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Journal Articles

AG-348 enhances pyruvate kinase activity in red blood cells from patients with pyruvate kinase deficiency

Charles Kung, Jeff Hixon, Penelope A. Kosinski, Giovanni Cianchetta, Gavin Histen, Yue Chen, Collin Hill, Stefan Gross, Yaguang Si, Kendall Johnson, Byron DeLaBarre, Zhiyong Luo, Zhiwei Gu, Gui Yao, Huachun Tang, Cheng Fang, Yingxia Xu, Xiaobing Lv, Scott Biller, Shin-San Michael Su, Hua Yang, Janeta Popovici-Muller, Francesco Salituro, Lee Silverman, Lenny Dang
Journal: Blood
Blood (2017) 130 (11): 1347–1356.
https://doi.org/10.1182/blood-2016-11-753525
Published: 2017
Includes: Supplemental data
Journal Articles

AG-348 Activation of Pyruvate Kinase in Vivo Enhances Red Cell Glycolysis in Mice

Charles Kung, Collin Hill, Yue Chen, Abhishek Jha, Penelope Kosinski, Michelle Clasquin, Yaguang Si, Hyeryun Kim, Jeff Hixon, Lenny Dang, Sam Agresta, Lee Silverman, Hua Yang
Journal: Blood
Blood (2014) 124 (21): 4010.
https://doi.org/10.1182/blood.V124.21.4010.4010
Published: 2014
Journal Articles

Phase I Single (SAD) and Multiple Ascending Dose (MAD) Studies of the Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of AG-348, a First-in-Class Allosteric Activator of Pyruvate Kinase-R, in Healthy Subjects

Hua Yang, Elizabeth Merica, Yue Chen, Marvin Cohen, Ronald Goldwater, Collin Hill, Hyeryun Kim, Penelope Kosinski, Charles Kung, Bruce Silver, Luke Utley, Sam Agresta
Journal: Blood
Blood (2014) 124 (21): 4007.
https://doi.org/10.1182/blood.V124.21.4007.4007
Published: 2014
Journal Articles

Small Molecule Activation Of Pyruvate Kinase Normalizes Metabolic Activity In Red Cells From Patients With Pyruvate Kinase Deficiency-Associated Hemolytic Anemia

Charles Kung, Ph.D., Jeff Hixon, Penelope Kosinski, Gavin Histen, Collin Hill, Yaguang Si, Andrew Kernytsky, Yue Chen, Ph.D., Byron DeLaBarre, Michelle Clasquin, Helen Ho, Furha I. Cossor, MD MS, Ellis J. Neufeld, MD, PhD, Frank Salituro, Janeta Popovici-Muller, Samuel Agresta, MD, Lee Silverman, Lenny Dang
Journal: Blood
Blood (2013) 122 (21): 2180.
https://doi.org/10.1182/blood.V122.21.2180.2180
Published: 2013