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Journal Articles

Ixazomib, Thalidomide and Dexamethasone Is an Effective and Well Tolerated Re-Induction Regimen Leading to Salvage Autologous Stem Cell Transplantation (sASCT): Results from the Re-Induction Interim Analysis of UK-MRA Myeloma XII (ACCoRD) Trial

Gordon Cook, Christopher Parrish, MBBChir, MRCP, FRCPath, MA, PhD, Kwee Yong, PhD, Jamie Cavenagh, MD PhD, John A Snowden, MD, Mark T Drayson, Mamta Garg, David Cairns, John Ashcroft, Alina Striha, Anna Hockaday, Ruth M De Tute, BSc,MSc, Roger G. Owen, Cathy Williams, Mark Cook, MBChB,PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 255.
https://doi.org/10.1182/blood-2018-99-112116
Published: 2018
Journal Articles

Progression Free Survival below 12 Months Following Stem Cell Transplant Is a Hallmark of High-Risk Myeloma Which Is Associated with Inferior Overall Survival — Data from the Ukmrc Myeloma XI Trial

Ceri A Bygrave, MD FRCPath, FRCP, MPhil, Charlotte Pawlyn, BA,PhDMBBChir,MRCP,FRCPath, Faith E. Davies, MD, David Cairns, Alina Striha, Anna Hockaday, Andrea Paterson, John R Jones, Bhuvan Kishore, Mamta Garg, Cathy Williams, Kamaraj Karunanithi, Jindriska Lindsay, Matthew W Jenner, Gordon Cook, Mark T Drayson, Roger G. Owen, Nigel H Russel, Walter M Gregory, Gareth J. Morgan, Graham Jackson, Martin Kaiser, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 122.
https://doi.org/10.1182/blood-2018-99-111117
Published: 2018
Journal Articles

Characterisation of Long-Term Responders to First-Line Myeloma Therapy - Results from the UK Myeloma IX and XI Trials

Vallari Shah, MBBS, David C. Johnson, PhD, Amy L Sherborne, PhD, Sidra Ellis, Amy Price, Jack Kendall, Laura Chiecchio, PhD, Alina Striha, Anna Hockaday, Charlotte Pawlyn, BA,PhDMBBChir,MRCP,FRCPath, Matthew Jenner, Mark T Drayson, Roger G Owen, MD, Walter M Gregory, Gareth Morgan, MD, Faith E. Davies, MD, Richard S Houlston, MD PhD, Gordon Cook, David Cairns, Graham H Jackson, Martin Kaiser, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2000.
https://doi.org/10.1182/blood-2018-99-110149
Published: 2018
Journal Articles

A Quadruplet Regimen Comprising Carfilzomib, Cyclophosphamide, Lenalidomide, Dexamethasone (KCRD) Vs an Immunomodulatory Agent Containing Triplet (CTD/CRD) Induction Therapy Prior to Autologous Stem Cell Transplant: Results of the Myeloma XI Study

Graham H Jackson, Faith E. Davies, MD, Charlotte Pawlyn, BA,PhDMBBChir,MRCP,FRCPath, David Cairns, Alina Striha, Anna Hockaday, Corinne Collett, John R Jones, Bhuvan Kishore, Mamta Garg, Catherine Williams, Kamaraj Karunanithi, Jindriska Lindsay, Matthew Jenner, Gordon Cook, Nigel H. Russell, Martin Kaiser, MD, Mark T Drayson, Roger G. Owen, Walter M Gregory, Gareth Morgan, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 302.
https://doi.org/10.1182/blood-2018-99-114956
Published: 2018
Journal Articles

Maximizing Pre-Transplant Response Is Associated with Improved Outcome for Myeloma Patients: Exploratory Analysis of the Myeloma XI Trial

Charlotte Pawlyn, BA, PhD MBBChir, MRCP, FRCPath, Graham H Jackson, David Cairns, Alina Striha, Anna Hockaday, Gwen Jacques, John R Jones, Kevin Boyd, Bhuvan Kishore, Mamta Garg, Catherine Williams, Kamaraj Karunanithi, Jindriska Lindsay, Matthew Jenner, Gordon Cook, Nigel H. Russell, Martin Kaiser, MD, Mark T Drayson, Roger G. Owen, Walter M Gregory, Gareth Morgan, MD, Faith E. Davies, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3280.
https://doi.org/10.1182/blood-2018-99-118868
Published: 2018
Journal Articles

