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Paula Proszek
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Journal Articles

Euroclonality-NGS DNA Capture Panel for Integrated Analysis of IG/TR Rearrangements, Translocations, Copy Number and Sequence Variation in Lymphoproliferative Disorders

Peter Stewart, PhD, Jana Gazdova, MSc, Nikos Darzentas, PhD, Dorte Wren, PhDFRCPath, Paula Proszek, Grazia Fazio, Simona Songia, Miguel Alcoceba, Maria Eugenia Sarasquete, PhD, Patrick Villarese, PhD, Michèle Y van der Klift, Kim Heezen, Neil McCafferty, MSc, Karol Pal, MSc, Mark Catherwood, PhD, Chang Sik Kim, PhD, Shambhavi Srivastava, PhD, Elizabeth Hodges, PhD, Kostas Stamatopoulos, Wolfram Klapper, Simone Ferrero, MD, Michiel van den Brand, MD, Giovanni Cazzaniga, PhD, Frederic Davi, MD PhD, Ramon Garcia-Sanz, MD PhD, Patricia Groenen, Elizabeth Macintyre, PhDMD, Monika Brüggemann, Christiane Pott, MD PhD, Elisa Genuardi, Anton W Langerak, PhD, David Gonzalez, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 888.
https://doi.org/10.1182/blood-2019-127822
Published: 2019
Journal Articles

The genomic landscape of plasma cells in systemic light chain amyloidosis

Eileen M. Boyle, Cody Ashby, Christopher P. Wardell, Dorota Rowczenio, Sajitha Sachchithanantham, Yan Wang, Sarah K. Johnson, Michael A. Bauer, Niels Weinhold, Martin F. Kaiser, David C. Johnson, John R. Jones, Charlotte Pawlyn, Paula Proszek, Carolina Schinke, Thierry Facon, Charles Dumontet, Faith E. Davies, Gareth J. Morgan, Brian A. Walker, Ashutosh D. Wechalekar
Journal: Blood
Blood (2018) 132 (26): 2775–2777.
https://doi.org/10.1182/blood-2018-08-872226
Published: 2018
Includes: Supplemental data
Journal Articles

Spatiotemporal Analysis of Intraclonal Heterogeneity in Multiple Myeloma: Unravelling the Impact of Treatment and the Propagating Capacity of Subclones Using Whole Exome Sequencing

Lorenzo Melchor, PhD, John R Jones, MD, Oleg Lenive, Erich Allen Peterson, PhD BS, MS, Annamaria Brioli, MD PhD, Alex Murison, PhD, Christopher P Wardell, PhD, Martin F Kaiser, Paula Proszek, Eileen Mary Boyle, MD PhD, Dil B Begum, Charlotte Pawlyn, MB BChir, David C Johnson, PhD, Inmaculada Rapado, David A Cairns, Walter M Gregory, Roger G Owen, Graham H Jackson, MD PhD, Mark T Drayson, MD PhD, Faith E Davies, MD, Joaquín Martínez-López, MD PhD, Richard S Houlston, MDPhDFRCP, Mel Greaves, FRS, Brian A Walker, PhD, Gareth J Morgan, MD PhD
Journal: Blood
Blood (2015) 126 (23): 371.
https://doi.org/10.1182/blood.V126.23.371.371
Published: 2015
Journal Articles

Specific Identification of High Risk Disease Using Molecular Profiling By Mymap (Myeloma MLPA and translocation PCR) of 1,036 Cases

Martin F Kaiser, MD, Eileen Mary Boyle, MD PhD, Brian A Walker, PhD, Dil B Begum, Paula Proszek, David C Johnson, PhD, Charlotte Pawlyn, MB BChir, John R Jones, MD, Suvi Savola, PhD, Roger G Owen, Mark T Drayson, MD PhD, David A Cairns, Gordon Cook, MD PhD, Walter M Gregory, Richard S Houlston, MDPhDFRCP, Faith E Davies, MD, Graham H Jackson, MD, Gareth J Morgan, MD PhD
Journal: Blood
Blood (2015) 126 (23): 2981.
https://doi.org/10.1182/blood.V126.23.2981.2981
Published: 2015
Journal Articles

Molecular Subgroups of Hyperdiploidy and Their Prognostic Relevance - an Analysis of 1,036 Myeloma Trial Patients

