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Journal Articles

Transfer of mRNA Encoding CEBPA in Lipid Nanoparticles to CEBPA Mutated Leukemia Cell Line KO52 and Primary AML Reduces Cell Growth and Induces Myeloid Differentiation

Chunxiao Zhang, Brenda Loera, Jianying Zhang, Richard Gelinas, Youmna Kfoury, Jonathan Hoggatt, Guido Marcucci, Pamela S. Becker

Blood (2023) 142 (Supplement 1): 7122.

https://doi.org/10.1182/blood-2023-190191

Published: 2023

Journal Articles

Human NGFR+/VCAM-1+/Mcam+ Bone Marrow-Derived Stromal Cells (NVML) Provide Enhanced Support for Normal Hematopoiesis and Are Disrupted in Myelodysplastic Syndrome

Yuko Kawano, Hiroki Kawano, Daniel K. Byun, Dalia Ghoneim, Thomas J Fountaine, Mark W. LaMere, John M. Ashton, Mitra Azadniv, Jane L. Liesveld, Youmna Kfoury, David T. Scadden, Michael W. Becker, Laura M. Calvi

Blood (2022) 140 (Supplement 1): 5772–5773.

https://doi.org/10.1182/blood-2022-170070

Published: 2022

Journal Articles

Cap-Independent Protein Translation in Hematopoiesis

Michael Mazzola, Ting Zhao, Karin Gustafsson, Trine Kristiansen, Giulia Schiroli, Jelena Milosevic, Youmna Kfoury, Tsuyoshi Fukushima, Anna Kiem, Azeem Sharda, Hiroki Kato, David Sykes, Pavel Ivanov, Vijay G. Sankaran, David T. Scadden

Blood (2022) 140 (Supplement 1): 1983–1984.

https://doi.org/10.1182/blood-2022-170506

Published: 2022

Journal Articles

A Specific Mesenchymal Stem and Progenitor Cell (MSPC) Subpopulation with a Multi-Potent Gene Signature Is Transcriptionally Altered in the Setting of Myelodysplastic Syndrome (MDS) in Primary Human Bone Marrow Aspirates

Thomas J Fountaine, MD, Mark W LaMere, BA, Daniel K Byun, BS, Jason R Myers, MS, John M Ashton, PhD, Jane L. Liesveld, MD, Youmna Kfoury, PhD, David T. Scadden, MD, Michael W. Becker, MD, Laura M. Calvi, MD

Blood (2019) 134 (Supplement_1): 1708.

https://doi.org/10.1182/blood-2019-130227

Published: 2019

Journal Articles

Niche Transfer of Small Non-Coding RNAs Regulates Hematopoietic Response to Stress

Youmna Kfoury, PhD, Fei Ji, Michael Mazzola, BS, David B Sykes, MD PhD, Anselmo Anthony, Yasutoshi Akiyama, Allison Scherer, PhD, Francois Mercier, MD FRCPC, Nicolas Severe, PhD, Borja Saez, Jefferson Seidl, BA, Ani Papazian, BS, Thomas Brouse, Michael K Mansour, MD PhD, Pavel Ivanov, Ruslan I Sadreyev, PhD, David T. Scadden, MD

Blood (2019) 134 (Supplement_1): 1207.

https://doi.org/10.1182/blood-2019-124794

Published: 2019

Journal Articles

DHODH Inhibitors in the Treatment of Acute Myeloid Leukemia: Defining the Mechanism of Action and the Basis of the Metabolic Therapeutic Window

Peggy P. Hsu, MD PhD, Youmna Kfoury, PhD, Najihah Aziz, Jenna Elkhoury, Brittany Hallgren, David T. Scadden, MD, Matthew Vander Heiden, MD PhD, David B Sykes, MD PhD

Blood (2018) 132 (Supplement 1): 2716.

https://doi.org/10.1182/blood-2018-99-113387

Published: 2018

Journal Articles

Specific Bone Marrow Mesenchymal Subsets in Patients with Myelodysplastic Syndromes Harbor Molecular Perturbations That Alter the Dynamics of Competition between Pre-Leukemic Clones and Normal Cells

