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Journal Articles

Dysregulation of Stem-Progenitor and Differentiation Programmes through Modulation of Bivalent Chromatin Drives Leukemogenesis in Mutant IDH2 Acute Myeloid Leukaemia

Douglas RA RA Silveira, Prodromos Chatzikyriakou, Maria del Pilar Casares Alaez, Sarah Mackie, Roan Hulks, Olena Yavorska, Paulina Siejka-Zielinska, Marlen Metzner, Alastair Smith, Batchimeg Usukhbayar, Virginie Penard-Lacronique, Chunxiao Song, Anita K. Gandhi, Maroof Hasan, Paresh Vyas, Thomas A. Milne, Skirmantas Kriaucionis, Lynn Quek

Blood (2022) 140 (Supplement 1): 8698–8699.

https://doi.org/10.1182/blood-2022-165898

Published: 2022

Journal Articles

Repressed Chromatin Drives Leukaemogenesis in Mutant IDH2 Acute Myeloid Leukaemia Via Inhibition of Granulocyte Differentiation and Cell Cycle Progression

Douglas RA Silveira, Prodromos Chatzikyriakou, Olena Yavorska, Sarah Mackie, Roan Hulks, Paulina Siejka-Zielinska, Anna Corby, Alastair Smith, Benjamin Brown, Marlen Metzner, Thomas A. Milne, Virginie Penard-Lacronique, Chunxiao Song, Maroof Hasan, Anjan Thakurta, Paresh Vyas, Skirmantas Kriaucionis, Lynn Quek

Blood (2021) 138 (Supplement 1): 3467.

https://doi.org/10.1182/blood-2021-149519

Published: 2021

Journal Articles

Genetic Profiling and Deep IDH1 Mutation Clearance to ≤0.04% in Ivosidenib (AG-120)-Treated Patients with Mutant IDH1 Relapsed or Refractory and Untreated AML

Richard M. Stone, MD, Sung Choe, PhD, Vickie Zhang, PhD, Benoit Marteyn, PhD, Virginie Penard-Lacronique, PhD, Hongfang Wang, PhD, Courtney D. DiNardo, MDMSc, Eytan M. Stein, MD, Amir T. Fathi, MD MD BS, Martin S. Tallman, MD, Hagop M. Kantarjian, MD, Eyal C. Attar, MD, Bin Wu, Stephane de Botton, MD PhD

Blood (2017) 130 (Supplement 1): 2684.

https://doi.org/10.1182/blood.V130.Suppl_1.2684.2684

Published: 2017

Journal Articles

Efficacy of 5-Azacitidine on IDH1/2 Acute Myeloid Leukemia/Myelodysplastic Syndromes and Correlation with 2-Hydroxyglutarate Production

Christophe Willekens, MD, Veronique Saada, Sophie Broutin, Julia Delahousse, Aline Renneville, MDPhD, Cynthia Petrovanu, Christophe Marzac, Jean-Baptiste Micol, MD PhD, Éric Solary, MD PhD, Florence Pasquier, MD PhD, Julien Lazarovici, MD, Vincent Ribrag, Claude Preudhomme, PharmD, PhD, Cyril Quivoron, Virginie Penard-Lacronique, PhD, Angelo Paci, Stephane de Botton, MD PhD

Blood (2017) 130 (Supplement 1): 1313.

https://doi.org/10.1182/blood.V130.Suppl_1.1313.1313

Published: 2017

Journal Articles

Clonal Heterogeneity in Differentiation Response and Resistance to the IDH2 Inhibitor Enasidenib in Acute Myeloid Leukemia

Blood (2017) 130 (Supplement 1): 724.

https://doi.org/10.1182/blood.V130.Suppl_1.724.724

Published: 2017

Journal Articles

Spliceosomal Dysfunction Is a Critical Mediator of IDH2 Mutant Leukemogenesis

Blood (2017) 130 (Supplement 1): 473.

https://doi.org/10.1182/blood.V130.Suppl_1.473.473

Published: 2017

Journal Articles

Enasidenib induces acute myeloid leukemia cell differentiation to promote clinical response

Michael D. Amatangelo, Lynn Quek, Alan Shih, Eytan M. Stein, Mikhail Roshal, Muriel D. David, Benoit Marteyn, Noushin Rahnamay Farnoud, Stephane de Botton, Olivier A. Bernard, Bin Wu, Katharine E. Yen, Martin S. Tallman, Elli Papaemmanuil, Virginie Penard-Lacronique, Anjan Thakurta, Paresh Vyas, Ross L. Levine

Blood (2017) 130 (6): 732–741.

https://doi.org/10.1182/blood-2017-04-779447

Published: 2017

Includes: Supplemental data

Journal Articles

AG-120, an Oral, Selective, First-in-Class, Potent Inhibitor of Mutant IDH1, Reduces Intracellular 2HG and Induces Cellular Differentiation in TF-1 R132H Cells and Primary Human IDH1 Mutant AML Patient Samples Treated Ex Vivo

Erica Hansen, Cyril Quivoron, Kim Straley, René M Lemieux, Janeta Popovici-Muller, Hossein Sadrzadeh, Amir T Fathi, Camelia Gliser, Muriel David, Véronique Saada, Jean-Baptiste Micol, Olivier Bernard, Marion Dorsch, Hua Yang, Michael Su, Sam Agresta, Stéphane de Botton, Virginie Penard-Lacronique, Katharine Yen

Blood (2014) 124 (21): 3734.

https://doi.org/10.1182/blood.V124.21.3734.3734

Published: 2014

Journal Articles

AG-221, an Oral, Selective, First-in-Class, Potent IDH2-R140Q Mutant Inhibitor, Induces Differentiation in a Xenotransplant Model

