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David P. Schenkein
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Journal Articles

IDH2 mutation-induced histone and DNA hypermethylation is progressively reversed by small-molecule inhibition

Andrew Kernytsky, Fang Wang, Erica Hansen, Stefanie Schalm, Kimberly Straley, Camelia Gliser, Hua Yang, Jeremy Travins, Stuart Murray, Marion Dorsch, Sam Agresta, David P. Schenkein, Scott A. Biller, Shinsan M. Su, Wei Liu, Katharine E. Yen
Journal: Blood
Blood (2015) 125 (2): 296–303.
https://doi.org/10.1182/blood-2013-10-533604
Published: 2015
Includes: Supplemental data
Journal Articles

IDH1 Mutant Inhibitor Induces Cellular Differentiation and Offers a Combination Benefit With Ara-C In a Primary Human Idh1 Mutant AML Xenograft Model

Katharine Yen, Ph.D., Rene Lemieux, Ph.D., Janeta Popovici-Muller, Yue Chen, Ph.D., Hua Yang, Kim Straley, Sung Choe, Marion Dorsch, Samuel Agresta, MD, David P. Schenkein, MD, Scott Biller, Michael Su, Fang Wang
Journal: Blood
Blood (2013) 122 (21): 3946.
https://doi.org/10.1182/blood.V122.21.3946.3946
Published: 2013
Journal Articles

AG-221 Offers a Survival Advantage In a Primary Human IDH2 Mutant AML Xenograft Model

Katharine Yen, Ph.D., Fang Wang, Jeremy Travins, Yue Chen, Ph.D., Hua Yang, Kim Straley, Sung Choe, Marion Dorsch, David P. Schenkein, MD, Samuel Agresta, MD, Scott Biller, Michael Su
Journal: Blood
Blood (2013) 122 (21): 240.
https://doi.org/10.1182/blood.V122.21.240.240
Published: 2013
Journal Articles

Prospective serial evaluation of 2-hydroxyglutarate, during treatment of newly diagnosed acute myeloid leukemia, to assess disease activity and therapeutic response

Brief Report
Amir T. Fathi, Hossein Sadrzadeh, Darrell R. Borger, Karen K. Ballen, Philip C. Amrein, Eyal C. Attar, Julia Foster, Meghan Burke, Hector U. Lopez, Christina R. Matulis, Katherine M. Edmonds, A. John Iafrate, Kimberly S. Straley, Katharine E. Yen, Samuel Agresta, David P. Schenkein, Cedric Hill, Ashkan Emadi, Donna S. Neuberg, Richard M. Stone, Yi-Bin Chen
Journal: Blood
Blood (2012) 120 (23): 4649–4652.
https://doi.org/10.1182/blood-2012-06-438267
Published: 2012
Includes: Supplemental data
Journal Articles

Mutation Selective IDH Inhibitors Mediate Histone and DNA Methylation Changes

Katharine Yen, Fang Wang, Stefanie Schalm, Erica Hansen, Kimberly Straley, BS, Andrew Kernytsky, Sung Choe, Wei Liu, Janeta Popovici-Muller, Jeremy Travins, Hua Yang, Lee Silverman, Julie Losman Aurore, William G. Kaelin, Jr., MD, Stefan Gross, Lenny Dang, Frank Salituro, Jeffrey Saunders, Marion Dorsch, Samuel Agresta, MD, David P. Schenkein, MD, Michael Su, Scott Biller
Journal: Blood
Blood (2012) 120 (21): 3509.
https://doi.org/10.1182/blood.V120.21.3509.3509
Published: 2012
Journal Articles

2-Hydroxyglutarate in IDH mutant AML: Predicting Patient Responses, Minimal Residual Disease and Correlations with Methylcytosine and Hydroxymethylcytosine Levels

Daniel A Pollyea, MD, MS, Holbrook E Kohrt, MD, Bing Zhang, MD, MS, James L. Zehnder, MD, David P. Schenkein, MD, Valeria Fantin, PhD, Kimberly Straley, BS, Aparna Vasanthakumar, BSc, MSc, PhD, Omar Abdel-Wahab, MD, Ross L Levine, MD, Lucy Godley, MD, PhD, Bruno C. Medeiros, MD
Journal: Blood
Blood (2011) 118 (21): 2509.
https://doi.org/10.1182/blood.V118.21.2509.2509
Published: 2011
Journal Articles

