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Gary Acton
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Journal Articles

Initial results of a CRUK phase I/II, first in human trial of the CAR t-cell engager protein aleta-001 in patients who have received anti-CD19 CAR t-cell therapy for the treatment of b-cell malignancies

Free
Sridhar Chaganti, William Townsend, Bernard Maybury, Shankara Paneesha, Victoria Peacock, Alice Feast, Ram Malladi, Ben Uttenthal, Cathy Burton, Mary Owen, Adam Gibb, Jane Norman, Sunil Iyengar, Adrian Shields, Saly Al-Taei, Gareth Veal, Lucia Gargiulo, Jenny Craigen, Alka Lal, Emma Anderton, Aikaterini Lalatsa, Lisa Loram, Marco Schupp, Gary Acton, Paul Rennert
Journal: Blood
Blood (2025) 146 (Supplement 1): 925.
https://doi.org/10.1182/blood-2025-925
Published: 2025
Journal Articles

Cancer-selective targeting of the NF-κB pathway via GADD45β/MKK7 inhibition: Results from the phase I trial of the first-in-class inhibitor, DTP3, in patients with relapsed or refractory multiple myeloma

Free
Aristeidis Chaidos, Dimitrios Potolidis, Jessica Cornice, Holger Auner, Gary Acton, Ceri Bygrave, Gordon Cook, Rakesh Popat, Andrew Davies, Christopher Parrish, Maria Atta, Kim Linton, Dean Smith, Christopher Fox, Iain McNeish, Elizabeth Hadley, Elena Ferrer Martinez Del Peral, Mario Pellegatti, Nigel Adams, Albert Chau, Precious Nnebedum, Daria Capece, Daniela Verzella, Daniel D'Andrea, Jan Rekowski, Christina Yap, Laura Tornatore, Guido Franzoso
Journal: Blood
Blood (2025) 146 (Supplement 1): 5825.
https://doi.org/10.1182/blood-2025-5825
Published: 2025
Journal Articles

Ongoing Results of a Phase 1B/2 Dose-Escalation and Cohort-Expansion Study of the Selective, Noncovalent, Reversible Bruton'S Tyrosine Kinase Inhibitor, Vecabrutinib, in B-Cell Malignancies

Free
John N. Allan, MD, Krish Patel, MD, Anthony R. Mato, MDMSCE, William G. Wierda, MD PhD, Javier Pinilla Ibarz, MD PhD, Michael Y. Choi, MD, Susan M. O'Brien, MD, Jeff P. Sharman, MD, Mazyar Shadman, MD, Douglas E Gladstone, MD, Matthew S. Davids, MD, John M. Pagel, MD PhD DSc, Renee Ward, MD PhD, Gary Acton, MD, Pietro Taverna, PhD, Judith A. Fox, PhD, Richard R. Furman, MD, Jennifer R. Brown, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3041.
https://doi.org/10.1182/blood-2019-126286
Published: 2019
Journal Articles

Cancer-Selective Targeting of the NF-κB Survival Pathway in Multiple Myeloma with the GADD45β/MKK7 Inhibitor, DTP3

Free
Laura Tornatore, Gary Acton, Nigel Adams, Elizabeth A Campbell, James Kelly, Richard M Szydlo, BSc, PhD, Mike Tarbit, Salina Bannoo, Daniel D'Andrea, Daria Capece, Annamaria Sandomenico, Julian Dyson, Antonio Leonardi, Christoph Driessen, Menotti Ruvo, Ishara Anees, Metod Oblak, Sheena Quaid, Magda J Al-Obaidi, Holger Auner, Reuben Benbenjamin, Richard S Kaczmarski, Martin F Kaiser, Atul Mehta, Heather E Oakervee, Stephen A Schey, Ashutosh Wechalekar, Jane F. Apperley, MD, Guido Franzoso
Journal: Blood
Blood (2015) 126 (23): 868.
https://doi.org/10.1182/blood.V126.23.868.868
Published: 2015
Journal Articles

Improved Survival in Patients with First Relapsed or Refractory Acute Myeloid Leukemia (AML) Treated with Vosaroxin Plus Cytarabine Versus Placebo Plus Cytarabine: Results of a Phase 3 Double-Blind Randomized Controlled Multinational Study (VALOR)

Free
Farhad Ravandi, MD, Ellen Ritchie, MD, Hamid Sayar, MD, Jeffrey Lancet, MD, Michael D. Craig, MD, Norbert Vey, MD, Stephen A. Strickland, MD, Gary Schiller, MD, Elias Jabbour, MD, Harry P. Erba, MD PhD, Arnaud Pigneux, MD, Heinz-August Horst, MD, Christian Recher, MD, Virginia M. Klimek, MD, Jorge Cortes, MD, Eric J. Feldman, MD, Adam R. Craig, MD PhD, Judith A. Fox, PhD, Renee Ward, MD PhD, Jennifer Smith, PhD, Gary Acton, MD, Cyrus Mehta, PhD, Hagop M. Kantarjian, MD, Robert K Stuart, MD
Journal: Blood
Blood (2014) 124 (21): LBA-6.
https://doi.org/10.1182/blood.V124.21.LBA-6.LBA-6
Published: 2014
Journal Articles

Relapsed and Refractory Acute Myeloid Leukemia (AML) Treated with AS1411 and Cytarabine: A Randomized Phase II Trial.

Free
Robert Kenneth Stuart, MD, Gary Acton, AS1411-201 Investigator Group
Journal: Blood
Blood (2008) 112 (11): 1935.
https://doi.org/10.1182/blood.V112.11.1935.1935
Published: 2008