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Angelo Agathanggelou
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Journal Articles

DNA damage response defects in hematologic malignancies: mechanistic insights and therapeutic strategies

Marwan Kwok, Angelo Agathanggelou, Tatjana Stankovic
Journal: Blood
Blood (2024) 143 (21): 2123–2144.
https://doi.org/10.1182/blood.2023019963
Published: 2024
Journal Articles

TLR9 expression in chronic lymphocytic leukemia identifies a promigratory subpopulation and novel therapeutic target

Emma Kennedy, Eve Coulter, Emma Halliwell, Nuria Profitos-Peleja, Elisabeth Walsby, Barnaby Clark, Elizabeth H. Phillips, Thomas A. Burley, Simon Mitchell, Stephen Devereux, Christopher D. Fegan, Christopher I. Jones, Rosalynd Johnston, Tim Chevassut, Ralph Schulz, Martina Seiffert, Angelo Agathanggelou, Ceri Oldreive, Nicholas Davies, Tatjana Stankovic, Triantafillos Liloglou, Chris Pepper, Andrea G. S. Pepper
Journal: Blood
Blood (2021) 137 (22): 3064–3078.
https://doi.org/10.1182/blood.2020005964
Published: 2021
Includes: Supplemental data
Journal Articles

Integrative analysis of spontaneous CLL regression highlights genetic and microenvironmental interdependency in CLL

Clinical Trials & Observations
Marwan Kwok, Ceri Oldreive, Andy C. Rawstron, Anshita Goel, Grigorios Papatzikas, Rhiannon E. Jones, Samantha Drennan, Angelo Agathanggelou, Archana Sharma-Oates, Paul Evans, Edward Smith, Surita Dalal, Jingwen Mao, Robert Hollows, Naheema Gordon, Mayumi Hamada, Nicholas J. Davies, Helen Parry, Andrew D. Beggs, Talha Munir, Paul Moreton, Shankara Paneesha, Guy Pratt, A. Malcolm R. Taylor, Francesco Forconi, Duncan M. Baird, Jean-Baptiste Cazier, Paul Moss, Peter Hillmen, Tatjana Stankovic
Journal: Blood
Blood (2020) 135 (6): 411–428.
https://doi.org/10.1182/blood.2019001262
Published: 2020
Includes: Supplemental data
Journal Articles

BCR Unresponsiveness and 13q14 Duplication Underpin Spontaneous Disease Regression in Chronic Lymphocytic Leukemia

Marwan Kwok, MBBS,MRCP, Andy Rawstron, PhD, Angelo Agathanggelou, PhD, Anshita Goel, PhD, Ceri Oldreive, PhD, Rhiannon E Jones, PhD, Samantha Drennan, PhD, Archana Sharma-Oates, PhD, Paul Evans, PhD, Edward Smith, MSc, Jingwen Mao, Jamie Beaumont, Jusveen Rai, Mayumi Hamada, MB ChB, Surita Dalal, PhD, Naheema Gordon, MSc, Nicholas Davies, PhD, Helen Parry, MB ChB, MRCP, PhD, Andrew Beggs, MBBS, PhD FRCS, Talha Munir, Paul Moreton, MD MRCP, FRCPath, Shankara Paneesha, MD MRCP, FRCPath, Guy Pratt, MD FRCP, FRCPath, Malcolm Taylor, PhD, Francesco Forconi, MD DM, PhD FRCPath, Duncan M Baird, PhD, Jean-Baptiste Cazier, PhD, Paul Moss, MBBS, PhD FRCP, Peter Hillmen, MBChB, PhD, Tatjana Stankovic, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3004.
https://doi.org/10.1182/blood.V130.Suppl_1.3004.3004
Published: 2017
Journal Articles

USP7 inhibition alters homologous recombination repair and targets CLL cells independently of ATM/p53 functional status

Angelo Agathanggelou, Edward Smith, Nicholas J. Davies, Marwan Kwok, Anastasia Zlatanou, Ceri E. Oldreive, Jingwen Mao, David Da Costa, Sina Yadollahi, Tracey Perry, Pamela Kearns, Anna Skowronska, Elliot Yates, Helen Parry, Peter Hillmen, Celine Reverdy, Remi Delansorne, Shankara Paneesha, Guy Pratt, Paul Moss, A. Malcolm R. Taylor, Grant S. Stewart, Tatjana Stankovic
Journal: Blood
Blood (2017) 130 (2): 156–166.
https://doi.org/10.1182/blood-2016-12-758219
Published: 2017
Includes: Supplemental data
Journal Articles

