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Helen J Lachmann
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Journal Articles

Defining a New “Mayo Stage IIIc” Ultra Poor Risk Category in Systemic AL Amyloidosis: Incorporating Echocardiographic Global Longitudinal Strain to the European Modified Mayo Staging System

Jahanzaib Khwaja, Sriram Ravichandran, Joshua Bomsztyk, Oliver Charles Cohen, Darren Foard, Ana Martinez-Naharro, Lucia Venneri, Marianna Fontana, Carol Whelan, Philip N Hawkins, Julian Gillmore, Helen J Lachmann, Shameem Mahmood, Amy A Kirkwood, Ashutosh D. Wechalekar
Journal: Blood
Blood (2024) 144 (Supplement 1): 890.
https://doi.org/10.1182/blood-2024-203527
Published: 2024
Journal Articles

Prognostication in IgM and Lymphoplasmacytic Lymphoma Associated Systemic AL Amyloidosis

Jahanzaib Khwaja, Sriram Ravichandran, Darren Foard, Ana Martinez-Naharro, Lucia Venneri, Marianna Fontana, Carol Whelan, Philip N Hawkins, Julian Gillmore, Helen J Lachmann, Shameem Mahmood, Shirley D'Sa, Ashutosh D. Wechalekar
Journal: Blood
Blood (2024) 144 (Supplement 1): 4684.
https://doi.org/10.1182/blood-2024-207522
Published: 2024
Journal Articles

Limited Utility of Mayo 2012 Cardiac Staging System for Risk Stratification of Patients with Advanced Cardiac AL Amyloidosis - Analysis of a Uniformly Treated Cohort of 1275 Patients

Jahanzaib Khwaja, Sriram Ravichandran, Joshua Bomsztyk, Oliver Charles Cohen, Darren Foard, Ana Martinez - Naharro, Lucia Venneri, Marianna Fontana, Philip N Hawkins, Julian Gillmore, Helen J Lachmann, Shameem Mahmood, Carol Whelan, Ashutosh D. Wechalekar
Journal: Blood
Blood (2023) 142 (Supplement 1): 537.
https://doi.org/10.1182/blood-2023-178243
Published: 2023
Journal Articles

Use of Matrix-Assisted Laser Desorption/Ionisation Time-of-Flight Mass Spectrometry (MALDI-TOF MS) Free Light Chain Assessment for the Diagnosis and Monitoring of Systemic Immunoglobulin Light Chain (AL) Amyloidosis

Joshua Bomsztyk, Sriram Ravichandran, Hannah Victoria Giles, Oscar Berlanga, Stephen Harding, Jahanzaib Khwaja, Shameem Mahmood, Brendan Wisniowski, Oliver C Cohen, Darren Foard, Janet Gilbertson, Ana Martinez De Azcona Naharro, Lucia Venneri, Carol Whelan, Marianna Fontana, Philip N Hawkins, Julian D Gillmore, Helen J Lachmann, Guy Pratt, Ashutosh D. Wechalekar
Journal: Blood
Blood (2022) 140 (Supplement 1): 2351–2353.
https://doi.org/10.1182/blood-2022-160018
Published: 2022
Journal Articles

Graded Renal Response Criteria for Light Chain (AL) Amyloidosis

Eli Muchtar, Brendan Wisniowski, Giovanni Palladini, Paolo Milani, Giampaolo Merlini, Stefan Schönland, Kaya Veelken, Ute Hegenbart, Angela Dispenzieri, Shaji Kumar, Nelson Leung, Efstathios Kastritis, Meletios A. Dimopoulos, Michaela Liedtke, Ronald Witteles, Vaishali Sanchorawala, Raphael Szalat, Heather J Landau, Erica Petrlik, Suzanne Lentzsch, Alexander Coltoff, Joan Bladé, M. Teresa Cibeira, Oliver C Cohen, Darren Foard, Julian D Gillmore, Helen J Lachmann, Ashutosh D. Wechalekar, Morie A. Gertz
Journal: Blood
Blood (2021) 138 (Supplement 1): 2721.
https://doi.org/10.1182/blood-2021-149594
Published: 2021
Journal Articles

The Prognostic Importance of the 6-Minute Walk Test in AL Amyloidosis

Oliver C Cohen, MBBS, BSc, FRCPath, Ananth Sathyanath, Sriram Ravichandran, MBBS, MRCP, FRCPath, Steven Law, MBBS, BSc, Richa Manwani, MBBS, FRCPath, BSc, Darren Foard, Sajitha Sachchithanantham, MBBS, BSc, FRCPath, Shameem Mahmood, Ana Martinez-Naharro, Marianna Fontana, Carol Whelan, Philip N Hawkins, Helen J Lachmann, Julian D Gillmore, Ashutosh D. Wechalekar, MBBS,FRCP,FRCPath,DM
Journal: Blood
Blood (2020) 136 (Supplement 1): 16–17.
https://doi.org/10.1182/blood-2020-137036
Published: 2020
Journal Articles

The Impact of Longitudinal Strain on Haematological and Cardiac Response and Survival in Patients with Systemic AL Amyloidosis

