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Molly Melhem
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Journal Articles

Dual targeting of the PI3K/Akt/mTOR pathway as an antitumor strategy in Waldenstrom macroglobulinemia

Aldo M. Roccaro, Antonio Sacco, Emanuel N. Husu, Costas Pitsillides, Steven Vesole, Abdel Kareem Azab, Feda Azab, Molly Melhem, Hai T. Ngo, Phong Quang, Patricia Maiso, Judith Runnels, Mei-Chih Liang, Kwok-Kin Wong, Charles Lin, Irene M. Ghobrial
Journal: Blood
Blood (2010) 115 (3): 559–569.
https://doi.org/10.1182/blood-2009-07-235747
Published: 2010
Includes: Supplemental data
Journal Articles

Selective Inhibition of the Chymotrypsin-Like Activity of the Immunoproteasome and Constitutive Proteasome Represents a Valid Anti-Tumor Strategy in Waldenstrom Macroglobulinemia.

Aldo M. Roccaro, MD, PhD, Antonio Sacco, Monette Aujay, Hai Ngo, Feda Azab, BPharm, Abdel Kareem Azab, PhD, BPharm, Molly Melhem, Judith M. Runnels, PhD, Phong Quang, Susan Demo, PhD, Irene Ghobrial, M.D.
Journal: Blood
Blood (2009) 114 (22): 4911.
https://doi.org/10.1182/blood.V114.22.4911.4911
Published: 2009
Journal Articles

Primary Waldesntrom Macroglobulinemia Cells Harbor Constitutive Activation of Akt, mTOR, Rictor and Raptor: Rational for Testing a Dual Inhibitor of the PI3K/Akt and mTOR Pathways in This Disease.

Aldo M. Roccaro, MD, PhD, Antonio Sacco, Emanuel N. Husu, Costas M Pitsillides, PhD, Steven Vesole, Abdel Kareem Azab, BPharm, PhD, Feda Azab, BPharm, Molly Melhem, Hai Ngo, Phong Quang, Patricia Maiso, PhD, Judith M. Runnels, PhD, Charles P. Lin, PhD, Kenneth C. Anderson, MD, Irene Ghobrial, M.D.
Journal: Blood
Blood (2009) 114 (22): 3843.
https://doi.org/10.1182/blood.V114.22.3843.3843
Published: 2009
Journal Articles

Gene Transcriptional Activity Analysis in the 6q Region in Waldenstrom Macroglobulinemia (WM) Using ChIP-on-Chip Technology

Xavier Leleu, MD, PhD, Fangxin Hong, PhD, Aldo M. Roccaro, MD, PhD, Xiaoying Jia, Antonio Sacco, Anne-Sophie Moreau, MD, Hai Ngo, Abdel kareem Azab, PhD, Feda Azab, Molly Melhem, Kenneth C. Anderson, MD, Irene M. Ghobrial, MD
Journal: Blood
Blood (2008) 112 (11): 628.
https://doi.org/10.1182/blood.V112.11.628.628
Published: 2008
Journal Articles

SDF-1/CXCR4 and VLA-4 interaction regulates homing in Waldenstrom macroglobulinemia

Hai T. Ngo, Xavier Leleu, Jack Lee, Xiaoying Jia, Molly Melhem, Judith Runnels, Anne-Sophie Moreau, Nicholas Burwick, Abdel Kareem Azab, Aldo Roccaro, Feda Azab, Antonio Sacco, Mena Farag, Robert Sackstein, Irene M. Ghobrial
Journal: Blood
Blood (2008) 112 (1): 150–158.
https://doi.org/10.1182/blood-2007-12-129395
Published: 2008
Journal Articles

Dual targeting of the proteasome regulates survival and homing in Waldenström macroglobulinemia

Aldo M. Roccaro, Xavier Leleu, Antonio Sacco, Xiaoying Jia, Molly Melhem, Anne-Sophie Moreau, Hai T. Ngo, Judith Runnels, Abdelkareem Azab, Feda Azab, Nicholas Burwick, Mena Farag, Steven P. Treon, Michael A. Palladino, Teru Hideshima, Dharminder Chauhan, Kenneth C. Anderson, Irene M. Ghobrial
Journal: Blood
Blood (2008) 111 (9): 4752–4763.
https://doi.org/10.1182/blood-2007-11-120972
Published: 2008
Includes: Supplemental data