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Journal Articles

IDH2 mutation-induced histone and DNA hypermethylation is progressively reversed by small-molecule inhibition

Andrew Kernytsky, Fang Wang, Erica Hansen, Stefanie Schalm, Kimberly Straley, Camelia Gliser, Hua Yang, Jeremy Travins, Stuart Murray, Marion Dorsch, Sam Agresta, David P. Schenkein, Scott A. Biller, Shinsan M. Su, Wei Liu, Katharine E. Yen
Journal: Blood
Blood (2015) 125 (2): 296–303.
https://doi.org/10.1182/blood-2013-10-533604
Published: 2015
Includes: Supplemental data
Journal Articles

AG-221, a Small Molecule Mutant IDH2 Inhibitor, Remodels the Epigenetic State of IDH2-Mutant Cells and Induces Alterations in Self-Renewal/Differentiation in IDH2-Mutant AML Model in Vivo

Alan H. Shih, MDPhD, Kaitlyn R Shank, B.S., Cem Meydan, Andrew M. Intlekofer, MD PhD, Patrick Ward, Craig B. Thompson, MD, Ari M Melnick, MD, Jeremy Travins, Kim Straley, Camelia Gliser, Katherine Yen, Ross L Levine, MD
Journal: Blood
Blood (2014) 124 (21): 437.
https://doi.org/10.1182/blood.V124.21.437.437
Published: 2014
Journal Articles

AG-120, an Oral, Selective, First-in-Class, Potent Inhibitor of Mutant IDH1, Reduces Intracellular 2HG and Induces Cellular Differentiation in TF-1 R132H Cells and Primary Human IDH1 Mutant AML Patient Samples Treated Ex Vivo

Erica Hansen, Cyril Quivoron, Kim Straley, René M Lemieux, Janeta Popovici-Muller, Hossein Sadrzadeh, Amir T Fathi, Camelia Gliser, Muriel David, Véronique Saada, Jean-Baptiste Micol, Olivier Bernard, Marion Dorsch, Hua Yang, Michael Su, Sam Agresta, Stéphane de Botton, Virginie Penard-Lacronique, Katharine Yen
Journal: Blood
Blood (2014) 124 (21): 3734.
https://doi.org/10.1182/blood.V124.21.3734.3734
Published: 2014