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Katherine Yen
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Journal Articles

Evaluation of the Pharmacokinetics of AG-221, a Potent Mutant IDH2 Inhibitor, in Patients with IDH2-Mutation Positive Advanced Hematologic Malignancies in a Phase 1/2 Trial

Yue Gao, PhD, Bin Fan, PhD, Kha Le, PhD, Erika Manyak, BASc, Hua Yang, PhD, Katherine Yen, PhD, Sam Agresta, MD, Eyal C. Attar, MD, Jian Chen, PhD, Qiang Xu, PhD, Alessandra Tosolini, BS, Jay M. Mei, MD PhD, Anjan Thakurta, Robert D. Knight, MD, Yan Li, PhD
Journal: Blood
Blood (2015) 126 (23): 2509.
https://doi.org/10.1182/blood.V126.23.2509.2509
Published: 2015
Journal Articles

Safety and Efficacy of AG-221, a Potent Inhibitor of Mutant IDH2 That Promotes Differentiation of Myeloid Cells in Patients with Advanced Hematologic Malignancies: Results of a Phase 1/2 Trial

Eytan M. Stein, MD, Courtney DiNardo, MD, Jessica K. Altman, MD, Robert Collins, MD, Daniel J. DeAngelo, MD PhD, Hagop M. Kantarjian, MD, Mikkael A. Sekeres, MD MS, Amir T. Fathi, MD, Ian W. Flinn, MD PhD, Arthur E. Frankel, MD, Ross L. Levine, MD, Bruno C. Medeiros, MD, Manish R. Patel, MD, Daniel Pollyea, MD MS, Gail J. Roboz, MD, Richard M. Stone, MD, Ronan T. Swords, MDPhDFRCPI FRCPath, Martin S. Tallman, MD, Katherine Yen, PhD, Eyal C. Attar, MD, Qiang Xu, PhD, Alessandra Tosolini, BS, Jay M. Mei, MD PhD, Anjan Thakurta, Robert D. Knight, MD, Stéphane De Botton, MD PhD
Journal: Blood
Blood (2015) 126 (23): 323.
https://doi.org/10.1182/blood.V126.23.323.323
Published: 2015
Journal Articles

AG-221, a Small Molecule Mutant IDH2 Inhibitor, Remodels the Epigenetic State of IDH2-Mutant Cells and Induces Alterations in Self-Renewal/Differentiation in IDH2-Mutant AML Model in Vivo

Alan H. Shih, MDPhD, Kaitlyn R Shank, B.S., Cem Meydan, Andrew M. Intlekofer, MD PhD, Patrick Ward, Craig B. Thompson, MD, Ari M Melnick, MD, Jeremy Travins, Kim Straley, Camelia Gliser, Katherine Yen, Ross L Levine, MD
Journal: Blood
Blood (2014) 124 (21): 437.
https://doi.org/10.1182/blood.V124.21.437.437
Published: 2014