Lenalidomide Maintenance Significantly Improves Outcomes Compared to Observation Irrespective of Cytogenetic Risk: Results of the Myeloma XI Trial

Graham Jackson, MDPhD, Faith E Davies, MD, Charlotte Pawlyn, BA,PhDMBBChir,MRCP,FRCPath, David Cairns, BSc, MSc, PhD, Alina Striha, MSc, Anna Hockaday, Inga Sakauskiene, John R Jones, MD, Bhuvan Kishore, MD, Mamta Garg, MD, Cathy Williams, Kamaraj Karunanithi, Jindriska Lindsay, MD, Matthew W Jenner, Gordon Cook, MD PhD, Martin F Kaiser, MD, Mark T Drayson, MD PhD, Roger G Owen, MD, Nigel H. Russell, Walter M Gregory, PhD, Gareth J. Morgan, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 436.
https://doi.org/10.1182/blood.V130.Suppl_1.436.436
Published: 2017
Journal Articles

Minimal Residual Disease in the Maintenance Setting in Myeloma: Prognostic Significance and Impact of Lenalidomide

Ruth M de Tute, PhD FRCPath, David Cairns, BSc, MSc, PhD, Andy Rawstron, PhD, Charlotte Pawlyn, BA,PhDMBBChir,MRCP,FRCPath, Faith E. Davies, MD, John R Jones, MD, Martin F Kaiser, MD, Anna Hockaday, Alina Striha, MSc, Rowena Henderson, PhD, Gordon Cook, PhD, Nigel H. Russell, Mark T Drayson, MD PhD, Matthew W Jenner, Walter M Gregory, PhD, Graham Jackson, MDPhD, Gareth J. Morgan, MD PhD, Roger G. Owen, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 904.
https://doi.org/10.1182/blood.V130.Suppl_1.904.904
Published: 2017
Journal Articles

Factors Predicting Poor Outcomes for Myeloma Patients at Different Ages: Results from 3894 Patients in the Myeloma XI Trial

Charlotte Pawlyn, BA,PhDMBBChir,MRCP,FRCPath, Martin F Kaiser, MD, David Cairns, BSc, MSc, PhD, Alina Striha, MSc, John R Jones, MD, Vallari Shah, MBBS, Matthew W Jenner, Mark T Drayson, MD PhD, Roger G Owen, MD, Walter M Gregory, PhD, Gordon Cook, MD PhD, Graham Jackson, MDPhD, Gareth J. Morgan, MD PhD, Faith E Davies, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3040.
https://doi.org/10.1182/blood.V130.Suppl_1.3040.3040
Published: 2017
Journal Articles

Continuous Treatment with Lenalidomide Improves Outcomes in Newly Diagnosed Myeloma Patients Not Eligible for Autologous Stem Cell Transplant: Results of the Myeloma XI Trial

Charlotte Pawlyn, BA,PhDMBBChir,MRCP,FRCPath, Faith E. Davies, MD, David Cairns, BSc, MSc, PhD, Alina Striha, MSc, Phillip Best, Rachel Sigsworth, John R Jones, MD, Bhuvan Kishore, MD, Mamta Garg, MD, Cathy Williams, Kamaraj Karunanithi, Jindriska Lindsay, MD, Matthew W Jenner, Gordon Cook, MD PhD, Martin F Kaiser, MD, Mark T Drayson, MD PhD, Roger G Owen, MD, Nigel H. Russell, Walter M Gregory, PhD, Graham Jackson, MDPhD, Gareth J. Morgan, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1854.
https://doi.org/10.1182/blood.V130.Suppl_1.1854.1854
Published: 2017
Journal Articles

Thrombotic Events in Patients with Myeloma Treated with Immunomodulatory Drugs; Results of the Myeloma XI Study