Youmna Kfoury, PhD, Esha Jain, Jason R Myers, MS, Fei Ji, David B Sykes, MD PhD, Francois Mercier, MD FRCPC, Ani Papazian, BS, Cam Le, Mark A Randolph, M.A.Sc., David P. Steensma, MD, Omar I Abdel-Wahab, MD, Laura M. Calvi, MD, Ruslan I Sadreyev, PhD, Michael W. Becker, MD, David T. Scadden, MD

Blood (2018) 132 (Supplement 1): 938.

https://doi.org/10.1182/blood-2018-99-115242

Published: 2018

Journal Articles

Osteoblastic Cell-Derived Extracellular Vesicles Transfer Small RNAs That Alter the Physiology of Hematopoietic Cells In Vivo

Youmna Kfoury, PhD, Anthony Anselmo, PhD, Jefferson Seidl, BA, Ani Papazian, BS, Francois Mercier, MD FRCPC, David B Sykes, MD PhD, Nicolas Severe, PhD, Borja Saez, PhD, Ruslan I Sadreyev, PhD, David T. Scadden, MD

Blood (2017) 130 (Supplement 1): 93.

https://doi.org/10.1182/blood.V130.Suppl_1.93.93

Published: 2017

Journal Articles

A Genome-Wide, In Vivo, Dropout CRISPR Screen in Acute Myeloid Leukemia Identifies an Essential Role for Beta-Galactosylation in Leukemic Cell Homing

Francois Mercier, MD, Jiantao Shi, PhD, David B Sykes, MD PhD, Elizabeth Miller, Toshihiko Oki, MD PhD, Cheuk-Him Man, PhD, Xiao-Jing Yan, MD PhD, Youmna Kfoury, PhD, Dongjun Lee, PhD, John G Doench, PhD, Franziska Michor, PhD, David T. Scadden, MD

Blood (2017) 130 (Supplement 1): 2493.

https://doi.org/10.1182/blood.V130.Suppl_1.2493.2493

Published: 2017

Journal Articles

ATL response to arsenic/interferon therapy is triggered by SUMO/PML/RNF4-dependent Tax degradation

Zeina Dassouki, Umut Sahin, Hiba El Hajj, Florence Jollivet, Youmna Kfoury, Valérie Lallemand-Breitenbach, Olivier Hermine, Hugues de Thé, Ali Bazarbachi

Blood (2015) 125 (3): 474–482.

https://doi.org/10.1182/blood-2014-04-572750

Published: 2015

Includes: Supplemental data

Journal Articles

Proximity-Based Single Cell Analysis of the Bone Marrow Niche Identifies Interleukin-18 As a Quiescence Regulator of Early Hematopoietic Progenitors

Lev Silberstein, MDPhD, Peter Kharchenko, PhD, Youmna Kfoury, PhD, Francois Mercier, MD, Masatake Osawa, PhD, Jonathan Hoggatt, PhD, Tiffany Tate, Charles Lin, PhD, David T. Scadden, MD

Blood (2014) 124 (21): 773.

https://doi.org/10.1182/blood.V124.21.773.773

Published: 2014

Journal Articles

Cellular thrust and parry in the leukemic niche

Youmna Kfoury, David T. Scadden

Blood (2014) 124 (18): 2760–2761.

https://doi.org/10.1182/blood-2014-09-597716

Published: 2014

Journal Articles

Tax ubiquitylation and SUMOylation control the dynamic shuttling of Tax and NEMO between Ubc9 nuclear bodies and the centrosome

Youmna Kfoury, Niclas Setterblad, Marwan El-Sabban, Alessia Zamborlini, Zeina Dassouki, Hiba El Hajj, Olivier Hermine, Claudine Pique, Hugues de Thé, Ali Saïb, Ali Bazarbachi

Blood (2011) 117 (1): 190–199.

https://doi.org/10.1182/blood-2010-05-285742

Published: 2011

Includes: Supplemental data

Journal Articles

The Combination of Arsenic Trioxide and Interferon-Alpha Eradicates Leukemia Initiating Cells in TAX-Driven Murine Adult T Cell Leukemia/Lymphoma.

