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Journal Articles

Normal ABL1 is a tumor suppressor and therapeutic target in human and mouse leukemias expressing oncogenic ABL1 kinases

Yashodhara Dasgupta, Mateusz Koptyra, Grazyna Hoser, Kanchan Kantekure, Darshan Roy, Barbara Gornicka, Margaret Nieborowska-Skorska, Elisabeth Bolton-Gillespie, Sabine Cerny-Reiterer, Markus Müschen, Peter Valent, Mariusz A. Wasik, Christine Richardson, Oliver Hantschel, Heiko van der Kuip, Tomasz Stoklosa, Tomasz Skorski

Blood (2016) 127 (17): 2131–2143.

https://doi.org/10.1182/blood-2015-11-681171

Published: 2016

Includes: Supplemental data

Journal Articles

Normal ABL1 Is a Tumor Suppressor and Therapeutic Target In BCR-ABL1–positive Leukemias

Yashodhara Dasgupta, Mateusz Koptyra, PhD, Margaret Nieborowska-Skorska, MD, PhD, Elisabeth Bolton Gillespie, PhD, Tomasz Stoklosa, MD, PhD, Grazyna Hoser, PhD, Mariusz Wasik, MD, Markus Muschen, Christine Richardson, PhD, Tomasz Skorski, MD, PhD

Blood (2013) 122 (21): 1466.

https://doi.org/10.1182/blood.V122.21.1466.1466

Published: 2013

Journal Articles

Genomic instability may originate from imatinib-refractory chronic myeloid leukemia stem cells

Elisabeth Bolton-Gillespie, Mirle Schemionek, Hans-Ulrich Klein, Sylwia Flis, Grazyna Hoser, Thoralf Lange, Margaret Nieborowska-Skorska, Jacqueline Maier, Linda Kerstiens, Mateusz Koptyra, Martin C. Müller, Hardik Modi, Tomasz Stoklosa, Ilona Seferynska, Ravi Bhatia, Tessa L. Holyoake, Steffen Koschmieder, Tomasz Skorski

Blood (2013) 121 (20): 4175–4183.

https://doi.org/10.1182/blood-2012-11-466938

Published: 2013

Includes: Supplemental data

Journal Articles

Rac2-MRC-cIII–generated ROS cause genomic instability in chronic myeloid leukemia stem cells and primitive progenitors

Blood (2012) 119 (18): 4253–4263.

https://doi.org/10.1182/blood-2011-10-385658

Published: 2012

Includes: Supplemental data

Journal Articles

Targeting Rac2 - Mitochondrial Respiratory Chain Complex III Signaling to Prevent Genomic Instability in Leukemia Stem and Progenitor Cells

Blood (2011) 118 (21): 2736.

https://doi.org/10.1182/blood.V118.21.2736.2736

Published: 2011

Journal Articles

Sensitivity to Imatinib In BCR-ABL1-Positive Chronic Myeloid Leukemia Cells Depends on the Presence of Normal ABL1.

Yashodhara Dasgupta, Anna Virgili, Mateusz Koptyra, Elisabeth P. Nacheva, MD, PhD, Tomasz Skorski, MD, PhD

Blood (2010) 116 (21): 3405.

https://doi.org/10.1182/blood.V116.21.3405.3405

Published: 2010

Journal Articles

Mitochondrial Respiratory Chain Complex III Causes Genomic Instability In CML-CP.

Piotr Kopinski, Margaret Nieborowska-Skorska, MD, PhD, Grazyna Hoser, PhD, Danielle Ngaba, Regina Ray, Mateusz Koptyra, PhD, Elisabeth Bolton, Ilona Seferynska, MD, PhD, Tomasz Stoklosa, MD, PhD, Artur Slupianek, PhD, Mamatha R. Reddy, Martin Sattler, PhD, Tomasz Skorski, MD, PhD

Blood (2010) 116 (21): 1211.

https://doi.org/10.1182/blood.V116.21.1211.1211

Published: 2010

Journal Articles

BCR/ABL Requires Fanconi Anemia D2 (FANCD2) Protein to Transform Hematopoetic Stem Cells.

Tomasz Stoklosa, MD, PhD, Mateusz Koptyra, PhD, Grazyna Hoser, PhD, Ilona Seferynska, MD, PhD, Eliza Glodkowska, MD, Tomasz Skorski, MD, PhD

Blood (2009) 114 (22): 3249.

https://doi.org/10.1182/blood.V114.22.3249.3249

Published: 2009

Journal Articles

ROS-Induced DNA Damage Causing Genomic Instability in CML Stem and/or Progenitor Cells and in Quiescent and/or Proliferating Cells: Role of Mitochondrial Respiratory Chain Complex III.

Margaret Nieborowska-Skorska, Ph.D., Mateusz Koptyra, PhD, Elisabeth Bolton, Regina Ray, Danielle Ngaba, Grazyna Hoser, PhD, Tomasz Stoklosa, M.D., Ph.D., Artur Slupianek, PhD, Piotr Kopinski, Tomasz Skorski, MD, PhD

Blood (2009) 114 (22): 3268.

https://doi.org/10.1182/blood.V114.22.3268.3268

Published: 2009

Journal Articles

Mechanisms Generating free Radicals in CML Stem/Progenitor Cell Populations Causing DNA Damage and Genomic Instability

Margaret Nieborowska-Skorska, MD, PhD, Mateusz Koptyra, PhD, Grazyna Hoser, PhD, Regina Ray, Danielle Ngaba, Elisabeth Bolton, Tomasz Skorski, MD, PhD

Blood (2008) 112 (11): 192.

https://doi.org/10.1182/blood.V112.11.192.192

Published: 2008

Journal Articles

Monoubiquitination of the Fanconi Anemia D2 (FANCD2) Protein Regulates the Transforming Potential of BCR/ABL

Mateusz Koptyra, PhD, Tomasz Stoklosa, MD, PhD, Grazyna Hoser, PhD, Ilona Seferynska, MD, PhD, Eliza Glodkowska, MD, Tomasz Skorski, MD, PhD

Blood (2008) 112 (11): 3189.

https://doi.org/10.1182/blood.V112.11.3189.3189

Published: 2008

Journal Articles

Fanconi Anemia D2 (FANCD2) Is Required To Overcome Reactive Oxygen Species (ROS) - Induced DNA Double-Strand Breaks in BCR/ABL-Positive Leukemias.

