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DNA Methylation Profiling of Myeloma Trial Patients Reveals Specific Epigenetic Changes Associated with Outcome

David C Johnson, PhD, Dil B Begum, Sidra Ellis, Amy L Sherborne, Amy Price, Charlotte Smith, Fabio Mirabella, PhD, Karen Menezes, Scott Kimber, John R Jones, MD, Charlotte Pawlyn, MB BChir, Matthew W Jenner, MD, Richard S Houlston, MD PhD FRCP, Gordon Cook, Nigel H. Russell, V, MD, Alina Striha, MSc, Corinne Collett, Anna Waterhouse, Walter M Gregory, PhD, David A Cairns, MSc, PhD, Mark T Drayson, MD PhD, Roger G Owen, MD PhD, Faith E Davies, MD, Gareth J Morgan, MD PhD, Graham H Jackson, MD PhD, Martin F Kaiser, MD
Journal: Blood
Blood (2016) 128 (22): 804.
https://doi.org/10.1182/blood.V128.22.804.804
Published: 2016
Journal Articles

The Impact of Maintenance Lenalidomide on the Mutational Status of the Myeloma Clone at Relapse in the NCRI Myeloma XI Trial for Newly Diagnosed Multiple Myeloma Patients (NDMM)

John R Jones, MD, Niels Weinhold, PhD, Shweta S. Chavan, PhD, Charlotte Pawlyn, MB BChir, Lorenzo Melchor, PhD, David A Cairns, MSc, PhD, Dil B Begum, Charlotte Smith, Sidra Ellis, Amy Price, Amy L Sherborne, Brian A Walker, PhD, Christopher P Wardell, PhD, Gordon Cook, MD PhD, Matthew W Jenner, MD, Nigel H Russell, MD, Mark T Drayson, MD PhD, Roger G Owen, MD PhD, Faith E Davies, MD, Martin F Kaiser, MD, Graham H Jackson, MD PhD, Walter M Gregory, PhD, Mel Greaves, Gareth J Morgan, MD PhD
Journal: Blood
Blood (2016) 128 (22): 4412.
https://doi.org/10.1182/blood.V128.22.4412.4412
Published: 2016
Journal Articles

Identifying Ultra-High Risk Myeloma By Integrated Molecular Genetic and Gene Expression Profiling

Amy L Sherborne, Dil B Begum, Amy Price, David C Johnson, PhD, Sidra Ellis, Charlotte Smith, Fabio Mirabella, PhD, Karen Menezes, Scott Kimber, John R Jones, MD, Charlotte Pawlyn, MB BChir, Richard S Houlston, MD PhD FRCP, Nigel H. Russell, V, MD, Matthew W Jenner, MD, Gordon Cook, Alina Striha, MSc, Corinne Collett, Anna Waterhouse, Walter M Gregory, PhD, David A Cairns, MSc, PhD, Mark T Drayson, MD PhD, Roger G Owen, MD PhD, Faith E Davies, MD, Gareth J Morgan, MD PhD, Graham H Jackson, MD PhD, Martin F Kaiser, MD
Journal: Blood
Blood (2016) 128 (22): 4407.
https://doi.org/10.1182/blood.V128.22.4407.4407
Published: 2016
Journal Articles

Spatiotemporal Analysis of Intraclonal Heterogeneity in Multiple Myeloma: Unravelling the Impact of Treatment and the Propagating Capacity of Subclones Using Whole Exome Sequencing

Lorenzo Melchor, PhD, John R Jones, MD, Oleg Lenive, Erich Allen Peterson, PhD BS, MS, Annamaria Brioli, MD PhD, Alex Murison, PhD, Christopher P Wardell, PhD, Martin F Kaiser, Paula Proszek, Eileen Mary Boyle, MD PhD, Dil B Begum, Charlotte Pawlyn, MB BChir, David C Johnson, PhD, Inmaculada Rapado, David A Cairns, Walter M Gregory, Roger G Owen, Graham H Jackson, MD PhD, Mark T Drayson, MD PhD, Faith E Davies, MD, Joaquín Martínez-López, MD PhD, Richard S Houlston, MDPhDFRCP, Mel Greaves, FRS, Brian A Walker, PhD, Gareth J Morgan, MD PhD
Journal: Blood
Blood (2015) 126 (23): 371.
https://doi.org/10.1182/blood.V126.23.371.371
Published: 2015
Journal Articles