Cyril Quivoron, Muriel David, Kim Straley, Jeremy Travins, Hyeryun Kim, Yue Chen, Dongwei Zhu, Véronique Saada, Olivia Bawa, Paule Opolon, Mélanie Polrot, Jean-Baptiste Micol, Christophe Willekens, Olivier Bernard, Hua Yang, Sam Agresta, Stéphane de Botton, Katharine Yen, Virginie Penard-Lacronique

Blood (2014) 124 (21): 3735.

https://doi.org/10.1182/blood.V124.21.3735.3735

Published: 2014

Journal Articles

The transcription factor Srf regulates hematopoietic stem cell adhesion

Christine Ragu, Gaelle Elain, Elena Mylonas, Chris Ottolenghi, Nicolas Cagnard, Dominique Daegelen, Emmanuelle Passegué, William Vainchenker, Olivier A. Bernard, Virginie Penard-Lacronique

Blood (2010) 116 (22): 4464–4473.

https://doi.org/10.1182/blood-2009-11-251587

Published: 2010

Includes: Supplemental data

Journal Articles

NUP98-MLL fusion in human acute myeloblastic leukemia

Sophie Kaltenbach, Gwendoline Soler, Carole Barin, Carine Gervais, Olivier A. Bernard, Virginie Penard-Lacronique, Serge P. Romana

Blood (2010) 116 (13): 2332–2335.

https://doi.org/10.1182/blood-2010-04-277806

Published: 2010

Journal Articles

Activating mutations in human acute megakaryoblastic leukemia

Sébastien Malinge, Christine Ragu, Veronique Della-Valle, Didier Pisani, Stefan N. Constantinescu, Christelle Perez, Jean-Luc Villeval, Dirk Reinhardt, Judith Landman-Parker, Lucienne Michaux, Nicole Dastugue, André Baruchel, William Vainchenker, Jean-Pierre Bourquin, Virginie Penard-Lacronique, Olivier A. Bernard

Blood (2008) 112 (10): 4220–4226.

https://doi.org/10.1182/blood-2008-01-136366

Published: 2008

Includes: Supplemental data

Journal Articles

HOX11L2 / TLX3 is transcriptionally activated through T-cell regulatory elements downstream of BCL11B as a result of the t(5;14)(q35;q32)

Xin-Ying Su, Véronique Della-Valle, Isabelle Andre-Schmutz, Claudie Lemercier, Isabelle Radford-Weiss, Paola Ballerini, Michel Lessard, Marina Lafage-Pochitaloff, Francine Mugneret, Roland Berger, Serge P. Romana, Olivier A. Bernard, Virginie Penard-Lacronique

Blood (2006) 108 (13): 4198–4201.

https://doi.org/10.1182/blood-2006-07-032953

Published: 2006

Includes: Supplemental data

Journal Articles

Novel activating JAK2 mutation in a patient with Down syndrome and B-cell precursor acute lymphoblastic leukemia

Sebastien Malinge, Raouf Ben-Abdelali, Catherine Settegrana, Isabelle Radford-Weiss, Marianne Debre, Kheira Beldjord, Elizabeth A. Macintyre, Jean-Luc Villeval, William Vainchenker, Roland Berger, Olivier A. Bernard, Eric Delabesse, Virginie Penard-Lacronique

Blood (2006) 109 (5): 2202–2204.

https://doi.org/10.1182/blood-2006-09-045963

Published: 2006

Includes: Supplemental data

NARROW

Dysregulation of Stem-Progenitor and Differentiation Programmes through Modulation of Bivalent Chromatin Drives Leukemogenesis in Mutant IDH2 Acute Myeloid Leukaemia

Repressed Chromatin Drives Leukaemogenesis in Mutant IDH2 Acute Myeloid Leukaemia Via Inhibition of Granulocyte Differentiation and Cell Cycle Progression

Genetic Profiling and Deep IDH1 Mutation Clearance to ≤0.04% in Ivosidenib (AG-120)-Treated Patients with Mutant IDH1 Relapsed or Refractory and Untreated AML

Efficacy of 5-Azacitidine on IDH1/2 Acute Myeloid Leukemia/Myelodysplastic Syndromes and Correlation with 2-Hydroxyglutarate Production

Clonal Heterogeneity in Differentiation Response and Resistance to the IDH2 Inhibitor Enasidenib in Acute Myeloid Leukemia

Spliceosomal Dysfunction Is a Critical Mediator of IDH2 Mutant Leukemogenesis

Enasidenib induces acute myeloid leukemia cell differentiation to promote clinical response

AG-120, an Oral, Selective, First-in-Class, Potent Inhibitor of Mutant IDH1, Reduces Intracellular 2HG and Induces Cellular Differentiation in TF-1 R132H Cells and Primary Human IDH1 Mutant AML Patient Samples Treated Ex Vivo

AG-221, an Oral, Selective, First-in-Class, Potent IDH2-R140Q Mutant Inhibitor, Induces Differentiation in a Xenotransplant Model

The transcription factor Srf regulates hematopoietic stem cell adhesion

NUP98-MLL fusion in human acute myeloblastic leukemia

Activating mutations in human acute megakaryoblastic leukemia

HOX11L2 / TLX3 is transcriptionally activated through T-cell regulatory elements downstream of BCL11B as a result of the t(5;14)(q35;q32)

Novel activating JAK2 mutation in a patient with Down syndrome and B-cell precursor acute lymphoblastic leukemia

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American Society of Hematology

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ASH Publications

American Society of Hematology

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