Charlotte A Bradbury, PhD MD FRCPath, FRCP, MSc, Matthew W Jenner, Alina Striha, MSc, Gordon Cook, MD PhD, Charlotte Pawlyn, BA,PhDMBBChir,MRCP,FRCPath, John R Jones, MD, David Cairns, BSc, MSc, PhD, Anna Hockaday, Andrea Paterson, Mark T Drayson, MD PhD, Roger G Owen, MD, Martin F Kaiser, MD, Walter M Gregory, PhD, Faith E. Davies, MD, Gareth J. Morgan, MD PhD, Graham H Jackson, MDPhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 553.
https://doi.org/10.1182/blood.V130.Suppl_1.553.553
Published: 2017
Journal Articles

Impact of Minimal Residual Disease in Transplant Ineligible Myeloma Patients: Results from the UK NCRI Myeloma XI Trial

Ruth Mary de Tute, PhD FRCPath, Andy C Rawstron, BSc, PhD, David A Cairns, MSc, PhD, Charlotte Pawlyn, MB BChir, Faith E Davies, MD, Corinne Collett, Martin F Kaiser, John R Jones, MD, Anna Waterhouse, Alina Striha, MSc, Gordon Cook, MDPhD, Matthew W Jenner, MD, Nigel H Russell, MD, Mark T Drayson, MD PhD, Walter M Gregory, PhD, Graham H Jackson, MD PhD, Gareth J Morgan, MD PhD, Roger G Owen, MD
Journal: Blood
Blood (2016) 128 (22): 245.
https://doi.org/10.1182/blood.V128.22.245.245
Published: 2016
Journal Articles

Lenalidomide Is a Highly Effective Maintenance Therapy in Myeloma Patients of All Ages; Results of the Phase III Myeloma XI Study

Graham H Jackson, MD PhD, Faith E Davies, MD, Charlotte Pawlyn, MB BChir, David A Cairns, MSc, PhD, Alina Striha, MSc, Corinne Collett, Anna Waterhouse, John R Jones, MD, Bhuvan Kishore, MBBS, MRCP, FRCPath, Mamta Garg, MD, Cathy D Williams, Kamaraj Karunanithi, MBBS, MD, Jindriska Lindsay, MD, Matthew W Jenner, MD, Gordon Cook, MDPhD, Martin F Kaiser, MD, Mark T Drayson, MD PhD, Roger G Owen, MB BCh, MD, Nigel H Russell, MD, Walter M Gregory, PhD, Gareth J Morgan, MD PhD
Journal: Blood
Blood (2016) 128 (22): 1143.
https://doi.org/10.1182/blood.V128.22.1143.1143
Published: 2016
Journal Articles

Primary IMiD Refractory Myeloma; Results from 3894 Patients Treated in the Phase III Myeloma XI Study

Charlotte Pawlyn, MB BChir, Faith E Davies, MD, Martin F Kaiser, MD, David A Cairns, MSc, PhD, Alina Striha, MSc, Corinne Collett, Anna Waterhouse, John R Jones, MD, Bhuvan Kishore, MBBS, MRCP, FRCPath, Mamta Garg, MD, Cathy D Williams, Kamaraj Karunanithi, MBBS, MD, Jindriska Lindsay, MD, Matthew W Jenner, MD, Gordon Cook, MD PhD, Mark T Drayson, MD PhD, Roger G Owen, MB BCh, MD, Nigel H Russell, MD, Walter M Gregory, PhD, Graham H Jackson, MD PhD, Gareth J Morgan, MD PhD
Journal: Blood
Blood (2016) 128 (22): 1144.
https://doi.org/10.1182/blood.V128.22.1144.1144
Published: 2016
Journal Articles

Response Adapted Induction Treatment Improves Outcomes for Myeloma Patients; Results of the Phase III Myeloma XI Study

Graham H Jackson, MD PhD, Faith E Davies, MD, Charlotte Pawlyn, MB BChir, David A Cairns, MSc, PhD, Alina Striha, MSc, Corinne Collett, Anna Waterhouse, John R Jones, MD, Bhuvan Kishore, MBBS, MRCP, FRCPath, Mamta Garg, MD, Cathy D Williams, Kamaraj Karunanithi, MBBS, MD, Jindriska Lindsay, MD, Matthew W Jenner, MD, Gordon Cook, MDPhD, Martin F Kaiser, MD, Mark T Drayson, MD PhD, Roger G Owen, MB BCh, MD, Nigel H Russell, MD, Walter M Gregory, PhD, Gareth J Morgan, MD PhD
Journal: Blood
Blood (2016) 128 (22): 244.
https://doi.org/10.1182/blood.V128.22.244.244
Published: 2016
Journal Articles