Martin F Kaiser, MD, Eileen Mary Boyle, MD PhD, Brian A Walker, PhD, Dil B Begum, Paula Proszek, David C Johnson, PhD, Charlotte Pawlyn, MB BChir, John R Jones, MD, Suvi Savola, PhD, Roger G Owen, Mark T Drayson, MD PhD, David A Cairns, Gordon Cook, MD PhD, Walter M Gregory, Richard S Houlston, MDPhDFRCP, Faith E Davies, MD, Graham H Jackson, MD, Gareth J Morgan, MD PhD
Journal: Blood
Blood (2015) 126 (23): 2983.
https://doi.org/10.1182/blood.V126.23.2983.2983
Published: 2015
Journal Articles

Coexistent hyperdiploidy does not abrogate poor prognosis in myeloma with adverse cytogenetics and may precede IGH translocations

Charlotte Pawlyn, Lorenzo Melchor, Alex Murison, Christopher P. Wardell, Annamaria Brioli, Eileen M. Boyle, Martin F. Kaiser, Brian A. Walker, Dil B. Begum, Nasrin B. Dahir, Paula Proszek, Walter M. Gregory, Mark T. Drayson, Graham H. Jackson, Fiona M. Ross, Faith E. Davies, Gareth J. Morgan
Journal: Blood
Blood (2015) 125 (5): 831–840.
https://doi.org/10.1182/blood-2014-07-584268
Published: 2015
Includes: Supplemental data
Journal Articles

Rapid, Robust and Accessible Molecular Profiling of Biologically and Clinically Relevant Copy Number Alterations in Multiple Myeloma from Small Amounts of Tumor DNA

Martin F Kaiser, MD, Paula Proszek, MSc, Dil Begum, BSc, Nasrin Dahir, BSc, Brian A Walker, PhD, Suvi Savola, PhD, Eileen M Boyle, MD, David C Johnson, PhD, David A Cairns, PhD, Walter Gregory, PhD, Graham Jackson, MD, Roger G Owen, MD, Gordon Cook, MD PhD, Mark T Drayson, MDPhD, Faith E Davies, MD, Gareth J Morgan, MD PhD
Journal: Blood
Blood (2014) 124 (21): 5168.
https://doi.org/10.1182/blood.V124.21.5168.5168
Published: 2014
Journal Articles

Apobec Family Mutational Signatures Are Associated with Poor Prognosis Translocations in Multiple Myeloma

Brian A Walker, PhD, Christopher P Wardell, PhD, Alexander Murison, PhD, Eileen M Boyle, MD, Lorenzo Melchor, PhD, Charlotte Pawlyn, MD, Martin F Kaiser, MD, Dil Begum, BSc, Nasrin Dahir, BSc, Paula Proszek, MSc, David C Johnson, PhD, Ya-Wei Qiang, MD PhD, John Jones, MD, David A Cairns, PhD, Walter Gregory, PhD, Roger G Owen, MD, Gordon Cook, MD, Mark T Drayson, MDPhD, Graham Jackson, MD, Faith E Davies, MD, Gareth J. Morgan, MD PhD
Journal: Blood
Blood (2014) 124 (21): 723.
https://doi.org/10.1182/blood.V124.21.723.723
Published: 2014
Journal Articles

Mutational Patterns and Copy Number Changes at Diagnosis Are a Powerful Tool to Predict Outcome: Result of the Sequencing Study of 463 Newly Diagnosed Myeloma Trial Patients

Eileen M Boyle, MD, Brian A Walker, PhD, Christopher P Wardell, PhD, Alexander Murison, PhD, Lorenzo Melchor, PhD, Martin F Kaiser, MD, Dil Begum, BSc, Paula Proszek, MSc, Nasrin Dahir, BSc, David C Johnson, PhD, Charlotte Pawlyn, MBBChir, John Jones, MD, Fabio Mirabella, PhD, Annamaria Brioli, Aneta Mikulasova, M.Sc., David A Cairns, PhD, Walter Gregory, PhD, Ana Quartilho, PhD, Mark T Drayson, MDPhD, Nigel Russell, Gordon Cook, MD PhD, Graham H Jackson, MD PhD, Faith E Davies, MD, Gareth J. Morgan, MD PhD
Journal: Blood
Blood (2014) 124 (21): 637.
https://doi.org/10.1182/blood.V124.21.637.637
Published: 2014
Journal Articles

