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Journal Articles

Venetoclax plus R- or G-CHOP in non-Hodgkin lymphoma: results from the CAVALLI phase 1b trial

Clinical Trials & Observations
Andrew D. Zelenetz, Gilles Salles, Kylie D. Mason, Carla Casulo, Steven Le Gouill, Laurie H. Sehn, Herve Tilly, Guillaume Cartron, Martine E. D. Chamuleau, Andre Goy, Constantine S. Tam, Pieternella J. Lugtenburg, Adam M. Petrich, Arijit Sinha, Divya Samineni, Sylvia Herter, Ellen Ingalla, Edith Szafer-Glusman, Christian Klein, Deepak Sampath, Martin Kornacker, Mehrdad Mobasher, Franck Morschhauser
Journal: Blood
Blood (2019) 133 (18): 1964–1976.
https://doi.org/10.1182/blood-2018-11-880526
Published: 2019
Includes: Supplemental data
Journal Articles

Resistance of Natural Killer and T Cells to Venetoclax Allows for Combination Treatment with Cancer Immunotherapy Agents

Elisabeth A Lasater, PhD, An D Do, Luciana Burton, Yijin Li, Erin Williams, Jason Oeh, Luciana Molinero, Elicia Penuel, Deepak Sampath, Monique Dail, Marcia Belvin, Teiko Sumiyoshi, Elizabeth A Punnoose, Jeffrey Venstrom, Aparna Raval
Journal: Blood
Blood (2018) 132 (Supplement 1): 1118.
https://doi.org/10.1182/blood-2018-99-116405
Published: 2018
Journal Articles

FLT3-ITD Activation Mediates Resistance to the BCL-2 Selective Antagonist, Venetoclax, in FLT3-ITD Mutant AML Models

Raghuveer Singh Mali, PhD, Elisabeth A. Lasater, PhD, Kelly Doyle, Ritu Malla, Erwin Boghaert, Andrew Souers, Joel D. Leverson, PhD, Deepak Sampath, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1348.
https://doi.org/10.1182/blood.V130.Suppl_1.1348.1348
Published: 2017
Journal Articles

Alvocidib Enhances Venetoclax Sensitivity in Unfavorable-Risk Multiple Myeloma Cells In Vitro and In Vivo

Liang Zhou, PhD, Yu Zhang, PhD, Deepak Sampath, PhD, Joel D. Leverson, PhD, Yun Dai, MD, Maciej Kmieciak, Matthew Nguyen, Robert Z. Orlowski, MD PhD, Steven Grant, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2540.
https://doi.org/10.1182/blood.V130.Suppl_1.2540.2540
Published: 2017
Journal Articles

Targeting MAPK Signaling Pathway with Cobimetinib (GDC-0973) Enhances Anti-Leukemia Efficacy of Venetoclax (ABT-199/GDC-0199) in Acute Myeloid Leukemia Models

Lina Han, MD PhD, Qi Zhang, MD PhD, Ce Shi, MD PhD, Antonio Cavazos, MS, Vivian Ruvolo, MS, Joel Leverson, Dail Monique, PhD, Darren C. Phillips, PhD, Jun Chen, MD PhD, Sha S Jin, Rodrigo Omar Jacamo, PhD, Naval Daver, MD, Elias J. Jabbour, MD, Hagop M. Kantarjian, MD, Michael Andreeff, MD PhD, Deepak Sampath, PhD, Marina Konopleva, MD PhD
Journal: Blood
Blood (2016) 128 (22): 97.
https://doi.org/10.1182/blood.V128.22.97.97
Published: 2016
Journal Articles

Resistant T-Cell Acute Lymphoblastic Leukemias That Emerge after In Vivo Treatment with Dexamethasone Frequently Down-Regulate Glucocorticoid Receptor Protein Expression

Anica M. Wandler, PhD, Benjamin Huang, MD, Alessandro Scacchetti, Jeff Craig, MD PhD, Hannah Yan, Gabriela Monsalve, PhD, Qing Li, MD PhD, Monique Dail, Jasmine C. Wong, PhD, Joy Nakitandwe, BSc,MSc,PhD, Olga Weinberg, MD, Robert P. Hasserjian, MD, Scott C. Kogan, MD, Deepak Sampath, PhD, James R. Downing, MD PhD, Keith Yamamoto, PhD, Barry S. Taylor, PhD, Jon C. Aster, MD PhD, Jinghui Zhang, PhD, Kevin Shannon, MD
Journal: Blood
Blood (2016) 128 (22): 753.
https://doi.org/10.1182/blood.V128.22.753.753
Published: 2016
Journal Articles

