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Journal Articles

In vitro efficacy of forodesine and nelarabine (ara-G) in pediatric leukemia

Irene Homminga, C. Michel Zwaan, Chantal Y. Manz, Cynthia Parker, Shanta Bantia, Willem Korstiaan Smits, Fiona Higginbotham, Rob Pieters, Jules P. P. Meijerink

Blood (2011) 118 (8): 2184–2190.

https://doi.org/10.1182/blood-2011-02-337840

Published: 2011

Includes: Supplemental data

Journal Articles

Phase 2 and pharmacodynamic study of oral forodesine in patients with advanced, fludarabine-treated chronic lymphocytic leukemia

Kumudha Balakrishnan, Dushyant Verma, Susan O'Brien, John Michael Kilpatrick, Yuling Chen, Brenita F. Tyler, Susan Bickel, Shanta Bantia, Michael J. Keating, Hagop Kantarjian, Varsha Gandhi, Farhad Ravandi

Blood (2010) 116 (6): 886–892.

https://doi.org/10.1182/blood-2010-02-272039

Published: 2010

Journal Articles

Phase II, Single Center Study of Oral Forodesine in Patients with Advanced, Fludarabine-Treated Chronic Lymphocytic Leukemia (CLL).

Dushyant Verma, MD, FACP, Kumudha Balakrishnan, PhD, Susan O'Brien, MD, Deborah A. Thomas, MD, Alessandra Ferrajoli, MD, William G. Wierda, MD, PhD, Amit Verma, MD, Stefan Faderl, MD, Susan M Bickel, Shanta Bantia, PhD, Hagop M Kantarjian, MD, Michael J. Keating, MBBS, Varsha Gandhi, PhD, Farhad Ravandi, MD

Blood (2009) 114 (22): 2369.

https://doi.org/10.1182/blood.V114.22.2369.2369

Published: 2009

Journal Articles

In-Vitro Efficacy of the Deoxyguanoside Analogs Forodesine (BCX-1777) and ARA-G in Pediatric Acute Lymphoblastic Leukemia.

Irene Homminga, MD, Michel C. Zwaan, MD, PhD, Amel Seghouani, MD, Chantal Y. Manz, PhD, Shanta Bantia, PhD, Wilco Smits, Rob Pieters, MD, PhD, Jules P.P. Meijerink, PhD

Blood (2009) 114 (22): 2038.

https://doi.org/10.1182/blood.V114.22.2038.2038

Published: 2009

Journal Articles

Forodesine has high antitumor activity in chronic lymphocytic leukemia and activates p53-independent mitochondrial apoptosis by induction of p73 and BIM

Roberto Alonso, Mónica López-Guerra, Ramanda Upshaw, Shanta Bantia, Caroline Smal, Françoise Bontemps, Chantal Manz, Thomas Mehrling, Neus Villamor, Elias Campo, Emili Montserrat, Dolors Colomer

Blood (2009) 114 (8): 1563–1575.

https://doi.org/10.1182/blood-2009-02-207654

Published: 2009

Includes: Supplemental data

Journal Articles

In-Vitro Efficacy of the Deoxyguanoside Analogs Forodesine (BCX- 1777) and ARA-G in Pediatric Acute Lymphoblastic Leukemia Cells.

Irene Homminga, MD, Christian M Zwaan, MD, PhD, Chantal Y. Manz, PhD, Shanta Bantia, PhD, Cynthia Parker, Jessica Buijs-Gladdines, Wilco Smits, Martin A. Horstmann, MD, Rob Pieters, MD, PhD, Jules P.P. Meijerink, MSc, PhD

Blood (2008) 112 (11): 1925.

https://doi.org/10.1182/blood.V112.11.1925.1925

Published: 2008

Journal Articles

A Phase II Study of the Purine Nucleoside Phosphorylase (PNP) Inhibitor RO5092888 (BCX-4208) in Patients with Moderate to Severe Chronic Plaque Psoriasis: Safety, Tolerability and Lymphocyte Effects

Joseph P Gomes, PharmD, MS, BCPS, Angela Georgy, Sharon Passe, Adrienne Farid, Shanta Bantia, PhD, Gerhard Wolff

Blood (2008) 112 (11): 2583.

