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Journal Articles

Arsenic Trioxide and Interferon-Alpha Eradicate Adult T Cell Leukemia Initiating Cells through PML/p53 Senescence and Activation of Innate Immunity

Hiba El Hajj, Dr, Rita Hleihel, Zaatari Ghazi, Julie Bruneau, Hideki Hasegawa, William Hall, Olivier Hermine, MD PhD, Hugues de The, MD PhD, Ali Bazarbachi, MD PhD

Blood (2017) 130 (Supplement 1): 1233.

https://doi.org/10.1182/blood.V130.Suppl_1.1233.1233

Published: 2017

Journal Articles

Arsenic Trioxide and Lenalidomide: A Promising Combination Therapy for Primary Effusion Lymphoma

Rita Hleihel, Nadim Tawil, Martin Karam, Raghida Abou Merhi, Ali Bazarbachi, MD PhD, Hiba El Hajj, Dr

Blood (2017) 130 (Supplement 1): 2817.

https://doi.org/10.1182/blood.V130.Suppl_1.2817.2817

Published: 2017

Journal Articles

Retinoic acid and arsenic trioxide trigger degradation of mutated NPM1, resulting in apoptosis of AML cells

Hiba El Hajj, Zeina Dassouki, Caroline Berthier, Emmanuel Raffoux, Lionel Ades, Olivier Legrand, Rita Hleihel, Umut Sahin, Nadim Tawil, Ala Salameh, Kazem Zibara, Nadine Darwiche, Mohamad Mohty, Hervé Dombret, Pierre Fenaux, Hugues de Thé, Ali Bazarbachi

Blood (2015) 125 (22): 3447–3454.

https://doi.org/10.1182/blood-2014-11-612416

Published: 2015

Includes: Supplemental data

Journal Articles

ATL response to arsenic/interferon therapy is triggered by SUMO/PML/RNF4-dependent Tax degradation

Zeina Dassouki, Umut Sahin, Hiba El Hajj, Florence Jollivet, Youmna Kfoury, Valérie Lallemand-Breitenbach, Olivier Hermine, Hugues de Thé, Ali Bazarbachi

Blood (2015) 125 (3): 474–482.

https://doi.org/10.1182/blood-2014-04-572750

Published: 2015

Includes: Supplemental data

Journal Articles

Preclinical efficacy of the synthetic retinoid ST1926 for treating adult T-cell leukemia/lymphoma

Hiba El Hajj, Bariaa Khalil, Botheina Ghandour, Rihab Nasr, Sharif Shahine, Akram Ghantous, Rana Abdel-Samad, Ansam Sinjab, Hideki Hasegawa, Mark Jabbour, William W. Hall, Ghazi Zaatari, Ghassan Dbaibo, Claudio Pisano, Ali Bazarbachi, Nadine Darwiche

Blood (2014) 124 (13): 2072–2080.

https://doi.org/10.1182/blood-2014-03-560060

Published: 2014

Includes: Supplemental data

Journal Articles

Combination Of Arsenic and Interferon-a Inhibits Expression Of KSHV Latent Transcripts and Synergistically Improves Survival Of Mice With Primary Effusion Lymphomas

Hiba El Hajj, PhD, Jihane Ali, Akram Ghantous, Dana Hodroj, Ahmad Daher, Ahmad Daher, Kazem Zibara, Chloé Journo, Zaher K. Otrock, MD, Ghazi Zaatari, MD, Renaud Mahieux, PhD, Marwan El Sabban, Raghida Abou Merhi, Ali Bazarbachi, MD, PhD

Blood (2013) 122 (21): 5154.

https://doi.org/10.1182/blood.V122.21.5154.5154

Published: 2013

Journal Articles

The Combination Of Arsenic, Interferon-Alpha, and Zidovudine Restores An “Immunocompetent-like” Micro-Environment In Patients With Adult T-Cell Leukemia/Lymphoma

Ghada Kchour, S. A. Rahim Rezaee, Reza Farid, Akram Ghantous, Houshang Rafatpana, Mahdi Tarhini, Mohamad-Mehdi Kooshyar, Hiba El Hajj, PhD, Fadwa Berry, Roudaina Nasser, Abbas Shirdel, Zeina Dassouki, Mohamad Ezzedine, Hossein Rahimi, Ardeshir Ghavamzadeh, Hugues de Thé, MD, PhD, Olivier Hermine, MD, PhD, Mahmoud Mahmoudi, Ali Bazarbachi, MD, PhD

Blood (2013) 122 (21): 5100.

https://doi.org/10.1182/blood.V122.21.5100.5100

Published: 2013

Journal Articles

Tax ubiquitylation and SUMOylation control the dynamic shuttling of Tax and NEMO between Ubc9 nuclear bodies and the centrosome

Youmna Kfoury, Niclas Setterblad, Marwan El-Sabban, Alessia Zamborlini, Zeina Dassouki, Hiba El Hajj, Olivier Hermine, Claudine Pique, Hugues de Thé, Ali Saïb, Ali Bazarbachi

Blood (2011) 117 (1): 190–199.

https://doi.org/10.1182/blood-2010-05-285742

Published: 2011

Includes: Supplemental data

Journal Articles

The Combination of Arsenic Trioxide and Interferon-Alpha Eradicates Leukemia Initiating Cells in TAX-Driven Murine Adult T Cell Leukemia/Lymphoma.

