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David A Cairns
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Journal Articles

IMWG Frailty Score-Adjusted Therapy Delivery Reduces the Early Mortality Risk in Newly Diagnosed Tne Multiple Myeloma: Results of the UK Myeloma Research Alliance (UK-MRA) Myeloma XIV Fitness Trial

Gordon Cook, Charlotte Pawlyn, Kara-Louise Royle, Ethan R Senior, Dax Everritt, Jenny Bird, Stella Bowcock, Bryony Dawkins, Mark Drayson, Sharon Gillson, Catherine Olivier, Matthew W. Jenner, John Jones, Martin F Kaiser, Bhuvan Kishore, David Meads, Neil Rabin, Roger G Owen, Ruth M de Tute, Christopher Parrish, Alan Chant, David A. Cairns, Graham Jackson
Journal: Blood
Blood (2024) 144 (Supplement 1): 673.
https://doi.org/10.1182/blood-2024-209653
Published: 2024
Journal Articles

Cost-Effectiveness of Frailty-Adjusted Therapy in Transplant Non-Eligible Patients with Newly Diagnosed Multiple Myeloma - an Economic Evaluation of the Fitness Trial

Bryony Dawkins, Georgios Gkountouras, David Meads, Charlotte Pawlyn, Kara-Louise Royle, Ethan R Senior, Dax Everritt, Jenny Bird, Stella Bowcock, Mark Drayson, Sharon Gillson, Catherine Olivier, Matthew W. Jenner, John R Jones, Martin F Kaiser, Bhuvan Kishore, Neil Rabin, Roger G Owen, Ruth M de Tute, Christopher Parrish, David A. Cairns, Alan Chant, Graham Jackson, Gordon Cook
Journal: Blood
Blood (2024) 144 (Supplement 1): 385.
https://doi.org/10.1182/blood-2024-209720
Published: 2024
Journal Articles

Optimising the Duration of Therapy for Newly Diagnosed Transplant Ineligible Patients - Analysis of Long Term Follow up Data from the UK MRA Myeloma XI Trial

Charlotte Pawlyn, Faith E Davies, Gordon Cook, Heather McIntyre, Jeanine Richards, Sharon Jackson, Elizabeth Hodson, Catherine Olivier, Anna Hockaday, John R Jones, Martin F Kaiser, Matthew W. Jenner, Walter Martin Gregory, Ruth M de Tute, Roger G Owen, Mark Drayson, David A. Cairns, Gareth Morgan, Graham Jackson
Journal: Blood
Blood (2024) 144 (Supplement 1): 1987.
https://doi.org/10.1182/blood-2024-205788
Published: 2024
Journal Articles

IGHV Unmutated Status, Low Tumor Lysis Risk Disease and BRAF Mutated Status Are Predictors for Early MRD Responders Treated with MRD Defined Ibrutinib with Venetoclax: Report of the UK NCRI FLAIR Study

Talha Munir, Abraham Mullasseril Varghese, Adrian Bloor, David Allsup, Kate Cwynarski, Andrew Pettitt, Shankara Paneesha, Christopher P Fox, Toby A. Eyre, Francesco Forconi, Nagah Elmusharaf, Ben Kennedy, Prof. John G. Gribben, Nicholas Pemberton, Oonagh Sheehy, Gavin Preston, Anna Schuh, Anna Hockaday, David A. Cairns, Sharon Jackson, Natasha Greatorex, Sean Girvan, Sue Bell, David Stones, Nichola McWhirter, Surita Dalal, Andrew Rawstron, Piers Patten, Peter Hillmen
Journal: Blood
Blood (2024) 144 (Supplement 1): 585.
https://doi.org/10.1182/blood-2024-211449
Published: 2024
Journal Articles

Early Relapse in Patients with Newly-Diagnosed Multiple Myeloma: A European Myeloma Network/Harmony Alliance Analysis Including 10843 Patients

Elias K. Mai, Andrea Manubens, Mattia D'Agostino, David A. Cairns, Alessandra Larocca, Juan José Lahuerta Palacios, Ruth Wester, Uta Bertsch, Anders Waage, Elena Zamagni, María-Victoria Mateos, Daniele Dall'Olio, Niels W.C.J. van de Donk, Graham Jackson, Serena Rocchi, Hans Salwender, Joan Bladé, Bronno van der Holt, Gastone Castellani, Katja C. Weisel, Francesca Gay, Sonja Zweegman, Michele Cavo, Jesus Maria Hernandez Rivas, Benedetto Bruno, Gordon Cook, Martin F Kaiser, Hartmut Goldschmidt, Mario Boccadoro, Jesús F. San-Miguel, Pieter Sonneveld
Journal: Blood
Blood (2024) 144 (Supplement 1): 898.
https://doi.org/10.1182/blood-2024-193310
Published: 2024
Journal Articles

