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Marion Dorsch
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Journal Articles

IDH2 mutation-induced histone and DNA hypermethylation is progressively reversed by small-molecule inhibition

Andrew Kernytsky, Fang Wang, Erica Hansen, Stefanie Schalm, Kimberly Straley, Camelia Gliser, Hua Yang, Jeremy Travins, Stuart Murray, Marion Dorsch, Sam Agresta, David P. Schenkein, Scott A. Biller, Shinsan M. Su, Wei Liu, Katharine E. Yen
Journal: Blood
Blood (2015) 125 (2): 296–303.
https://doi.org/10.1182/blood-2013-10-533604
Published: 2015
Includes: Supplemental data
Journal Articles

AG-120, an Oral, Selective, First-in-Class, Potent Inhibitor of Mutant IDH1, Reduces Intracellular 2HG and Induces Cellular Differentiation in TF-1 R132H Cells and Primary Human IDH1 Mutant AML Patient Samples Treated Ex Vivo

Erica Hansen, Cyril Quivoron, Kim Straley, René M Lemieux, Janeta Popovici-Muller, Hossein Sadrzadeh, Amir T Fathi, Camelia Gliser, Muriel David, Véronique Saada, Jean-Baptiste Micol, Olivier Bernard, Marion Dorsch, Hua Yang, Michael Su, Sam Agresta, Stéphane de Botton, Virginie Penard-Lacronique, Katharine Yen
Journal: Blood
Blood (2014) 124 (21): 3734.
https://doi.org/10.1182/blood.V124.21.3734.3734
Published: 2014
Journal Articles

PIM inhibitors target CD25-positive AML cells through concomitant suppression of STAT5 activation and degradation of MYC oncogene

Zhuyan Guo, Anlai Wang, Weidong Zhang, Mikhail Levit, Qiang Gao, Claude Barberis, Michel Tabart, Jingxin Zhang, Dietmar Hoffmann, Dmitri Wiederschain, Jennifer Rocnik, Fangxian Sun, Josh Murtie, Christoph Lengauer, Stefan Gross, Bailin Zhang, Hong Cheng, Vinod Patel, Laurent Schio, Francisco Adrian, Marion Dorsch, Carlos Garcia-Echeverria, Shih-Min A. Huang
Journal: Blood
Blood (2014) 124 (11): 1777–1789.
https://doi.org/10.1182/blood-2014-01-551234
Published: 2014
Includes: Supplemental data
Journal Articles

IDH1 Mutant Inhibitor Induces Cellular Differentiation and Offers a Combination Benefit With Ara-C In a Primary Human Idh1 Mutant AML Xenograft Model

Katharine Yen, Ph.D., Rene Lemieux, Ph.D., Janeta Popovici-Muller, Yue Chen, Ph.D., Hua Yang, Kim Straley, Sung Choe, Marion Dorsch, Samuel Agresta, MD, David P. Schenkein, MD, Scott Biller, Michael Su, Fang Wang
Journal: Blood
Blood (2013) 122 (21): 3946.
https://doi.org/10.1182/blood.V122.21.3946.3946
Published: 2013
Journal Articles

AG-221 Offers a Survival Advantage In a Primary Human IDH2 Mutant AML Xenograft Model

Katharine Yen, Ph.D., Fang Wang, Jeremy Travins, Yue Chen, Ph.D., Hua Yang, Kim Straley, Sung Choe, Marion Dorsch, David P. Schenkein, MD, Samuel Agresta, MD, Scott Biller, Michael Su
Journal: Blood
Blood (2013) 122 (21): 240.
https://doi.org/10.1182/blood.V122.21.240.240
Published: 2013
Journal Articles

Mutation Selective IDH Inhibitors Mediate Histone and DNA Methylation Changes

Katharine Yen, Fang Wang, Stefanie Schalm, Erica Hansen, Kimberly Straley, BS, Andrew Kernytsky, Sung Choe, Wei Liu, Janeta Popovici-Muller, Jeremy Travins, Hua Yang, Lee Silverman, Julie Losman Aurore, William G. Kaelin, Jr., MD, Stefan Gross, Lenny Dang, Frank Salituro, Jeffrey Saunders, Marion Dorsch, Samuel Agresta, MD, David P. Schenkein, MD, Michael Su, Scott Biller
Journal: Blood
Blood (2012) 120 (21): 3509.
https://doi.org/10.1182/blood.V120.21.3509.3509
Published: 2012
Journal Articles

Combination of the Hedgehog Pathway Inhibitor LDE225 and Nilotinib Eliminates Chronic Myeloid Leukemia Stem and Progenitor Cells.

David A Irvine, roMB, ChB, Bin Zhang, MD, PhD, Elaine K Allan, BSc, Tessa L Holyoake, PhD, MB, ChB, FRCP, FRCPath, FRSE, Marion Dorsch, PhD, Paul W Manley, PhD, Ravi Bhatia, MD, PhD, Mhairi Copland, PhD, BSc, MB, ChB, MRCP, FRCPath
Journal: Blood
Blood (2009) 114 (22): 1428.
https://doi.org/10.1182/blood.V114.22.1428.1428
Published: 2009
Journal Articles

Ectopic expression of Delta4 impairs hematopoietic development and leads to lymphoproliferative disease

Marion Dorsch, Gang Zheng, David Yowe, Prakash Rao, Yanjun Wang, Qiong Shen, Curran Murphy, Ximing Xiong, Qiuju Shi, Jose-Carlos Gutierrez-Ramos, Chris Fraser, Jean-Luc Villeval
Journal: Blood
Blood (2002) 100 (6): 2046–2055.
https://doi.org/10.1182/blood.V100.6.2046
Published: 2002
Journal Articles

A Thrombopoietin Receptor Mutant Deficient in Jak-STAT Activation Mediates Proliferation But Not Differentiation in UT-7 Cells

Marion Dorsch, Nika N. Danial, Paul B. Rothman, Stephen P. Goff
Journal: Blood
Blood (1999) 94 (8): 2676–2685.
https://doi.org/10.1182/blood.V94.8.2676.420k28_2676_2685
Published: 1999