Ali Bazarbachi, MD, PhD, Hiba El Hajj, Marwan El-Sabban, Hideki Hasegawa, Ghazi Zaatari, Shahrazad Saab, Anne Janin, Rami Mahfouz, Rihab Nasr, Youmna Kfoury, Christophe Nicot, Olivier Hermine, William Hall, Hugues de The, MD, PhD

Blood (2009) 114 (22): 2714.

https://doi.org/10.1182/blood.V114.22.2714.2714

Published: 2009

Journal Articles

Phase 2 study of the efficacy and safety of the combination of arsenic trioxide, interferon alpha, and zidovudine in newly diagnosed chronic adult T-cell leukemia/lymphoma (ATL)

Ghada Kchour, Mahdi Tarhini, Mohamad-Mehdi Kooshyar, Hiba El Hajj, Eric Wattel, Mahmoud Mahmoudi, Hassan Hatoum, Hossein Rahimi, Masoud Maleki, Houshang Rafatpanah, S. A. Rahim Rezaee, Mojtaba Tabatabaei Yazdi, Abbas Shirdel, Hugues de Thé, Olivier Hermine, Reza Farid, Ali Bazarbachi

Blood (2009) 113 (26): 6528–6532.

https://doi.org/10.1182/blood-2009-03-211821

Published: 2009

Journal Articles

EAPB0203, a member of the imidazoquinoxaline family, inhibits growth and induces caspase-dependent apoptosis in T-cell lymphomas and HTLV-I–associated adult T-cell leukemia/lymphoma

Georges Moarbess, Hiba El-Hajj, Youmna Kfoury, Marwan E. El-Sabban, Yves Lepelletier, Olivier Hermine, Carine Deleuze-Masquéfa, Pierre-Antoine Bonnet, Ali Bazarbachi

Blood (2008) 111 (7): 3770–3777.

https://doi.org/10.1182/blood-2007-11-121913

Published: 2008

Journal Articles

Molecular Mechanisms of NF-kappaB Activation by the HTLV-I Oncoprotein Tax: Role of Post Translational Protein Modification.

Youmna Kfoury, Rihab Nasr, PhD, Arnaud Favre-Bonvin, PhD, Marwan El-Sabban, PhD, Noemie Renault, Marie-Louise Giron, PhD, Hiba El Hajj, PhD, Estelle Chiari, PhD, Abdul Ghani Mikati, Olivier Hermine, MD, PhD, Ali Saib, PhD, Hugues de Thé, MD, PhD, Claudine Pique, PhD, Ali Bazarbachi, MD, PhD

Blood (2007) 110 (11): 4159.

https://doi.org/10.1182/blood.V110.11.4159.4159

Published: 2007

Journal Articles

Targeted Therapy with Arsenic Trioxide and Interferon alpha Eradicates Leukemic Cells in SCID Mice Model of Adult T-Cell Leukemia/Lymphoma.

Hiba El Hajj, PhD, Hideki Hasegawa, PhD, Marwan El-Sabban, PhD, Ghazi Zaatari, MD, Shehrazad Saab, MD, Rami Mahfouz, MD, Rihab Nasr, PhD, Youmna Kfoury, Olivier Hermine, MD, PhD, Hugues de Thé, MD, PhD, William Hall, Ali Bazarbachi, MD, PhD

Blood (2007) 110 (11): 1379.

https://doi.org/10.1182/blood.V110.11.1379.1379

Published: 2007

NARROW

Arsenic Trioxide and Interferon-Alpha Eradicate Adult T Cell Leukemia Initiating Cells through PML/p53 Senescence and Activation of Innate Immunity

Arsenic Trioxide and Lenalidomide: A Promising Combination Therapy for Primary Effusion Lymphoma

Retinoic acid and arsenic trioxide trigger degradation of mutated NPM1, resulting in apoptosis of AML cells

ATL response to arsenic/interferon therapy is triggered by SUMO/PML/RNF4-dependent Tax degradation

Preclinical efficacy of the synthetic retinoid ST1926 for treating adult T-cell leukemia/lymphoma

Combination Of Arsenic and Interferon-a Inhibits Expression Of KSHV Latent Transcripts and Synergistically Improves Survival Of Mice With Primary Effusion Lymphomas

The Combination Of Arsenic, Interferon-Alpha, and Zidovudine Restores An “Immunocompetent-like” Micro-Environment In Patients With Adult T-Cell Leukemia/Lymphoma

Tax ubiquitylation and SUMOylation control the dynamic shuttling of Tax and NEMO between Ubc9 nuclear bodies and the centrosome

The Combination of Arsenic Trioxide and Interferon-Alpha Eradicates Leukemia Initiating Cells in TAX-Driven Murine Adult T Cell Leukemia/Lymphoma.

Phase 2 study of the efficacy and safety of the combination of arsenic trioxide, interferon alpha, and zidovudine in newly diagnosed chronic adult T-cell leukemia/lymphoma (ATL)

EAPB0203, a member of the imidazoquinoxaline family, inhibits growth and induces caspase-dependent apoptosis in T-cell lymphomas and HTLV-I–associated adult T-cell leukemia/lymphoma

Molecular Mechanisms of NF-kappaB Activation by the HTLV-I Oncoprotein Tax: Role of Post Translational Protein Modification.

Targeted Therapy with Arsenic Trioxide and Interferon alpha Eradicates Leukemic Cells in SCID Mice Model of Adult T-Cell Leukemia/Lymphoma.

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