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Journal Articles

Celmods potently inhibit m-MDSC induction by targeting IL-10 and MIF in multiple myeloma

Free
Yui Niiyama-Uchibori, Yu Inoue, Shotaro Chinen, Takahisa Nakamura, Hiroaki Nagata, Haruya Okamoto, Takahiro Fujino, Taku Tsukamoto, Shinsuke Mizutani, Yuji Shimura, Junya Kuroda
Journal: Blood
Blood (2025) 146 (Supplement 1): 7447.
https://doi.org/10.1182/blood-2025-7447
Published: 2025
Journal Articles

Multistep molecular trajectory during monocytic myeloid-derived suppressor cell induction by diffuse large B-cell lymphoma cells

Free
Yu Inoue, Yuji Shimura, Yui Niiyama-Uchibori, Shotaro Chinen, Takahisa Nakamura, Haruya Okamoto, Takahiro Fujino, Taku Tsukamoto, Shinsuke Mizutani, Junya Kuroda
Journal: Blood
Blood (2025) 146 (Supplement 1): 7091.
https://doi.org/10.1182/blood-2025-7091
Published: 2025
Journal Articles

Non-infectious fever predicts poor survival in azacitidine-treated high-risk, but not low-risk, myelodysplastic syndromes：a multicenter real-world cohort study (KOTOSG)

Free
Takahisa Nakamura, Haruya Okamoto, Takahiro Fujino, Taku Tsukamoto, Shinsuke Mizutani, Yuji Shimura, Hiroto Kaneko, Mitsushige Nakao, Ryoichi Takahashi, Shin-ichi Fuchida, Daichi Nishiyama, Yuri Kamitsuji, Hitoji Uchiyama, Eri Kawata, Nobuhiko Uoshima, Junya Kuroda
Journal: Blood
Blood (2025) 146 (Supplement 1): 3850.
https://doi.org/10.1182/blood-2025-3850
Published: 2025
Journal Articles

Role of bortezomib maintenance therapy in the anti-CD38 antibody era: Interim analysis results of a randomized Phase III study for transplant-ineligible newly diagnosed multiple myeloma (JCOG1911/B-DASH Study)

Free
Tomotaka Suzuki, Ryunosuke Machida, Yusuke Sano, Kazuyuki Shimada, Shinsuke Iida, Nobuhiko Yamauchi, Nobuhiko Nakamura, Hiroshi Handa, Yoshikazu Hori, Yasuhiro Suzuki, Daisuke Ogiya, Keisuke Kataoka, Eiji Negoro, Hiroyuki Takahashi, Junya Kuroda, Junya Makiyama, Ichiro Hanamura, Kaname Miyashita, Satoshi Ito, Hideki Uryu, Shigeru Kusumoto, Masahiro Takeuchi, Yasuhiro Harada, Takahiro Kumode, Ritsuro Suzuki, Isao Yoshida, Naoko Harada, Wataru Munakata, Hirokazu Nagai, Dai Maruyama
Journal: Blood
Blood (2025) 146 (Supplement 1): 370.
https://doi.org/10.1182/blood-2025-370
Published: 2025
Journal Articles

Efficacy of upfront blinatumomab combined with reduced-intensity chemotherapy for newly diagnosed adult Philadelphia chromosome–negative B-lineage acute lymphoblastic leukemia: Interim analysis of two prospective studies of JSCT ALL/MRD2023 and ALL/MRD2019 in Japan

Free
Takahiro Shima, Koji Nagafuji, Toshihiro Miyamoto, Shuichi Ota, Yuna Katsuoka, Satoshi Yoshihara, Naoyuki Uchida, Senji Kasahara, Hiroki Hosoi, Mitsumasa Watanabe, Hitoji Uchiyama, Junya Kanda, Takeru Asano, Yuichiro Nawa, Ken Takase, Atsushi Satake, Junya Kuroda, Tetsuya Eto, Yutaka Imamura, Yasuhiko Miyazaki, Akio Mori, Satoshi Yamamoto, Takahiro Nagashima, Shinichi Masuda, Yoshiki Nakae, Hitoshi Minamiguchi, Yuta Katayama, Tatsunori Ishikawa, Shiro Fujii, Tomoaki Fujisaki, Katsuto Takenaka, Goichi Yoshimoto, Ilseung Choi, Masao Ogata, Koji Kato, Naoki Harada, Mika Kuroiwa, Masahiro Onozawa, Hisashi Yamamoto, Junichi Kitagawa, Taku Tsukamoto, Noboru Asada, Ryota Imanaka, Kazushi Tanimoto, Shuro Yoshida, Yuichiro Semba, Yoshikane Kikushige, Yoshikiyo Ito, Takahiro Maeda, Koichi Akashi
Journal: Blood
Blood (2025) 146 (Supplement 1): 5116.
https://doi.org/10.1182/blood-2025-5116
Published: 2025
Journal Articles

