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Journal Articles

AG-348 enhances pyruvate kinase activity in red blood cells from patients with pyruvate kinase deficiency

Charles Kung, Jeff Hixon, Penelope A. Kosinski, Giovanni Cianchetta, Gavin Histen, Yue Chen, Collin Hill, Stefan Gross, Yaguang Si, Kendall Johnson, Byron DeLaBarre, Zhiyong Luo, Zhiwei Gu, Gui Yao, Huachun Tang, Cheng Fang, Yingxia Xu, Xiaobing Lv, Scott Biller, Shin-San Michael Su, Hua Yang, Janeta Popovici-Muller, Francesco Salituro, Lee Silverman, Lenny Dang
Journal: Blood
Blood (2017) 130 (11): 1347–1356.
https://doi.org/10.1182/blood-2016-11-753525
Published: 2017
Includes: Supplemental data
Journal Articles

Effects of AG-348, a Pyruvate Kinase Activator, on Anemia and Hemolysis in Patients with Pyruvate Kinase Deficiency: Data from the DRIVE PK Study

Rachael F Grace, MD, Christian Rose, D Mark Layton, Hassan M Yaish, Wilma Barcellini, Frédéric Galactéros, D Holmes Morton, Yaddanapudi Ravindranath, Kevin H.M. Kuo, MD MSc, FRCPC, Eduard J van Beers, Janet L Kwiatkowski, Bruce A Silver, Elizabeth Merica, Charles Kung, Marvin Cohen, Hua Yang, Jeffrey Hixon, Penelope A Kosinski, Lee Silverman, Lenny Dang, Zheng (Jason) Yuan, Ann J Barbier, Bertil Glader
Journal: Blood
Blood (2016) 128 (22): 402.
https://doi.org/10.1182/blood.V128.22.402.402
Published: 2016
Journal Articles

Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Multiple Doses of AG-519, an Allosteric Activator of Pyruvate Kinase-R, in Healthy Subjects

Ann J Barbier, Susan Bodie, Gary Connor, Elizabeth Merica, Charles Kung, Kha Le, Hua Yang, Penelope A Kosinski, Lee Silverman, Zheng (Jason) Yuan, Chris Bowden, Marvin Cohen
Journal: Blood
Blood (2016) 128 (22): 1264.
https://doi.org/10.1182/blood.V128.22.1264.1264
Published: 2016
Journal Articles

Characterization of Metabolic Response to AG-348, an Allosteric Activator of Red Cell Pyruvate Kinase, in Healthy Volunteers and Pyruvate Kinase Deficiency Patients

Victor Chubukov, Kendall Johnson, Penelope A Kosinski, Michelle Clasquin, Abhishek Jha, Hyeryun Kim, Thomas P Roddy, Elizabeth Merica, Ann J Barbier, Lenny Dang, Lee Silverman, Charles Kung
Journal: Blood
Blood (2016) 128 (22): 2452.
https://doi.org/10.1182/blood.V128.22.2452.2452
Published: 2016
Journal Articles

Population Pharmacokinetics and Pharmacodynamics of AG-348 in Healthy Human Volunteers Guide Dose Selection for the Treatment of Pyruvate Kinase Deficiency

Kha Le, PhD, Marvin Cohen, Yue Chen, Hyeryun Kim, Bruce Silver, Sam Agresta, MD, Elizabeth Merica, Charles Kung, Penelope Kosinski, Lee Silverman, Scott Biller, Hua Yang, PhD
Journal: Blood
Blood (2015) 126 (23): 3336.
https://doi.org/10.1182/blood.V126.23.3336.3336
Published: 2015
Journal Articles

AG-348 Activation of Pyruvate Kinase in Vivo Enhances Red Cell Glycolysis in Mice

Charles Kung, Collin Hill, Yue Chen, Abhishek Jha, Penelope Kosinski, Michelle Clasquin, Yaguang Si, Hyeryun Kim, Jeff Hixon, Lenny Dang, Sam Agresta, Lee Silverman, Hua Yang
Journal: Blood
Blood (2014) 124 (21): 4010.
https://doi.org/10.1182/blood.V124.21.4010.4010
Published: 2014
Journal Articles