https://doi.org/10.1182/blood.V112.11.2583.2583

Published: 2008

Journal Articles

Forodesine (Immucillin H, BCX-1777) Shows Activity on Mantle Cell Lymphoma Primary Cells

Andrea Rinaldi, Emilia Ceresa, Davide Rossi, Gianluca Gaidano, Shanta Bantia, PhD, Chantal Y. Manz, PhD, Carlo Catapano, Emanuele Zucca, Francesco Bertoni, MD

Blood (2008) 112 (11): 4997.

https://doi.org/10.1182/blood.V112.11.4997.4997

Published: 2008

Journal Articles

BCX-4208 (RO5092888), a Purine Nucleoside Phosphorylase (PNP) Inhibitor, Is a Novel, Potent Orally Active Anti-T-Cell and B-Cell Agent.

Shanta Bantia, PhD, Cynthia Parker, Ramanda Upshaw, John Michael Kilpatrick, PhD, Amanda Cunningham, Jianwen Zhang, PhD, Pravin Kotian, PhD, Philip Morris, PhD, Pooran Chand, PhD, Yarlagadda S. Babu, PhD

Blood (2008) 112 (11): 1547.

https://doi.org/10.1182/blood.V112.11.1547.1547

Published: 2008

Journal Articles

The Purine Nucleoside Phosphorylase Inhibitor Forodesine (BCX-1777) Is a Potent Cytotoxic Agent and Has Synergistic Activity with Bendamustine in Chronic Lymphocytic Leukemia (CLL) Irrespective of ZAP-70 Levels and p53 Status.

Roberto Alonso, PhD, Neus Villamor, MD, Ramanda Upshaw, BS, Shanta Bantia, PhD, Thomas Mehrling, MD, Elias Campo, MD, Emili Montserrat, MD, Dolors Colomer, PhD

Blood (2007) 110 (11): 3122.

https://doi.org/10.1182/blood.V110.11.3122.3122

Published: 2007

Journal Articles

A proof-of-principle pharmacokinetic, pharmacodynamic, and clinical study with purine nucleoside phosphorylase inhibitor immucillin-H (BCX-1777, forodesine)

Varsha Gandhi, John M. Kilpatrick, William Plunkett, Mary Ayres, Leigh Harman, Min Du, Shanta Bantia, Jan Davisson, William G. Wierda, Stefan Faderl, Hagop Kantarjian, Deborah Thomas

Blood (2005) 106 (13): 4253–4260.

https://doi.org/10.1182/blood-2005-03-1309

Published: 2005

Journal Articles

Phase I/II Study of Oral Fodosine TM , a PNP Inhibitor in Refractory Cutaneous T-Cell Lymphoma Patients.

Madeleine Duvic, MD, Debra Breneman, MD, Maureen Cooper, MD, Gustavo Fonseca, MD, J. Claude Bennett, MD, J. Michael Kilpatrick, PhD, Shanta Bantia, PhD

Blood (2005) 106 (11): 2683.

https://doi.org/10.1182/blood.V106.11.2683.2683

Published: 2005

Journal Articles

Forodesine (Fodosine TM ), a PNP Inhibitor Active in Relapsed or Refractory T-Cell Leukemia Patients (Phase II Study).

Richard R. Furman, MD, Genadi Iosava, MD, Luis Isola, MD, Farhad Ravandi, MD, Mamia Zodelava, MD, J. Claude Bennett, MD, J. Michael Kilpatrick, PhD, Shanta Bantia, PhD, Fodosine Development Group

Blood (2005) 106 (11): 881.

https://doi.org/10.1182/blood.V106.11.881.881

Published: 2005

Journal Articles

Antileukemic Activity and Pharmacodynamics of Intravenous Forodesine (BCX-1777), a Novel Purine Nucleoside Phosphorylase (PNP) Inhibitor, in Phase I/II Trials in Patients with Advanced T-Cell Malignancies.

Luis Isola, MD, Richard R. Furman, MD, Varsha Gandhi, PhD, Deborah A. Thomas, MD, J. Claude Bennett, MD, Shanta Bantia, PhD, J. Michael Kilpatrick, PhD

Blood (2004) 104 (11): 4501.

https://doi.org/10.1182/blood.V104.11.4501.4501

Published: 2004

Journal Articles

Intravenous Forodesine (BCX-1777), a Novel Purine Nucleoside Phosphorylase (PNP) Inhibitor, Demonstrates Clinical Activity in Patients with Refractory Cutaneous T-Cell Lymphoma.

