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Journal Articles

Simultaneous Inhibition of BCR-ABL1 Tyrosine Kinase and PAK1/2 Serine/Threonine Kinases Exerts Synergistic Effect Against Chronic Myeloid Leukemia Cells

Sylwia Flis, Ewelina Bratek, Tomasz Chojnacki, Marlena Piskorek, Tomasz Skorski, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4143.
https://doi.org/10.1182/blood-2019-129093
Published: 2019
Journal Articles

Ruxolitinib-induced defects in DNA repair cause sensitivity to PARP inhibitors in myeloproliferative neoplasms

Margaret Nieborowska-Skorska, Silvia Maifrede, Yashodhara Dasgupta, Katherine Sullivan, Sylwia Flis, Bac Viet Le, Martyna Solecka, Elizaveta A. Belyaeva, Lucia Kubovcakova, Morgan Nawrocki, Martin Kirschner, Huaqing Zhao, Josef T. Prchal, Katarzyna Piwocka, Alison R. Moliterno, Mariusz Wasik, Steffen Koschmieder, Tony R. Green, Radek C. Skoda, Tomasz Skorski
Journal: Blood
Blood (2017) 130 (26): 2848–2859.
https://doi.org/10.1182/blood-2017-05-784942
Published: 2017
Includes: Supplemental data
Journal Articles

Chronic Myeloid Leukemia Stem Cells (LSCs) and Leukemia Progenitor Cells (LPCs) Display Overlapping and Unique Mechanisms of Genomic Instability: The Role of PI3k-AKT and PI3k-Rac2-PAK Pathways

Margaret Nieborowska-Skorska, MD PhD, Sylwia Flis, PhD, Tomasz Skorski, MD PhD
Journal: Blood
Blood (2014) 124 (21): 1791.
https://doi.org/10.1182/blood.V124.21.1791.1791
Published: 2014
Journal Articles

Genomic instability may originate from imatinib-refractory chronic myeloid leukemia stem cells

Elisabeth Bolton-Gillespie, Mirle Schemionek, Hans-Ulrich Klein, Sylwia Flis, Grazyna Hoser, Thoralf Lange, Margaret Nieborowska-Skorska, Jacqueline Maier, Linda Kerstiens, Mateusz Koptyra, Martin C. Müller, Hardik Modi, Tomasz Stoklosa, Ilona Seferynska, Ravi Bhatia, Tessa L. Holyoake, Steffen Koschmieder, Tomasz Skorski
Journal: Blood
Blood (2013) 121 (20): 4175–4183.
https://doi.org/10.1182/blood-2012-11-466938
Published: 2013
Includes: Supplemental data
Journal Articles

BCR-ABL1 Kinase Inhibits DNA Glycosylases to Enhance Oxidative DNA Damage and Stimulate Genomic Instability

Artur Slupianek, PhD, Rafal Falinski, PhD, Pawel Znojek, Tomasz Stoklosa, MD, PhD, Sylwia Flis, Valentina Doneddu, Ewelina Synowiec, Janusz Blasiak, Alfonso Bellacosa, Tomasz Skorski, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 520.
https://doi.org/10.1182/blood.V120.21.520.520
Published: 2012
Journal Articles

Genomic Instability in CML-CP originates From the Most Primitive Imatinib-Refractory Leukemia Stem Cells

Elisabeth Bolton, Mirle Schemionek, PhD, Hans-Urlich Klein, Grazyna Hoser, PhD, Sylwia Flis, Thoralf Lange, Linda Kerstiens, Margaret Nieborowska-Skorska, MD, PhD, Martin C. Müller, MD, Hardik Modi, Ravi Bhatia, MD, Steffen Koschmieder, MD, Tomasz Skorski, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 909.
https://doi.org/10.1182/blood.V120.21.909.909
Published: 2012
Journal Articles

Rac2-MRC-cIII–generated ROS cause genomic instability in chronic myeloid leukemia stem cells and primitive progenitors

Margaret Nieborowska-Skorska, Piotr K. Kopinski, Regina Ray, Grazyna Hoser, Danielle Ngaba, Sylwia Flis, Kimberly Cramer, Mamatha M. Reddy, Mateusz Koptyra, Tyrone Penserga, Eliza Glodkowska-Mrowka, Elisabeth Bolton, Tessa L. Holyoake, Connie J. Eaves, Sabine Cerny-Reiterer, Peter Valent, Andreas Hochhaus, Timothy P. Hughes, Heiko van der Kuip, Martin Sattler, Wieslaw Wiktor-Jedrzejczak, Christine Richardson, Adrienne Dorrance, Tomasz Stoklosa, David A. Williams, Tomasz Skorski
Journal: Blood
Blood (2012) 119 (18): 4253–4263.
https://doi.org/10.1182/blood-2011-10-385658
Published: 2012
Includes: Supplemental data
Journal Articles

Targeting Rac2 - Mitochondrial Respiratory Chain Complex III Signaling to Prevent Genomic Instability in Leukemia Stem and Progenitor Cells

Margaret Nieborowska-Skorska, MD, PhD, Piotr Kopinski, Regina Ray, Grazyna Hoser, PhD, Danielle Ngaba, Sylwia Flis, Kimberly Cramer, Mamatha M. Reddy, PhD, Mateusz Koptyra, PhD, Tyrone Penserga, Eliza Glodkowska-Mrowka, MD, Magdalena Ambrozek, Ilona Seferynska, MD, PhD, Joanna Niesiobedzka-Krezel, MD, Elisabeth Bolton, Artur Slupianek, PhD, Tessa L. Holyoake, PhD, FRCP, FRCPath, Connie J. Eaves, PhD, Sabine Cerny-Reiterer, D.V.M., Peter Valent, M.D., Andreas Hochhaus, MD, Timothy P. Hughes, MD, MBBS, Heiko van der Kuip, Martin Sattler, PhD, Wieslaw Wiktor-Jedrzejczak, MD, PhD, Christine Richardson, PhD, Adrienne M. Dorrance, PhD, Tomasz Stoklosa, MD, PhD, David A. Williams, MD, Tomasz Skorski, MD, PhD
Journal: Blood
Blood (2011) 118 (21): 2736.
https://doi.org/10.1182/blood.V118.21.2736.2736
Published: 2011
Journal Articles

Targeting DNA Repair Gene, RAD52, Induces Exhaustion of the Proliferating CML-CP Leukemia Stem Cells Carrying Oxidative DNA Damage

Kimberly Cramer, Elisabeth Bolton, Margaret Nieborowska-Skorska, MD, PhD, Sylwia Flis, Tomasz Skorski, MD, PhD
Journal: Blood
Blood (2011) 118 (21): 447.
https://doi.org/10.1182/blood.V118.21.447.447
Published: 2011