Ali Bazarbachi, MD, PhD, Hiba El Hajj, Marwan El-Sabban, Hideki Hasegawa, Ghazi Zaatari, Shahrazad Saab, Anne Janin, Rami Mahfouz, Rihab Nasr, Youmna Kfoury, Christophe Nicot, Olivier Hermine, William Hall, Hugues de The, MD, PhD

Blood (2009) 114 (22): 2714.

https://doi.org/10.1182/blood.V114.22.2714.2714

Published: 2009

Journal Articles

EAPB0203, a member of the imidazoquinoxaline family, inhibits growth and induces caspase-dependent apoptosis in T-cell lymphomas and HTLV-I–associated adult T-cell leukemia/lymphoma

Georges Moarbess, Hiba El-Hajj, Youmna Kfoury, Marwan E. El-Sabban, Yves Lepelletier, Olivier Hermine, Carine Deleuze-Masquéfa, Pierre-Antoine Bonnet, Ali Bazarbachi

Blood (2008) 111 (7): 3770–3777.

https://doi.org/10.1182/blood-2007-11-121913

Published: 2008

Journal Articles

Molecular Mechanisms of NF-kappaB Activation by the HTLV-I Oncoprotein Tax: Role of Post Translational Protein Modification.

Youmna Kfoury, Rihab Nasr, PhD, Arnaud Favre-Bonvin, PhD, Marwan El-Sabban, PhD, Noemie Renault, Marie-Louise Giron, PhD, Hiba El Hajj, PhD, Estelle Chiari, PhD, Abdul Ghani Mikati, Olivier Hermine, MD, PhD, Ali Saib, PhD, Hugues de Thé, MD, PhD, Claudine Pique, PhD, Ali Bazarbachi, MD, PhD

Blood (2007) 110 (11): 4159.

https://doi.org/10.1182/blood.V110.11.4159.4159

Published: 2007

Journal Articles

Targeted Therapy with Arsenic Trioxide and Interferon alpha Eradicates Leukemic Cells in SCID Mice Model of Adult T-Cell Leukemia/Lymphoma.

Hiba El Hajj, PhD, Hideki Hasegawa, PhD, Marwan El-Sabban, PhD, Ghazi Zaatari, MD, Shehrazad Saab, MD, Rami Mahfouz, MD, Rihab Nasr, PhD, Youmna Kfoury, Olivier Hermine, MD, PhD, Hugues de Thé, MD, PhD, William Hall, Ali Bazarbachi, MD, PhD

Blood (2007) 110 (11): 1379.

https://doi.org/10.1182/blood.V110.11.1379.1379

Published: 2007

Journal Articles

Tax ubiquitylation and sumoylation control critical cytoplasmic and nuclear steps of NF-κB activation

Rihab Nasr, Estelle Chiari, Marwan El-Sabban, Renaud Mahieux, Youmna Kfoury, Maher Abdulhay, Victor Yazbeck, Olivier Hermine, Hugues de Thé, Claudine Pique, Ali Bazarbachi

Blood (2006) 107 (10): 4021–4029.

https://doi.org/10.1182/blood-2005-09-3572

Published: 2006

Journal Articles

Tax Ubiquitylation and Sumoylation Control the Two Distinct Steps of NF-κB Activation.

Rihab Nasr, PhD, Estelle Chiari, PhD, Marwan El-Sabban, PhD, Renaud Mahieux, PhD, Youmna Kfoury, Mohammad M. Abdulhay, MD, Olivier Hermine, MD, PhD, Hugues de Thé, MD, PhD, Claudine Pique, PhD, Ali Bazarbachi, MD, PhD

Blood (2005) 106 (11): 4353.

https://doi.org/10.1182/blood.V106.11.4353.4353

Published: 2005

Journal Articles

The Inhibitor of VEGF-Receptors Tyrosine Kinase PTK-787 Blocks the Invasive Potential of Adult T-Cell Leukemia Cells through the Endothelium.

