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Edward Smith
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Journal Articles

Serious Adverse Drug Reactions (sADRs) Involving Hematology and Resulting in Black Box Warnings or FDA Non-Approval: Results from the First Quarter Century of RADAR/Sonar

Swetha Kambhampati, Nikhil Thiruvengadam, Steven T. Rosen, Chadi Nabhan, Kevin Knopf, Linda Martin, Kenneth R. Carson, Peter Georgantopoulos, Gretchen Watson, Edward Smith, Edward Zyszkowski, Sony Jacob, Dennis Banegas, William Hrushesky, Iain Cumming Macdougall, Manuel Gonzalez-Brio, David Aboulafia, Oliver Sartor, Robert Peter Gale, Charles Bennett
Journal: Blood
Blood (2024) 144 (Supplement 1): 3638.
https://doi.org/10.1182/blood-2024-206590
Published: 2024
Journal Articles

Integrative analysis of spontaneous CLL regression highlights genetic and microenvironmental interdependency in CLL

Clinical Trials & Observations
Marwan Kwok, Ceri Oldreive, Andy C. Rawstron, Anshita Goel, Grigorios Papatzikas, Rhiannon E. Jones, Samantha Drennan, Angelo Agathanggelou, Archana Sharma-Oates, Paul Evans, Edward Smith, Surita Dalal, Jingwen Mao, Robert Hollows, Naheema Gordon, Mayumi Hamada, Nicholas J. Davies, Helen Parry, Andrew D. Beggs, Talha Munir, Paul Moreton, Shankara Paneesha, Guy Pratt, A. Malcolm R. Taylor, Francesco Forconi, Duncan M. Baird, Jean-Baptiste Cazier, Paul Moss, Peter Hillmen, Tatjana Stankovic
Journal: Blood
Blood (2020) 135 (6): 411–428.
https://doi.org/10.1182/blood.2019001262
Published: 2020
Includes: Supplemental data
Journal Articles

BCR Unresponsiveness and 13q14 Duplication Underpin Spontaneous Disease Regression in Chronic Lymphocytic Leukemia

Marwan Kwok, MBBS,MRCP, Andy Rawstron, PhD, Angelo Agathanggelou, PhD, Anshita Goel, PhD, Ceri Oldreive, PhD, Rhiannon E Jones, PhD, Samantha Drennan, PhD, Archana Sharma-Oates, PhD, Paul Evans, PhD, Edward Smith, MSc, Jingwen Mao, Jamie Beaumont, Jusveen Rai, Mayumi Hamada, MB ChB, Surita Dalal, PhD, Naheema Gordon, MSc, Nicholas Davies, PhD, Helen Parry, MB ChB, MRCP, PhD, Andrew Beggs, MBBS, PhD FRCS, Talha Munir, Paul Moreton, MD MRCP, FRCPath, Shankara Paneesha, MD MRCP, FRCPath, Guy Pratt, MD FRCP, FRCPath, Malcolm Taylor, PhD, Francesco Forconi, MD DM, PhD FRCPath, Duncan M Baird, PhD, Jean-Baptiste Cazier, PhD, Paul Moss, MBBS, PhD FRCP, Peter Hillmen, MBChB, PhD, Tatjana Stankovic, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3004.
https://doi.org/10.1182/blood.V130.Suppl_1.3004.3004
Published: 2017
Journal Articles

USP7 inhibition alters homologous recombination repair and targets CLL cells independently of ATM/p53 functional status

Angelo Agathanggelou, Edward Smith, Nicholas J. Davies, Marwan Kwok, Anastasia Zlatanou, Ceri E. Oldreive, Jingwen Mao, David Da Costa, Sina Yadollahi, Tracey Perry, Pamela Kearns, Anna Skowronska, Elliot Yates, Helen Parry, Peter Hillmen, Celine Reverdy, Remi Delansorne, Shankara Paneesha, Guy Pratt, Paul Moss, A. Malcolm R. Taylor, Grant S. Stewart, Tatjana Stankovic
Journal: Blood
Blood (2017) 130 (2): 156–166.
https://doi.org/10.1182/blood-2016-12-758219
Published: 2017
Includes: Supplemental data
Journal Articles

ATR inhibition induces synthetic lethality and overcomes chemoresistance in TP53 - or ATM -defective chronic lymphocytic leukemia cells

Marwan Kwok, Nicholas Davies, Angelo Agathanggelou, Edward Smith, Ceri Oldreive, Eva Petermann, Grant Stewart, Jeff Brown, Alan Lau, Guy Pratt, Helen Parry, Malcolm Taylor, Paul Moss, Peter Hillmen, Tatjana Stankovic
Journal: Blood
Blood (2016) 127 (5): 582–595.
https://doi.org/10.1182/blood-2015-05-644872
Published: 2016
Includes: Supplemental data
Journal Articles

UCHL1 Is a New Therapeutic Target in Lymphoid Malignancies, Independent of ATM and TP53 status

Edward Smith, MSc, Angelo Agathanggelou, PhD, Guy Pratt, MDPhD, Paul Moss, Wenbin Wei, PhD, Leanine Harrigan, Xavier Jacq, PhD, Tatjana Stankovic
Journal: Blood
Blood (2015) 126 (23): 1746.
https://doi.org/10.1182/blood.V126.23.1746.1746
Published: 2015
Journal Articles

ATR Inhibition Exacerbates Replication Stress in TP53 or ATM Deficient CLL Cells and Enhances Sensitivity to Chemotherapy and Targeted Therapy

Marwan Kwok, MB ChB, MRCP, Nicholas Davies, PhD, Angelo Agathanggelou, PhD, Edward Smith, BSc, Eva Petermann, PhD, Eliot Yates, BMedSc, Jeffrey Brown, PhD, Alan Lau, PhD, Tatjana Stankovic, MD PhD
Journal: Blood
Blood (2014) 124 (21): 3340.
https://doi.org/10.1182/blood.V124.21.3340.3340
Published: 2014
Journal Articles

Synthetic Lethality In CLL With DNA Damage Response Defect By Targeting ATR Pathway

Tatjana Stankovic, MD, PhD, Davies Nicholas, Marwan Kwok, Edward Smith, Eliot Yates, Angelo Agathanggelou, Brown Jeff, Alan Lau
Journal: Blood
Blood (2013) 122 (21): 120.
https://doi.org/10.1182/blood.V122.21.120.120
Published: 2013