501.

https://doi.org/10.1182/blood.V110.11.2501.2501

Published: 2007

Journal Articles

The Combination of Bortezomib and NPI-0052 Exerts Anti-Tumor Activity in Waldenstrom Macroglobulinemia (WM).

Aldo Roccaro, MD, Xavier Leleu, MD, Antonio Sacco, Xiaoying Jia, Anne-Sophie Moreau, MD, Hai Ngo, Abdelkareem Azab, Feda Azab, Evdoxia Hatjiharissi, MD, Steven Treon, MD, Teru Hideshima, MD, Michael Palladino, Kenneth Anderson, MD, Dharminder Chuahan, Irene Ghobrial, MD

Blood (2007) 110 (11): 1516.

https://doi.org/10.1182/blood.V110.11.1516.1516

Published: 2007

Journal Articles

Mechanisms of regulation of CXCR4/SDF-1 (CXCL12)–dependent migration and homing in multiple myeloma

Blood (2006) 109 (7): 2708–2717.

https://doi.org/10.1182/blood-2006-07-035857

Published: 2006

Journal Articles

A Novel Real-Time In Vivo Homing Model of Multiple Myeloma.

Judith M. Runnels, PhD, Costas Pitsillides, PhD, Joel A. Spencer, Joji Fujisaki, PhD, Hai Ngo, Evdoxia Hatjiharissi, MD, Xavier Leleu, MD, Anne-Sophie Moreau, MD, Xiaoying Jia, Teru Hideshima, MD, Nikhil Munshi, MD, Kenneth C. Anderson, PhD, Charles P. Lin, PhD, Irene M. Ghobrial, MD

Blood (2006) 108 (11): 242.

https://doi.org/10.1182/blood.V108.11.242.242

Published: 2006

Journal Articles

Novel Agent Perifosine Enhances Antitumor Activity of Bortezomib, Rituximab and Other Conventional Therapies in Waldenstrom’s Macroglobulinemia.

Xavier Leleu, MD, Garrett O’Sullivan, Xiaoying Jia, Anne-Sophie Moreau, MD, Hai Ngo, Evdoxia Hatjiharisi, MD, Hiroshi Yasui, Zachary Hunter, Yu-Tsu Tai, PhD, Judith Runnels, PhD, Steven Treon, MD, Teru Hideshima, MD, Kenneth Anderson, MD, Irene Ghobrial, MD

Blood (2006) 108 (11): 2517.

https://doi.org/10.1182/blood.V108.11.2517.2517

Published: 2006

Journal Articles

The Combination of the mTOR Inhibitor Rapamycin and Proteasome Inhibitor Bortezomib Is Synergistic In Vitro in Multiple Myeloma.

Garrett O’Sullivan, Xavier Leleu, MD, Xiaoying Jia, Evdoxia Hatjiharisi, MD, Hai Ngo, Anne-Sophie Moreau, MD, Yu-Tsu Tai, PhD, Douglas McMillin, Constantine Mitsiades, MD, Noopur Raje, MD, Teru Hideshima, MD, Robert Schlossman, MD, Paul Richardson, MD, Nikhil Munshi, MD, Kenneth Anderson, MD, Irene Ghobrial, MD

Blood (2006) 108 (11): 3495.

https://doi.org/10.1182/blood.V108.11.3495.3495

Published: 2006

Journal Articles

The Proteasome Inhibitor NPI-0052 in Combination with Bortezomib Induces Antitumor Activity in Waldenstrom Macroglobulinemia.

Xiaoying Jia, Xavier Leleu, MD, Anne-Sophie Moreau, MD, Evdoxia Hatjiharisi, MD, Hai Ngo, Garrett O’Sullivan, Douglas McMillin, PhD, Steven Treon, MD, Constantine Mitsiades, MD, Teru Hideshima, MD, Michael Palladino, Kenneth Anderson, MD, Dharminder Chauhan, PhD, Irene Ghobrial, MD

Blood (2006) 108 (11): 4746.

https://doi.org/10.1182/blood.V108.11.4746.4746

Published: 2006

Journal Articles

Perifosine, an Oral Bioactive Novel Akt Inhibitor, Induces In Vitro and In Vivo Antitumor Activity in Waldenstrom Macroglobulinemia.

Xavier Leleu, MD, Xiaoying Jia, Anne-Sophie Moreau, MD, Evdoxia Hatjiharisi, MD, Hai Ngo, Garrett O’Sullivan, Daisy Moreno, Tanyel Kiziltepe, PhD, Enrique Ocio, MD, Allen Ho, MD, Thierry Facon, MD, Steven Treon, MD, Teru Hideshima, MD, Kenneth Anderson, MD, Irene Ghobrial, MD

Blood (2006) 108 (11): 2488.

https://doi.org/10.1182/blood.V108.11.2488.2488

Published: 2006

Journal Articles

The Selective Protein Kinase CB Inhibitor, Enzastaurin, Induces In Vitro and In Vivo Antitumor Activity in Waldenstrom’s Macroglobulinemia.

Anne-Sophie Moreau, MD, Xiaoying Jia, Garrett O’Sullivan, Xavier Leleu, MD, Klaus Podar, MD, John Daley, Suzan Lalo, Evdoxia Hatjiharisi, MD, Hai Ngo, Mark Raab, MD, Jean-Claude D’Halluin, PhD, Thierry Facon, MD, Teru Hideshima, MD PhD, Steven Treon, MD PhD, Kenneth Anderson, MD, Irene Ghobrial, MD

Blood (2006) 108 (11): 2496.

https://doi.org/10.1182/blood.V108.11.2496.2496

Published: 2006

Journal Articles

Molecular Mechanisms Regulating Resistance to the Akt Inhibitor Perifosine in Waldenstrom’s Macroglobulinemia, the Role of the ERK and PKC Pathways.