High Resolution Genome Wide DNA Methylation Analysis in a Large Trial Group Reveals a Novel Epigenetically Defined Subgroup of Myeloma Patients Characterized By Developmental Gene Hypermethylation

Martin F Kaiser, MD, Alexander Murison, PhD, Charlotte Pawlyn, MBBChir, Eileen M Boyle, MD, David C Johnson, PhD, Brian A Walker, PhD, Ping Wu, MBBS, MSc, Dil Begum, BSc, Nasrin Dahir, BSc, Christopher P Wardell, PhD, Paula Proszek, MSc, David A Cairns, PhD, Walter Gregory, PhD, Graham Jackson, MD, Roger G Owen, MD, Gordon Cook, MD PhD, Mark T Drayson, MDPhD, Faith E Davies, MD, Gareth J. Morgan, MD PhD
Journal: Blood
Blood (2014) 124 (21): 2189.
https://doi.org/10.1182/blood.V124.21.2189.2189
Published: 2014
Journal Articles

The Spectrum of Epigenetic Mutations in Myeloma and Their Clinical Impact

Charlotte Pawlyn, MBBChir, Martin F Kaiser, MD, Brian A Walker, PhD, Christopher P Wardell, PhD, Alexander Murison, PhD, David C Johnson, PhD, Lorenzo Melchor, PhD, Eileen M Boyle, MD, John Jones, MD, Dil Begum, BSc, Nasrin Dahir, BSc, Paula Proszek, MSc, David A Cairns, PhD, Walter Gregory, PhD, Gordon Cook, MD, Roger G Owen, MD, Mark T Drayson, MDPhD, Graham Jackson, MD, Faith E Davies, MD, Gareth J. Morgan, MD PhD
Journal: Blood
Blood (2014) 124 (21): 2194.
https://doi.org/10.1182/blood.V124.21.2194.2194
Published: 2014
Journal Articles

High Throughput Genetic Profiling Using a Robust All-Molecular Diagnostic Approach Is Feasible to Specifically Identify a High Risk Group of Myeloma Patients

Martin F Kaiser, MD, Eileen M Boyle, MD, Brian A Walker, PhD, Charlotte Pawlyn, MBBChir, Dil Begum, BSc, Paula Proszek, MSc, Nasrin Dahir, BSc, David C Johnson, PhD, Suvi Savola, PhD, David A Cairns, PhD, Walter Gregory, PhD, Graham Jackson, MD, Roger G Owen, MD, Gordon Cook, MD PhD, Mark T Drayson, MDPhD, Faith E Davies, MD, Gareth J. Morgan, MD PhD
Journal: Blood
Blood (2014) 124 (21): 172.
https://doi.org/10.1182/blood.V124.21.172.172
Published: 2014
Journal Articles

The Extent of Intra-Clonal Genetic Diversity within the Myeloma Clone Is a Predictive Biomarker of Progression and Outcome after Treatment

Lorenzo Melchor, PhD, Alexander Murison, PhD, Eileen M Boyle, MD, Christopher P Wardell, PhD, John Jones, MD, Martin F Kaiser, MD, Charlotte Pawlyn, MBBChir, David C Johnson, PhD, Dil Begum, BSc, Paula Proszek, MSc, Nasrin Dahir, BSc, David A Cairns, PhD, Walter Gregory, PhD, Roger G Owen, MD, Gordon Cook, MD PhD, Mark T Drayson, MDPhD, Graham H Jackson, MD PhD, Faith E Davies, MD, Brian A Walker, PhD, Gareth J. Morgan, MD PhD
Journal: Blood
Blood (2014) 124 (21): 640.
https://doi.org/10.1182/blood.V124.21.640.640
Published: 2014
Journal Articles

A Rapid and Robust Molecular Diagnostic Approach For Multiple Myeloma – Results From a Large Trial Cohort

Martin F. Kaiser, MD, Dil Begum, BSc, Paula Proszek, MSc, Nasrin Dahir, BSc, David Gonzalez de Castro, PhD, Charlotte Pawlyn, MD, Annamaria Brioli, MD, Suvi Savola, PhD, Walter Gregory, PhD, Roger G. Owen, MD, Graham H. Jackson, MD, Faith E Davies, MD, Brian A Walker, PhD, Gareth J Morgan, MD PhD
Journal: Blood
Blood (2013) 122 (21): 3097.
https://doi.org/10.1182/blood.V122.21.3097.3097
Published: 2013