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Heiko van der Kuip
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Journal Articles

Cyclin D1 Driven CDK4 Activity Is Responsible for Hypersensitivity to NOXA Inducing Combination Treatment in Mantle Cell Lymphoma (MCL) Cells

Simon Heine, MSc, Elisabeth Silkenstedt, MD, Michael A Dengler, PhD, Kleih Markus, MSc, German Ott, MD, Neus Giménez Carabaza, B.Pharm, Colomer Dolors, PhD, Heiko van der Kuip, PhD, Walter E. Aulitzky, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2811.
https://doi.org/10.1182/blood.V130.Suppl_1.2811.2811
Published: 2017
Journal Articles

Notch1 Signaling in NOTCH1 -Mutated Mantle Cell Lymphoma Depends on DLL4 and Is a Potential Target for Specific Antibody Therapy

Elisabeth Höring, MD, Berta Colom Sanmarti, Silvia Xargay-Torrent, PhD, Walter E Aulitzky, MD, Heiko van der Kuip, PhD, Elias Campo, Mónica López-Guerra, PhD, Dolors Colomer, PhD
Journal: Blood
Blood (2016) 128 (22): 1846.
https://doi.org/10.1182/blood.V128.22.1846.1846
Published: 2016
Journal Articles

Normal ABL1 is a tumor suppressor and therapeutic target in human and mouse leukemias expressing oncogenic ABL1 kinases

Yashodhara Dasgupta, Mateusz Koptyra, Grazyna Hoser, Kanchan Kantekure, Darshan Roy, Barbara Gornicka, Margaret Nieborowska-Skorska, Elisabeth Bolton-Gillespie, Sabine Cerny-Reiterer, Markus Müschen, Peter Valent, Mariusz A. Wasik, Christine Richardson, Oliver Hantschel, Heiko van der Kuip, Tomasz Stoklosa, Tomasz Skorski
Journal: Blood
Blood (2016) 127 (17): 2131–2143.
https://doi.org/10.1182/blood-2015-11-681171
Published: 2016
Includes: Supplemental data
Journal Articles

Dual Targeting of NOXA/MCL-1 Synergistically Induces Cell Death in Mantle Cell Lymphoma (MCL) Cells

Elisabeth Höring, German Ott, MD, Christine Bayha, Kleih Markus, Matthias C. Voehringer, MD, Heiko van Der Kuip, Walter E. Aulitzky, MD
Journal: Blood
Blood (2015) 126 (23): 2757.
https://doi.org/10.1182/blood.V126.23.2757.2757
Published: 2015
Journal Articles

The Phenotype High Noxa mRNA/Low NOXA Protein Levels Constitutes a Critical Achilles Heel Of Mantle Cell Lymphoma (MCL) Cells

Michael A. Dengler, Andrea Weilbacher, Matthias Gutekunst, Annette M. Staiger, Heike Horn, German Ott, MD, Heiko van der Kuip, Walter E. Aulitzky
Journal: Blood
Blood (2013) 122 (21): 644.
https://doi.org/10.1182/blood.V122.21.644.644
Published: 2013
Journal Articles

Rac2-MRC-cIII–generated ROS cause genomic instability in chronic myeloid leukemia stem cells and primitive progenitors

Margaret Nieborowska-Skorska, Piotr K. Kopinski, Regina Ray, Grazyna Hoser, Danielle Ngaba, Sylwia Flis, Kimberly Cramer, Mamatha M. Reddy, Mateusz Koptyra, Tyrone Penserga, Eliza Glodkowska-Mrowka, Elisabeth Bolton, Tessa L. Holyoake, Connie J. Eaves, Sabine Cerny-Reiterer, Peter Valent, Andreas Hochhaus, Timothy P. Hughes, Heiko van der Kuip, Martin Sattler, Wieslaw Wiktor-Jedrzejczak, Christine Richardson, Adrienne Dorrance, Tomasz Stoklosa, David A. Williams, Tomasz Skorski
Journal: Blood
Blood (2012) 119 (18): 4253–4263.
https://doi.org/10.1182/blood-2011-10-385658
Published: 2012
Includes: Supplemental data
Journal Articles

Targeting Rac2 - Mitochondrial Respiratory Chain Complex III Signaling to Prevent Genomic Instability in Leukemia Stem and Progenitor Cells

Margaret Nieborowska-Skorska, MD, PhD, Piotr Kopinski, Regina Ray, Grazyna Hoser, PhD, Danielle Ngaba, Sylwia Flis, Kimberly Cramer, Mamatha M. Reddy, PhD, Mateusz Koptyra, PhD, Tyrone Penserga, Eliza Glodkowska-Mrowka, MD, Magdalena Ambrozek, Ilona Seferynska, MD, PhD, Joanna Niesiobedzka-Krezel, MD, Elisabeth Bolton, Artur Slupianek, PhD, Tessa L. Holyoake, PhD, FRCP, FRCPath, Connie J. Eaves, PhD, Sabine Cerny-Reiterer, D.V.M., Peter Valent, M.D., Andreas Hochhaus, MD, Timothy P. Hughes, MD, MBBS, Heiko van der Kuip, Martin Sattler, PhD, Wieslaw Wiktor-Jedrzejczak, MD, PhD, Christine Richardson, PhD, Adrienne M. Dorrance, PhD, Tomasz Stoklosa, MD, PhD, David A. Williams, MD, Tomasz Skorski, MD, PhD
Journal: Blood
Blood (2011) 118 (21): 2736.
https://doi.org/10.1182/blood.V118.21.2736.2736
Published: 2011
Journal Articles

