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Journal Articles

IDH2 mutation-induced histone and DNA hypermethylation is progressively reversed by small-molecule inhibition

Andrew Kernytsky, Fang Wang, Erica Hansen, Stefanie Schalm, Kimberly Straley, Camelia Gliser, Hua Yang, Jeremy Travins, Stuart Murray, Marion Dorsch, Sam Agresta, David P. Schenkein, Scott A. Biller, Shinsan M. Su, Wei Liu, Katharine E. Yen

Blood (2015) 125 (2): 296–303.

https://doi.org/10.1182/blood-2013-10-533604

Published: 2015

Includes: Supplemental data

Journal Articles

AG-221, a Small Molecule Mutant IDH2 Inhibitor, Remodels the Epigenetic State of IDH2-Mutant Cells and Induces Alterations in Self-Renewal/Differentiation in IDH2-Mutant AML Model in Vivo

Alan H. Shih, MDPhD, Kaitlyn R Shank, B.S., Cem Meydan, Andrew M. Intlekofer, MD PhD, Patrick Ward, Craig B. Thompson, MD, Ari M Melnick, MD, Jeremy Travins, Kim Straley, Camelia Gliser, Katherine Yen, Ross L Levine, MD

Blood (2014) 124 (21): 437.

https://doi.org/10.1182/blood.V124.21.437.437

Published: 2014

Journal Articles

AG-221, an Oral, Selective, First-in-Class, Potent IDH2-R140Q Mutant Inhibitor, Induces Differentiation in a Xenotransplant Model

Cyril Quivoron, Muriel David, Kim Straley, Jeremy Travins, Hyeryun Kim, Yue Chen, Dongwei Zhu, Véronique Saada, Olivia Bawa, Paule Opolon, Mélanie Polrot, Jean-Baptiste Micol, Christophe Willekens, Olivier Bernard, Hua Yang, Sam Agresta, Stéphane de Botton, Katharine Yen, Virginie Penard-Lacronique

Blood (2014) 124 (21): 3735.

https://doi.org/10.1182/blood.V124.21.3735.3735

Published: 2014

Journal Articles

AG-221 Offers a Survival Advantage In a Primary Human IDH2 Mutant AML Xenograft Model

Katharine Yen, Ph.D., Fang Wang, Jeremy Travins, Yue Chen, Ph.D., Hua Yang, Kim Straley, Sung Choe, Marion Dorsch, David P. Schenkein, MD, Samuel Agresta, MD, Scott Biller, Michael Su

Blood (2013) 122 (21): 240.

https://doi.org/10.1182/blood.V122.21.240.240

Published: 2013

Journal Articles

Mutation Selective IDH Inhibitors Mediate Histone and DNA Methylation Changes

Blood (2012) 120 (21): 3509.

https://doi.org/10.1182/blood.V120.21.3509.3509

Published: 2012

NARROW

IDH2 mutation-induced histone and DNA hypermethylation is progressively reversed by small-molecule inhibition

AG-221, a Small Molecule Mutant IDH2 Inhibitor, Remodels the Epigenetic State of IDH2-Mutant Cells and Induces Alterations in Self-Renewal/Differentiation in IDH2-Mutant AML Model in Vivo

AG-221, an Oral, Selective, First-in-Class, Potent IDH2-R140Q Mutant Inhibitor, Induces Differentiation in a Xenotransplant Model

AG-221 Offers a Survival Advantage In a Primary Human IDH2 Mutant AML Xenograft Model

Mutation Selective IDH Inhibitors Mediate Histone and DNA Methylation Changes

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ASH Publications

American Society of Hematology

IDH2 mutation-induced histone and DNA hypermethylation is progressively reversed by small-molecule inhibition

AG-221, a Small Molecule Mutant IDH2 Inhibitor, Remodels the Epigenetic State of IDH2-Mutant Cells and Induces Alterations in Self-Renewal/Differentiation in IDH2-Mutant AML Model in Vivo

AG-221, an Oral, Selective, First-in-Class, Potent IDH2-R140Q Mutant Inhibitor, Induces Differentiation in a Xenotransplant Model

AG-221 Offers a Survival Advantage In a Primary Human IDH2 Mutant AML Xenograft Model

Mutation Selective IDH Inhibitors Mediate Histone and DNA Methylation Changes

Email alerts

ASH Publications

American Society of Hematology

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