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Journal Articles

Results Update from the DRIVE PK Study: Effects of AG-348, a Pyruvate Kinase Activator, in Patients with Pyruvate Kinase Deficiency

Rachael F. Grace, MD, D. Mark Layton, MB, FRCP, Frédéric Galactéros, MDPhD, Christian Rose, MD, Wilma Barcellini, MD, D. Holmes Morton, MD, Eduard J. Van Beers, MD, Hassan M. Yaish, MD, Yaddanapudi Ravindranath, MBBS, Kevin H.M. Kuo, MD MSc, FRCPC, Sujit Sheth, MD, Janet L. Kwiatkowski, MD, Bruce Silver, MD, Charles Kung, Marvin Cohen, Hua Yang, Penelope A. Kosinski, MS, Lei Hua, Ann Barbier, Bertil Glader, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2194.
https://doi.org/10.1182/blood.V130.Suppl_1.2194.2194
Published: 2017
Journal Articles

Effects of AG-348, a Pyruvate Kinase Activator, on Anemia and Hemolysis in Patients with Pyruvate Kinase Deficiency: Data from the DRIVE PK Study

Rachael F Grace, MD, Christian Rose, D Mark Layton, Hassan M Yaish, Wilma Barcellini, Frédéric Galactéros, D Holmes Morton, Yaddanapudi Ravindranath, Kevin H.M. Kuo, MD MSc, FRCPC, Eduard J van Beers, Janet L Kwiatkowski, Bruce A Silver, Elizabeth Merica, Charles Kung, Marvin Cohen, Hua Yang, Jeffrey Hixon, Penelope A Kosinski, Lee Silverman, Lenny Dang, Zheng (Jason) Yuan, Ann J Barbier, Bertil Glader
Journal: Blood
Blood (2016) 128 (22): 402.
https://doi.org/10.1182/blood.V128.22.402.402
Published: 2016
Journal Articles

Population Pharmacokinetics and Pharmacodynamics of AG-519, a Pyruvate Kinase Activator for the Treatment of Pyruvate Kinase Deficiency, in Human Healthy Volunteers

Kha Le, Marvin Cohen, Ann J Barbier, Elizabeth Merica, Charles Kung, Penelope A Kosinski, Scott Biller, Hua Yang
Journal: Blood
Blood (2016) 128 (22): 1263.
https://doi.org/10.1182/blood.V128.22.1263.1263
Published: 2016
Journal Articles

Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Multiple Doses of AG-519, an Allosteric Activator of Pyruvate Kinase-R, in Healthy Subjects

Ann J Barbier, Susan Bodie, Gary Connor, Elizabeth Merica, Charles Kung, Kha Le, Hua Yang, Penelope A Kosinski, Lee Silverman, Zheng (Jason) Yuan, Chris Bowden, Marvin Cohen
Journal: Blood
Blood (2016) 128 (22): 1264.
https://doi.org/10.1182/blood.V128.22.1264.1264
Published: 2016
Journal Articles

Population Pharmacokinetics and Pharmacodynamics of AG-348 in Healthy Human Volunteers Guide Dose Selection for the Treatment of Pyruvate Kinase Deficiency

Kha Le, PhD, Marvin Cohen, Yue Chen, Hyeryun Kim, Bruce Silver, Sam Agresta, MD, Elizabeth Merica, Charles Kung, Penelope Kosinski, Lee Silverman, Scott Biller, Hua Yang, PhD
Journal: Blood
Blood (2015) 126 (23): 3336.
https://doi.org/10.1182/blood.V126.23.3336.3336
Published: 2015
Journal Articles

DRIVE PK: A Phase 2 Trial of AG-348 in Patients with Pyruvate Kinase Deficiency

Ann Barbier, Bruce Silver, Elizabeth Merica, Marvin Cohen, Charles Kung, Hua Yang, PhD, Rachael F. Grace, MD, Bertil Glader, MD PhD, Sam Agresta, MD
Journal: Blood
Blood (2015) 126 (23): 4548.
https://doi.org/10.1182/blood.V126.23.4548.4548
Published: 2015
Journal Articles

Phase I Single (SAD) and Multiple Ascending Dose (MAD) Studies of the Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of AG-348, a First-in-Class Allosteric Activator of Pyruvate Kinase-R, in Healthy Subjects

Hua Yang, Elizabeth Merica, Yue Chen, Marvin Cohen, Ronald Goldwater, Collin Hill, Hyeryun Kim, Penelope Kosinski, Charles Kung, Bruce Silver, Luke Utley, Sam Agresta
Journal: Blood
Blood (2014) 124 (21): 4007.
https://doi.org/10.1182/blood.V124.21.4007.4007
Published: 2014