Final Analysis of the Randomised UK MRA Myeloma XI+ Trial Examining Krdc (carfilzomib, lenalidomide, dexamethasone and cyclophosphamide) As Induction Therapy for Newly Diagnosed Multiple Myeloma Patients

Charlotte Pawlyn, Faith E Davies, Martin F Kaiser, Ruth M de Tute, Heather McIntyre, Jeanine Richards, Sharon Jackson, Elizabeth Hodson, Anna Hockaday, Catherine Olivier, John R Jones, Matthew W. Jenner, Gordon Cook, Walter Martin Gregory, Mark Drayson, Roger G Owen, Gareth Morgan, David A. Cairns, Graham Jackson
Journal: Blood
Blood (2024) 144 (Supplement 1): 771.
https://doi.org/10.1182/blood-2024-208255
Published: 2024
Journal Articles

Development and Validation of Novel Machine Learning-Based Risk Scores for Multiple Myeloma: Insights from the Harmony Alliance Big Data Platform

Adrian Mosquera Orgueira, Marta Sonia Gonzalez Perez, Mattia D'Agostino, David A. Cairns, Alessandra Larocca, Juan José Lahuerta Palacios, Ruth Wester, Uta Bertsch, Anders Waage, Elena Zamagni, Carlos Pérez Míguez, Niels W.C.J. Van De Donk, Graham Jackson, Davide Crucitti, Hans Salwender, Daniele Dall'Olio, Gastone Castellani, Manuel Piñeiro Fiel, Sara Bringhen, Sonja Zweegman, Michele Cavo, Jesus Maria Hernandez Rivas, Benedetto Bruno, Gordon Cook, Martin F Kaiser, Hartmut Goldschmidt, Pieter Sonneveld, Jesús F. San-Miguel, Mario Boccadoro, Maria- Victoria Mateos
Journal: Blood
Blood (2024) 144 (Supplement 1): 2226.
https://doi.org/10.1182/blood-2024-201448
Published: 2024
Journal Articles

MRD and Molecular Risk Status Help to Define Optimal Maintenance Delivery Strategies after ASCT: Long Term Outcomes of the UK MRA Myeloma XI Trial Comparing Lenalidomide to Observation

Graham Jackson, Charlotte Pawlyn, Faith E Davies, Martin F Kaiser, Ruth M de Tute, Heather McIntyre, Jeanine Richards, Sharon Jackson, Elizabeth Hodson, Anna Hockaday, Catherine Olivier, John R Jones, Matthew W. Jenner, Gordon Cook, Walter Martin Gregory, Mark Drayson, Roger G Owen, David A. Cairns, Gareth Morgan
Journal: Blood
Blood (2024) 144 (Supplement 1): 3375.
https://doi.org/10.1182/blood-2024-205871
Published: 2024
Journal Articles

Risk Assignment Using the Myeloma Genome Project Panel: A Comparison to Standard of Care Genetic Testing within the UK-MRA RADAR Trial

Sarah Gooding, Kara-Louise Royle, Mohammad Kazeroun, Robert Cicero, Laura Chiecchio, Dipal Mehta, Emma J Lyon, Bethan Hudson-Lund, Jasmin Rahman, Khrystal McBean, Martin F Kaiser, Catherine Olivier, Doina Levinte, Charlotte Kennaway, Dean Smith, Jonathan Sive, Ceri Bygrave, Guy Pratt, Michael A. Chapman, Graham Jackson, Rakesh Popat, Christopher Parrish, Gordon Cook, Angela Hamblin, Naser Ansari-Pour, David A. Cairns, Anjan Thakurta, Karthik Ramasamy, Eileen M Boyle, Kwee Yong, Matthew W. Jenner
Journal: Blood
Blood (2024) 144 (Supplement 1): 3333.
https://doi.org/10.1182/blood-2024-209772
Published: 2024
Journal Articles

Optimizing the value of lenalidomide maintenance by extended genetic profiling: an analysis of 556 patients in the Myeloma XI trial

Clinical Trials & Observations
Aikaterini Panopoulou, David A. Cairns, Amy Holroyd, Isabel Nichols, Nikita Cray, Charlotte Pawlyn, Gordon Cook, Mark Drayson, Kevin Boyd, Faith E. Davies, Matthew Jenner, Gareth J. Morgan, Roger Owen, Richard Houlston, Graham Jackson, Martin F. Kaiser
Journal: Blood
Blood (2023) 141 (14): 1666–1674.
https://doi.org/10.1182/blood.2022018339
Published: 2023
Includes: Supplemental data
Journal Articles

