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Kevin M. Haigis
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Journal Articles

Genetic disruption of N-Ras G12D palmitoylation perturbs hematopoiesis and prevents myeloid transformation in mice

Noemi A. Zambetti, Ari J. Firestone, Jarrett R. Remsberg, Benjamin J. Huang, Jasmine C. Wong, Amanda M. Long, Marina Predovic, Radu M. Suciu, Anagha Inguva, Scott C. Kogan, Kevin M. Haigis, Benjamin F. Cravatt, Kevin Shannon
Journal: Blood
Blood (2020) 135 (20): 1772–1782.
https://doi.org/10.1182/blood.2019003530
Published: 2020
Includes: Supplemental data
Journal Articles

Genetic Validation of the Palmitoylation/Depalmitoylation Cycle As a Drug Target in NRAS Mutant Hematologic Malignancies In Vivo

Noemi A. Zambetti, PhD, Ari J. Firestone, PhD, Jasmine C. Wong, PhD, Amanda Long, BA, Anagha Inguva, BA, Radu M. Suciu, B.Sc., Benjamin F. Cravatt, PhD, Kevin M. Haigis, PhD, Kevin M. Shannon, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1221.
https://doi.org/10.1182/blood.V130.Suppl_1.1221.1221
Published: 2017
Journal Articles

Preclinical efficacy of MEK inhibition in Nras -mutant AML

Michael R. Burgess, Eugene Hwang, Ari J. Firestone, Tannie Huang, Jin Xu, Johannes Zuber, Natacha Bohin, Tiffany Wen, Scott C. Kogan, Kevin M. Haigis, Deepak Sampath, Scott Lowe, Kevin Shannon, Qing Li
Journal: Blood
Blood (2014) 124 (26): 3947–3955.
https://doi.org/10.1182/blood-2014-05-574582
Published: 2014
Includes: Supplemental data
Journal Articles

Preclinical Efficacy of MEK Inhibition in Nras Mutant Acute Myeloid Leukemia

Michael R. Burgess, MD PhD, Eugene Hwang, BA, Ari J Firestone, PhD, Tannie Huang, MD, Jin Xu, PhD, Johannes Zuber, MD, Natacha Bohin, BS, Tiffany Wen, BS, Scott C. Kogan, MD, Kevin M. Haigis, PhD, Scott W. Lowe, PhD, Kevin Shannon, MD, Qing Li, MD PhD
Journal: Blood
Blood (2014) 124 (21): 3753.
https://doi.org/10.1182/blood.V124.21.3753.3753
Published: 2014
Journal Articles

Inhibiting the palmitoylation/depalmitoylation cycle selectively reduces the growth of hematopoietic cells expressing oncogenic Nras

Brief Report
Jin Xu, Christian Hedberg, Frank J. Dekker, Qing Li, Kevin M. Haigis, Eugene Hwang, Herbert Waldmann, Kevin Shannon
Journal: Blood
Blood (2012) 119 (4): 1032–1035.
https://doi.org/10.1182/blood-2011-06-358960
Published: 2012
Includes: Supplemental data
Journal Articles

Hematopoiesis and leukemogenesis in mice expressing oncogenic Nras G12D from the endogenous locus

Qing Li, Kevin M. Haigis, Andrew McDaniel, Emily Harding-Theobald, Scott C. Kogan, Keiko Akagi, Jasmine C. Y. Wong, Benjamin S. Braun, Linda Wolff, Tyler Jacks, Kevin Shannon
Journal: Blood
Blood (2011) 117 (6): 2022–2032.
https://doi.org/10.1182/blood-2010-04-280750
Published: 2011
Includes: Supplemental data