Ali Bazarbachi, MD, PhD, Roa Harb, MD, Hilda Khoury, Lara Haddad, Youmna Kfoury, Lamia Atweh, MD, Eva Hamadeh, PhD, Olivier Hermine, MD, PhD, Hugues de The, MD, PhD, Marwan E. El-Sabban, PhD

Blood (2004) 104 (11): 84.

https://doi.org/10.1182/blood.V104.11.84.84

Published: 2004

NARROW

Transfer of mRNA Encoding CEBPA in Lipid Nanoparticles to CEBPA Mutated Leukemia Cell Line KO52 and Primary AML Reduces Cell Growth and Induces Myeloid Differentiation

Human NGFR+/VCAM-1+/Mcam+ Bone Marrow-Derived Stromal Cells (NVML) Provide Enhanced Support for Normal Hematopoiesis and Are Disrupted in Myelodysplastic Syndrome

Cap-Independent Protein Translation in Hematopoiesis

A Specific Mesenchymal Stem and Progenitor Cell (MSPC) Subpopulation with a Multi-Potent Gene Signature Is Transcriptionally Altered in the Setting of Myelodysplastic Syndrome (MDS) in Primary Human Bone Marrow Aspirates

Niche Transfer of Small Non-Coding RNAs Regulates Hematopoietic Response to Stress

DHODH Inhibitors in the Treatment of Acute Myeloid Leukemia: Defining the Mechanism of Action and the Basis of the Metabolic Therapeutic Window

Specific Bone Marrow Mesenchymal Subsets in Patients with Myelodysplastic Syndromes Harbor Molecular Perturbations That Alter the Dynamics of Competition between Pre-Leukemic Clones and Normal Cells

Osteoblastic Cell-Derived Extracellular Vesicles Transfer Small RNAs That Alter the Physiology of Hematopoietic Cells In Vivo

A Genome-Wide, In Vivo, Dropout CRISPR Screen in Acute Myeloid Leukemia Identifies an Essential Role for Beta-Galactosylation in Leukemic Cell Homing

ATL response to arsenic/interferon therapy is triggered by SUMO/PML/RNF4-dependent Tax degradation

Proximity-Based Single Cell Analysis of the Bone Marrow Niche Identifies Interleukin-18 As a Quiescence Regulator of Early Hematopoietic Progenitors

Cellular thrust and parry in the leukemic niche

Tax ubiquitylation and SUMOylation control the dynamic shuttling of Tax and NEMO between Ubc9 nuclear bodies and the centrosome

The Combination of Arsenic Trioxide and Interferon-Alpha Eradicates Leukemia Initiating Cells in TAX-Driven Murine Adult T Cell Leukemia/Lymphoma.

EAPB0203, a member of the imidazoquinoxaline family, inhibits growth and induces caspase-dependent apoptosis in T-cell lymphomas and HTLV-I–associated adult T-cell leukemia/lymphoma

Molecular Mechanisms of NF-kappaB Activation by the HTLV-I Oncoprotein Tax: Role of Post Translational Protein Modification.

Targeted Therapy with Arsenic Trioxide and Interferon alpha Eradicates Leukemic Cells in SCID Mice Model of Adult T-Cell Leukemia/Lymphoma.

Tax ubiquitylation and sumoylation control critical cytoplasmic and nuclear steps of NF-κB activation

Tax Ubiquitylation and Sumoylation Control the Two Distinct Steps of NF-κB Activation.

The Inhibitor of VEGF-Receptors Tyrosine Kinase PTK-787 Blocks the Invasive Potential of Adult T-Cell Leukemia Cells through the Endothelium.

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American Society of Hematology

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American Society of Hematology

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