Mateusz Koptyra, MS, Tomasz Skorski, MD, PhD

Blood (2006) 108 (11): 2119.

https://doi.org/10.1182/blood.V108.11.2119.2119

Published: 2006

Journal Articles

BCR/ABL kinase induces self-mutagenesis via reactive oxygen species to encode imatinib resistance

Mateusz Koptyra, Rafal Falinski, Michal O. Nowicki, Tomasz Stoklosa, Ireneusz Majsterek, Margaret Nieborowska-Skorska, Janusz Blasiak, Tomasz Skorski

Blood (2006) 108 (1): 319–327.

https://doi.org/10.1182/blood-2005-07-2815

Published: 2006

Includes: Supplemental data

Journal Articles

Fanconi Anemia D2 Protein Contributes to BCR/ABL-Mediated Transformation of Hematopoietic Cells.

Mateusz Koptyra, Scott Houghtaling, Marcus Grompe, PhD, Tomasz Skorski, MD, PhD

Blood (2005) 106 (11): 2878.

https://doi.org/10.1182/blood.V106.11.2878.2878

Published: 2005

Journal Articles

BCR/ABL oncogenic kinase promotes unfaithful repair of the reactive oxygen species–dependent DNA double-strand breaks

Michal O. Nowicki, Rafal Falinski, Mateusz Koptyra, Artur Slupianek, Tomasz Stoklosa, Ewa Gloc, Margaret Nieborowska-Skorska, Janusz Blasiak, Tomasz Skorski

Blood (2004) 104 (12): 3746–3753.

https://doi.org/10.1182/blood-2004-05-1941

Published: 2004

Journal Articles

BCR/ABL Oncogenic Kinase Promotes Unfaithful Repair of the Reactive Oxygen Species - Dependent DNA Double-Strand Breaks.

Tomasz Skorski, MD, PhD, Michal O. Nowicki, MS, Rafal Falinski, MS, Mateusz Koptyra, MS, Artur Slupianek, PhD, Tomasz Stoklosa, MD, Ewa Gloc, Margaret Nieborowska-Skorska, MD, PhD, Janusz Blasiak, PhD

Blood (2004) 104 (11): 712.

https://doi.org/10.1182/blood.V104.11.712.712

Published: 2004

Journal Articles

BCR/ABL Oncogenic Kinase Stimulates DNA Oxidative Damage To Induce Self-Mutagenesis Causing Resistance to Imatinib Mesylate.

Mateusz Koptyra, MS, Rafal Falinski, MS, Michal O. Nowicki, MS, Janusz Blasiak, PhD, Tomasz Skorski, MD, PhD

Blood (2004) 104 (11): 714.

https://doi.org/10.1182/blood.V104.11.714.714

Published: 2004

NARROW

Normal ABL1 is a tumor suppressor and therapeutic target in human and mouse leukemias expressing oncogenic ABL1 kinases

Normal ABL1 Is a Tumor Suppressor and Therapeutic Target In BCR-ABL1–positive Leukemias

Genomic instability may originate from imatinib-refractory chronic myeloid leukemia stem cells

Rac2-MRC-cIII–generated ROS cause genomic instability in chronic myeloid leukemia stem cells and primitive progenitors

Targeting Rac2 - Mitochondrial Respiratory Chain Complex III Signaling to Prevent Genomic Instability in Leukemia Stem and Progenitor Cells

Sensitivity to Imatinib In BCR-ABL1-Positive Chronic Myeloid Leukemia Cells Depends on the Presence of Normal ABL1.

Mitochondrial Respiratory Chain Complex III Causes Genomic Instability In CML-CP.

BCR/ABL Requires Fanconi Anemia D2 (FANCD2) Protein to Transform Hematopoetic Stem Cells.

ROS-Induced DNA Damage Causing Genomic Instability in CML Stem and/or Progenitor Cells and in Quiescent and/or Proliferating Cells: Role of Mitochondrial Respiratory Chain Complex III.

Mechanisms Generating free Radicals in CML Stem/Progenitor Cell Populations Causing DNA Damage and Genomic Instability

Monoubiquitination of the Fanconi Anemia D2 (FANCD2) Protein Regulates the Transforming Potential of BCR/ABL

Fanconi Anemia D2 (FANCD2) Is Required To Overcome Reactive Oxygen Species (ROS) - Induced DNA Double-Strand Breaks in BCR/ABL-Positive Leukemias.

BCR/ABL kinase induces self-mutagenesis via reactive oxygen species to encode imatinib resistance

Fanconi Anemia D2 Protein Contributes to BCR/ABL-Mediated Transformation of Hematopoietic Cells.

BCR/ABL oncogenic kinase promotes unfaithful repair of the reactive oxygen species–dependent DNA double-strand breaks

BCR/ABL Oncogenic Kinase Promotes Unfaithful Repair of the Reactive Oxygen Species - Dependent DNA Double-Strand Breaks.

BCR/ABL Oncogenic Kinase Stimulates DNA Oxidative Damage To Induce Self-Mutagenesis Causing Resistance to Imatinib Mesylate.

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American Society of Hematology

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American Society of Hematology

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