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Anagha Inguva
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Journal Articles

STAT3-VDAC1 Axis Modulates Mitochondrial Function and Plays a Critical Role in the Survival of Leukemic Stem Cells

Kellen B Gil, Jamie Borg, Rosana Moreira Pereira, Anagha Inguva Sheth, Jeremy Rahkola, William Showers, Angelo D'Alessandro, Christine M. McMahon, Daniel A Pollyea, Austin E Gillen, Maria L Amaya
Journal: Blood
Blood (2024) 144 (Supplement 1): 2722.
https://doi.org/10.1182/blood-2024-207887
Published: 2024
Journal Articles

Mitochondrial STAT3 Plays a Critical Role in Survival of AML Cells

Kellen Gil, Jamie Borg, Anagha Inguva Sheth, Rosana Pereira, Jeremy Rahkola, Maria L Amaya
Journal: Blood
Blood (2023) 142 (Supplement 1): 4170.
https://doi.org/10.1182/blood-2023-179453
Published: 2023
Journal Articles

Targeting Mitochondrial Calcium Uptake to Eradicate Venetoclax-Resistant Acute Myeloid Leukemia Stem Cells

Anagha Inguva Sheth, Krysta Engel, Hunter Tolison, Mark Jordan Althoff, Anna Krug, Maria L Amaya, Shanshan Pei, Tracy Young, Sweta B Patel, Mohd Minhajuddin, Regan Miller, Ian Shelton, Ana Vujovic, Courtney L Jones, Austin E Gillen, Monica Ransom, Sarah Staggs, Clayton Smith, Daniel A. Pollyea, Brett M Stevens, Craig T. Jordan
Journal: Blood
Blood (2023) 142 (Supplement 1): 588.
https://doi.org/10.1182/blood-2023-188285
Published: 2023
Journal Articles

Results from a Phase (Ph) 1 Clinical Study of the All-Oral Regimen of CC-486 and Venetoclax for Relapsed and Refractory Acute Myeloid Leukemia

Maria L Amaya, Christine M. McMahon, Marc Schwartz, Jonathan A Gutman, Connor Sohalski, Jennifer Tobin, Austin E Gillen, Anagha Inguva Sheth, Brett M Stevens, Clayton Smith, Craig T. Jordan, Daniel A. Pollyea
Journal: Blood
Blood (2023) 142 (Supplement 1): 2914.
https://doi.org/10.1182/blood-2023-182966
Published: 2023
Journal Articles

Intracellular Calcium Localization Mediates the Activity of Venetoclax in Targeting Acute Myeloid Leukemia Stem Cells

Anagha Inguva, Krysta L. Engel, Hunter Tolison, Mark J Althoff, Shanshan Pei, Maria L. Amaya, Anna Krug, Mohammad Minhajuddin, Courtney L Jones, Austin E. Gillen, Monica Ransom, Sarah Staggs, Daniel A. Pollyea, Clayton Smith, Brett M. Stevens, Craig T. Jordan
Journal: Blood
Blood (2022) 140 (Supplement 1): 5922–5923.
https://doi.org/10.1182/blood-2022-167787
Published: 2022
Journal Articles

The STAT3-MYC axis promotes survival of leukemia stem cells by regulating SLC1A5 and oxidative phosphorylation

Maria L. Amaya, Anagha Inguva, Shanshan Pei, Courtney Jones, Anna Krug, Haobin Ye, Mohammad Minhajuddin, Amanda Winters, Steffanie L. Furtek, Fabia Gamboni, Brett Stevens, Angelo D’Alessandro, Daniel A. Pollyea, Philip Reigan, Craig T. Jordan
Journal: Blood
Blood (2022) 139 (4): 584–596.
https://doi.org/10.1182/blood.2021013201
Published: 2022
Includes: Supplemental data
Journal Articles

Lysosomal Acid Lipase a (LIPA) Modulates Leukemia Stem Cell (LSC) Response to Venetoclax/TKI Combination Therapy in Blast Phase Chronic Myeloid Leukemia

Mohd Minhajuddin, Haobin Ye, Amanda C. Winters, Shanshan Pei, Nabilah Khan, Brett M. Stevens, Biniam Adane, Maria L. Amaya, Anagha Inguva, Anna Krug, Maura Gasparetto, Daniel W. Sherbenou, Daniel A. Pollyea, Clayton Smith, Craig T. Jordan
Journal: Blood
Blood (2021) 138 (Supplement 1): 630.
https://doi.org/10.1182/blood-2021-151400
Published: 2021
Journal Articles

Genetic disruption of N-Ras G12D palmitoylation perturbs hematopoiesis and prevents myeloid transformation in mice

Noemi A. Zambetti, Ari J. Firestone, Jarrett R. Remsberg, Benjamin J. Huang, Jasmine C. Wong, Amanda M. Long, Marina Predovic, Radu M. Suciu, Anagha Inguva, Scott C. Kogan, Kevin M. Haigis, Benjamin F. Cravatt, Kevin Shannon
Journal: Blood
Blood (2020) 135 (20): 1772–1782.
https://doi.org/10.1182/blood.2019003530
Published: 2020
Includes: Supplemental data
Journal Articles

STAT3 Plays a Critical Role in Mitochondrial Function and Survival of Primary AML Cells

Maria L Amaya, MD PhD, Anagha Inguva, BSc, Courtney L Jones, PhD, Anna Krug, BS, Shanshan Pei, PhD, Phillip Reigan, PhD, Craig T Jordan, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1275.
https://doi.org/10.1182/blood-2019-127669
Published: 2019
Journal Articles

Developmental Plasticity of Acute Myeloid Leukemia Mediates Resistance to Venetoclax-Based Therapy

Shanshan Pei, PhD, Daniel A Pollyea, MD, Annika Gustafson, Mohammad Minhajuddin, PhD, Brett M. Stevens, PhD, Haobin Ye, PhD, Anagha Inguva, BSc, Maria L Amaya, MD PhD, Anna Krug, BS, Courtney L Jones, PhD, Biniam Adane, PhD, Amanda Winters, MD PhD, Nabilah Khan, Jessica Ponder, PhD, Jeffrey Schowinsky, Andrew Hammes, MS, Diana Abbott, PhD, Jason R Myers, MS, John M Ashton, PhD, Jonathan A Gutman, MD, Enkhtsetseg Purev, MD PhD, Haley E. Ramsey, PhDMSc, Michael R. Savona, MD, Stephen W. Fesik, PhD, Clayton Smith, MD, Craig T Jordan, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 185.
https://doi.org/10.1182/blood-2019-131390
Published: 2019
Journal Articles

Genetic Validation of the Palmitoylation/Depalmitoylation Cycle As a Drug Target in NRAS Mutant Hematologic Malignancies In Vivo

Noemi A. Zambetti, PhD, Ari J. Firestone, PhD, Jasmine C. Wong, PhD, Amanda Long, BA, Anagha Inguva, BA, Radu M. Suciu, B.Sc., Benjamin F. Cravatt, PhD, Kevin M. Haigis, PhD, Kevin M. Shannon, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1221.
https://doi.org/10.1182/blood.V130.Suppl_1.1221.1221
Published: 2017