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Journal Articles

Clonal Haematopoiesis with TP53 Mutations Exhibits Abnormal Erythropoiesis and Erythroid Metabolic Stress

Xuesen Zheng, Prodromos Chatzikyriakou, Louis-Francois Handfield, Maroof Hasan, Diego A. Pereira-Martins, Sarah J Mackie, Maria del Pilar Casares Alaez, Isabel Weinhäuser, Nogayhan Seymen, Kai Yi Mok, Viktorija Uksaite, Marta Rzepkowska, Laarni Bogaanay, Matthew Sadler, Jovan Mircetic, Martin Bornhäuser, James Carmichael, Daniel Bromage, Pramila Krishnamurthy, Rajasekhar N.V.S. Suragani, Ghulam Mufti, Giorgio Napolitani, Anita K. Gandhi, Lynn Quek
Journal: Blood
Blood (2024) 144 (Supplement 1): 944.
https://doi.org/10.1182/blood-2024-200108
Published: 2024
Journal Articles

DNMT3A-Mutant Clonal Haematopoiesis Is Associated with Worse Recovery after ST-Elevation Myocardial Infarction Via Increased Inflammation

Sarah J Mackie, Matthew Sadler, Maroof Hasan, Lynette Graver, Rupavidhya Mondi Anandhakrishna, Fulye Argunhan, Louis-Francois Handfield, Hosanna Assefa-Kebede, Laarni Bogaanay, Prodromos Chatzikyriakou, Pilar Casares Alaez, Antonio Cannata, Mohammad Al-Agil, Amandine Tan, Maria Ortiz Estevez, Ching-Pin Chang, Rajasekhar N.V.S. Suragani, Anita K. Gandhi, Ajay Shah, Theresa McDonagh, Aleksander Ivetic, Ghulam Mufti, Giorgio Napolitani, Daniel Bromage, Lynn Quek
Journal: Blood
Blood (2024) 144 (Supplement 1): 1284.
https://doi.org/10.1182/blood-2024-203813
Published: 2024
Journal Articles

DGAT1 Inhibition Enhances Metformin-Induced Ferroptosis in AML By Targeting Lipid Metabolism

Dominique Sternadt, Diego A. Pereira-Martins, Douglas RA Silveira, Isabel Weinhaeuser, Ming Yang, Prodromos Chatzikyriakou, Pilar Casares Alaez, Ayşegül Erdem, Lieve Oudejans, Shanna Hogeling, Emanuele Ammatuna, Gerwin Huls, Christian Frezza, Lynn Quek, Jan Jacob Schuringa
Journal: Blood
Blood (2024) 144 (Supplement 1): 1393.
https://doi.org/10.1182/blood-2024-208239
Published: 2024
Journal Articles

An Integrated Single Cell Immunogenomic Atlas Reveals Pathways of Clonal Expansion, Inflammation and Dyserythropoiesis in Low and High-Risk Clonal Haematopoiesis

Xuesen Zheng, Amandine Tan, Maria del Pilar Casares Alaez, Garry Mallett, Deniz Ece Kaya, Nogayhan Seymen, Marta Rzepkowska, Sarah Mackie, Prodromos Chatzikyriakou, Laarni Bogaanay, Jen Lewis, Maroof Hasan, Rajasekhar N.V.S. Suragani, James Carmichael, Ghulam Mufti, Anita K. Gandhi, Giorgio Napolitani, Lynn Quek
Journal: Blood
Blood (2023) 142 (Supplement 1): 812.
https://doi.org/10.1182/blood-2023-174947
Published: 2023
Journal Articles

Metformin-Induced Ferroptosis Is a Therapeutic Vulnerability in IDH2 -Mutant AML Linked to Metabolic Rewiring Towards Fatty Acid Oxidation

Dominique Sternadt, Diego Pereira-Martins, Douglas RA Silveira, Isabel Weinhaeuser, Ming Yang, Prodromos Chatzikyriakou, Pilar Casares Alaez, Emanuele Ammatuna, Lieve Oudejans, Gerwin A. Huls, Christian Frezza, Lynn Quek, Jan Jacob Schuringa
Journal: Blood
Blood (2023) 142 (Supplement 1): 1586.
https://doi.org/10.1182/blood-2023-188524
Published: 2023
Journal Articles

Dysregulation of Stem-Progenitor and Differentiation Programmes through Modulation of Bivalent Chromatin Drives Leukemogenesis in Mutant IDH2 Acute Myeloid Leukaemia

Douglas RA RA Silveira, Prodromos Chatzikyriakou, Maria del Pilar Casares Alaez, Sarah Mackie, Roan Hulks, Olena Yavorska, Paulina Siejka-Zielinska, Marlen Metzner, Alastair Smith, Batchimeg Usukhbayar, Virginie Penard-Lacronique, Chunxiao Song, Anita K. Gandhi, Maroof Hasan, Paresh Vyas, Thomas A. Milne, Skirmantas Kriaucionis, Lynn Quek
Journal: Blood
Blood (2022) 140 (Supplement 1): 8698–8699.
https://doi.org/10.1182/blood-2022-165898
Published: 2022
Journal Articles

Single Cell Characterisation of Transcriptional Programmes of Responsive and Resistant Leukaemic Progenitors in IDH2 -Mutant Acute Myeloid Leukaemia in the AG221-AML-005 Study

Prodromos Chatzikyriakou, Douglas RA Silveira, Maria del Pilar Casares Aláez, Batchimeg Usukhbayar, Marlen Metzner, Paresh Vyas, Anita K. Gandhi, Alberto Risueño, Maroof Hasan, Lynn Quek
Journal: Blood
Blood (2022) 140 (Supplement 1): 3414–3415.
https://doi.org/10.1182/blood-2022-163717
Published: 2022
Journal Articles

Impaired Metabolic Plasticity Under Stress Constitutes a Therapeutic Vulnerability in IDH1/2 -Mutant Acute Myeloid Leukemia

Dominique Sternadt, Diego Pereira-Martins, Douglas RA Silveira, Prodromos Chatzikyriakou, Maria del Pilar Casares Alaez, Isabel Weinhaeuser, Shanna M Hogeling, Emanuele Ammatuna, Gerwin A. Huls, Lynn Quek, Jan Jacob Schuringa
Journal: Blood
Blood (2022) 140 (Supplement 1): 8813–8814.
https://doi.org/10.1182/blood-2022-163282
Published: 2022