Cyclin D1 Over-Expressing Mantle Cell Lymphoma Cells Are Hypersensitive to Inhibition of Fatty Acid Synthase (FASN)

Michael A. Dengler, Matthias Gutekunst, Stephanie Kopacz, Heike Horn, Ute Hofmann, Matthias Schwab, German Ott, MD, Heiko van der Kuip, Walter E. Aulitzky
Journal: Blood
Blood (2011) 118 (21): 1656.
https://doi.org/10.1182/blood.V118.21.1656.1656
Published: 2011
Journal Articles

Glucocorticoids Inhibit Cell Death Induced by Oncogenic Stress After Imatinib Withdrawal In TKI Resistant p190Bcr/Abl Overexpressing Cells

Michael A. Dengler, Annette M. Staiger, Ute Hofmann, Matthias Gutekunst, Heiko van der Kuip, Walter E. Aulitzky, MD
Journal: Blood
Blood (2010) 116 (21): 3150.
https://doi.org/10.1182/blood.V116.21.3150.3150
Published: 2010
Journal Articles

Combination of Imatinib with Cisplatin and Nutlin-3: Functional and Molecular Effects on Bcr-Abl Positive Cells.

Ioanna Skorta, Heiko van der Kuip, Martin Henkes, Moshe Oren, Walter E. Aulitzky
Journal: Blood
Blood (2007) 110 (11): 2954.
https://doi.org/10.1182/blood.V110.11.2954.2954
Published: 2007
Journal Articles

Dominant Negative Effect of Kinase-Inactive Bcr-Abl on Cell Survival and DNA Damage Response Pathways in Imatinib-Treated Cells.

Heiko van der Kuip, PhD, Fabienne Fiesel, Alexandra Moehring, Walter E. Aulitzky, MD
Journal: Blood
Blood (2005) 106 (11): 2887.
https://doi.org/10.1182/blood.V106.11.2887.2887
Published: 2005
Journal Articles

A cell-based screen for resistance of Bcr-Abl-positive leukemia identifies the mutation pattern for PD166326, an alternative Abl kinase inhibitor

Nikolas von Bubnoff, Darren R. Veach, Heiko van der Kuip, Walter E. Aulitzky, Jana Sänger, Petra Seipel, William G. Bornmann, Christian Peschel, Bayard Clarkson, Justus Duyster
Journal: Blood
Blood (2005) 105 (4): 1652–1659.
https://doi.org/10.1182/blood-2004-06-2445
Published: 2005
Journal Articles

Repeated Application of Sequence-Specific SiRNA Molecules Leads to an Effective Downmodulation of All Clinically Relevant bcr-abl Gene Variants.

Lara Wohlbold, Heiko van der Kuip, Alexandra Moehring, Galit Granot, Dr, Moshe Oren, Prof Dr, Hans-Peter Vornlocher, Dr, Walter E. Aulitzky
Journal: Blood
Blood (2004) 104 (11): 4319.
https://doi.org/10.1182/blood.V104.11.4319.4319
Published: 2004
Journal Articles

A Cell-Based Screening Method for Resistance of Bcr-Abl Positive Leukemia Identifies the Mutation Pattern for an Alternative Abl Kinase Inhibitor.

Nikolas von Bubnoff, M.D., Darren R. Veach, Ph.D., Heiko van der Kuip, Ph.D., Walter E. Aulitzky, M.D., Jana Saenger, Petra Seipel, William G. Bornmann, Ph.D., Christian Peschel, M.D., Bayard Clarkson, M.D., Justus Duyster, M.D.
Journal: Blood
Blood (2004) 104 (11): 558.
https://doi.org/10.1182/blood.V104.11.558.558
Published: 2004
Journal Articles

Inhibition of bcr-abl gene expression by small interfering RNA sensitizes for imatinib mesylate (STI571)

Brief Report
Lara Wohlbold, Heiko van der Kuip, Cornelius Miething, Hans-Peter Vornlocher, Cornelius Knabbe, Justus Duyster, Walter E. Aulitzky
Journal: Blood
Blood (2003) 102 (6): 2236–2239.
https://doi.org/10.1182/blood-2002-12-3899
Published: 2003
Journal Articles

Adhesion to fibronectin selectively protects Bcr-Abl + cells from DNA damage–induced apoptosis

Heiko van der Kuip, Alexander W. Goetz, Cornelius Miething, Justus Duyster, Walter E. Aulitzky
Journal: Blood
Blood (2001) 98 (5): 1532–1541.
https://doi.org/10.1182/blood.V98.5.1532
Published: 2001
Journal Articles

Bcr-Abl kinase down-regulates cyclin-dependent kinase inhibitor p27 in human and murine cell lines

Tarja Jonuleit, Heiko van der Kuip, Cornelius Miething, Heike Michels, Michael Hallek, Justus Duyster, Walter E. Aulitzky
Journal: Blood
Blood (2000) 96 (5): 1933–1939.
https://doi.org/10.1182/blood.V96.5.1933
Published: 2000