Redefining nonmeasurable multiple myeloma using mass spectrometry

Clinical Trials & Observations
Hannah V. Giles, Mark A. Cook, Mark Trehane Drayson, Gordon Cook, Nicola Jane Wright, Simon John North, Stephen Harding, David A. Cairns, Anna Hockaday, Martin F. Kaiser, Paul Moss, Faith E. Davies, Gareth J. Morgan, Graham Jackson, Guy Pratt
Journal: Blood
Blood (2022) 139 (6): 946–950.
https://doi.org/10.1182/blood.2021013794
Published: 2022
Includes: Supplemental data
Journal Articles

Thrombosis in patients with myeloma treated in the Myeloma IX and Myeloma XI phase 3 randomized controlled trials

Charlotte A. Bradbury, Zoe Craig, Gordon Cook, Charlotte Pawlyn, David A. Cairns, Anna Hockaday, Andrea Paterson, Matthew W. Jenner, John R. Jones, Mark T. Drayson, Roger G. Owen, Martin F. Kaiser, Walter M. Gregory, Faith E. Davies, J. Anthony Child, Gareth J. Morgan, Graham H. Jackson
Journal: Blood
Blood (2020) 136 (9): 1091–1104.
https://doi.org/10.1182/blood.2020005125
Published: 2020
Includes: Supplemental data
Journal Articles

Subclonal TP53 copy number is associated with prognosis in multiple myeloma

Clinical Trials & Observations Brief Report
Vallari Shah, David C. Johnson, Amy L. Sherborne, Sidra Ellis, Frances M. Aldridge, Julie Howard-Reeves, Farzana Begum, Amy Price, Jack Kendall, Laura Chiecchio, Suvi Savola, Matthew W. Jenner, Mark T. Drayson, Roger G. Owen, Walter M. Gregory, Gareth J. Morgan, Faith E. Davies, Richard S. Houlston, Gordon Cook, David A. Cairns, Graham Jackson, Martin F. Kaiser
Journal: Blood
Blood (2018) 132 (23): 2465–2469.
https://doi.org/10.1182/blood-2018-06-857250
Published: 2018
Includes: Supplemental data
Journal Articles

The Impact of Maintenance Lenalidomide on the Mutational Status of the Myeloma Clone at Relapse in the NCRI Myeloma XI Trial for Newly Diagnosed Multiple Myeloma Patients (NDMM)

John R Jones, MD, Niels Weinhold, PhD, Shweta S. Chavan, PhD, Charlotte Pawlyn, MB BChir, Lorenzo Melchor, PhD, David A Cairns, MSc, PhD, Dil B Begum, Charlotte Smith, Sidra Ellis, Amy Price, Amy L Sherborne, Brian A Walker, PhD, Christopher P Wardell, PhD, Gordon Cook, MD PhD, Matthew W Jenner, MD, Nigel H Russell, MD, Mark T Drayson, MD PhD, Roger G Owen, MD PhD, Faith E Davies, MD, Martin F Kaiser, MD, Graham H Jackson, MD PhD, Walter M Gregory, PhD, Mel Greaves, Gareth J Morgan, MD PhD
Journal: Blood
Blood (2016) 128 (22): 4412.
https://doi.org/10.1182/blood.V128.22.4412.4412
Published: 2016
Journal Articles

Lenalidomide Is a Highly Effective Maintenance Therapy in Myeloma Patients of All Ages; Results of the Phase III Myeloma XI Study

Graham H Jackson, MD PhD, Faith E Davies, MD, Charlotte Pawlyn, MB BChir, David A Cairns, MSc, PhD, Alina Striha, MSc, Corinne Collett, Anna Waterhouse, John R Jones, MD, Bhuvan Kishore, MBBS, MRCP, FRCPath, Mamta Garg, MD, Cathy D Williams, Kamaraj Karunanithi, MBBS, MD, Jindriska Lindsay, MD, Matthew W Jenner, MD, Gordon Cook, MDPhD, Martin F Kaiser, MD, Mark T Drayson, MD PhD, Roger G Owen, MB BCh, MD, Nigel H Russell, MD, Walter M Gregory, PhD, Gareth J Morgan, MD PhD
Journal: Blood
Blood (2016) 128 (22): 1143.
https://doi.org/10.1182/blood.V128.22.1143.1143
Published: 2016
Journal Articles

Primary IMiD Refractory Myeloma; Results from 3894 Patients Treated in the Phase III Myeloma XI Study