Xavier Leleu, MD, Hai Ngo, Xiaoying Jia, Anne-Sophie Moreau, MD, Evdoxia Hatjiharisi, MD, Ruben Carrasco, MD, Garrett O’Sullivan, Judith Runnels, PhD, Yu-Tsu Tai, PhD, Steven Treon, MD, Teru Hideshima, MD, Kenneth Anderson, MD, Irene Ghobrial, MD

Blood (2006) 108 (11): 2416.

https://doi.org/10.1182/blood.V108.11.2416.2416

Published: 2006

Journal Articles

The PI3K/Akt Pathway Is an Important Regulator of Homing and Adhesion in Waldenstrom’s Macroglobulinemia.

Xavier Leleu, MD, Hai Ngo, Judy Runnels, PhD, Costas Pitsillides, Joel Spencer, Anne-Sophie Moreau, MD, Evdoxia Hatjiharisi, MD, Xiaoying Jia, Garrett O’Sullivan, Steven Treon, MD, Teru Hideshima, MD, Charles Lin, PhD, Kenneth Anderson, MD, Irene Ghobrial, MD

Blood (2006) 108 (11): 2417.

https://doi.org/10.1182/blood.V108.11.2417.2417

Published: 2006

Journal Articles

The CXCR4/SDF-1 Axis Regulates Migration and Adhesion in Waldenstrom Macroglobulinemia.

Hai Ngo, Evdoxia Hatjiharissi, MD, Xavier Leleu, MD, Judith Runnels, PhD, Anne-Sophie Moreau, MD, Xiaoying Jia, Garrett O’Sullivan, Daniel Santos, MD, Lian Xu, Steven Treon, Teru Hideshima, MD, Kenneth Anderson, MD, Irene Ghobrial, MD

Blood (2006) 108 (11): 2418.

https://doi.org/10.1182/blood.V108.11.2418.2418

Published: 2006

Journal Articles

Serum Free Light Chain in Waldenstrom Macroglobulinemia.

Anne-Sophie Moreau, MD, Xavier Leleu, MD, Robert Manning, Valérie Coiteux, MD, Stéphane Darre, MD, Evdoxia Hatjiharisi, MD, Zachary Hunter, Xiaoying Jia, Hai Ngo, Garrett O’Sullivan, Daniel Santos, MD, Steven Treon, MD, Thierry Facon, MD, Kenneth Anderson, MD, Irene Ghobrial, MD

Blood (2006) 108 (11): 2420.

https://doi.org/10.1182/blood.V108.11.2420.2420

Published: 2006

NARROW

LNA-mediated anti–miR-155 silencing in low-grade B-cell lymphomas

Defining the role of TORC1/2 in multiple myeloma

MicroRNA Changes Occur in Multiple Myeloma Cells in the Context of Bone Marrow Milieu.

Selective Inhibition of the Chymotrypsin-Like Activity of the Immunoproteasome and Constitutive Proteasome Represents a Valid Anti-Tumor Strategy in Waldenstrom Macroglobulinemia.

Carfilzomib Exerts Anti-Neoplastic Activity in Waldenstrom Macroglobulinemia.

Primary Waldesntrom Macroglobulinemia Cells Harbor Constitutive Activation of Akt, mTOR, Rictor and Raptor: Rational for Testing a Dual Inhibitor of the PI3K/Akt and mTOR Pathways in This Disease.

Gene Transcriptional Activity Analysis in the 6q Region in Waldenstrom Macroglobulinemia (WM) Using ChIP-on-Chip Technology

In Vivo Mobilization of Multiple Myeloma Cells Out of the Bone Marrow Using the CXCR4 Inhibitor AMD3100 and Bortezomib: Implications for Sensitization of Myeloma Cells to Apoptosis.

The Combination of Bortezomib and NPI-0052 Exerts Anti-Tumor Activity in Waldenstrom Macroglobulinemia (WM).

Mechanisms of regulation of CXCR4/SDF-1 (CXCL12)–dependent migration and homing in multiple myeloma

A Novel Real-Time In Vivo Homing Model of Multiple Myeloma.

Novel Agent Perifosine Enhances Antitumor Activity of Bortezomib, Rituximab and Other Conventional Therapies in Waldenstrom’s Macroglobulinemia.

The Combination of the mTOR Inhibitor Rapamycin and Proteasome Inhibitor Bortezomib Is Synergistic In Vitro in Multiple Myeloma.

The Proteasome Inhibitor NPI-0052 in Combination with Bortezomib Induces Antitumor Activity in Waldenstrom Macroglobulinemia.

Perifosine, an Oral Bioactive Novel Akt Inhibitor, Induces In Vitro and In Vivo Antitumor Activity in Waldenstrom Macroglobulinemia.

The Selective Protein Kinase CB Inhibitor, Enzastaurin, Induces In Vitro and In Vivo Antitumor Activity in Waldenstrom’s Macroglobulinemia.

Molecular Mechanisms Regulating Resistance to the Akt Inhibitor Perifosine in Waldenstrom’s Macroglobulinemia, the Role of the ERK and PKC Pathways.

The PI3K/Akt Pathway Is an Important Regulator of Homing and Adhesion in Waldenstrom’s Macroglobulinemia.

The CXCR4/SDF-1 Axis Regulates Migration and Adhesion in Waldenstrom Macroglobulinemia.

Serum Free Light Chain in Waldenstrom Macroglobulinemia.

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American Society of Hematology

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American Society of Hematology

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