Oliver C Cohen, MBBS, BSc, FRCPath, Andreia Ismael, Richa Manwani, MBBS, FRCPath, BSc, Sriram Ravichandran, MBBS, MRCP, FRCPath, Steven Law, MBBS, BSc, Darren Foard, Ana Martinez-Naharro, Shameem Mahmood, Sajitha Sachchithananthan, Philip N Hawkins, Helen J Lachmann, Julian D Gillmore, Marianna Fontana, Rodney H Falk, MD, Carol Whelan, Ashutosh D. Wechalekar, MBBS,FRCP,FRCPath,DM
Journal: Blood
Blood (2020) 136 (Supplement 1): 40.
https://doi.org/10.1182/blood-2020-137391
Published: 2020
Journal Articles

A prospective observational study of 915 patients with systemic AL amyloidosis treated with upfront bortezomib

Clinical Trials & Observations
Richa Manwani, Oliver Cohen, Faye Sharpley, Shameem Mahmood, Sajitha Sachchithanantham, Darren Foard, Helen J. Lachmann, Cristina Quarta, Marianna Fontana, Julian D. Gillmore, Carol Whelan, Philip N. Hawkins, Ashutosh D. Wechalekar
Journal: Blood
Blood (2019) 134 (25): 2271–2280.
https://doi.org/10.1182/blood.2019000834
Published: 2019
Journal Articles

A Phase 1 Study of Carfilzomib-Thalidomide-Dexamethasone in Patients with Relapsed/Refractory AL Amyloidosis - Catalyst Trial Results

Mamta Garg, MD FRCP, FRCPath, Andrew Hall, Matthew Jenner, MBBS, MRCP, FRCPath, Bhuvan Kishore, MB BS, MRCP, FRCPath, Helen J Lachmann, MA MB BChir MDFRCP, Julian D Gillmore, MBBS, MD PhD FRCP, Alexandra Pitchford, Louise Flanagan, PhD, Jamie B Oughton, MPhil, BSc, Shameem Mahmood, Sajitha Sachchithanantham, Sarah R Brown, PhD MSc, BSc, Ashutosh D Wechalekar, MBBS, MD FRCP, FRCPath, DM
Journal: Blood
Blood (2019) 134 (Supplement_1): 1890.
https://doi.org/10.1182/blood-2019-126567
Published: 2019
Journal Articles

Quantitative Immunoprecipitation Free Light Chain Mass Spectrometry (QIP-FLC-MS) Simplifies Monoclonal Protein Assessment and Provides Added Clinical Value in Systemic AL Amyloidosis

Faye Amelia Sharpley, BA MA MSc MBBChir FRCPath, Hannah Victoria Giles, FRCPath, MRCP, Richa Manwani, MBBS, FRCPath, BSc, Shameem Mahmood, Sajitha Sachchithanantham, Helen J Lachmann, MA MB BChir MDFRCP, Julian D Gillmore, MBBS, MD PhD FRCP, Carol J Whelan, Philip N Hawkins, Ashutosh D Wechalekar, MB BS, MD FRCP, FRCPath, DM
Journal: Blood
Blood (2019) 134 (Supplement_1): 4375.
https://doi.org/10.1182/blood-2019-128175
Published: 2019
Journal Articles

Treatment of IgM-associated immunoglobulin light-chain amyloidosis with rituximab-bendamustine

Clinical Trials & Observations
Richa Manwani, Sajitha Sachchithanantham, Shameem Mahmood, Darren Foard, Faye Sharpley, Tamer Rezk, Thirusha Lane, Cristina Quarta, Marianna Fontana, Helen J. Lachmann, Julian D. Gillmore, Carol Whelan, Philip N. Hawkins, Ashutosh D. Wechalekar
Journal: Blood
Blood (2018) 132 (7): 761–764.
https://doi.org/10.1182/blood-2018-04-846493
Published: 2018
Journal Articles

Molecular genetic investigation, clinical features, and response to treatment in 21 patients with Schnitzler syndrome

Dorota M. Rowczenio, Shelly Pathak, Juan I. Arostegui, Anna Mensa-Vilaro, Ebun Omoyinmi, Paul Brogan, Dan Lipsker, Thomas Scambler, Roger Owen, Hadija Trojer, Anna Baginska, Julian D. Gillmore, Ashutosh D. Wechalekar, Thirusha Lane, Rene Williams, Taryn Youngstein, Philip N. Hawkins, Sinisa Savic, Helen J. Lachmann
Journal: Blood
Blood (2018) 131 (9): 974–981.
https://doi.org/10.1182/blood-2017-10-810366
Published: 2018
Includes: Supplemental data
Journal Articles

Natural history and outcome of light chain deposition disease

CME Clinical Trials & Observations
Rabya H. Sayed, Ashutosh D. Wechalekar, Janet A. Gilbertson, Paul Bass, Shameem Mahmood, Sajitha Sachchithanantham, Marianna Fontana, Ketna Patel, Carol J. Whelan, Helen J. Lachmann, Philip N. Hawkins, Julian D. Gillmore
Journal: Blood
Blood (2015) 126 (26): 2805–2810.
https://doi.org/10.1182/blood-2015-07-658872
Published: 2015
Includes: Supplemental data
Journal Articles

