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Joseph T Opferman
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Journal Articles

MCL1 Promotes Fatty Acid β-Oxidation in Therapy-Resistant AML through Cytoplasmic Sequestration of the Transcriptional Repressor IRF2BP2

Mark J Althoff, Mohd Minhajuddin, Brett M Stevens, Austin E Gillen, Regan Miller, Ana Vujovic, Sweta B Patel, William Showers, Stephanie Gipson, Monika Dzieciatkowska, Jana M Ellegast, Tristen Wright, Kimberly Stegmaier, Joseph T Opferman, Craig T Jordan
Journal: Blood
Blood (2024) 144 (Supplement 1): 39.
https://doi.org/10.1182/blood-2024-206516
Published: 2024
Journal Articles

Requirement for antiapoptotic MCL-1 during early erythropoiesis

Meghan E. Turnis, Ewa Kaminska, Kaitlyn H. Smith, Brittany J. Kartchner, Peter Vogel, Jonathan D. Laxton, Richard A. Ashmun, Paul A. Ney, Joseph T. Opferman
Journal: Blood
Blood (2021) 137 (14): 1945–1958.
https://doi.org/10.1182/blood.2020006916
Published: 2021
Includes: Supplemental data
Journal Articles

Venetoclax and Navitoclax in Pediatric Patients with Acute Lymphoblastic Leukemia and Lymphoblastic Lymphoma

Jeffrey E. Rubnitz, MD, Thomas B. Alexander, MDMPH, Theodore W. Laetsch, MD, Seong Lin Khaw, MD, Vinod A. Pullarkat, MD, Joseph T. Opferman, PhD, Kathryn G Roberts, PhD, Lindsey Rosenwinkel, Bo Tong, PhD, John C. Pesko, PhD, Mohamed Badawi, Deeksha Vishwamitra, PhD, Su Young Kim, Charles G Mullighan, MBBS, MD, Norman J. Lacayo, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 12–13.
https://doi.org/10.1182/blood-2020-134582
Published: 2020
Journal Articles

Safety and Efficacy of Venetoclax in Combination with Navitoclax in Adult and Pediatric Relapsed/Refractory Acute Lymphoblastic Leukemia and Lymphoblastic Lymphoma

Norman J. Lacayo, MD, Vinod A. Pullarkat, MD, Wendy Stock, MD, Elias Jabbour, MD, Ashish Bajel, MBBS, FRACP, FRCPA, Jeffrey Rubnitz, MD PhD, Jessica Leonard, MD, Charles G. Mullighan, MBBS, MD, Seong Lin Khaw, MD, Susan I. Vear, MD MSCI, Joseph T. Opferman, PhD, Ahmed Hamed Salem, PhD FCP, Michelle Schmidt, Bo Tong, PhD, Lang Zhou, PhD, Jeremy A. Ross, PhD, Lindsey Bensman, Amanda Jacobson, PhD, Robin Norris, MD MS, MPH, Thomas Alexander, MDMPH
Journal: Blood
Blood (2019) 134 (Supplement_1): 285.
https://doi.org/10.1182/blood-2019-126977
Published: 2019
Journal Articles

Venetoclax in Combination with High-Dose Chemotherapy Is Active and Well-Tolerated in Children with Relapsed or Refractory Acute Myeloid Leukemia

Seth E Karol, MD, Thomas Alexander, MDMPH, Amit Budraja, PhD, Stanley Pounds, PhD, Kristin E Canavera, PhD, Lei Wang, MS, Joshua Wolf, MBBS, PhD, Jeffery M. Klco, MD PhD, Ahmed Hamed Salem, PhD FCP, Tammy Palenski, PhD, Norman J. Lacayo, MD, Ching-Hon Pui, MD, Joseph T. Opferman, PhD, Jeffrey Rubnitz, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 178.
https://doi.org/10.1182/blood-2019-127716
Published: 2019
Journal Articles

Antagonism between MCL-1 and PUMA governs stem/progenitor cell survival during hematopoietic recovery from stress

Alex R. D. Delbridge, Joseph T. Opferman, Stephanie Grabow, Andreas Strasser
Journal: Blood
Blood (2015) 125 (21): 3273–3280.
https://doi.org/10.1182/blood-2015-01-621250
Published: 2015
Includes: Supplemental data
Journal Articles

Mito-protective autophagy is impaired in erythroid cells of aged mtDNA-mutator mice

XiuJie Li-Harms, Sandra Milasta, John Lynch, Christopher Wright, Aashish Joshi, Rekha Iyengar, Geoffrey Neale, Xi Wang, Yong-Dong Wang, Tomas A. Prolla, James E. Thompson, Joseph T. Opferman, Douglas R. Green, John Schuetz, Mondira Kundu
Journal: Blood
Blood (2015) 125 (1): 162–174.
https://doi.org/10.1182/blood-2014-07-586396
Published: 2015
Includes: Supplemental data
Journal Articles

Requirement for antiapoptotic MCL-1 in the survival of BCR-ABL B-lineage acute lymphoblastic leukemia

Brian Koss, Jeffrey Morrison, Rhonda M. Perciavalle, Harpreet Singh, Jerold E. Rehg, Richard T. Williams, Joseph T. Opferman
Journal: Blood
Blood (2013) 122 (9): 1587–1598.
https://doi.org/10.1182/blood-2012-06-440230
Published: 2013
Includes: Supplemental data
Journal Articles

MCL1 Haploinsufficiency Protects Mice From MYC-Induced Acute Myeloid Leukemia.

Zhifu Xiang, MD, PhD, Hui Luo, PhD, Jacqueline E. Payton, MD, PhD, Lukas D Wartman, MD, Julie Ritchey, John F. DiPersio, MD, PhD, Timothy J. Ley, MD, Joseph T Opferman, PhD, Michael Tomasson, MD
Journal: Blood
Blood (2009) 114 (22): 764.
https://doi.org/10.1182/blood.V114.22.764.764
Published: 2009
Journal Articles

Selective roles for antiapoptotic MCL-1 during granulocyte development and macrophage effector function

Desiree A. Steimer, Kelli Boyd, Osamu Takeuchi, Jill K. Fisher, Gerard P. Zambetti, Joseph T. Opferman
Journal: Blood
Blood (2009) 113 (12): 2805–2815.
https://doi.org/10.1182/blood-2008-05-159145
Published: 2009
Includes: Supplemental data
Journal Articles

The Role of Mcl-1 Expression and Phosphorlyation in Resistance to Chemotherapy and Kinase Inhibitors in FLT3-ITD-Positive Acute Myeloid Leukemia (AML)

Florian H Heidel, MD, Henning Schulze-Bergkamen, MD, Binje Vick, Daniel B Lipka, MD, Fian K Mirea, Toni Urbanik, Joseph T Opferman, PhD, Thomas Fischer, MD
Journal: Blood
Blood (2008) 112 (11): 220.
https://doi.org/10.1182/blood.V112.11.220.220
Published: 2008
Journal Articles

Multiple signaling pathways promote B lymphocyte stimulator–dependent B-cell growth and survival

Robert T. Woodland, Casey J. Fox, Madelyn R. Schmidt, Peter S. Hammerman, Joseph T. Opferman, Stanley J. Korsmeyer, David M. Hilbert, Craig B. Thompson
Journal: Blood
Blood (2008) 111 (2): 750–760.
https://doi.org/10.1182/blood-2007-03-077222
Published: 2008
Includes: Supplemental data