Small Molecule Activation Of Pyruvate Kinase Normalizes Metabolic Activity In Red Cells From Patients With Pyruvate Kinase Deficiency-Associated Hemolytic Anemia

Charles Kung, Ph.D., Jeff Hixon, Penelope Kosinski, Gavin Histen, Collin Hill, Yaguang Si, Andrew Kernytsky, Yue Chen, Ph.D., Byron DeLaBarre, Michelle Clasquin, Helen Ho, Furha I. Cossor, MD MS, Ellis J. Neufeld, MD, PhD, Frank Salituro, Janeta Popovici-Muller, Samuel Agresta, MD, Lee Silverman, Lenny Dang
Journal: Blood
Blood (2013) 122 (21): 2180.
https://doi.org/10.1182/blood.V122.21.2180.2180
Published: 2013
Journal Articles

Mutation Selective IDH Inhibitors Mediate Histone and DNA Methylation Changes

Katharine Yen, Fang Wang, Stefanie Schalm, Erica Hansen, Kimberly Straley, BS, Andrew Kernytsky, Sung Choe, Wei Liu, Janeta Popovici-Muller, Jeremy Travins, Hua Yang, Lee Silverman, Julie Losman Aurore, William G. Kaelin, Jr., MD, Stefan Gross, Lenny Dang, Frank Salituro, Jeffrey Saunders, Marion Dorsch, Samuel Agresta, MD, David P. Schenkein, MD, Michael Su, Scott Biller
Journal: Blood
Blood (2012) 120 (21): 3509.
https://doi.org/10.1182/blood.V120.21.3509.3509
Published: 2012
Journal Articles

Bortezomib-Associated Peripheral Neuropathy: Relationship Between Clinical Neurophysiologic Evidence in Previously Untreated Multiple Myeloma Patients and Preclinical Characterization in a Mouse Model.

Paul G. Richardson, Jordi Bruna, Anthony A. Amato, Esther Udina, Constantine S. Mitsiades, Patrick Y. Wen, E. Tessa Hedley-Whyte, Anne Louise Oaklander, Johan Monbaliu, An Vynckier, Lee Silverman, Kenneth C. Anderson, Xavier Navarro
Journal: Blood
Blood (2009) 114 (22): 3860.
https://doi.org/10.1182/blood.V114.22.3860.3860
Published: 2009
Journal Articles

Evaluating the Antitumor Activity of MLN9708 in a Disseminated Mouse Model of Double Transgenic iMyc Ca /Bcl-X L Plasma Cell Malignancy.

Michael Fitzgerald, Yueying Cao, Bret Bannerman, Zhi Li, Olga Tayber, Ping Li, Jennifer Terkelsen, Daniel Bradley, Jonathan Frazer, Lee Silverman, PhD, Siegfried Janz, Brian G Van Ness, Erik Kupperman, Mark Manfredi, Edmund Lee
Journal: Blood
Blood (2009) 114 (22): 3835.
https://doi.org/10.1182/blood.V114.22.3835.3835
Published: 2009
Journal Articles

Proteasome Inhibitor Associated Neuropathy Is Mechanism Based

Lee Silverman, Vilmos Csizmadia, Katherine Brewer, Chris Simpson, Carl Alden
Journal: Blood
Blood (2008) 112 (11): 2646.
https://doi.org/10.1182/blood.V112.11.2646.2646
Published: 2008
Journal Articles

HTLV-1 Rex is required for viral spread and persistence in vivo but is dispensable for cellular immortalization in vitro

Jianxin Ye, Lee Silverman, Michael D. Lairmore, Patrick L. Green
Journal: Blood
Blood (2003) 102 (12): 3963–3969.
https://doi.org/10.1182/blood-2003-05-1490
Published: 2003