Specific Identification of High Risk Disease Using Molecular Profiling By Mymap (Myeloma MLPA and translocation PCR) of 1,036 Cases

Martin F Kaiser, MD, Eileen Mary Boyle, MD PhD, Brian A Walker, PhD, Dil B Begum, Paula Proszek, David C Johnson, PhD, Charlotte Pawlyn, MB BChir, John R Jones, MD, Suvi Savola, PhD, Roger G Owen, Mark T Drayson, MD PhD, David A Cairns, Gordon Cook, MD PhD, Walter M Gregory, Richard S Houlston, MDPhDFRCP, Faith E Davies, MD, Graham H Jackson, MD, Gareth J Morgan, MD PhD
Journal: Blood
Blood (2015) 126 (23): 2981.
https://doi.org/10.1182/blood.V126.23.2981.2981
Published: 2015
Journal Articles

Molecular Subgroups of Hyperdiploidy and Their Prognostic Relevance - an Analysis of 1,036 Myeloma Trial Patients

Martin F Kaiser, MD, Eileen Mary Boyle, MD PhD, Brian A Walker, PhD, Dil B Begum, Paula Proszek, David C Johnson, PhD, Charlotte Pawlyn, MB BChir, John R Jones, MD, Suvi Savola, PhD, Roger G Owen, Mark T Drayson, MD PhD, David A Cairns, Gordon Cook, MD PhD, Walter M Gregory, Richard S Houlston, MDPhDFRCP, Faith E Davies, MD, Graham H Jackson, MD, Gareth J Morgan, MD PhD
Journal: Blood
Blood (2015) 126 (23): 2983.
https://doi.org/10.1182/blood.V126.23.2983.2983
Published: 2015
Journal Articles

Coexistent hyperdiploidy does not abrogate poor prognosis in myeloma with adverse cytogenetics and may precede IGH translocations

Charlotte Pawlyn, Lorenzo Melchor, Alex Murison, Christopher P. Wardell, Annamaria Brioli, Eileen M. Boyle, Martin F. Kaiser, Brian A. Walker, Dil B. Begum, Nasrin B. Dahir, Paula Proszek, Walter M. Gregory, Mark T. Drayson, Graham H. Jackson, Fiona M. Ross, Faith E. Davies, Gareth J. Morgan
Journal: Blood
Blood (2015) 125 (5): 831–840.
https://doi.org/10.1182/blood-2014-07-584268
Published: 2015
Includes: Supplemental data
Journal Articles

Inherited genetic susceptibility to monoclonal gammopathy of unknown significance

CME Brief Report
Niels Weinhold, David C. Johnson, Andrew C. Rawstron, Asta Försti, Chi Doughty, Jayaram Vijayakrishnan, Peter Broderick, Nasrin B. Dahir, Dil B. Begum, Fay J. Hosking, Kwee Yong, Brian A. Walker, Per Hoffmann, Thomas W. Mühleisen, Christian Langer, Elisabeth Dörner, Karl-Heinz Jöckel, Lewin Eisele, Markus M. Nöthen, Dirk Hose, Faith E. Davies, Hartmut Goldschmidt, Gareth J. Morgan, Kari Hemminki, Richard S. Houlston
Journal: Blood
Blood (2014) 123 (16): 2513–2517.
https://doi.org/10.1182/blood-2013-10-532283
Published: 2014
Includes: Supplemental data
Journal Articles

Characterization of IGH locus breakpoints in multiple myeloma indicates a subset of translocations appear to occur in pregerminal center B cells

Brian A. Walker, Christopher P. Wardell, David C. Johnson, Martin F. Kaiser, Dil B. Begum, Nasrin B. Dahir, Fiona M. Ross, Faith E. Davies, David Gonzalez, Gareth J. Morgan
Journal: Blood
Blood (2013) 121 (17): 3413–3419.
https://doi.org/10.1182/blood-2012-12-471888
Published: 2013
Includes: Supplemental data
Journal Articles

Base-Pair Resolution Mapping of IGH Translocations in Multiple Myeloma Using Targeted Capture and Massively Parallel Sequencing

Brian A Walker, BSc, PhD, Christopher P Wardell, PhD, Dil B Begum, BSc, Nasrin B Dahir, BSc, Fiona M Ross, DPhil, Faith E. Davies, MD, David Gonzalez, PhD, Gareth J. Morgan, MD PhD
Journal: Blood
Blood (2012) 120 (21): 3490.
https://doi.org/10.1182/blood.V120.21.3490.3490
Published: 2012