DNA Methylation Profiling of Myeloma Trial Patients Reveals Specific Epigenetic Changes Associated with Outcome

David C Johnson, PhD, Dil B Begum, Sidra Ellis, Amy L Sherborne, Amy Price, Charlotte Smith, Fabio Mirabella, PhD, Karen Menezes, Scott Kimber, John R Jones, MD, Charlotte Pawlyn, MB BChir, Matthew W Jenner, MD, Richard S Houlston, MD PhD FRCP, Gordon Cook, Nigel H. Russell, V, MD, Alina Striha, MSc, Corinne Collett, Anna Waterhouse, Walter M Gregory, PhD, David A Cairns, MSc, PhD, Mark T Drayson, MD PhD, Roger G Owen, MD PhD, Faith E Davies, MD, Gareth J Morgan, MD PhD, Graham H Jackson, MD PhD, Martin F Kaiser, MD
Journal: Blood
Blood (2016) 128 (22): 804.
https://doi.org/10.1182/blood.V128.22.804.804
Published: 2016
Journal Articles

Identifying Ultra-High Risk Myeloma By Integrated Molecular Genetic and Gene Expression Profiling

Amy L Sherborne, Dil B Begum, Amy Price, David C Johnson, PhD, Sidra Ellis, Charlotte Smith, Fabio Mirabella, PhD, Karen Menezes, Scott Kimber, John R Jones, MD, Charlotte Pawlyn, MB BChir, Richard S Houlston, MD PhD FRCP, Nigel H. Russell, V, MD, Matthew W Jenner, MD, Gordon Cook, Alina Striha, MSc, Corinne Collett, Anna Waterhouse, Walter M Gregory, PhD, David A Cairns, MSc, PhD, Mark T Drayson, MD PhD, Roger G Owen, MD PhD, Faith E Davies, MD, Gareth J Morgan, MD PhD, Graham H Jackson, MD PhD, Martin F Kaiser, MD
Journal: Blood
Blood (2016) 128 (22): 4407.
https://doi.org/10.1182/blood.V128.22.4407.4407
Published: 2016
Journal Articles

Myeloma XI Trial for Newly Diagnosed Multiple Myeloma (NDMM); A Report of Second Primary Malignancy (SPM) Rates and the Importance of Review of Reported Cases

John R Jones, MD, David A Cairns, Rachel Sigsworth, Corinne Collett, Charlotte Pawlyn, MB BChir, Alina Striha, Lorenzo Melchor, PhD, Martin F Kaiser, MD, Mark T Drayson, MD PhD, Faith E Davies, MD, Walter M Gregory, Kevin Boyd, MD, Roger G Owen, Graham H Jackson, MD, Gareth J Morgan, MD PhD
Journal: Blood
Blood (2015) 126 (23): 1847.
https://doi.org/10.1182/blood.V126.23.1847.1847
Published: 2015
Journal Articles

Quadruplet Vs Sequential Triplet Induction Therapy Approaches to Maximise Response for Newly Diagnosed, Transplant Eligible, Myeloma Patients

Charlotte Pawlyn, MB BChir, Faith E Davies, MD, David A Cairns, Corinne Collett, Anna Chalmers, Alina Striha, John R Jones, MD, Mamta Garg, MD, David Allotey, MD, Kamaraj Karunanithi, MBBS, MD, Donald Milligan, MD MBChB, Martin F Kaiser, MD, Matthew W Jenner, MD, Gordon Cook, MD PhD, Nigel H. Russell, MD, Mark T Drayson, MD PhD, Roger G Owen, MD, Walter M Gregory, Graham H Jackson, MD, Gareth J Morgan, MD PhD
Journal: Blood
Blood (2015) 126 (23): 189.
https://doi.org/10.1182/blood.V126.23.189.189
Published: 2015