A Matched Case Control Study of Doxycycline Added to Chemotherapy for Reducing Early Mortality in Patients with Advanced Cardiac AL Amyloidosis from the Alchemy Study Cohort

Ashutosh Wechalekar, MD FRCPath, Carol Whelan, MD, Sajitha Sachchithanantham, MRCP, FRCPath, Marianna Fontana, MD, Shameem Mahmood, MRCP. FRCPath, Darren Foard, RN, Thirusha Lane, RN, Helen J Lachmann, MD FRCP, Julian D Gillmore, MD FRCP, Philip N Hawkins, MD FRCP, FMedSci
Journal: Blood
Blood (2014) 124 (21): 3485.
https://doi.org/10.1182/blood.V124.21.3485.3485
Published: 2014
Journal Articles

Exome Sequencing to Define a Genetic Signature of Plasma Cells in Systemic AL Amyloidosis

Eileen M Boyle, MD, Brian A Walker, PhD, Dorota Rowczienio, MSc, Christopher P Wardell, PhD, Alexander Murison, PhD, Aneta Mikulasova, M.Sc., Sajitha Sachchithanantham, BSc,MBBS,MRCP,FRCPath,, Anna Baginska, Shameem Mahmood, MRCP. FRCPath, Julian D Gillmore, Helen J Lachmann, MD FRCP, Philip N Hawkins, MD FRCP, FMedSci, Xavier Leleu, MD PhD, Faith E Davies, MD, Gareth J. Morgan, MD PhD, Ashutosh Wechalekar, MDFRCPath
Journal: Blood
Blood (2014) 124 (21): 726.
https://doi.org/10.1182/blood.V124.21.726.726
Published: 2014
Journal Articles

Longterm Outcomes and Improved Renal Function with Autologous Stem Cell Transplantation (ASCT) in Light Chain Deposition Disease (LCDD)

Kate Stringaris, MBBS, MRCP, FRCPath, PhD, Rabya Sayed, MRCP, Helen J Lachmann, MD FRCP, Julian D Gillmore, Philip N Hawkins, Ashutosh Wechelaker, MDMRCP FRCPath
Journal: Blood
Blood (2014) 124 (21): 1198.
https://doi.org/10.1182/blood.V124.21.1198.1198
Published: 2014
Journal Articles

The Prognostic Significance of Phenotypically ‘Normal’ Plasma Cells in Chemotherapy Treated AL Patients with Underlying MGUS and Multiple Myeloma

Sajitha Sachchithanantham, BSc,MBBS,MRCP,FRCPath,, Ruth M de Tute, Anna Baginska, Christopher Parrish, MD, Shameem Mahmood, MRCP. FRCPath, Andy Rawstron, PhD, Julian D Gillmore, MD FRCP, Helen J Lachmann, MD FRCP, Philip N Hawkins, Roger G Owen, MD, Ashutosh Wechalekar, Dr
Journal: Blood
Blood (2014) 124 (21): 2073.
https://doi.org/10.1182/blood.V124.21.2073.2073
Published: 2014
Journal Articles

Two types of amyloid in a single heart

Shameem Mahmood, Janet A. Gilbertson, Nigel Rendell, Carol J. Whelan, Helen J. Lachmann, Ashutosh D. Wechalekar, Philip N. Hawkins, Julian D. Gillmore
Journal: Blood
Blood (2014) 124 (19): 3025–3027.
https://doi.org/10.1182/blood-2014-06-580720
Published: 2014
Journal Articles

Exome Sequencing To Define A Genetic Signature Of Plasma Cells In Systemic AL Amyloidosis

Brian A Walker, PhD, Dorota Rowczienio, MSc, Eileen M Boyle, MD, Christopher P Wardell, PhD, Sajitha Sachchithanantham, MRCP, FRCPath, Anna Baginska, Julian D Gillmore, MD, Shameem Mahmood, MRCP. FRCPath, Helen J Lachmann, MD, FRCP, Philip N Hawkins, Faith E Davies, MD, Gareth J Morgan, MD PhD, Ashutosh Wechalekar, MD, FRCPath
Journal: Blood
Blood (2013) 122 (21): 3098.
https://doi.org/10.1182/blood.V122.21.3098.3098
Published: 2013
Journal Articles

Risk Of Progression Of Localised Amyloidosis To Systemic Disease In 606 Patients Over 30 Years

Shameem Mahmood, MRCP. FRCPath, Sajitha Sachchithanantham, MRCP. FRCPath, Frank Bridoux, Thirusha Lane, RN, Lisa Rannigan, RN, Darren Foard, RN, Rabya Sayed, MRCP, Ketna Patel, MRCP, Marianna Fontanna, MD, Carol Whelan, MD, Helen J Lachmann, MD, FRCP, Julian D Gillmore, MD, Philip N Hawkins, MD, Ashutosh Wechalekar, MD FRCPath
Journal: Blood
Blood (2013) 122 (21): 3143.
https://doi.org/10.1182/blood.V122.21.3143.3143
Published: 2013