Charlotte Pawlyn, MB BChir, Faith E Davies, MD, Martin F Kaiser, MD, David A Cairns, MSc, PhD, Alina Striha, MSc, Corinne Collett, Anna Waterhouse, John R Jones, MD, Bhuvan Kishore, MBBS, MRCP, FRCPath, Mamta Garg, MD, Cathy D Williams, Kamaraj Karunanithi, MBBS, MD, Jindriska Lindsay, MD, Matthew W Jenner, MD, Gordon Cook, MD PhD, Mark T Drayson, MD PhD, Roger G Owen, MB BCh, MD, Nigel H Russell, MD, Walter M Gregory, PhD, Graham H Jackson, MD PhD, Gareth J Morgan, MD PhD
Journal: Blood
Blood (2016) 128 (22): 1144.
https://doi.org/10.1182/blood.V128.22.1144.1144
Published: 2016
Journal Articles

Identifying Ultra-High Risk Myeloma By Integrated Molecular Genetic and Gene Expression Profiling

Amy L Sherborne, Dil B Begum, Amy Price, David C Johnson, PhD, Sidra Ellis, Charlotte Smith, Fabio Mirabella, PhD, Karen Menezes, Scott Kimber, John R Jones, MD, Charlotte Pawlyn, MB BChir, Richard S Houlston, MD PhD FRCP, Nigel H. Russell, V, MD, Matthew W Jenner, MD, Gordon Cook, Alina Striha, MSc, Corinne Collett, Anna Waterhouse, Walter M Gregory, PhD, David A Cairns, MSc, PhD, Mark T Drayson, MD PhD, Roger G Owen, MD PhD, Faith E Davies, MD, Gareth J Morgan, MD PhD, Graham H Jackson, MD PhD, Martin F Kaiser, MD
Journal: Blood
Blood (2016) 128 (22): 4407.
https://doi.org/10.1182/blood.V128.22.4407.4407
Published: 2016
Journal Articles

Response Adapted Induction Treatment Improves Outcomes for Myeloma Patients; Results of the Phase III Myeloma XI Study

Graham H Jackson, MD PhD, Faith E Davies, MD, Charlotte Pawlyn, MB BChir, David A Cairns, MSc, PhD, Alina Striha, MSc, Corinne Collett, Anna Waterhouse, John R Jones, MD, Bhuvan Kishore, MBBS, MRCP, FRCPath, Mamta Garg, MD, Cathy D Williams, Kamaraj Karunanithi, MBBS, MD, Jindriska Lindsay, MD, Matthew W Jenner, MD, Gordon Cook, MDPhD, Martin F Kaiser, MD, Mark T Drayson, MD PhD, Roger G Owen, MB BCh, MD, Nigel H Russell, MD, Walter M Gregory, PhD, Gareth J Morgan, MD PhD
Journal: Blood
Blood (2016) 128 (22): 244.
https://doi.org/10.1182/blood.V128.22.244.244
Published: 2016
Journal Articles

Impact of Minimal Residual Disease in Transplant Ineligible Myeloma Patients: Results from the UK NCRI Myeloma XI Trial

Ruth Mary de Tute, PhD FRCPath, Andy C Rawstron, BSc, PhD, David A Cairns, MSc, PhD, Charlotte Pawlyn, MB BChir, Faith E Davies, MD, Corinne Collett, Martin F Kaiser, John R Jones, MD, Anna Waterhouse, Alina Striha, MSc, Gordon Cook, MDPhD, Matthew W Jenner, MD, Nigel H Russell, MD, Mark T Drayson, MD PhD, Walter M Gregory, PhD, Graham H Jackson, MD PhD, Gareth J Morgan, MD PhD, Roger G Owen, MD
Journal: Blood
Blood (2016) 128 (22): 245.
https://doi.org/10.1182/blood.V128.22.245.245
Published: 2016
Journal Articles

DNA Methylation Profiling of Myeloma Trial Patients Reveals Specific Epigenetic Changes Associated with Outcome

David C Johnson, PhD, Dil B Begum, Sidra Ellis, Amy L Sherborne, Amy Price, Charlotte Smith, Fabio Mirabella, PhD, Karen Menezes, Scott Kimber, John R Jones, MD, Charlotte Pawlyn, MB BChir, Matthew W Jenner, MD, Richard S Houlston, MD PhD FRCP, Gordon Cook, Nigel H. Russell, V, MD, Alina Striha, MSc, Corinne Collett, Anna Waterhouse, Walter M Gregory, PhD, David A Cairns, MSc, PhD, Mark T Drayson, MD PhD, Roger G Owen, MD PhD, Faith E Davies, MD, Gareth J Morgan, MD PhD, Graham H Jackson, MD PhD, Martin F Kaiser, MD
Journal: Blood
Blood (2016) 128 (22): 804.
https://doi.org/10.1182/blood.V128.22.804.804
Published: 2016