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Nicholas Williams
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Journal Articles

Mutagenic DNA Lesions in Normal Hematopoietic Stem Cells Persist for Years Causing Distinct Patterns of Mutation

Michael Spencer Chapman, Emily Mitchell, Kenichi Yoshida, Nicholas Williams, Margarete A. Fabre, Anna Maria Ranzoni, Philip S. Robinson, Lori Kregar, C. Matthias Wilk, Steffen Boettcher, Krishnaa Mahbubani, Kourosh Saeb-Parsy, Stanley Ng, George S Vassiliou, Kate Gowers, Sam Janes, Matt Hoare, Anthony R Green, Ana Cvejic, Markus G. Manz, Elisa Laurenti, Inigo Martincorena, Michael Stratton, Jyoti Nangalia, Tim H.H. Coorens, Peter Campbell
Journal: Blood
Blood (2024) 144 (Supplement 1): 2673.
https://doi.org/10.1182/blood-2024-208773
Published: 2024
Journal Articles

Pervasive Positive Selection in Blood in 200,618 Individuals and Novel Drivers of Clonal Hematopoiesis

Nicholas Bernstein, Michael Spencer Chapman, Kudzai Nyamondo, Zhenghao Chen, Nicholas Williams, Emily Mitchell, Peter Campbell, Robert L Cohen, Jyoti Nangalia
Journal: Blood
Blood (2023) 142 (Supplement 1): 4062.
https://doi.org/10.1182/blood-2023-185188
Published: 2023
Journal Articles

Clonal Dynamics after Haematopoietic Stem Cell Transplantation Using Genome-Wide Somatic Mutations

Michael Spencer Chapman, C. Matthias Wilk, Steffen Boettcher, Emily Mitchell, Kevin J Dawson, Larisa V. Kovtonyuk, Jan Müller, Nicholas Williams, Jyoti Nangalia, Markus G Manz, Peter J. Campbell
Journal: Blood
Blood (2022) 140 (Supplement 1): 1572–1573.
https://doi.org/10.1182/blood-2022-166701
Published: 2022
Journal Articles

Clonal Hematopoiesis in Mice Is Common with Age and Accelerated By Microbial Exposure

Chiraag D. Kapadia, Matthew Yousefzadeh, Emily Mitchell, Duy Le, Nicholas Williams, Marcus A. Florez, Katherine Y. King, Laura Niedernhofer, Jyoti Nangalia, Margaret A. Goodell
Journal: Blood
Blood (2022) 140 (Supplement 1): 5741–5742.
https://doi.org/10.1182/blood-2022-168231
Published: 2022
Journal Articles

The Longitudinal Dynamics and Natural History of Clonal Hematopoiesis

Margarete A Fabre, Jose Guillherme de Almeida, Edoardo Fiorillo, Emily Mitchell, Aristi Damaskou, Justyna Rak, Valeria Orru, Michele Marongiu, MS Vijayabaskar, Joanna E Baxter, Claire Hardy, Federico Abascal, Michael Spencer Chapman, Nicholas Williams, Jyoti Nangalia, Inigo Martincorena, Peter J Campbell, Eoin F Mckinney, Francesco Cucca, Moritz Gerstung, George S Vassiliou
Journal: Blood
Blood (2021) 138 (Supplement 2): LBA-2.
https://doi.org/10.1182/blood-2021-154938
Published: 2021
Journal Articles

Clonal Dynamics of Normal Haematopoiesis with Human Ageing

Emily Mitchell, Michael Spencer Chapman, Nicholas Williams, Kevin J Dawson, Nicole Mende, Emily Calderbank, Hyunchul Jung, Thomas J Mitchell, Tim Coorens, David Spencer, Heather E Machado, Henry Lee-Six, Megan Davies, Daniel Hayler, Margarete Alice Fabre, Krishnaa Mahbubani, Federico Abascal, George S. Vassiliou, Joanna E Baxter, Inigo Martincorena, Michael Stratton, David G. Kent, Krishna Chatterjee, Kourosh Saeb-Parsy, Anthony R Green, Jyoti Nangalia, Elisa Laurenti, Peter J. Campbell
Journal: Blood
Blood (2021) 138 (Supplement 1): 598.
https://doi.org/10.1182/blood-2021-150152
Published: 2021
Journal Articles

Changes in Clonal Architecture Inform MPN Disease Course in Advance of Phenotypic Manifestations

Joe S Lee, Nicholas Williams, Joanna E Baxter, Anna L Godfrey, Kate Milne, Karim Mane, David C Wedge, Peter J. Campbell, Anthony R Green, Jyoti Nangalia
Journal: Blood
Blood (2021) 138 (Supplement 1): 3590.
https://doi.org/10.1182/blood-2021-152436
Published: 2021
Journal Articles

Inherited Blood Cancer Predisposition through Altered Transcription Elongation

Liam Cato, Jiawei Zhao, Erik L. Bao, Samuel Bryant, Nicholas Williams, Yuemeng Jia, Jyoti Nangalia, Michael Erb, Seychelle Vos, Scott A. Armstrong, Vijay G. Sankaran
Journal: Blood
Blood (2021) 138 (Supplement 1): 629.
https://doi.org/10.1182/blood-2021-153381
Published: 2021
Journal Articles

Long-Term Clonal Dynamics upon Allogeneic Haematopoietic Stem Cell Transplantation Revealed Using Somatic Mutations As Clonal Tracking Marks in HSC Donor and Recipient Pairs

Michael Spencer Chapman, C. Matthias Wilk, Steffen Boettcher, Larisa V. Kovtonyuk, Emily Mitchell, Nicholas Williams, Jyoti Nangalia, Markus G Manz, Peter J. Campbell
Journal: Blood
Blood (2021) 138 (Supplement 1): 3813.
https://doi.org/10.1182/blood-2021-146151
Published: 2021
Journal Articles

Driver Mutation Acquisition in Utero and Childhood Followed By Lifelong Clonal Evolution Underlie Myeloproliferative Neoplasms

Nicholas Williams, PhD, Joe Lee, MBBS, Luiza Moore, PhD, Joanna E Baxter, PhD, James Hewinson, PhD, Kevin J Dawson, PhD, Andrew Menzies, MSc, Anna L Godfrey, PhD, Anthony R Green, PhDFRCPath FMedSci, Peter J Campbell, PhD, Jyoti Nangalia, MBBChir
Journal: Blood
Blood (2020) 136 (Supplement_2): LBA-1.
https://doi.org/10.1182/blood-2020-143813
Published: 2020