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Journal Articles

Aging drives Tet2 +/− clonal hematopoiesis via IL-1 signaling

Francisco Caiado, Larisa V. Kovtonyuk, Nagihan G. Gonullu, Jonas Fullin, Steffen Boettcher, Markus G. Manz

Blood (2023) 141 (8): 886–903.

https://doi.org/10.1182/blood.2022016835

Published: 2023

Includes: Supplemental data

Journal Articles

Clonal Dynamics after Haematopoietic Stem Cell Transplantation Using Genome-Wide Somatic Mutations

Michael Spencer Chapman, C. Matthias Wilk, Steffen Boettcher, Emily Mitchell, Kevin J Dawson, Larisa V. Kovtonyuk, Jan Müller, Nicholas Williams, Jyoti Nangalia, Markus G Manz, Peter J. Campbell

Blood (2022) 140 (Supplement 1): 1572–1573.

https://doi.org/10.1182/blood-2022-166701

Published: 2022

Journal Articles

IL-1 mediates microbiome-induced inflammaging of hematopoietic stem cells in mice

Larisa V. Kovtonyuk, Francisco Caiado, Santiago Garcia-Martin, Eva-Maria Manz, Patrick Helbling, Hitoshi Takizawa, Steffen Boettcher, Fatima Al-Shahrour, Cesar Nombela-Arrieta, Emma Slack, Markus G. Manz

Blood (2022) 139 (1): 44–58.

https://doi.org/10.1182/blood.2021011570

Published: 2022

Includes: Supplemental data

Journal Articles

Long-Term Clonal Dynamics upon Allogeneic Haematopoietic Stem Cell Transplantation Revealed Using Somatic Mutations As Clonal Tracking Marks in HSC Donor and Recipient Pairs

Michael Spencer Chapman, C. Matthias Wilk, Steffen Boettcher, Larisa V. Kovtonyuk, Emily Mitchell, Nicholas Williams, Jyoti Nangalia, Markus G Manz, Peter J. Campbell

Blood (2021) 138 (Supplement 1): 3813.

https://doi.org/10.1182/blood-2021-146151

Published: 2021

Journal Articles

Clonal Expansion of Tet2 +/- hematopoiesis Is Driven By Inflamm-Ageing Associated IL-1 Increase in Mice

Francisco Caiado, Larisa V. Kovtonyuk, Markus G Manz

Blood (2021) 138 (Supplement 1): 1086.

https://doi.org/10.1182/blood-2021-146815

Published: 2021

Journal Articles

Hematopoietic Stem Cells Increase Quiescence during Aging

Larisa V. Kovtonyuk, PhD, Peter Ashcroft, PhD, Gianluca Spaltro, MD, Nageswara Rao Tata, Radek C. Skoda, Sebastian Bonhoeffer, Markus G. Manz, Prof.Dr.MD

Blood (2019) 134 (Supplement_1): 2484.

https://doi.org/10.1182/blood-2019-130668

Published: 2019

Journal Articles

Inflammageing of Hematopoietic Stem Cells Is Driven By IL-1

Larisa V. Kovtonyuk, PhD, Francisco Caiado, PhD, Emma Marie Caroline Slack, Prof. Dr., Hitoshi Takizawa, PhD, Markus G. Manz, Prof.Dr.MD

Blood (2019) 134 (Supplement_1): 819.

https://doi.org/10.1182/blood-2019-130361

Published: 2019

Journal Articles

Inv(16) AML Engrafts Human Cytokine Knock-in Mice

Philipp J Rauch, MD, Jana M Ellegast, MD, Larisa V Kovtonyuk, PhD, Ulrich Wagner, PhD, Rouven Müller, MD, Yasuyuki Saito, MD PhD, Nicole Wildner-Verhey van Wijk, PhD, Christine Fritz, Anahita Rafiei, PhD, Veronika Lysenko, Ewa Dudkiewicz, Davide Soldini, MD PhD, Jeroen S Goede, MD, Richard Flavell, PhD, Markus G Manz, MD

Blood (2016) 128 (22): 1078.

https://doi.org/10.1182/blood.V128.22.1078.1078

Published: 2016

Journal Articles

inv(16) and NPM1 mut AMLs engraft human cytokine knock-in mice

Jana M. Ellegast, Philipp J. Rauch, Larisa V. Kovtonyuk, Rouven Müller, Ulrich Wagner, Yasuyuki Saito, Nicole Wildner-Verhey van Wijk, Christine Fritz, Anahita Rafiei, Veronika Lysenko, Ewa Dudkiewicz, Alexandre P. Theocharides, Davide Soldini, Jeroen S. Goede, Richard A. Flavell, Markus G. Manz

Blood (2016) 128 (17): 2130–2134.

https://doi.org/10.1182/blood-2015-12-689356

Published: 2016

Includes: Supplemental data

Journal Articles

Enhanced thrombopoietin but not G-CSF receptor stimulation induces self-renewing hematopoietic stem cell divisions in vivo

Larisa V. Kovtonyuk, Markus G. Manz, Hitoshi Takizawa

Blood (2016) 127 (25): 3175–3179.

https://doi.org/10.1182/blood-2015-09-669929

Published: 2016

Includes: Supplemental data

Journal Articles

Direct Sensing of Lipopolysaccharide Limits Hematopoietic Stem Cell Selfrenewal Via TLR4-TRIF-ROS-p38 Pathway

Hitoshi Takizawa, PhD, Yasuyuki Saito, MD PhD, Larisa V. Kovtonyuk, Kristin Frisch, Markus G. Manz, MD

Blood (2014) 124 (21): 604.

https://doi.org/10.1182/blood.V124.21.604.604

Published: 2014

Journal Articles

Thrombopoietin-Receptor Signalling Induces Proliferation of Dormant HSC.

Larisa V. Kovtonyuk, Markus G. Manz, MD, Hitoshi Takizawa, PhD

Blood (2012) 120 (21): 2343.

https://doi.org/10.1182/blood.V120.21.2343.2343

Published: 2012

NARROW

Aging drives Tet2 +/− clonal hematopoiesis via IL-1 signaling

Clonal Dynamics after Haematopoietic Stem Cell Transplantation Using Genome-Wide Somatic Mutations

IL-1 mediates microbiome-induced inflammaging of hematopoietic stem cells in mice

Long-Term Clonal Dynamics upon Allogeneic Haematopoietic Stem Cell Transplantation Revealed Using Somatic Mutations As Clonal Tracking Marks in HSC Donor and Recipient Pairs

Clonal Expansion of Tet2 +/- hematopoiesis Is Driven By Inflamm-Ageing Associated IL-1 Increase in Mice

Hematopoietic Stem Cells Increase Quiescence during Aging

Inflammageing of Hematopoietic Stem Cells Is Driven By IL-1

Inv(16) AML Engrafts Human Cytokine Knock-in Mice

inv(16) and NPM1 mut AMLs engraft human cytokine knock-in mice

Enhanced thrombopoietin but not G-CSF receptor stimulation induces self-renewing hematopoietic stem cell divisions in vivo

Direct Sensing of Lipopolysaccharide Limits Hematopoietic Stem Cell Selfrenewal Via TLR4-TRIF-ROS-p38 Pathway

Thrombopoietin-Receptor Signalling Induces Proliferation of Dormant HSC.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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