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Journal Articles

Integrative analysis of spontaneous CLL regression highlights genetic and microenvironmental interdependency in CLL

Clinical Trials & Observations
Marwan Kwok, Ceri Oldreive, Andy C. Rawstron, Anshita Goel, Grigorios Papatzikas, Rhiannon E. Jones, Samantha Drennan, Angelo Agathanggelou, Archana Sharma-Oates, Paul Evans, Edward Smith, Surita Dalal, Jingwen Mao, Robert Hollows, Naheema Gordon, Mayumi Hamada, Nicholas J. Davies, Helen Parry, Andrew D. Beggs, Talha Munir, Paul Moreton, Shankara Paneesha, Guy Pratt, A. Malcolm R. Taylor, Francesco Forconi, Duncan M. Baird, Jean-Baptiste Cazier, Paul Moss, Peter Hillmen, Tatjana Stankovic
Journal: Blood
Blood (2020) 135 (6): 411–428.
https://doi.org/10.1182/blood.2019001262
Published: 2020
Includes: Supplemental data
Journal Articles

High Surface IgM Levels Associate with Shorter Response Duration and Bypass of the BTK Blockade during Ibrutinib Therapy in CLL Patients

Giorgia Chiodin, David Dutton, MD, Enrica Antonia Martino, MD, Samantha Drennan, PhD, Ian Tracy, PhD, Laura Ondrisova, Isla Henderson, Annalisa D'Avola, PhD, Christina Pitsillidou, Marek Mraz, MD, Peter Johnson, MDFRCP, Andrew Duncombe, MD, Graham Packham, PhD, Andrew J Steele, PhD, Helen Parker, PhD, Silvia Bonfiglio, Lydia Scarfo, MD, Lesley-Ann Sutton, Paolo Ghia, MD PhD, Matthew John Jerome Rose-Zerilli, PhD, Jonathan C Strefford, PhD, Freda K. Stevenson, DPhil, Francesco Forconi, MD DM, PhD FRCPath
Journal: Blood
Blood (2019) 134 (Supplement_1): 1752.
https://doi.org/10.1182/blood-2019-128899
Published: 2019
Journal Articles

BCR Unresponsiveness and 13q14 Duplication Underpin Spontaneous Disease Regression in Chronic Lymphocytic Leukemia

Marwan Kwok, MBBS,MRCP, Andy Rawstron, PhD, Angelo Agathanggelou, PhD, Anshita Goel, PhD, Ceri Oldreive, PhD, Rhiannon E Jones, PhD, Samantha Drennan, PhD, Archana Sharma-Oates, PhD, Paul Evans, PhD, Edward Smith, MSc, Jingwen Mao, Jamie Beaumont, Jusveen Rai, Mayumi Hamada, MB ChB, Surita Dalal, PhD, Naheema Gordon, MSc, Nicholas Davies, PhD, Helen Parry, MB ChB, MRCP, PhD, Andrew Beggs, MBBS, PhD FRCS, Talha Munir, Paul Moreton, MD MRCP, FRCPath, Shankara Paneesha, MD MRCP, FRCPath, Guy Pratt, MD FRCP, FRCPath, Malcolm Taylor, PhD, Francesco Forconi, MD DM, PhD FRCPath, Duncan M Baird, PhD, Jean-Baptiste Cazier, PhD, Paul Moss, MBBS, PhD FRCP, Peter Hillmen, MBChB, PhD, Tatjana Stankovic, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3004.
https://doi.org/10.1182/blood.V130.Suppl_1.3004.3004
Published: 2017
Journal Articles

Early Enhancement of IgM Expression and Signaling Capacity during Ibrutinib Therapy in CLL Patients

Samantha Drennan, PhD, Giorgia Chiodin, MS, Annalisa D'Avola, MSc, Peter W Johnson, MD, Livio Trentin, MD, Graham Packham, PhD, Andrew J Steele, PhD, Freda K Stevenson, DPhil, Francesco Forconi, MD DM, PhD FRCPath
Journal: Blood
Blood (2016) 128 (22): 4381.
https://doi.org/10.1182/blood.V128.22.4381.4381
Published: 2016
Journal Articles

Global and MYC-Specific Translation Is Enhanced in Activated Chronic Lymphocytic Leukemia Cells Carrying NOTCH1 C.7541_7542delct Mutations

Annalisa D'Avola, MSc, Alison Yeomans, PhD, Samantha Drennan, PhD, Matthew Rose-Zerilli, PhD, Jonathan C. Strefford, Freda K Stevenson, DPhil, Andrew J Steele, PhD, Graham Packham, PhD, Francesco Forconi, MD DM, PhD FRCPath
Journal: Blood
Blood (2016) 128 (22): 970.
https://doi.org/10.1182/blood.V128.22.970.970
Published: 2016
Journal Articles

Surface IgM expression and function are associated with clinical behavior, genetic abnormalities, and DNA methylation in CLL

Clinical Trials & Observations
Annalisa D’Avola, Samantha Drennan, Ian Tracy, Isla Henderson, Laura Chiecchio, Marta Larrayoz, Matthew Rose-Zerilli, Jonathan Strefford, Christoph Plass, Peter W. Johnson, Andrew J. Steele, Graham Packham, Freda K. Stevenson, Christopher C. Oakes, Francesco Forconi
Journal: Blood
Blood (2016) 128 (6): 816–826.
https://doi.org/10.1182/blood-2016-03-707786
Published: 2016
Includes: Supplemental data
Journal Articles

IL-10 Production By CLL Cells Is Enhanced in the Anergic IGHV Mutated Subset and Associates with Reduced DNA Methylation of the IL-10 Locus

Samantha Drennan, PhD, Annalisa D'Avola, MSc, Yifang Gao, PhD, Eleni Chrysostomou, MSc, Andrew J Steele, PhD, Thorsten Zenz, MD, Christoph Plass, PhD, Peter W Johnson, MD, Anthony P Williams, PhD FRCPath, Graham Packham, PhD, Freda K Stevenson, DPhil, Christopher C. Oakes, PhD, Francesco Forconi, MD DM, PhD FRCPath
Journal: Blood
Blood (2015) 126 (23): 2917.
https://doi.org/10.1182/blood.V126.23.2917.2917
Published: 2015
Journal Articles

The Kinin-Kallikre System in Chronic Lymphocytic Leukemia - A Potential Target for Therapy?

Elena Kashuba, PhD student, James R Bailey, MA, MBBS, MRCP, Laura R Sadofsky, PhD, Samantha Drennan Drennan, PhD student HYMS, Paula Johnson, David Allsup, Lynn Cawkwell, PhD
Journal: Blood
Blood (2012) 120 (21): 3904.
https://doi.org/10.1182/blood.V120.21.3904.3904
Published: 2012