A New Murine Model for B Cell Malignancies on ATM-Deficient Background Reveals Involvement of Multiple Pathogenic Mechanisms

Tegan A Francis, PhD, Nicholas J Davies, PhD, Michael John Griffiths, BSc, Angelo Agathanggelou, PhD, Maha Ibrahim, Paul G. Murray, PhD, Zbigniew Rudzki, Tatjana Stankovic, MD PhD, Alexander M R Taylor, PhD
Journal: Blood
Blood (2016) 128 (22): 4093.
https://doi.org/10.1182/blood.V128.22.4093.4093
Published: 2016
Journal Articles

ATR inhibition induces synthetic lethality and overcomes chemoresistance in TP53 - or ATM -defective chronic lymphocytic leukemia cells

Marwan Kwok, Nicholas Davies, Angelo Agathanggelou, Edward Smith, Ceri Oldreive, Eva Petermann, Grant Stewart, Jeff Brown, Alan Lau, Guy Pratt, Helen Parry, Malcolm Taylor, Paul Moss, Peter Hillmen, Tatjana Stankovic
Journal: Blood
Blood (2016) 127 (5): 582–595.
https://doi.org/10.1182/blood-2015-05-644872
Published: 2016
Includes: Supplemental data
Journal Articles

UCHL1 Is a New Therapeutic Target in Lymphoid Malignancies, Independent of ATM and TP53 status

Edward Smith, MSc, Angelo Agathanggelou, PhD, Guy Pratt, MDPhD, Paul Moss, Wenbin Wei, PhD, Leanine Harrigan, Xavier Jacq, PhD, Tatjana Stankovic
Journal: Blood
Blood (2015) 126 (23): 1746.
https://doi.org/10.1182/blood.V126.23.1746.1746
Published: 2015
Journal Articles

CLL Progression Is Associated with Increased Clonal Diversity and Replication Stress

Angelo Agathanggelou, PhD, Anna Skowronska, PhD, Nick Davies, PhD, Marwan Kwok, MB ChB, MRCP, Samuel Clockie, Mike Griffiths, Alexander Taylor, Tatjana Stankovic, MD PhD
Journal: Blood
Blood (2014) 124 (21): 1977.
https://doi.org/10.1182/blood.V124.21.1977.1977
Published: 2014
Journal Articles

Primary CLL Xenograft: A Model System to Study the Role of T-Cells in CLL Biology and Therapeutic Response

Ceri E Oldreive, PhD, Anna Skowronska, PhD, Angelo Agathanggelou, PhD, Helen M Parry, Sergey Krysov, Graham K Packham, PhD, Rudzki Zbgniew, Guy Pratt, A. Malcolm R Taylor, PhD, Paul Moss, MDPhD, Tatjana Stankovic, MD PhD
Journal: Blood
Blood (2014) 124 (21): 3284.
https://doi.org/10.1182/blood.V124.21.3284.3284
Published: 2014
Journal Articles

ATR Inhibition Exacerbates Replication Stress in TP53 or ATM Deficient CLL Cells and Enhances Sensitivity to Chemotherapy and Targeted Therapy

Marwan Kwok, MB ChB, MRCP, Nicholas Davies, PhD, Angelo Agathanggelou, PhD, Edward Smith, BSc, Eva Petermann, PhD, Eliot Yates, BMedSc, Jeffrey Brown, PhD, Alan Lau, PhD, Tatjana Stankovic, MD PhD
Journal: Blood
Blood (2014) 124 (21): 3340.
https://doi.org/10.1182/blood.V124.21.3340.3340
Published: 2014
Journal Articles

Synthetic Lethality In CLL With DNA Damage Response Defect By Targeting ATR Pathway

Tatjana Stankovic, MD, PhD, Davies Nicholas, Marwan Kwok, Edward Smith, Eliot Yates, Angelo Agathanggelou, Brown Jeff, Alan Lau
Journal: Blood
Blood (2013) 122 (21): 120.
https://doi.org/10.1182/blood.V122.21.120.120
Published: 2013
Journal Articles

Targeted Treatments: Pre-Clinical Evaluation Of Efficacy By Tracking Clonal Diversity In CLL Xenograft Models

Nicholas J Davies, Ceri E Oldreive, PhD, Angelo Agathanggelou, Clive Gould, Guy Pratt, Mike Griffiths, Tatjana Stankovic, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 875.
https://doi.org/10.1182/blood.V122.21.875.875
Published: 2013
Journal Articles