A prognostic model integrating disease‑ and patient‑oriented factors identifies poor‑outcome patients with low‑risk MDS: A multicenter real‑world cohort study (KOTOSG)

Free
Takahisa Nakamura, Haruya Okamoto, Takahiro Fujino, Taku Tsukamoto, Shinsuke Mizutani, Yuji Shimura, Hiroto Kaneko, Mitsushige Nakao, Ryoichi Takahashi, Shin-ichi Fuchida, Daichi Nishiyama, Yuri Kamitsuji, Hitoji Uchiyama, Eri Kawata, Nobuhiko Uoshima, Junya Kuroda
Journal: Blood
Blood (2025) 146 (Supplement 1): 5633.
https://doi.org/10.1182/blood-2025-5633
Published: 2025
Journal Articles

Real-World (RW) Treatment (Tx) Patterns and Outcomes in Patients (Pts) with Relapsed/Refractory Multiple Myeloma (RRMM) Previously Treated with Lenalidomide and an Anti-CD38 Monoclonal Antibody: Data from the Japan Medical Data Vision Database

Free
Junya Kuroda, Teofilia Acheampong, Mayuko Nakakoji, Tohru Miyazaki, Ryosuke Hinosugi, Shigeki Kuwayama, Yu-Hsuan Shih
Journal: Blood
Blood (2024) 144 (Supplement 1): 7894.
https://doi.org/10.1182/blood-2024-198399
Published: 2024
Journal Articles

Trends and Outcomes of Hematopoietic Stem Cell Transplantation for Malignant Lymphoma in Japan between 2006 and 2021

Free
Ayako Muramatsu, Ayumi Fujimoto, Koji Izutsu, Tsutomu Kobayashi, Takahiro Fukuda, Go Yamamoto, Yasufumi Uehara, Masashi Sawa, Nobuhiro Hiramoto, Tsuyoshi Muta, Keisuke Kataoka, Yoshinobu Kanda, Jun Ishikawa, Makoto Onizuka, Koji Kawamura, Junya Kanda, Yoshiko Atsuta, Junya Kuroda, Shinichi Kako, Ritsuro Suzuki
Journal: Blood
Blood (2024) 144 (Supplement 1): 4472.
https://doi.org/10.1182/blood-2024-206515
Published: 2024
Journal Articles

MagnetisMM-9: Efficacy and Safety of Step-up Priming Doses and Longer Dosing Intervals of Elranatamab (ELRA) in Patients with Relapsed or Refractory Multiple Myeloma (RRMM)

Free
Matthew Pianko, Charlotte Pawlyn, Shang-Yi Huang, Tadao Ishida, Douglas W Sborov, Shinsuke Iida, Aravind Ramakrishnan, Reuben Benjamin, Rakesh Popat, Steven Schuster, Junya Kuroda, Chia-Jen Liu, Anne Philippe, Umberto Conte, Fangxin Hong, Erik Vandendries, Rafael Fonseca
Journal: Blood
Blood (2024) 144 (Supplement 1): 4743.
https://doi.org/10.1182/blood-2024-205872
Published: 2024
Journal Articles

The Anti-Myeloma Efficacy of TAS0612, a Triple Inhibitor of RSK, AKT, and S6K, and Itssynergistic Combination with Venetoclax in Multiple Myeloma Irrespective of Cytogeneticabnormalities

Free
Haruya Okamoto, Shinsuke Mizutani, Taku Tsukamoto, Yoko Katsuragawa-Taminishi, Yuka Kawaji-Kanayama, Kentaro Mizuhara, Ayako Muramatsu, Reiko Isa, Takahiro Fujino, Yuji Shimura, Koji Ichikawa, Junya Kuroda
Journal: Blood
Blood (2024) 144 (Supplement 1): 4178.
https://doi.org/10.1182/blood-2024-199695
Published: 2024
Journal Articles