Concomitantly Targeting BCL-2 with Venetoclax (ABT-199/GDC-0199) and MAPK Signaling with Cobimetinib (GDC-0973) in Acute Myeloid Leukemia Models

Lina Han, PhD, Qi Zhang, Ce Shi, PhD, Joel Leverson, PhD, Monique Dail, Darren C. Phillips, PhD, Jun Chen, MDPhD, Sha S Jin, Rodrigo Omar Jacamo, PhD, Naval Daver, MD, Elias J Jabbour, MD, Hagop M Kantarjian, MD, Michael Andreeff, MD PhD, Deepak Sampath, PhD, Marina Konopleva, MD PhD
Journal: Blood
Blood (2015) 126 (23): 2544.
https://doi.org/10.1182/blood.V126.23.2544.2544
Published: 2015
Journal Articles

Preclinical efficacy of MEK inhibition in Nras -mutant AML

Michael R. Burgess, Eugene Hwang, Ari J. Firestone, Tannie Huang, Jin Xu, Johannes Zuber, Natacha Bohin, Tiffany Wen, Scott C. Kogan, Kevin M. Haigis, Deepak Sampath, Scott Lowe, Kevin Shannon, Qing Li
Journal: Blood
Blood (2014) 124 (26): 3947–3955.
https://doi.org/10.1182/blood-2014-05-574582
Published: 2014
Includes: Supplemental data
Journal Articles

Preclinical Testing Of a PI3K Inhibitor In T Lineage Leukemia: Target Validation and Notch1/Myc Down-Regulation In Drug Resistant Clones

Monique Dail, PhD, Jason Wong, Jessica Lawrence, Daniel O'Connor, Joy Nakitandwe, PhD., Shann-Ching Chen, PhD, Keiko Akagi, Leslie Lee, Jon C. Aster, MD, PhD, Warren S. Pear, MD, PhD, Deepak Sampath, PhD, James R. Downing, MD, Kevin Shannon, MD
Journal: Blood
Blood (2013) 122 (21): 2677.
https://doi.org/10.1182/blood.V122.21.2677.2677
Published: 2013
Journal Articles

Combination of the glycoengineered Type II CD20 antibody obinutuzumab (GA101) and The novel Bcl-2 selective Inhibitor GDC-0199 Results in superior In Vitro and In Vivo Anti-tumor activity in models Of B-Cell Malignancies

Deepak Sampath, PhD, Sylvia Herter, PhD, Frank Herting, Ellen Ingalla, Michelle Nannini, Marina Bacac, Wayne J. Fairbrother, PhD, Christian Klein, PhD
Journal: Blood
Blood (2013) 122 (21): 4412.
https://doi.org/10.1182/blood.V122.21.4412.4412
Published: 2013
Journal Articles

The PI3K Inhibitor GDC-0941 Attenuates Disease in a Kras G12D Mouse Model of CMML and JMML.

Jon Akutagawa, B.S., Monique Dail, PhD, Lori S Friedman, PhD, Kevin M. Shannon, MD, Deepak Sampath, PhD, Benjamin S. Braun, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 2862.
https://doi.org/10.1182/blood.V120.21.2862.2862
Published: 2012
Journal Articles

Expression of Bcl-2 Pro-Survival Family Proteins Predicts Pharmacological Responses to ABT-199, a Novel and Selective Bcl-2 Antagonist, in Multiple Myeloma Models

Deepak Sampath, PhD, Elizabeth Punnoose, PhD, Erwin R. Boghaert, PhD, Lisa Belmont, PhD, Jun Chen, PhD, Franklin Peale, MD, PhD, Nguyen Tan, Walter Darbonne, Peng Yue, PhD, Jason Oeh, Leslie Lee, Wayne J. Fairbrother, PhD, Andrew J. Souers, PhD, Steve W. Elmore, PhD, Joel D. Leverson, PhD
Journal: Blood
Blood (2012) 120 (21): 5028.
https://doi.org/10.1182/blood.V120.21.5028.5028
Published: 2012