Inhibition of Histone Deacetylase Activity Compromises Homologous Recombination Repair and Increases Sensitivity of Chemo-Resistant Chronic Lymphocytic Leukemia Cells to Olaparib

Angelo Agathanggelou, David Cartwright, Helen Parry, Guy Pratt, Paul Moss, Tatjana Stankovic, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 3891.
https://doi.org/10.1182/blood.V120.21.3891.3891
Published: 2012
Journal Articles

Inhibition of BRD4 Bromodomains Is a Potent Novel Strategy to Target Apoptosis Resistance in Paediatric ALL

David Da Costa, Victoria J Weston, PhD, Wenbin Wei, PhD, Angelo Agathanggelou, PhD, Eva Petermann, PhD, Stefan Knapp, PhD, Pamela R Kearns, BSc, MBBCh, MRCP, PhD, Tatjana Stankovic, MD, PhD
Journal: Blood
Blood (2011) 118 (21): 77.
https://doi.org/10.1182/blood.V118.21.77.77
Published: 2011
Journal Articles

New Therapeutic Strategy for Sensitisation of CLL Cells with Inactivation of the DNA Damage Response by Targeting the Deubiquitylating Enzyme USP7-Dependent Pathways,

Angelo Agathanggelou, PhD, Anastasia Zlatanou, PhD, Ahmed Gulshanara, MSc, Grant Stewart, PhD, Pamela R Kearns, BSc, MBBCh, MRCP, PhD, Guy Pratt, MD, Paul AH Moss, MD PhD, A. Malcolm R Taylor, PhD, Frederic Colland, PhD, Tatjana Stankovic, MD, PhD
Journal: Blood
Blood (2011) 118 (21): 3865.
https://doi.org/10.1182/blood.V118.21.3865.3865
Published: 2011
Journal Articles

ATM Mutant Lymphoid Tumour Cells Exhibit Impaired Activation of the Redox-Sensitive Nrf2-ARE Detoxification Pathway and Are Differentially Sensitive to Nrf2-Activating Compounds

Victoria J Weston, PhD, Angelo Agathanggelou, PhD, Paul AH Moss, MD, PhD, Pamela R. Kearns, BSc, MBBCh, MRCP, PhD, A. Malcolm R Taylor, PhD, Tatjana Stankovic, MD, PhD
Journal: Blood
Blood (2010) 116 (21): 49.
https://doi.org/10.1182/blood.V116.21.49.49
Published: 2010
Journal Articles

Induction of a CD8 + T-cell response to the MAGE cancer testis antigen by combined treatment with azacitidine and sodium valproate in patients with acute myeloid leukemia and myelodysplasia

Clinical Trials & Observations
Oliver Goodyear, Angelo Agathanggelou, Igor Novitzky-Basso, Shamyla Siddique, Tina McSkeane, Gordon Ryan, Paresh Vyas, Jamie Cavenagh, Tanja Stankovic, Paul Moss, Charles Craddock
Journal: Blood
Blood (2010) 116 (11): 1908–1918.
https://doi.org/10.1182/blood-2009-11-249474
Published: 2010
Includes: Supplemental data
Journal Articles

The Epigenetic Therapies Azacitidine and Sodium Valproate Augment Immune Responses to the MAGE Cancer Testis Antigen in Acute Myeloid Leukemia and Myeloma.

Oliver Charles Goodyear, PhD, Angelo Agathanggelou, PhD, Gordon Ryan, Igor Novitsky-Basso, Tatjana Stankovic, MD., PhD, Paul Moss, MBBS, PhD, FRCP, Charles F. Craddock, BM, MRCP, MRCPath
Journal: Blood
Blood (2009) 114 (22): 2086.
https://doi.org/10.1182/blood.V114.22.2086.2086
Published: 2009
Journal Articles

Stratification of pediatric ALL by in vitro cellular responses to DNA double-strand breaks provides insight into the molecular mechanisms underlying clinical response

Eliot Marston, Victoria Weston, Jennifer Jesson, Esther Maina, Carmel McConville, Angelo Agathanggelou, Anna Skowronska, Katie Mapp, Katrin Sameith, Judith E. Powell, Sarah Lawson, Pamela Kearns, Francesco Falciani, Malcolm Taylor, Tatjana Stankovic
Journal: Blood
Blood (2009) 113 (1): 117–126.
https://doi.org/10.1182/blood-2008-03-142950
Published: 2009
Includes: Supplemental data