Randomized Phase III Study of Watchful Waiting Vs. Rituximab As First-Line Treatment in Patients with Advanced Stage Low Tumor Burden Follicular Lymphoma: JCOG1411/Flora Study

Free
Noriko Fukuhara, Dai Maruyama, Kenichi Ishizawa, Yusuke Sano, Ryunosuke Machida, Shinichi Makita, Wataru Munakata, Satoshi Ichikawa, Keiko Aizawa, Kana Miyazaki, Yoshihiro Kameoka, Shinya Rai, Yu Yagi, Naoki Takahashi, Toshiki Mushino, Takeharu Kato, Yuri Miyazawa, Toko Saito, Kazuyuki Shimada, Junya Kuroda, Hideki Uryu, Yuko Mishima, Nobuyuki Takayama, Yasuhiro Suzuki, Toshiki Uchida, Nobuhiko Nakamura, Takayuki Tabayashi, Yosuke Minami, Nobuaki Dobashi, Kunihiro Tsukasaki, Hirokazu Nagai
Journal: Blood
Blood (2024) 144 (Supplement 1): 338.
https://doi.org/10.1182/blood-2024-199868
Published: 2024
Journal Articles

AML-Mrg Mutation Spectrum and Its Prognosis: A Japanese Multicenter Study HM01-02 Analysis with Full Analysis Sets

Free
Naoko Hosono, Tomoki Naito, Sunggi Chi, Hironori Arai, Koichi Onodera, Kentaro Fukushima, Daisuke Ikeda, Satoshi Iyama, Akihiko Gotoh, Takayuki Ikezoe, Naoto Takahashi, Kensuke Kojima, Junya Kanda, Koji Izutsu, Suguru Fukuhara, Hirotaka Matsui, Goichi Yoshimoto, Junya Kuroda, Takahiro Yamauchi, Kensuke Usuki, Yosuke Minami
Journal: Blood
Blood (2024) 144 (Supplement 1): 6123.
https://doi.org/10.1182/blood-2024-202327
Published: 2024
Journal Articles

ctDNA improves prognostic prediction for patients with relapsed/refractory MM receiving ixazomib, lenalidomide, and dexamethasone

Free
Yasunori Kogure, Hiroshi Handa, Yuta Ito, Masaki Ri, Yuichi Horigome, Masaki Iino, Yoriko Harazaki, Takahiro Kobayashi, Masahiro Abe, Tadao Ishida, Shigeki Ito, Hiromi Iwasaki, Junya Kuroda, Hirohiko Shibayama, Kazutaka Sunami, Hiroyuki Takamatsu, Hideto Tamura, Toshiaki Hayashi, Kiwamu Akagi, Tomohiro Shinozaki, Takahiro Yoshida, Ikuo Mori, Shinsuke Iida, Takahiro Maeda, Keisuke Kataoka
Journal: Blood
Blood (2024) 143 (23): 2401–2413.
https://doi.org/10.1182/blood.2023022540
Published: 2024
Includes: Supplemental data
Journal Articles

TAS0612, a Triple Inhibitor for RSK, AKT, and S6K, Is a Promising Anti-Myeloma Agent Regardless of Types of Cytogenetic/Genetic Abnormality

Free
Haruya Okamoto, Shinsuke Mizutani, Taku Tsukamoto, Yoko Katsuragawa-Taminishi, Reiko Isa, Kentaro Mizuhara, Ayako Muramatsu, Yuka Kawaji-Kanayama, Takahiro Fujino, Yuji Shimura, Junya Kuroda
Journal: Blood
Blood (2023) 142 (Supplement 1): 3313.
https://doi.org/10.1182/blood-2023-174157
Published: 2023
Journal Articles

The Activation Status of RSK2, but Not PDPK1 and AKT, Associates with the Prognosis of Diffuse Large B Cell Lymphoma

Free
Akio Onishi, Aya Miyagawa-Hayashino, Kentaro Mizuhara, Ayako Muramatsu, Haruya Okamoto, Yuka Kawaji-Kanayama, Yoko Katsuragawa-Taminishi, Takahiro Fujino, Taku Tsukamoto, Shinsuke Mizutani, Yuji Shimura, Eiichi Konishi, Junya Kuroda
Journal: Blood
Blood (2023) 142 (Supplement 1): 4390.
https://doi.org/10.1182/blood-2023-184365
Published: 2023
Journal Articles

