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Yashodhara Dasgupta
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Journal Articles

Tyrosine kinase inhibitor–induced defects in DNA repair sensitize FLT3(ITD)-positive leukemia cells to PARP1 inhibitors

Silvia Maifrede, Margaret Nieborowska-Skorska, Katherine Sullivan-Reed, Yashodhara Dasgupta, Paulina Podszywalow-Bartnicka, Bac Viet Le, Martyna Solecka, Zhaorui Lian, Elizaveta A. Belyaeva, Alina Nersesyan, Marcin M. Machnicki, Monika Toma, Nicolas Chatain, Malgorzata Rydzanicz, Huaqing Zhao, Jaroslav Jelinek, Katarzyna Piwocka, Tomasz Sliwinski, Tomasz Stoklosa, Rafal Ploski, Thomas Fischer, Stephen M. Sykes, Steffen Koschmieder, Lars Bullinger, Peter Valent, Mariusz A. Wasik, Jian Huang, Tomasz Skorski
Journal: Blood
Blood (2018) 132 (1): 67–77.
https://doi.org/10.1182/blood-2018-02-834895
Published: 2018
Includes: Supplemental data
Journal Articles

Ruxolitinib-induced defects in DNA repair cause sensitivity to PARP inhibitors in myeloproliferative neoplasms

Margaret Nieborowska-Skorska, Silvia Maifrede, Yashodhara Dasgupta, Katherine Sullivan, Sylwia Flis, Bac Viet Le, Martyna Solecka, Elizaveta A. Belyaeva, Lucia Kubovcakova, Morgan Nawrocki, Martin Kirschner, Huaqing Zhao, Josef T. Prchal, Katarzyna Piwocka, Alison R. Moliterno, Mariusz Wasik, Steffen Koschmieder, Tony R. Green, Radek C. Skoda, Tomasz Skorski
Journal: Blood
Blood (2017) 130 (26): 2848–2859.
https://doi.org/10.1182/blood-2017-05-784942
Published: 2017
Includes: Supplemental data
Journal Articles

Tyrosine Kinase Inhibitor-Induced Defects in DNA Repair Sensitize FLT3(ITD)-Positive Acute Myeloid Leukemia Quiescent and Proliferative Cells to PARP Inhibitors

Silvia Maifrede, Margaret Nieborowska-Skorska, Katherine Sullivan, Yashodhara Dasgupta, Paulina Podszywalow-Bartnicka, Bac Viet Le, Martyna Solecka, Zhaorui Lian, Marcin M Machnicki, Huaqing Zhao, Jaroslav Jelinek, Katarzyna Piwocka, Tomasz Stoklosa, Thomas Fischer, Stephen M. Sykes, Steffen Koschmieder, Lars Bullinger, MD, Peter Valent, MD, Jian Huang, Tomasz Skorski
Journal: Blood
Blood (2017) 130 (Supplement 1): 2635.
https://doi.org/10.1182/blood.V130.Suppl_1.2635.2635
Published: 2017
Journal Articles

Simultaneous Targeting of PARP1 and RAD52 Triggers Dual Synthetic Lethality in BRCA-Deficient Leukemia Cells

Katherine Sullivan, Elisabeth Bolton-Gillespie, Yashodhara Dasgupta, Samantha Langer, Micheal Siciliano, Margaret Nieborowska-Skorska, Huaqing Zhao, Peter Valent, Tomasz Skorski
Journal: Blood
Blood (2017) 130 (Supplement 1): 4623.
https://doi.org/10.1182/blood.V130.Suppl_1.4623.4623
Published: 2017
Journal Articles

Drugging DNA Repair to Target T-ALL Cells

Yashodhara Dasgupta, Konstantin Golovine, Margaret Nieborowska-Skorska, Li Luo, Ksenia Matlawska-Wasowska, Charles G. Mullighan, MBBS, MD, Tomasz Skorski
Journal: Blood
Blood (2017) 130 (Supplement 1): 2610.
https://doi.org/10.1182/blood.V130.Suppl_1.2610.2610
Published: 2017
Journal Articles

Ruxolitinib-Induced Defects in DNA Repair Cause Sensitivity to PARP Inhibitors in Myeloproliferative Neoplasms

Margaret Nieborowska-Skorska, Silvia Maifrede, Yashodhara Dasgupta, Katherine Sullivan, Bac Viet Le, Martyna Solecka, Lucia Kubovcakova, Morgan Nawrocki, Martin Kirschner, MD, Huaqing Zhao, Josef T. Prchal, MD, Katarzyna Piwocka, Alison R. Moliterno, MD, Steffen Koschmieder, Anthony R Green, PhD FRCP, FRCPath, FMedSci, Radek C. Skoda, MD, Tomasz Skorski
Journal: Blood
Blood (2017) 130 (Supplement 1): 2938.
https://doi.org/10.1182/blood.V130.Suppl_1.2938.2938
Published: 2017
Journal Articles