Roles of tyrosine 589 and 591 in STAT5 activation and transformation mediated by FLT3-ITD

Jennifer L. Rocnik, Rachel Okabe, Jin-Chen Yu, Benjamin H. Lee, Neill Giese, David P. Schenkein, D. Gary Gilliland
Journal: Blood
Blood (2006) 108 (4): 1339–1345.
https://doi.org/10.1182/blood-2005-11-011429
Published: 2006
Includes: Supplemental data
Journal Articles

Risk factors and kinetics of thrombocytopenia associated with bortezomib for relapsed, refractory multiple myeloma

Clinical Trials & Observations
Sagar Lonial, Edmund K. Waller, Paul G. Richardson, Sundar Jagannath, Robert Z. Orlowski, Cynthia R. Giver, David L. Jaye, Dixil Francis, Sara Giusti, Claire Torre, Bart Barlogie, James R. Berenson, Seema Singhal, David P. Schenkein, Dixie-Lee W. Esseltine, Jessica Anderson, Hugh Xiao, Leonard T. Heffner, Kenneth C. Anderson, for the SUMMIT/CREST Investigators
Journal: Blood
Blood (2005) 106 (12): 3777–3784.
https://doi.org/10.1182/blood-2005-03-1173
Published: 2005
Journal Articles

A Phase 2 Study of Bortezomib in Relapsed/Refractory Diffuse Large B-Cell Lymphoma (DLBCL).

Sven de Vos, MD, PhD, Donna Fernando, MAOM, David P. Schenkein, MD, Peter J. Rosen, MD
Journal: Blood
Blood (2005) 106 (11): 4746.
https://doi.org/10.1182/blood.V106.11.4746.4746
Published: 2005
Journal Articles

PAD Combination Therapy (PS-341/Bortezomib, Adriamycin and Dexamethasone) for Previously Untreated Patients with Multiple Myeloma.

James D. Cavenagh, MD, Rakesh Popat, MB BS, Nikki Curry, MB BS, Jim Stec, PhD, Treen C. Morris, FRCP, Mary Drake, MRCPath, Samir Agrawal, PhD, Patricia Smith, RGN, David P. Schenkein, MD, Dixie-Lee Esseltine, MD, Heather Oakervee, MRCP
Journal: Blood
Blood (2004) 104 (11): 1478.
https://doi.org/10.1182/blood.V104.11.1478.1478
Published: 2004
Journal Articles

Phase I Dose Escalating Trial of Bortezomib (Velcade®) in Combination with Idarubicin and Cytarabine in Patients with Acute Myeloid Leukemia.

Eyal C. Attar, M.D., Daniel J. DeAngelo, M.D., Ph.D., Karen K. Ballen, M.D., Emily Learner, Elizabeth G. Trehu, M.D., David P. Schenkein, M.D., James D. Levine, M.D., Richard M. Stone, M.D., Philip C. Amrein, M.D.
Journal: Blood
Blood (2004) 104 (11): 1799.
https://doi.org/10.1182/blood.V104.11.1799.1799
Published: 2004
Journal Articles

Randomized trial of filgrastim versus chemotherapy and filgrastim mobilization of hematopoietic progenitor cells for rescue in autologous transplantation

Clinical Trials & Observations
Uma Narayanasami, Rajani Kanteti, Julie Morelli, Alanna Klekar, Asma Al-Olama, Claire Keating, Colleen O'Connor, Eugene Berkman, John K. Erban, Kellie A. Sprague, Kenneth B. Miller, David P. Schenkein
Journal: Blood
Blood (2001) 98 (7): 2059–2064.
https://doi.org/10.1182/blood.V98.7.2059
Published: 2001
Journal Articles

Immunomodulatory effects of extracorporeal photochemotherapy in patients with extensive chronic graft-versus-host disease

Clinical Trials & Observations Brief Report
Thierry Alcindor, Gullu Gorgun, Kenneth B. Miller, Todd F. Roberts, Kellie Sprague, David P. Schenkein, Francine M. Foss
Journal: Blood
Blood (2001) 98 (5): 1622–1625.
https://doi.org/10.1182/blood.V98.5.1622
Published: 2001