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Journal Articles

AG-221, a Small Molecule Mutant IDH2 Inhibitor, Remodels the Epigenetic State of IDH2-Mutant Cells and Induces Alterations in Self-Renewal/Differentiation in IDH2-Mutant AML Model in Vivo

Alan H. Shih, MDPhD, Kaitlyn R Shank, B.S., Cem Meydan, Andrew M. Intlekofer, MD PhD, Patrick Ward, Craig B. Thompson, MD, Ari M Melnick, MD, Jeremy Travins, Kim Straley, Camelia Gliser, Katherine Yen, Ross L Levine, MD

Blood (2014) 124 (21): 437.

https://doi.org/10.1182/blood.V124.21.437.437

Published: 2014

Journal Articles

AG-120, an Oral, Selective, First-in-Class, Potent Inhibitor of Mutant IDH1, Reduces Intracellular 2HG and Induces Cellular Differentiation in TF-1 R132H Cells and Primary Human IDH1 Mutant AML Patient Samples Treated Ex Vivo

Erica Hansen, Cyril Quivoron, Kim Straley, René M Lemieux, Janeta Popovici-Muller, Hossein Sadrzadeh, Amir T Fathi, Camelia Gliser, Muriel David, Véronique Saada, Jean-Baptiste Micol, Olivier Bernard, Marion Dorsch, Hua Yang, Michael Su, Sam Agresta, Stéphane de Botton, Virginie Penard-Lacronique, Katharine Yen

Blood (2014) 124 (21): 3734.

https://doi.org/10.1182/blood.V124.21.3734.3734

Published: 2014

Journal Articles

AG-221, an Oral, Selective, First-in-Class, Potent IDH2-R140Q Mutant Inhibitor, Induces Differentiation in a Xenotransplant Model

Cyril Quivoron, Muriel David, Kim Straley, Jeremy Travins, Hyeryun Kim, Yue Chen, Dongwei Zhu, Véronique Saada, Olivia Bawa, Paule Opolon, Mélanie Polrot, Jean-Baptiste Micol, Christophe Willekens, Olivier Bernard, Hua Yang, Sam Agresta, Stéphane de Botton, Katharine Yen, Virginie Penard-Lacronique

Blood (2014) 124 (21): 3735.

https://doi.org/10.1182/blood.V124.21.3735.3735

Published: 2014

Journal Articles

IDH1 Mutant Inhibitor Induces Cellular Differentiation and Offers a Combination Benefit With Ara-C In a Primary Human Idh1 Mutant AML Xenograft Model

Katharine Yen, Ph.D., Rene Lemieux, Ph.D., Janeta Popovici-Muller, Yue Chen, Ph.D., Hua Yang, Kim Straley, Sung Choe, Marion Dorsch, Samuel Agresta, MD, David P. Schenkein, MD, Scott Biller, Michael Su, Fang Wang

Blood (2013) 122 (21): 3946.

https://doi.org/10.1182/blood.V122.21.3946.3946

Published: 2013

Journal Articles

AG-221 Offers a Survival Advantage In a Primary Human IDH2 Mutant AML Xenograft Model

Katharine Yen, Ph.D., Fang Wang, Jeremy Travins, Yue Chen, Ph.D., Hua Yang, Kim Straley, Sung Choe, Marion Dorsch, David P. Schenkein, MD, Samuel Agresta, MD, Scott Biller, Michael Su

Blood (2013) 122 (21): 240.

https://doi.org/10.1182/blood.V122.21.240.240

Published: 2013

NARROW

AG-221, a Small Molecule Mutant IDH2 Inhibitor, Remodels the Epigenetic State of IDH2-Mutant Cells and Induces Alterations in Self-Renewal/Differentiation in IDH2-Mutant AML Model in Vivo

AG-120, an Oral, Selective, First-in-Class, Potent Inhibitor of Mutant IDH1, Reduces Intracellular 2HG and Induces Cellular Differentiation in TF-1 R132H Cells and Primary Human IDH1 Mutant AML Patient Samples Treated Ex Vivo

AG-221, an Oral, Selective, First-in-Class, Potent IDH2-R140Q Mutant Inhibitor, Induces Differentiation in a Xenotransplant Model

IDH1 Mutant Inhibitor Induces Cellular Differentiation and Offers a Combination Benefit With Ara-C In a Primary Human Idh1 Mutant AML Xenograft Model

AG-221 Offers a Survival Advantage In a Primary Human IDH2 Mutant AML Xenograft Model

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ASH Publications

American Society of Hematology

AG-221, a Small Molecule Mutant IDH2 Inhibitor, Remodels the Epigenetic State of IDH2-Mutant Cells and Induces Alterations in Self-Renewal/Differentiation in IDH2-Mutant AML Model in Vivo

AG-120, an Oral, Selective, First-in-Class, Potent Inhibitor of Mutant IDH1, Reduces Intracellular 2HG and Induces Cellular Differentiation in TF-1 R132H Cells and Primary Human IDH1 Mutant AML Patient Samples Treated Ex Vivo

AG-221, an Oral, Selective, First-in-Class, Potent IDH2-R140Q Mutant Inhibitor, Induces Differentiation in a Xenotransplant Model

IDH1 Mutant Inhibitor Induces Cellular Differentiation and Offers a Combination Benefit With Ara-C In a Primary Human Idh1 Mutant AML Xenograft Model

AG-221 Offers a Survival Advantage In a Primary Human IDH2 Mutant AML Xenograft Model

Email alerts

ASH Publications

American Society of Hematology

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