IGH/MYC Translocation in Burkitt Lymphoma Is Associated with BRCA2 Deficiency and Synthetic Lethality By PARP1 Inhibitors

Silvia Maifrede, Kayla Martin, Paulina Podszywalow-Bartnicka, PhD, Sullivan Katherine, Samantha Langer, Reza Nejati, Yashodhara Dasgupta, Daniel Gritsyuk, Margaret Nieborowska-Skorska, Lena Lupey, Katarzyna Piwocka, Mariusz A Wasik, MD, Italo Tempera, Tomasz Skorski
Journal: Blood
Blood (2016) 128 (22): 4111.
https://doi.org/10.1182/blood.V128.22.4111.4111
Published: 2016
Journal Articles

Normal ABL1 is a tumor suppressor and therapeutic target in human and mouse leukemias expressing oncogenic ABL1 kinases

Yashodhara Dasgupta, Mateusz Koptyra, Grazyna Hoser, Kanchan Kantekure, Darshan Roy, Barbara Gornicka, Margaret Nieborowska-Skorska, Elisabeth Bolton-Gillespie, Sabine Cerny-Reiterer, Markus Müschen, Peter Valent, Mariusz A. Wasik, Christine Richardson, Oliver Hantschel, Heiko van der Kuip, Tomasz Stoklosa, Tomasz Skorski
Journal: Blood
Blood (2016) 127 (17): 2131–2143.
https://doi.org/10.1182/blood-2015-11-681171
Published: 2016
Includes: Supplemental data
Journal Articles

Downregulation of BRCA1 Protein in BCR-ABL1–positive Cells Depends on Tiar-Mediated Repression of BRCA1 mRNA Translation

Paulina Podszywalow-Bartnicka, PhD, Magdalena Wolczyk, MSc, Monika Kusio-Kobialka, PhD, Kamila Wolanin, PhD, Krzysztof Skowronek, PhD, Margaret Nieborowska-Skorska, MD PhD, Yashodhara Dasgupta, PhD, Tomasz Skorski, MD PhD, Katarzyna Piwocka, PhD
Journal: Blood
Blood (2014) 124 (21): 3129.
https://doi.org/10.1182/blood.V124.21.3129.3129
Published: 2014
Journal Articles

Normal ABL1 Is a Tumor Suppressor and Therapeutic Target In BCR-ABL1–positive Leukemias

Yashodhara Dasgupta, Mateusz Koptyra, PhD, Margaret Nieborowska-Skorska, MD, PhD, Elisabeth Bolton Gillespie, PhD, Tomasz Stoklosa, MD, PhD, Grazyna Hoser, PhD, Mariusz Wasik, MD, Markus Muschen, Christine Richardson, PhD, Tomasz Skorski, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 1466.
https://doi.org/10.1182/blood.V122.21.1466.1466
Published: 2013
Journal Articles

Targeting RAD51 phosphotyrosine-315 to prevent unfaithful recombination repair in BCR-ABL1 leukemia

Artur Slupianek, Yashodhara Dasgupta, Shu-yue Ren, Ewa Gurdek, Milene Donlin, Margaret Nieborowska-Skorska, Fabrice Fleury, Tomasz Skorski
Journal: Blood
Blood (2011) 118 (4): 1062–1068.
https://doi.org/10.1182/blood-2010-09-307256
Published: 2011
Includes: Supplemental data
Journal Articles

Sensitivity to Imatinib In BCR-ABL1-Positive Chronic Myeloid Leukemia Cells Depends on the Presence of Normal ABL1.

Yashodhara Dasgupta, Anna Virgili, Mateusz Koptyra, Elisabeth P. Nacheva, MD, PhD, Tomasz Skorski, MD, PhD
Journal: Blood
Blood (2010) 116 (21): 3405.
https://doi.org/10.1182/blood.V116.21.3405.3405
Published: 2010
Journal Articles

Targeting Phosphotyrosine-315 In RAD51 Recombinase to Prevent BCR-ABL1 - Mediated Unfaithful Homeologous Recombination Repair.

Artur Slupianek, PhD, Yashodhara Dasgupta, Shu-yue Ren, PhD, Kimberly Cramer, Tomasz Skorski, MD, PhD
Journal: Blood
Blood (2010) 116 (21): 1190.
https://doi.org/10.1182/blood.V116.21.1190.1190
Published: 2010
Journal Articles

Targeting BCR/ABL-RAD51 Interaction to Prevent Unfaithful Homeologous Recombination Repair.

Artur Slupianek, PhD, Yashodhara Dasgupta, Shuyue Ren, MD, PhD, Kimberly Cramer, Tomasz Skorski, MD, PhD
Journal: Blood
Blood (2009) 114 (22): 3272.
https://doi.org/10.1182/blood.V114.22.3272.3272
Published: 2009