A Phase 1 Trial of OPB-111077 in Combination with Bendamustine (B) and Rituximab (R) in Patients with Relapsed or Refractory (R/R) Diffuse Large B-Cell Lymphoma (DLBCL): Preliminary Results of Dose-Escalation Stage

Free
Tomomi Toubai, Junya Kuroda, Youko Suehiro, Yuko Mishima, Kazutaka Sunami, Koji Kato, Nobuhiko Uoshima, Takahiro Kumode, Ai Ota, Kaori Mitsuki, Daisuke Yokota, Yuri Sano, Yasuhito Terui
Journal: Blood
Blood (2023) 142 (Supplement 1): 4464.
https://doi.org/10.1182/blood-2023-179716
Published: 2023
Journal Articles

Final Analysis of the Randomized Phase II/III Study of Standard R-CHOP Versus CHOP Combined with Dose-Dense Weekly Rituximab for DLBCL: JCOG0601

Free
Ken Ohmachi, Tomohiro Kinoshita, Dai Maruyama, Gakuto Ogawa, Yusuke Sano, Nobuhiko Yamauchi, Noriko Fukuhara, Toshiki Uchida, Kazuhito Yamamoto, Kana Miyazaki, Norifumi Tsukamoto, Shinsuke Iida, Isao Yoshida, Yasuhiro Suzuki, Yasufumi Masaki, Tohru Murayama, Yoshihiro Yakushijin, Youko Suehiro, Kisato Nosaka, Nobuaki Dobashi, Junya Kuroda, Wataru Munakata, Kiyoshi Ando, Kenichi Ishizawa, Michinori Ogura, Tadashi Yoshino, Tomomitsu Hotta, Kunihiro Tsukasaki, Kensei Tobinai, Hirokazu Nagai
Journal: Blood
Blood (2023) 142 (Supplement 1): 1724.
https://doi.org/10.1182/blood-2023-178551
Published: 2023
Journal Articles

NGS Profile and the Mathematical Prediction Model for Venetoclax Combination Therapy in HM-Screen-Japan 02 Study

Free
Tomoaki Ueda, Kentaro Fukushima, Naoki Hosen, Sunggi Chi, Hiroshi Haeno, Goichi Yoshimoto, Hironori Arai, Daisuke Ikeda, Kensuke Usuki, Naoto Takahashi, Naoko Hosono, Takahiro Yamauchi, Takeshi Kondo, Kazuhito Yamamoto, Junya Kuroda, Yosuke Minami
Journal: Blood
Blood (2023) 142 (Supplement 1): 5761.
https://doi.org/10.1182/blood-2023-180339
Published: 2023
Journal Articles

The Universal Antitumor Activity of TAS0612, a Triple Inhibitor for RSK, AKT, and S6K, in B-Cell Lymphomas Regardless of Disease Subtype

Free
Yoko Katsuragawa-Taminishi, Shinsuke Mizutani, Yuka Kawaji-Kanayama, Akio Onishi, Haruya Okamoto, Reiko Isa, Kentaro Mizuhara, Ayako Muramatsu, Takahiro Fujino, Taku Tsukamoto, Yuji Shimura, Masafumi Taniwaki, Aya Miyagawa-Hayashino, Eiichi Konishi, Junya Kuroda
Journal: Blood
Blood (2023) 142 (Supplement 1): 7135.
https://doi.org/10.1182/blood-2023-173485
Published: 2023
Journal Articles

An Open-Label, Multicenter, Single-Arm, Phase I Dose Escalation Study of OP-2100, an Orally Bioavailable Prodrug of Decitabine, for Patients with Relapsed or Refractory Higher-Risk Myelodysplastic Syndromes and Chronic Myelomonocytic Leukemia

Free
Shinya Kimura, Kensuke Usuki, Tatsuo Ichinohe, Takayuki Ikezoe, Junya Kuroda, Senji Kasahara, Sho Okamoto, Hiromitsu Iizuka, Hiroshi Ureshino, Tatsuro Watanabe, Tokihiro Ro, Kosuke Endo, Yuka Kagawa, Yuki Kurahashi, Toshiki Naito, Takahiro Yamauchi
Journal: Blood
Blood (2023) 142 (Supplement 1): 6466.
https://doi.org/10.1182/blood-2023-173174
Published: 2023