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Ari J. Firestone
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Journal Articles

Genetic disruption of N-Ras G12D palmitoylation perturbs hematopoiesis and prevents myeloid transformation in mice

Noemi A. Zambetti, Ari J. Firestone, Jarrett R. Remsberg, Benjamin J. Huang, Jasmine C. Wong, Amanda M. Long, Marina Predovic, Radu M. Suciu, Anagha Inguva, Scott C. Kogan, Kevin M. Haigis, Benjamin F. Cravatt, Kevin Shannon
Journal: Blood
Blood (2020) 135 (20): 1772–1782.
https://doi.org/10.1182/blood.2019003530
Published: 2020
Includes: Supplemental data
Journal Articles

Genetic Validation of the Palmitoylation/Depalmitoylation Cycle As a Drug Target in NRAS Mutant Hematologic Malignancies In Vivo

Noemi A. Zambetti, PhD, Ari J. Firestone, PhD, Jasmine C. Wong, PhD, Amanda Long, BA, Anagha Inguva, BA, Radu M. Suciu, B.Sc., Benjamin F. Cravatt, PhD, Kevin M. Haigis, PhD, Kevin M. Shannon, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1221.
https://doi.org/10.1182/blood.V130.Suppl_1.1221.1221
Published: 2017
Journal Articles

Preclinical efficacy of MEK inhibition in Nras -mutant AML

Michael R. Burgess, Eugene Hwang, Ari J. Firestone, Tannie Huang, Jin Xu, Johannes Zuber, Natacha Bohin, Tiffany Wen, Scott C. Kogan, Kevin M. Haigis, Deepak Sampath, Scott Lowe, Kevin Shannon, Qing Li
Journal: Blood
Blood (2014) 124 (26): 3947–3955.
https://doi.org/10.1182/blood-2014-05-574582
Published: 2014
Includes: Supplemental data
Journal Articles

Biochemical and Functional Analysis of Novel KRAS Insertions in MPN and Other Cancers

Yasmine N White, Aditi Bagchi, Jessica Van Ziffle, PhD, Gideon Bollag, PhD, Chao Zhang, PhD, David S Dickens, MD, Mignon L. Loh, MD, Kevin Shannon, MD, Ari J Firestone, PhD
Journal: Blood
Blood (2014) 124 (21): 2207.
https://doi.org/10.1182/blood.V124.21.2207.2207
Published: 2014
Journal Articles

Preclinical Efficacy of MEK Inhibition in Nras Mutant Acute Myeloid Leukemia

Michael R. Burgess, MD PhD, Eugene Hwang, BA, Ari J Firestone, PhD, Tannie Huang, MD, Jin Xu, PhD, Johannes Zuber, MD, Natacha Bohin, BS, Tiffany Wen, BS, Scott C. Kogan, MD, Kevin M. Haigis, PhD, Scott W. Lowe, PhD, Kevin Shannon, MD, Qing Li, MD PhD
Journal: Blood
Blood (2014) 124 (21): 3753.
https://doi.org/10.1182/blood.V124.21.3753.3753
Published: 2014