Madeleine Duvic, MD, Francine M. Foss, MD, Elise A. Olsen, MD, Andres Forero-Torres, MD, J. Claude Bennett, MD, Shanta Bantia, PhD, J. Michael Kilpatrick, PhD

Blood (2004) 104 (11): 2491.

https://doi.org/10.1182/blood.V104.11.2491.2491

Published: 2004

Journal Articles

Intravenous Forodesine (BCX-1777), a Novel Purine Nucleoside Phosphorylase (PNP) Inhibitor, Demonstrates Clinical Activity in Phase I/II Studies in Patients with B-Cell Acute Lymphoblastic Leukemia.

Richard R. Furman, MD, Varsha V. Gandhi, PhD, J. Claude Bennett, MD, Shanta Bantia, PhD, J. Michael Kilpatrick, PhD

Blood (2004) 104 (11): 2743.

https://doi.org/10.1182/blood.V104.11.2743.2743

Published: 2004

NARROW

In vitro efficacy of forodesine and nelarabine (ara-G) in pediatric leukemia

Phase 2 and pharmacodynamic study of oral forodesine in patients with advanced, fludarabine-treated chronic lymphocytic leukemia

Phase II, Single Center Study of Oral Forodesine in Patients with Advanced, Fludarabine-Treated Chronic Lymphocytic Leukemia (CLL).

In-Vitro Efficacy of the Deoxyguanoside Analogs Forodesine (BCX-1777) and ARA-G in Pediatric Acute Lymphoblastic Leukemia.

Forodesine has high antitumor activity in chronic lymphocytic leukemia and activates p53-independent mitochondrial apoptosis by induction of p73 and BIM

In-Vitro Efficacy of the Deoxyguanoside Analogs Forodesine (BCX- 1777) and ARA-G in Pediatric Acute Lymphoblastic Leukemia Cells.

A Phase II Study of the Purine Nucleoside Phosphorylase (PNP) Inhibitor RO5092888 (BCX-4208) in Patients with Moderate to Severe Chronic Plaque Psoriasis: Safety, Tolerability and Lymphocyte Effects

Forodesine (Immucillin H, BCX-1777) Shows Activity on Mantle Cell Lymphoma Primary Cells

BCX-4208 (RO5092888), a Purine Nucleoside Phosphorylase (PNP) Inhibitor, Is a Novel, Potent Orally Active Anti-T-Cell and B-Cell Agent.

The Purine Nucleoside Phosphorylase Inhibitor Forodesine (BCX-1777) Is a Potent Cytotoxic Agent and Has Synergistic Activity with Bendamustine in Chronic Lymphocytic Leukemia (CLL) Irrespective of ZAP-70 Levels and p53 Status.

A proof-of-principle pharmacokinetic, pharmacodynamic, and clinical study with purine nucleoside phosphorylase inhibitor immucillin-H (BCX-1777, forodesine)

Phase I/II Study of Oral Fodosine TM , a PNP Inhibitor in Refractory Cutaneous T-Cell Lymphoma Patients.

Forodesine (Fodosine TM ), a PNP Inhibitor Active in Relapsed or Refractory T-Cell Leukemia Patients (Phase II Study).

Antileukemic Activity and Pharmacodynamics of Intravenous Forodesine (BCX-1777), a Novel Purine Nucleoside Phosphorylase (PNP) Inhibitor, in Phase I/II Trials in Patients with Advanced T-Cell Malignancies.

Intravenous Forodesine (BCX-1777), a Novel Purine Nucleoside Phosphorylase (PNP) Inhibitor, Demonstrates Clinical Activity in Patients with Refractory Cutaneous T-Cell Lymphoma.

Intravenous Forodesine (BCX-1777), a Novel Purine Nucleoside Phosphorylase (PNP) Inhibitor, Demonstrates Clinical Activity in Phase I/II Studies in Patients with B-Cell Acute Lymphoblastic Leukemia.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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